The challenge of blocking a wider family members of EGFR against head and neck squamous cell carcinomas.

abstract：OBJECTIVES:Examine the effect of concordance between p16 overexpression and HR (high risk) HPV DNA status on overall survival in a large series of oropharyngeal squamous cell carcinoma (OPSCC) cases. MATERIALS AND METHODS:A total of 185 patients with primary OPSCC had genomic DNA tested by PCR for the HPV16 E6 and E7 ...

journal_title：Oral oncology

authors： Liu SZ,Zandberg DP,Schumaker LM,Papadimitriou JC,Cullen KJ

更新日期：2015-09-01 00:00:00

abstract：:Solitary fibrous tumor is an uncommon neoplasm with unpredictable clinical behavior. Malignant solitary fibrous tumor is a rare morphological variant with more aggressive behavior and higher rates of local recurrences and distant metastasis, exceeding rare in oral cavity; our case occurred in the floor of the mouth in...

journal_title：Oral oncology

authors： Iorio B,Ronchi A,Montella M,Cozzolino I,De Luca R,Rusciano M,Tartaro G,Colella G,Franco R

更新日期：2019-03-01 00:00:00

abstract：:To assess the prognostic value of apoptosis, proliferation and clinical factors in squamous cell carcinoma of the oropharynx after radical surgery and postoperative radiotherapy (RT). Between 1985 and 1995, a total of 82 patients with 84 tumors were entered onto the study. Forty-two primary tumors (50%) involved the t...

journal_title：Oral oncology

authors： Grabenbauer GG,Suckorada O,Niedobitek G,Rödel F,Iro H,Sauer R,Rödel C,Schultze-Mosgau S,Distel L

更新日期：2003-07-01 00:00:00

abstract：:Bisphosphonates (BP) have been associated with the occurrence of osteonecrosis of the jaw (ONJ), possibly by causing an excessive bone turnover inhibition. However, little in vivo evidence exists to support this theory. The (99m)Tc-medronate scintigrams of patients with skeletal metastases and BP use (n=40) were indiv...

journal_title：Oral oncology

authors： Van den Wyngaert T,Huizing MT,Fossion E,Vermorken JB

更新日期：2010-03-01 00:00:00

abstract：:To describe outcome and prognostic factors in a national Danish series of patients treated for salivary gland carcinoma. From three Danish nation-wide registries and supplementary patient records, 871 patients diagnosed with primary major or minor salivary gland carcinoma in the period from 1990 to 2005 were identifie...

journal_title：Oral oncology

authors： Bjørndal K,Krogdahl A,Therkildsen MH,Overgaard J,Johansen J,Kristensen CA,Homøe P,Sørensen CH,Andersen E,Bundgaard T,Primdahl H,Lambertsen K,Andersen LJ,Godballe C

更新日期：2012-02-01 00:00:00

abstract：:Metallothioneins (MTs) are a family of low molecular weight, cysteine-rich, inducible, intracellular proteins that bind heavy metals with high affinity. MT-1 is known as a stress-inducible protein and functions as an antioxidant enzyme. Areca quid chewing is a major risk factor in the development and further progressi...

journal_title：Oral oncology

authors： Lee SS,Yang SF,Ho YC,Tsai CH,Chang YC

更新日期：2008-02-01 00:00:00

abstract：:We performed a meta-analysis to evaluate the role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)FDG-PET/CT) in detecting distant metastases and second primary cancers in patients with head and neck cancer (HNC) at staging. Studies about (18)FDG-PET/CT for detecting distant metastase...

journal_title：Oral oncology

authors： Xu GZ,Guan DJ,He ZY

更新日期：2011-07-01 00:00:00

abstract：:This hospital-based cohort study evaluated the efficacy of three Epstein-Barr virus (EBV) - associated assays for nasopharyngeal carcinoma (NPC) primary screening and monitoring treatment outcome. Five hundred and seventeen consecutive subjects, including 156 NPC patients, 264 healthy volunteers and 97 patients with h...

journal_title：Oral oncology

authors： Chang KP,Hsu CL,Chang YL,Tsang NM,Chen CK,Lee TJ,Tsao KC,Huang CG,Chang YS,Yu JS,Hao SP

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:To report oncologic outcomes of patients with paranasal sinus cancer (PNSC) treated by surgery and radiotherapy or (chemo)radiation and to investigate the impact of improving the radiation technique on outcomes and toxicity. MATERIALS AND METHODS:Between 1999 and 2010, 82 consecutive patients with PNSC were...

journal_title：Oral oncology

authors： Al-Mamgani A,Monserez D,Rooij Pv,Verduijn GM,Hardillo JA,Levendag PC

更新日期：2012-09-01 00:00:00

abstract：:The recently identified single nucleotide polymorphism in the MDM2 promoter (SNP 309) may contribute to the early onset of both sporadic and hereditary malignancies in patients with defective p53. We tested this hypothesis by examining the effects of combined MDM2 polymorphisms and somatic p53 mutations on 351 oral sq...

journal_title：Oral oncology

authors： Huang SF,Chen IH,Liao CT,Wang HM,Liou SH,Hsieh LL

更新日期：2009-01-01 00:00:00

abstract：:There is relatively little data on salivary gland hypofunction (SGH) in patients with advanced cancer. The aim of the current study was to investigate the epidemiology, aetiology, and clinical features of SGH in this group of patients. The protocol involved completion of standard proforma, completion of a Memorial Sym...

journal_title：Oral oncology

authors： Davies AN,Broadley K,Beighton D

更新日期：2002-10-01 00:00:00

abstract：:The role of chemotherapy (CHX) in squamous cell carcinoma of the head and neck (SCCHN) has been expanding. Although combination chemotherapy regimens regularly produce significantly high response rates, meta-analyses show little benefit regarding final outcome. One way to improve induction CHX is to improve drug combi...

journal_title：Oral oncology

authors： Sasaki Y,Kjellén E,Ekblad L,Wahlberg P,Mineta H,Wennerberg J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Oral mucositis is a major event increasing treatment costs of head and neck squamous cell carcinoma (HNSCC) patients treated with chemoradiation (CRT). This study was designed to estimate the cost-effectiveness of low-level laser therapy (LLLT) to prevent oral mucositis in HNSCC patients receiving CRT. METH...

journal_title：Oral oncology

authors： Antunes HS,Schluckebier LF,Herchenhorn D,Small IA,Araújo CM,Viégas CM,Rampini MP,Ferreira EM,Dias FL,Teich V,Teich N,Ferreira CG

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Nasopharyngeal carcinoma (NPC) is common in Southeast Asia. Due to the influx of immigrants from this region, the incidence in British Columbia is increasing. Current literature from non-endemic populations encompasses heterogeneous cohorts. This study examines NPC in a North American population, with a high ...

journal_title：Oral oncology

authors： Howlett J,Hamilton S,Ye A,Jewett D,Riou-Green B,Prisman E,Thamboo A

更新日期：2021-01-24 00:00:00

abstract：:In this study, we focused on p53 mutations in specific regions, including DNA-binding surface regions, to clarify the correlation between mutations within the specific regions of p53 and clinical outcomes of patients with oral cancers. We analyzed p53 mutations in 121 fresh primary oral squamous cell carcinomas (SCCs)...

journal_title：Oral oncology

authors： Yamazaki Y,Chiba I,Hirai A,Sugiura C,Notani K,Kashiwazaki H,Tei K,Totsuka Y,Fukuda H

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:The chemokine receptor CCR7 is expressed on lymphocytes and dendritic cells and is responsible for trafficking of these cells in and out of secondary lymphoid organs. It has recently been shown that CCR7 expression is elevated in a number of cancers, including head and neck cancers, and that its expression c...

journal_title：Oral oncology

authors： Basheer HA,Pakanavicius E,Cooper PA,Shnyder SD,Martin L,Hunter KD,Vinader V,Afarinkia K

更新日期：2018-05-01 00:00:00

abstract：:Clear cell tumours, in the head and neck region, are usually derived from salivary or odontogenic tissues, or may be metastatic. A few clear cells may be present in odontogenic cysts, while, odontogenic neoplasms composed predominantly of clear cells are quite rare. They include calcifying epithelial odontogenic tumou...

journal_title：Oral oncology

authors： Iezzi G,Rubini C,Fioroni M,Piattelli A

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVES:While surgery with or without adjuvant radiation therapy (RT) is the standard of care for oral cavity cancer (OCC), a select group requires nonsurgical treatment. We provide a single-institution experience using definitive chemotherapy and RT for primary OCC. MATERIALS AND METHODS:We examined 73 patients wi...

journal_title：Oral oncology

authors： Scher ED,Romesser PB,Chen C,Ho F,Wuu Y,Sherman EJ,Fury MG,Wong RJ,McBride S,Lee NY,Riaz N

更新日期：2015-07-01 00:00:00

abstract：:To determine the aesthetic and functional outcomes of the most invasive approach to oral cavity/oropharyngeal lesions, the lip-splitting mandibulotomy approach (LSMA), versus the least invasive, the trans-oral approach (TOA). Retrospective paired-cohort study. Thirty-six patients with oral/oropharyngeal cancers treate...

journal_title：Oral oncology

authors： Dziegielewski PT,O'Connell DA,Rieger J,Harris JR,Seikaly H

更新日期：2010-08-01 00:00:00

abstract：:This study was aimed at estimating the pooled global leukoplakia prevalence using both well-designed studies, which were too few to be representative of the world situation, and less valuable studies. The inverse variance weighting and the random effect methods were used. The latter is based on the principle that if p...

journal_title：Oral oncology

authors： Petti S

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:To identify predictors of unplanned hospitalization and emergency department (ED) use among head and neck oncology patients. METHODS:Peer reviewed publications were identified through a systematic search of MEDLINE, Embase and Cochrane CENTRAL. Studies describing a cohort of HNC patients that detailed predic...

journal_title：Oral oncology

authors： Noel CW,Forner D,Wu V,Enepekides D,Irish JC,Husain Z,Chan KKW,Hallet J,Coburn N,Eskander A

更新日期：2020-12-01 00:00:00

abstract：:Betel quid, cigarettes and alcohol are well-recognized risk factors for oral cancer. However, the combined effect of the frequency and duration of these oral habits on the risk for developing oral pre-malignancies among betel quid users has not been fully addressed. In this study, an oral screening programme for men c...

journal_title：Oral oncology

authors： Yen AM,Chen SC,Chen TH

更新日期：2007-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSC...

journal_title：Oral oncology

authors： Lin SC,Liu CJ,Lin JA,Chiang WF,Hung PS,Chang KW

更新日期：2010-03-01 00:00:00

abstract：:Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial-mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal-epithelial transition (MET). Such changes allow the tumor to c...

journal_title：Oral oncology

authors： Zhou C,Liu J,Tang Y,Liang X

更新日期：2012-11-01 00:00:00

abstract：:Oral leukoplakia is the most prevalent and potentially malignant disorder of the oral mucosa. Previous studies have demonstrated that molecular changes of the WWOX gene (WW-domain containing oxidoreductase), a candidate tumor suppressor gene located at 16q23.3-24.1 that spans FRA16D, the second most common fragile sit...

journal_title：Oral oncology

authors： Pimenta FJ,Cordeiro GT,Pimenta LG,Viana MB,Lopes J,Gomez MV,Aldaz CM,De Marco L,Gomez RS

更新日期：2008-08-01 00:00:00

abstract：:Oral cancer models have attempted to demonstrate inhibition of oral carcinogenesis. These models used synthetic carcinogens, lacked a specific mechanism of activity or used non-physiologic doses for carcinogen or inhibitor. To correct these problems the tobacco and environmental carcinogen, dibenzo[a,l]pyrene (DB[a,l]...

journal_title：Oral oncology

authors： Schwartz J,Baker V,Larios E,Desai D,Amin S

更新日期：2004-07-01 00:00:00

abstract：:Cancer of the oropharynx has attracted considerable attention in recent years given: (1) an increasing incidence in selected populations over the past three decades; (2) the discovery of human papillomavirus (HPV) infection as the driver of the increase, as opposed to the traditional risk factors such as tobacco (smok...

journal_title：Oral oncology

authors： Kreimer AR,Chaturvedi AK,Alemany L,Anantharaman D,Bray F,Carrington M,Doorbar J,D'Souza G,Fakhry C,Ferris RL,Gillison M,Neil Hayes D,Hildesheim A,Huang SH,Kowalski LP,Lang Kuhs KA,Lewis J Jr,Lowy DR,Mehanna H,Ness A

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:The function of NOTCH signaling (oncogenic or oncosuppressive) remains controversial in head and neck squamous cell carcinomas (HNSCC). The purpose of this work is to investigate the role of NOTCH pathway in HNSCC prognosis. METHODS:Immunohistochemical NOTCH1 and HES1 expression was jointly evaluated and co...

journal_title：Oral oncology

authors： Grilli G,Hermida-Prado F,Álvarez-Fernández M,Allonca E,Álvarez-González M,Astudillo A,Moreno-Bueno G,Cano A,García-Pedrero JM,Rodrigo JP

更新日期：2020-11-01 00:00:00

abstract：:Oral and pharyngeal cancer (OC) mortality is very low in Greece, especially among men, compared to other European countries. We conducted a case-control study of OC in Athens, and obtained information on tobacco, alcohol use and other potential risk factors and confounding variables for 110 incident cases and 115 hosp...

journal_title：Oral oncology

authors： Zavras AI,Douglass CW,Joshipura K,Wu T,Laskaris G,Petridou E,Dokianakis G,Segas J,Lefantzis D,Nomikos P,Wang YF,Diehl SR

更新日期：2001-01-01 00:00:00

abstract：:The present investigation has examined the clinical benefits of tobramycin, polymyxin E and amphotericin therapy in the management of oral mucositis in children undergoing chemotherapy prior to bone marrow transplantation. Tobramycin, polymyxin E, and amphotericin reduced the degree of oral mucositis more than convent...

journal_title：Oral oncology

authors： Bondi E,Baroni C,Prete A,Gatti M,Carrassi A,Lodi G,Porter SR

更新日期：1997-09-01 00:00:00