Abstract：
:The objective of this study was to analyze the role of adjuvant chemotherapy and prognostic factors in malignant mucosal melanoma of the head and neck (HNMM). Thirty-two patients with mucosal melanoma of the head and neck who received local treatment with or without adjuvant chemotherapy were reviewed. Clinicopathologic parameters including anatomic sites, gender, age (60 vs.>60years), stage, level of invasion, p53 and MDM2 [murine double minute 2] expressions, performance status, and adjuvant chemotherapy were evaluated. The patients' median age was 62years, and 16 (50%) received adjuvant chemotherapy. Expressions of p53 and MDM2 were demonstrated in six of 24 and three of 26 cases, respectively. Predictors of poor survival according to univariate analysis were level of invasion and anatomic location of the primary tumor. Patients who received adjuvant chemotherapy had prolonged survival (p=0.002), which was also shown in the multivariate Cox regression model (HR, 0.24; p=0.014). Our analysis suggests a significant role of adjuvant chemotherapy and different patterns of p53 and MDM2 expression in HNMM relative to cutaneous melanomas. However, since this study is retrospective and observational, with a small sample size, further studies are needed to confirm the definitive role of adjuvant chemotherapy in the treatment of malignant mucosal melanoma of the head and neck.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Ahn HJ,Na II,Park YH,Cho SY,Lee BC,Lee GH,Koh JS,Lee YS,Shim YS,Kim YK,Kang HJ,Ryoo BY,Yang SHdoi
10.1016/j.oraloncology.2010.05.005subject
Has Abstractpub_date
2010-08-01 00:00:00pages
607-11issue
8eissn
1368-8375issn
1879-0593pii
S1368-8375(10)00167-3journal_volume
46pub_type
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