Abstract：
:Although the amelogenin gene is expressed in ameloblastoma, the precise expression pattern of X and Y amelogenin genes (AMGX, AMGY) in this tumor has not yet been identified. In this study, we analyzed amelogenin gene expression in 19 samples (9 male, 10 female) of oral ameloblastomas by RT-PCR and detect the chromosomal origin of amelogenin mRNA by restriction enzyme digestion of the RT-PCR product. All tumor samples expressed amelogenin mRNA. We could detect increased level of AMGY expression in all male samples, higher than that of AMEX. It is an interesting finding as in normal male tooth development, the expression of AMGY is very much lower than that of AMGX. We postulate that epigenetic change of sex chromosomes may have some correlations with tumorigenesis of ameloblastoma. We also discuss the other possible mechanisms and points for future studies on this change in expression pattern.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Tsujigiwa H,Nagatsuka H,Han PP,Gunduz M,Siar CH,Oida S,Nagai Ndoi
10.1016/j.oraloncology.2005.04.005subject
Has Abstractpub_date
2005-09-01 00:00:00pages
843-50issue
8eissn
1368-8375issn
1879-0593pii
S1368-8375(05)00122-3journal_volume
41pub_type
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