Abstract：
:In this study, we focused on p53 mutations in specific regions, including DNA-binding surface regions, to clarify the correlation between mutations within the specific regions of p53 and clinical outcomes of patients with oral cancers. We analyzed p53 mutations in 121 fresh primary oral squamous cell carcinomas (SCCs) by polymerase chain reaction-single-strand conformation polymorphism or a yeast functional assay. p53 mutations were detected in 51/121 (42%) cases. Mutation of p53 was not associated with any clinicopathological parameters; however, tumors containing specific p53 mutations, e.g. DNA-binding surface regions (L2, L3 and the LSH motif) and conserved regions (II-V), had significantly poorer prognoses than tumors with mutations outside of those regions. Moreover, locoregional failure, lymph node metastasis and the occurrence of subsequent distant metastasis were also significantly associated with mutations within DNA-binding surface regions. These data indicate that specific mutations of p53 could be important prognostic factors in oral SCCs.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Yamazaki Y,Chiba I,Hirai A,Sugiura C,Notani K,Kashiwazaki H,Tei K,Totsuka Y,Fukuda Hdoi
10.1016/s1368-8375(02)00064-7subject
Has Abstractpub_date
2003-02-01 00:00:00pages
163-9issue
2eissn
1368-8375issn
1879-0593pii
S1368837502000647journal_volume
39pub_type
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