Efficacy and safety of medical ozone (O(3)) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: Preliminary results of a phase I-II study.


:Osteonecrosis of the jaw (ONJ) is an adverse event that has been reported in patients receiving cancer treatment regimens, including bevacizumab, bisphosphonates, and denosumab. We performed a preliminary open label, prospective phase I-II study in patients treated with bisphosphonate to evaluate the treatment effect and tolerability of medical ozone (O(3)) delivered in an oil suspension on BONJ lesions ≤2.5cm. Ten consecutive patients with BONJ lesions not responsive to conservative treatment were pre-treated with 10days of antibiotics to reduce purulent secretions on the gum. The exposed bone lesion and osteomucosal edge was cleaned with an ultrasonic scaler. The BONJ lesion was treated with 10 local applications of medical O(3) delivered in an oil suspension for 10min. In all patients, mucosal lesions resolved with complete reconstitution of oral and jaw tissue, with 3-10 applications. No toxicity was reported. Unexpectedly, total sequestration of the necrotic bone, with spontaneous expulsion in eight patients and new bone formation around the necrotic area in two patients was observed. No patient required surgical intervention. In two patients with pre-and post-treatment X-rays, no residual bone lesions were observed after treatment. These preliminary results show the efficacy and tolerability of O(3) delivered in an oil suspension applied directly to BONJ lesions ≤2.5cm, thus indicating that BONJ can be a manageable and potentially curable condition.


Oral Oncol


Oral oncology


Ripamonti CI,Cislaghi E,Mariani L,Maniezzo M




Has Abstract


2011-03-01 00:00:00














  • Evaluation of type-specific antibodies to high risk-human papillomavirus (HPV) proteins in patients with oropharyngeal cancer.

    abstract:OBJECTIVES:High risk human papillomavirus (HR-HPV) infection leads to a subgroup of oropharyngeal cancer (OPSCC) characterized by improved treatment response. However an universally accepted definition of an HR-HPV-attributable cancer is lacking. METHODS:Detailed, type-specific HPV antibody responses were analyzed by ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Broglie MA,Jochum W,Michel A,Waterboer T,Foerbs D,Schoenegg R,Stoeckli SJ,Pawlita M,Holzinger D

    更新日期:2017-07-01 00:00:00

  • The role of salivary cytokine biomarkers in tongue cancer invasion and mortality.

    abstract:UNLABELLED:Squamous cell carcinoma of the tongue (TSCC) has one of the poorest prognoses of head and neck cancers. This study aims to improve early detection of the disease by identifying salivary biomarkers that can identify a spectrum of patients progressing from high-risk to TSCC. We also examine the mortality of ex...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Korostoff A,Reder L,Masood R,Sinha UK

    更新日期:2011-04-01 00:00:00

  • Expression of keratins in normal, immortalized and malignant oral epithelia in organotypic culture.

    abstract::Keratins have been extensively studied in tissues and cultured keratinocytes but limited information is available on epithelia reconstructed in vitro. The aim of this study was to examine keratin expression in organotypic epithelia with normal (NOK), immortalized (SVpgC2a) and malignant (SqCC/Y1) human buccal cells. O...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Hansson A,Bloor BK,Haig Y,Morgan PR,Ekstrand J,Grafström RC

    更新日期:2001-07-01 00:00:00

  • Radiation-induced second primary squamous cell carcinoma of the oral cavity after radiotherapy for nasopharyngeal carcinoma.

    abstract:BACKGROUND:The increasing occurrence of radiation-induced second primary squamous cell carcinoma of the oral cavity (RISCCO) after radiotherapy for nasopharyngeal carcinoma (NPC) has become a noteworthy complication that can influence long-term survival. This study aimed to analyze the associations of clinicopathologic...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Liu C,Liao L,Wu G,Yan H,Chen X,Wang C,Zheng X,Zeng Z,Zhao Z,Wu D,Liu X

    更新日期:2020-06-27 00:00:00

  • MicroRNAs as prognostic molecular signatures in human head and neck squamous cell carcinoma: a systematic review and meta-analysis.

    abstract::The aim of this study was to systematically review the articles investigating the prognostic value of different microRNAs (miRs) in human head and neck squamous cell carcinoma (HNSCC). Following the guidelines of the Meta-analysis of Observational Studies in Epidemiology group (MOOSE), we performed a broad and sensiti...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Jamali Z,Asl Aminabadi N,Attaran R,Pournagiazar F,Ghertasi Oskouei S,Ahmadpour F

    更新日期:2015-04-01 00:00:00

  • Long-term speech and swallowing function after primary resection and sentinel node biopsy for early oral squamous cell carcinoma.

    abstract:OBJECTIVES:Analysis of long-term speech and swallowing function and subjective quality of life (QOL) after primary resection and sentinel node biopsy (SNB) in patients with early stage (cT1/T2) oral squamous cell carcinomas (OSCC). MATERIAL AND METHODS:Eighty-one consecutive patients treated primarily by transoral res...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Romer CAE,Broglie Daeppen MA,Mueller M,Huber GF,Guesewell S,Stoeckli SJ

    更新日期:2019-02-01 00:00:00

  • Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features.

    abstract::To understand the role of 70 kDa heat shock protein (HSP70) in the pathogenesis of oral cancer, its expression was studied in human normal, premalignant and malignant oral mucosa. Cell surface expression of HSP70 was assessed in oral tissue specimens by flow cytometric analysis using a mouse monoclonal antibody agains...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kaur J,Das SN,Srivastava A,Ralhan R

    更新日期:1998-03-01 00:00:00

  • Predictive factors for distant metastasis from oral and oropharyngeal squamous cell carcinoma.

    abstract::The presence of distant metastasis after the initial treatment of head and neck squamous cell carcinoma is not considered a common event and is associated with a poor outcome. The objective of this study was to investigate the prevalence and risk factors associated with the diagnosis of distant metastasis in oral and ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kowalski LP,Carvalho AL,Martins Priante AV,Magrin J

    更新日期:2005-05-01 00:00:00

  • Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan oral squamous cell carcinomas.

    abstract:OBJECTIVES:It is well recognized that oral squamous cell carcinoma (OSCC) cases from Asia that are associated with betel quid chewing are phenotypically distinct to those from Western countries that are predominantly caused by smoking/drinking, but the molecular basis of these differences are largely unknown. The aim o...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Saeed AA,Sims AH,Prime SS,Paterson I,Murray PG,Lopes VR

    更新日期:2015-03-01 00:00:00

  • Salivary gland hypofunction in patients with advanced cancer.

    abstract::There is relatively little data on salivary gland hypofunction (SGH) in patients with advanced cancer. The aim of the current study was to investigate the epidemiology, aetiology, and clinical features of SGH in this group of patients. The protocol involved completion of standard proforma, completion of a Memorial Sym...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Davies AN,Broadley K,Beighton D

    更新日期:2002-10-01 00:00:00

  • Serum C-reactive protein as a prognostic indicator in patients with oral squamous cell carcinoma.

    abstract::Preoperative elevation of serum C-reactive protein (CRP) has been demonstrated as a prognostic indicator in oesophageal, gastric and colorectal cancer. This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamou...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Khandavilli SD,Ceallaigh PO,Lloyd CJ,Whitaker R

    更新日期:2009-10-01 00:00:00

  • Expression of cyclin dependent kinase inhibitor p21waf1/cip1 in premalignant and malignant oral lesions: relationship with p53 status.

    abstract::p21waf1/cip1 protein, an inhibitor of cyclin dependent kinases, is a critical downstream target in the p53-specific pathway of growth control, and can also be induced by p53 independent pathways in relation to terminal differentiation. p21waf1 is also a putative tumour suppressor. Hence, we sought to determine whether...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Agarwal S,Mathur M,Shukla NK,Ralhan R

    更新日期:1998-09-01 00:00:00

  • Topical agents for oral cancer chemoprevention: A systematic review of the literature.

    abstract:OBJECTIVES/HYPOTHESIS:We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD). METHODS:A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library....

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Chau L,Jabara JT,Lai W,Svider PF,Warner BM,Lin HS,Raza SN,Fribley AM

    更新日期:2017-04-01 00:00:00

  • Eosinophil ablation and tumor development.

    abstract::Tissue eosinophilia in squamous cell carcinoma has long been recognized; however, the role of eosinophils in tumor development remains unclear. Studies have reported both favorable and unfavorable prognoses for patients with tumors exhibiting tumor-associated tissue eosinophilia (TATE). This study seeks to elucidate t...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Wong DT,Bowen SM,Elovic A,Gallagher GT,Weller PF

    更新日期:1999-09-01 00:00:00

  • Maté consumption association with upper aerodigestive tract cancers: A systematic review and meta-analysis.

    abstract::Maté is a beverage regularly consumed by Latin American populations. Upper aerodigestive tract (UADT) cancers are frequent in this region and are suspected to be associated with maté consumption. The aim of this systematic review and meta-analysis was to answer a focused question: "Is there an association between maté...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析


    authors: Mello FW,Scotti FM,Melo G,Warnakulasuriya S,Guerra ENS,Rivero ERC

    更新日期:2018-07-01 00:00:00

  • Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: potential to guide treatment? A systematic review.

    abstract::Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamo...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Bernstein JM,Homer JJ,West CM

    更新日期:2014-10-01 00:00:00

  • ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion!

    abstract::ICAM-5 (telencephalin) is an intercellular adhesion molecule reported to be expressed only in the somatodendritic membrane of telencephalic neurons. We recently identified high ICAM-5 expression in a cDNA array study of head and neck neoplasms with a propensity for perineural invasion. To determine the association of ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Maruya SI,Myers JN,Weber RS,Rosenthal DI,Lotan R,El-Naggar AK

    更新日期:2005-07-01 00:00:00

  • ERCC1 plays an important role in predicting survival outcomes and treatment response for patients with HNSCC: a meta-analysis.

    abstract:BACKGROUND:Excision repair crosscomplementing-1 (ERCC1) has been reported to play a prognostic role and may indicate the treatment response in patients with head and neck squamous carcinoma (HNSCC). Nevertheless, the strength of evidence of ERCC1 predicting these two clinical outcomes are still controversial. METHODS:...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析


    authors: Xuelei M,Jingwen H,Wei D,Hongyu Z,Jing Z,Changle S,Lei L

    更新日期:2015-05-01 00:00:00

  • Paraneoplastic pemphigus caused by an epithelioid leiomyosarcoma and associated with fatal respiratory failure.

    abstract::A patient is described who initially presented with pemphigus vulgaris, limited to the oral cavity, and weight loss. Although the various laboratory studies pointed to the diagnosis of paraneoplastic pemphigus (PNP), the underlying neoplasm was not detected until 6 months later, when the patient developed shortness of...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: van der Waal RI,Pas HH,Nousari HC,Schulten EA,Jonkman MF,Nieboer C,Stoof TJ,Starink TM,Anhalt GJ

    更新日期:2000-07-01 00:00:00

  • Prognostic value of DNA ploidy status in patients with oral leukoplakia.

    abstract::Oral leukoplakia is a potentially malignant disorder that will develop into oral cancer at an estimated rate of 1-2% per year. Aim of the present study is to assess the possible predictive value of DNA ploidy for malignant progression of oral leukoplakia. A cohort of 62 leukoplakia patients was studied and their biops...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Bremmer JF,Brakenhoff RH,Broeckaert MA,Beliën JA,Leemans CR,Bloemena E,van der Waal I,Braakhuis BJ

    更新日期:2011-10-01 00:00:00

  • Accuracy of intraoperative tissue staining in delineating deep surgical margins in oral carcinoma surgery.

    abstract::The purpose of this study was to assess the accuracy of this tissue staining assessment of surgical specimens in delineating deep surgical margins in oral cancer surgery. Fifteen patients who underwent surgery for oral carcinoma were included in the study. Once the tumor was resected, a vertical section of the surgica...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kurita H,Sakai H,Kamata T,Koike T,Kobayashi H,Kurashina K

    更新日期:2008-10-01 00:00:00

  • A novel indole-3-carbinol derivative inhibits the growth of human oral squamous cell carcinoma in vitro.

    abstract::Indole-3-carbinol (I3C), a naturally occurring phytochemical found in cruciferous vegetables, has received much attention due to its translational potential in cancer prevention and therapy. In this study, we investigated the antitumor effects of OSU-A9, a structurally optimized I3C derivative, in a panel of oral squa...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Weng JR,Bai LY,Omar HA,Sargeant AM,Yeh CT,Chen YY,Tsai MH,Chiu CF

    更新日期:2010-10-01 00:00:00

  • Expression of vascular endothelial growth factor-C predicts regional lymph node metastasis in early oral squamous cell carcinoma.

    abstract::The purpose of this study was to investigate the association of the expression of vascular endothelial growth factor-C (VEGF-C) with regional lymph node metastasis in oral squamous cell carcinoma (OSCC). The expression of VEGF-C in biopsy specimens obtained from 62 patients with OSCC was examined by immunohistochemist...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kishimoto K,Sasaki A,Yoshihama Y,Mese H,Tsukamoto G,Matsumura T

    更新日期:2003-06-01 00:00:00

  • Programmed death ligand 1 (PD-L1) expression and tumor microenvironment: Implications for patients with oral precancerous lesions.

    abstract:OBJECTIVES:Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transf...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Yagyuu T,Hatakeyama K,Imada M,Kurihara M,Matsusue Y,Yamamoto K,Obayashi C,Kirita T

    更新日期:2017-05-01 00:00:00

  • Cytokeratin expression in precancerous lesions of the human oral cavity.

    abstract::Cytokeratin (CK) expression was studied in buccal mucosa (BM) from 20 leucoplakia and 7 submucous fibrosis patients using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting and two-dimensional gel electrophoresis with iso-electric focussing (IEF) as the first dimension. Normal BM exp...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Vaidya MM,Sawant SS,Borges AM,Ogale SB,Bhisey AN

    更新日期:1998-07-01 00:00:00

  • p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma.

    abstract::We evaluate whether p53-reactivating (p53RA) small molecules induce p53-dependent apoptosis in head and neck squamous cell carcinoma (HNSCC), a question that has not been previously addressed in head and neck cancer. PRIMA-1, CP-31398, RITA, and nutlin-3 were tested in four human HNSCC cell lines differing in TP53 sta...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Roh JL,Kang SK,Minn I,Califano JA,Sidransky D,Koch WM

    更新日期:2011-01-01 00:00:00

  • Inflammation linking EMT and cancer stem cells.

    abstract::Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial-mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal-epithelial transition (MET). Such changes allow the tumor to c...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Zhou C,Liu J,Tang Y,Liang X

    更新日期:2012-11-01 00:00:00

  • Vascular priming enhances chemotherapeutic efficacy against head and neck cancer.

    abstract:PURPOSE:The need to improve chemotherapeutic efficacy against head and neck squamous cell carcinomas (HNSCC) is well recognized. In this study, we investigated the potential of targeting the established tumor vasculature in combination with chemotherapy in head and neck cancer. METHODS:Experimental studies were carrie...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Folaron M,Kalmuk J,Lockwood J,Frangou C,Vokes J,Turowski SG,Merzianu M,Rigual NR,Sullivan-Nasca M,Kuriakose MA,Hicks WL Jr,Singh AK,Seshadri M

    更新日期:2013-09-01 00:00:00

  • Association of genetic variants with tumor HPV16 status and survival in squamous cell carcinoma of the oropharynx.

    abstract:OBJECTIVES:Genetic polymorphisms of genes in cell cycle, apoptosis, and inflammation/immune response pathways may control the mechanisms of HPV clearance and HPV escape of immune surveillance and thus may affect both tumor HPV16 status and possibly related outcomes of squamous cell carcinoma of the oropharynx (SCCOP) p...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Feng Y,Li Y,Zhang Y,Zheng H,Li G

    更新日期:2016-05-01 00:00:00

  • A critical evaluation of computed tomography-derived depth of invasion in the preoperative assessment of oral cancer staging.

    abstract:BACKGROUND:Depth of invasion (DOI) has been introduced into the latest TNM classification of oral squamous cell carcinoma (OSCC). Despite its primarily pathological definition (pDOI), a preoperative evaluation of a radiological DOI (rDOI) would be useful but a standard and practical definition is lacking. The primary a...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Locatello LG,Bruno C,Pietragalla M,Taverna C,Novelli L,Nardi C,Bonasera L,Cannavicci A,Maggiore G,Gallo O

    更新日期:2020-08-01 00:00:00