miR-24 up-regulation in oral carcinoma: positive association from clinical and in vitro analysis.

abstract：:In this study conducted amongst Indian male tobacco users with upper aero-digestive tract (UADT) squamous carcinoma, 30 patients with multiple primary neoplasms (MPN) were compared with 28 age and sex matched patients with a single primary neoplasm (SPN) for various environmental factors (form of tobacco use, alcohol,...

journal_title：Oral oncology

authors： Jhavar S,Sarin R,Mulherkar R,Benner A,Agarwal JP,Dinshaw K

更新日期：2004-01-01 00:00:00

abstract：:The purpose of this study was to assess the accuracy of this tissue staining assessment of surgical specimens in delineating deep surgical margins in oral cancer surgery. Fifteen patients who underwent surgery for oral carcinoma were included in the study. Once the tumor was resected, a vertical section of the surgica...

journal_title：Oral oncology

authors： Kurita H,Sakai H,Kamata T,Koike T,Kobayashi H,Kurashina K

更新日期：2008-10-01 00:00:00

abstract：:Histological assessment is an essential tool in the diagnosis and guidance of the treatment of various diseases, in particular cancer, of the head and neck. Recent major advances in optical imaging techniques have made it possible to acquire high-resolution in vivo images at the cellular scale. Confocal endomicroscopy...

journal_title：Oral oncology

authors： Abbaci M,Breuskin I,Casiraghi O,De Leeuw F,Ferchiou M,Temam S,Laplace-Builhé C

更新日期：2014-08-01 00:00:00

abstract：:Mel-CAM (CD146) is a cell-cell adhesion protein found in normal and tumoral tissues. The aim of this study was to analyse Mel-CAM expression in mucoepidermoid carcinoma (MEC), and assess its importance in prognosis and its utility in differentiating high-grade MEC from squamous cell carcinoma (SCC). Immunohistochemica...

journal_title：Oral oncology

authors： Pires FR,Shih IeM,da Cruz Perez DE,de Almeida OP,Kowalski LP

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor account for 1-2% of thyroid cancer. In this study, we aim to examine the characteristics and survival of patients with MTC. METHODS:A retrospective cohort study utilizing the National Cancer Data Base, 2004-2014. The study population included adult...

journal_title：Oral oncology

authors： Al-Qurayshi Z,Khadra H,Chang K,Pagedar N,Randolph GW,Kandil E

更新日期：2018-08-01 00:00:00

abstract：:ED-B fibronectin (ED-B FN), a glycoprotein involved in cell adhesion and migration, is expressed in fetal and neoplastic tissues and absent in their normal counterparts. The aim of this study is to evaluate the expression of this glycoprotein in relation to the histological and clinical data and to determine whether i...

journal_title：Oral oncology

authors： Mhawech P,Dulguerov P,Assaly M,Ares C,Allal AS

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. PATIENTS AND METHODS:This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated with ICIs. We predicted that inflammatory markers available thro...

journal_title：Oral oncology

authors： Bonomi M,Bhateja P,Issa M,Klamer B,Pan X,Blakaj A,Karivedu V,Mousa L,Mitchell D,Gamez M,Kang S,Seim NB,Old M,Carrau R,Rocco J,Blakaj D

更新日期：2020-11-01 00:00:00

abstract：:Nasopharyngeal carcinoma is well known to be a viral driven malignancy. Despite high loco-regional control rate with modern radiotherapy, distant metastasis remains as a major threat to the patients highlighting the importance of effective systemic therapy. Recent advances in the understanding of tumor biology, host c...

journal_title：Oral oncology

authors： Chiang AK,Mak NK,Ng WT

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:To assess the effect of the histological margins (HM) upon locoregional failure (LRF) and overall survival (OS) for oral tongue squamous cell carcinoma (OTSCC). MATERIALS AND METHODS:We undertook a retrospective review of 258 patients, across two institutions, treated for OTSCC between 2007 and 2016. A Cox-...

journal_title：Oral oncology

authors： Daniell J,Udovicich C,Rowe D,McDowell L,Vital D,Bressel M,Magarey MJR,Iseli TA,Wong T,Lekgabe E,Cavanagh K,Fua T,Rischin D,Wiesenfeld D

更新日期：2020-12-01 00:00:00

abstract：:Radiation-induced xerostomia can result in the rapid onset and progression of dental caries in head and neck cancer patients. Topically applied fluorides have been successfully used to inhibit the formation of dental caries in this population. However, because intensive daily self-application is required, compliance i...

journal_title：Oral oncology

authors： Chambers MS,Mellberg JR,Keene HJ,Bouwsma OJ,Garden AS,Sipos T,Fleming TJ

更新日期：2006-10-01 00:00:00

abstract：:Immunoreactivity of proliferating cell nuclear antigen (PCNA) was assessed in formalin-fixed, paraffin-embedded sections from human normal parotid gland (N; n = 12), chronic sialadenitis (CS; n = 8), Warthin's tumour (W; n = 10), benign pleomorphic adenoma (BPA; n = 11), mucoepidermoid carcinoma (MEC; n = 14), carcino...

journal_title：Oral oncology

authors： Zhu Q,White FH,Tipoe GL

更新日期：1997-01-01 00:00:00

abstract：:A new photosensitizing agent 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has been demonstrated as a useful method for treatment of superficial neoplastic lesions. The aim of this study was to determine the effects of topically and systemically ALA-based PDT in neoplastic lesions of the oral cavity. Pr...

journal_title：Oral oncology

authors： Ma G,Ikeda H,Inokuchi T,Sano K

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:Human papillomavirus (HPV)-positive tumor status is associated with improved prognosis after disease recurrence in oropharyngeal squamous cell carcinoma (OPSCC). In this study the potential role of survival bias in the relationship between HPV tumor status and the timing of recurrence was evaluated, given co...

journal_title：Oral oncology

authors： Guo T,Rettig E,Fakhry C

更新日期：2016-01-01 00:00:00

abstract：:Previous work from our laboratory has demonstrated overexpression of chemokines in head and neck cancer and the utility of targeting these proteins for tumor therapy in a preclinical model. However, the mechanisms involved are unexplored. Through gene expression analysis, we found that expression of vascular endotheli...

journal_title：Oral oncology

authors： Benke EM,Ji Y,Patel V,Wang H,Miyazaki H,Yeudall WA

更新日期：2010-04-01 00:00:00

abstract：:The development of locoregional recurrence is the main reason for treatment failure in head and neck squamous cell carcinomas (HNSCC) and the remaining of tumor cells in surgical margins is associated with recurrence. Surgical margins are considered negative based on histologic assessment of the pathological specimen....

journal_title：Oral oncology

authors： de Carvalho AC,Kowalski LP,Campos AH,Soares FA,Carvalho AL,Vettore AL

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:There is a clinical need to improve outcomes for patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN), especially in Human Papilloma Virus (HPV) negative and HPV positive subtypes with a significant history of tobacco use. In animal models bearing SCCHN, Cabazitaxel showed a...

journal_title：Oral oncology

authors： Camille N,Rozehnal J,Roy E,Uczkowski D,Olson A,Genden E,Teng M,Bakst R,Gupta V,Posner M,Misiukiewicz K

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The superiority of volumetric staging (VS) over TNM/TNM-grouping system was previously prospectively tested in our head neck cancer population treated with intensity-modulated radiotherapy (IMRT); gross tumor volume (GTV) was the strongest predictor for disease control. Aim of this work was to specifically a...

journal_title：Oral oncology

authors： Studer G,Glanzmann C

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:There exist no uniform decision criteria for conservative organ preservation treatments in head and neck cancer patients. Even with 18F-FDG-PET/CT after induction chemotherapy patient selection is challenging. This study correlated metabolic tumor response with treatment types and recurrence patterns. MATER...

journal_title：Oral oncology

authors： Semrau S,Schmidt D,Hecht M,Haderlein M,Kitzsteiner C,Müller S,Traxdorf M,Agaimy A,Iro H,Kuwert T,Fietkau R

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Although Multidisciplinary Team Management (MDT) is integrated in most international head and neck cancer treatment guidelines, its applications and proceedings were rarely described. The present study explores a 6-year real-life experience in a French Comprehensive Cancer Care Center. METHODS:Patients, t...

journal_title：Oral oncology

authors： Guy JB,Benna M,Xia Y,Daguenet E,Ben Mrad M,Jmour O,Vial N,Lelonge Y,Fournel P,Prades JM,Vallard A,Magné N

更新日期：2019-04-01 00:00:00

abstract：:Knowledge about the influence of biomarkers on cell proliferative activity might explain differences in radiosensitivity between head and neck tumors and might improve patient selection for the most optimal treatment strategy. p53 and bcl-2 protein expression were determined immunohistochemically in 56 head and neck c...

journal_title：Oral oncology

authors： Dijkema IM,Struikmans H,Dullens HF,Kal HB,van der Tweel I,Battermann JJ

更新日期：2000-01-01 00:00:00

abstract：:We evaluate whether p53-reactivating (p53RA) small molecules induce p53-dependent apoptosis in head and neck squamous cell carcinoma (HNSCC), a question that has not been previously addressed in head and neck cancer. PRIMA-1, CP-31398, RITA, and nutlin-3 were tested in four human HNSCC cell lines differing in TP53 sta...

journal_title：Oral oncology

authors： Roh JL,Kang SK,Minn I,Califano JA,Sidransky D,Koch WM

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:The prognostic value of metabolic tumor volume (MTV) in locally advanced laryngeal or hypopharyngeal cancer is established in the setting of chemoradiotherapy, while it remains unknown in the setting of upfront total laryngectomy. MATERIALS AND METHODS:We retrospectively analyzed 88 patients receiving total...

journal_title：Oral oncology

authors： Fujii T,Miyabe J,Yoshii T,Suzuki M,Otozai S,Komukai S,Kishikawa T,Takemoto N,Fukusumi T,Tatsumi M,Hatazawa J,Inohara H

更新日期：2019-06-01 00:00:00

abstract：:To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four ou...

journal_title：Oral oncology

authors： Locati LD,Guzzo M,Bossi P,Massone PP,Conti B,Fumagalli E,Bareggi C,Cantù G,Licitra L

更新日期：2005-10-01 00:00:00

abstract：:Epithelial cell adhesion molecule (EpCAM) is important for cell proliferation and differentiation but mechanisms regulating their expression are unclear. Because EpCAM may play a role in carcinogenesis, we investigated the clinicopathologic significance of its expression in oral squamous cell carcinoma (OSCC) and the ...

journal_title：Oral oncology

authors： Shiah SG,Chang LC,Tai KY,Lee GH,Wu CW,Shieh YS

更新日期：2009-01-01 00:00:00

abstract：:To determine the aesthetic and functional outcomes of the most invasive approach to oral cavity/oropharyngeal lesions, the lip-splitting mandibulotomy approach (LSMA), versus the least invasive, the trans-oral approach (TOA). Retrospective paired-cohort study. Thirty-six patients with oral/oropharyngeal cancers treate...

journal_title：Oral oncology

authors： Dziegielewski PT,O'Connell DA,Rieger J,Harris JR,Seikaly H

更新日期：2010-08-01 00:00:00

abstract：:Expression profile of 588 known genes relating to tumour biology, was examined between oral squamous cell carcinomas (OSCCs) and matching normal oral mucosal tissues (NOMTs) obtained from Sudanese (n=11) and Norwegian (n=11) patients. cDNA probes were synthesised from total RNA and hybridised with the Atlas human canc...

journal_title：Oral oncology

authors： Ibrahim SO,Aarsaether N,Holsve MK,Kross KW,Heimdal JH,Aarstad JH,Liavaag PG,Elgindi OA,Johannessen AC,Lillehaug JR,Vasstrand EN

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelia...

journal_title：Oral oncology

authors： de Vicente JC,Rodrigo JP,Rodriguez-Santamarta T,Lequerica-Fernández P,Allonca E,García-Pedrero JM

更新日期：2013-06-01 00:00:00

abstract：:Proliferative verrucous leukoplakia (PVL) is a very aggressive form of oral leukoplakia (OL) with high morbidity and mortality rates, hypothesised to be linked to HPV infection. This study aimed to determine the presence of HPV DNA in PVL in comparison with OL, and in relation to social-demographical variables (age, g...

journal_title：Oral oncology

authors： Campisi G,Giovannelli L,Ammatuna P,Capra G,Colella G,Di Liberto C,Gandolfo S,Pentenero M,Carrozzo M,Serpico R,D'Angelo M

更新日期：2004-09-01 00:00:00

abstract：:It has been reported that cyclooxygenase-2 (COX-2) plays roles in cell proliferation, tumor invasion and inhibition of apoptosis. We reported COX-2 expression in salivary adenoma and its involvement in inhibition of apoptosis. COX-2 is known to induce a number of cytokines and growth factors. On the other hand, hepato...

journal_title：Oral oncology

authors： Aoki T,Tsukinoki K,Kurabayashi H,Sasaki M,Yasuda M,Ota Y,Watanabe Y,Kaneko A

更新日期：2006-01-01 00:00:00

abstract：:Screening populations for the early detection of asymptomatic malignancies and potential malignancies are intuitively attractive strategies to control or reduce the burden of oral cancer on society. Subsequent preventive and/or therapeutic measures must, however, be substantiated by prospective randomized controlled t...

journal_title：Oral oncology

authors： Lavelle CL,Scully C

更新日期：2005-01-01 00:00:00