Efficacy and safety of medical ozone (O(3)) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: Preliminary results of a phase I-II study.


:Osteonecrosis of the jaw (ONJ) is an adverse event that has been reported in patients receiving cancer treatment regimens, including bevacizumab, bisphosphonates, and denosumab. We performed a preliminary open label, prospective phase I-II study in patients treated with bisphosphonate to evaluate the treatment effect and tolerability of medical ozone (O(3)) delivered in an oil suspension on BONJ lesions ≤2.5cm. Ten consecutive patients with BONJ lesions not responsive to conservative treatment were pre-treated with 10days of antibiotics to reduce purulent secretions on the gum. The exposed bone lesion and osteomucosal edge was cleaned with an ultrasonic scaler. The BONJ lesion was treated with 10 local applications of medical O(3) delivered in an oil suspension for 10min. In all patients, mucosal lesions resolved with complete reconstitution of oral and jaw tissue, with 3-10 applications. No toxicity was reported. Unexpectedly, total sequestration of the necrotic bone, with spontaneous expulsion in eight patients and new bone formation around the necrotic area in two patients was observed. No patient required surgical intervention. In two patients with pre-and post-treatment X-rays, no residual bone lesions were observed after treatment. These preliminary results show the efficacy and tolerability of O(3) delivered in an oil suspension applied directly to BONJ lesions ≤2.5cm, thus indicating that BONJ can be a manageable and potentially curable condition.


Oral Oncol


Oral oncology


Ripamonti CI,Cislaghi E,Mariani L,Maniezzo M




Has Abstract


2011-03-01 00:00:00














  • Podoplanin emerges as a functionally relevant oral cancer biomarker and therapeutic target.

    abstract::Oral cancer has become one of the most aggressive types of cancer, killing 140,000 people worldwide every year. Current treatments for oral cancer include surgery and radiation therapies. These procedures can be very effective; however, they can also drastically decrease the quality of life for survivors. New chemothe...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Retzbach EP,Sheehan SA,Nevel EM,Batra A,Phi T,Nguyen ATP,Kato Y,Baredes S,Fatahzadeh M,Shienbaum AJ,Goldberg GS

    更新日期:2018-03-01 00:00:00

  • Sebaceous adenoma of the cheek.

    abstract::Sebaceous adenoma is a tumour only rarely located in the oral cavity. Less than 10 cases have been reported. Sebaceous adenoma represents 0.5-0.7% of all monomorphic adenomas. Sebaceous adenoma is mainly constituted by two types of cells, undifferentiated peripheral basaloid cells and cells showing different degrees o...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Iezzi G,Rubini C,Fioroni M,Piattelli A

    更新日期:2002-01-01 00:00:00

  • Inflammation linking EMT and cancer stem cells.

    abstract::Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial-mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal-epithelial transition (MET). Such changes allow the tumor to c...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Zhou C,Liu J,Tang Y,Liang X

    更新日期:2012-11-01 00:00:00

  • Evaluation of the immunogenicity of ALDH(high) human head and neck squamous cell carcinoma cancer stem cells in vitro.

    abstract:OBJECTIVES:To establish the concept that the antigenicity/immunogenicity of ALDH(high) human head and neck squamous cell carcinoma (HNSCC) cancer stem cells (CSC) is distinct from that of ALDH(low) non-CSCs. METHODS:We generated CSC-loaded dendritic cells (DCs) to sensitize autologous peripheral blood T, B lymphocytes...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Prince MEP,Zhou L,Moyer JS,Tao H,Lu L,Owen J,Etigen M,Zheng F,Chang AE,Xia J,Wolf G,Wicha MS,Huang S,Ren X,Li Q

    更新日期:2016-08-01 00:00:00

  • Spindle-cell lipoma of the cheek: a case report.

    abstract::Spindle-cell lipoma (SCL) is a distinct histological variant of lipoma. Clinically, it appears as a solitary, subcutaneous, circumscribed lesion. SCL accounts for about 1.5% of all adipocytic tumours. Only nine cases of intraoral SCL were found in the literature. Microscopically, mature adipocytes and spindle cells ar...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Piattelli A,Rubini C,Fioroni M,Iezzi G

    更新日期:2000-09-01 00:00:00

  • Summary from an international cancer seminar focused on human papillomavirus (HPV)-positive oropharynx cancer, convened by scientists at IARC and NCI.

    abstract::Cancer of the oropharynx has attracted considerable attention in recent years given: (1) an increasing incidence in selected populations over the past three decades; (2) the discovery of human papillomavirus (HPV) infection as the driver of the increase, as opposed to the traditional risk factors such as tobacco (smok...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kreimer AR,Chaturvedi AK,Alemany L,Anantharaman D,Bray F,Carrington M,Doorbar J,D'Souza G,Fakhry C,Ferris RL,Gillison M,Neil Hayes D,Hildesheim A,Huang SH,Kowalski LP,Lang Kuhs KA,Lewis J Jr,Lowy DR,Mehanna H,Ness A

    更新日期:2020-09-01 00:00:00

  • Clinical significance of molecular alterations in histologically negative surgical margins of head and neck cancer patients.

    abstract::The development of locoregional recurrence is the main reason for treatment failure in head and neck squamous cell carcinomas (HNSCC) and the remaining of tumor cells in surgical margins is associated with recurrence. Surgical margins are considered negative based on histologic assessment of the pathological specimen....

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: de Carvalho AC,Kowalski LP,Campos AH,Soares FA,Carvalho AL,Vettore AL

    更新日期:2012-03-01 00:00:00

  • Comorbidity and diagnostic delay in cancer of the larynx, tongue and pharynx.

    abstract::Comorbidity and diagnostic delay are independent prognostic factors in head and neck cancer, most notably in laryngeal cancer. We investigated their inter-relationship and their relative significance in survival of three different head and neck cancers. A population-based retrospective cohort of 221 patients with canc...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Teppo H,Alho OP

    更新日期:2009-08-01 00:00:00

  • Evaluation of TS-1 based treatment and expression of thymidylate synthase and dihydropyrimidine dehydrogenase on oral squamous cell carcinoma.

    abstract::Seventeen oral squamous cell carcinoma (SCC) patients underwent chemotherapy with TS-1 (8 males and 9 females, mean age; 75.1 years, range; 47-102 years). TS-1 permitted five cases of oral chemotherapy on an outpatient basis and 8 cases in elder patients over 80-years of age. Excepting five patients who underwent TS-1...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Obara S,Yamamoto K,Hosogai N,Yoshimura Y

    更新日期:2005-03-01 00:00:00

  • Hepatocyte growth factor expression correlates with cyclooxygenase-2 pathway in human salivary gland tumors.

    abstract::It has been reported that cyclooxygenase-2 (COX-2) plays roles in cell proliferation, tumor invasion and inhibition of apoptosis. We reported COX-2 expression in salivary adenoma and its involvement in inhibition of apoptosis. COX-2 is known to induce a number of cytokines and growth factors. On the other hand, hepato...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Aoki T,Tsukinoki K,Kurabayashi H,Sasaki M,Yasuda M,Ota Y,Watanabe Y,Kaneko A

    更新日期:2006-01-01 00:00:00

  • Ameloblastic fibro-odontoma: report of two cases.

    abstract::Ameloblastic fibro-odontoma is a rare odontogenic tumour. It affects young people and is usually located in the posterior jaws. Two cases of this tumour are presented: both lesions had produced an asymptomatic swelling. The histology showed the presence of an odontogenic epithelium immersed in a fibrous mesenchyme; de...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Favia GF,Di Alberti L,Scarano A,Piattelli A

    更新日期:1997-11-01 00:00:00

  • Real-time PCR HPV genotyping in fine needle aspirations of metastatic head and neck squamous cell carcinoma: Exposing the limitations of conventional p16 immunostaining.

    abstract:BACKGROUND:Given the propensity for HPV-positive head and neck squamous cell carcinoma (HPV-HNSCC) to metastasize to cervical lymph nodes, fine needle aspiration (FNA) plays an important diagnostic role in their initial detection. Indeed, there is now an unwavering commitment to HPV testing of FNAs even in the absence ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: El-Salem F,Mansour M,Gitman M,Miles BA,Posner MR,Bakst RL,Genden EM,Westra WH

    更新日期:2019-03-01 00:00:00

  • Vocal process granuloma - A result of long-term observation in 53 patients.

    abstract::Vocal process granulomas are benign lesions involved in the healing of posterior glottis injuries. Here, we report the results of our conservative treatment of vocal process granulomas. Fifty-three patients with 54 occurrences of granulomas between 1998 and 2007 were enrolled. All patients were observed without surgic...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Wang CP,Ko JY,Wang YH,Hu YL,Hsiao TY

    更新日期:2009-09-01 00:00:00

  • Primary oral melanoma: population-based incidence.

    abstract::Primary oral melanoma (POM) is a rare form of melanoma, generally diagnosed at a late stage and has poor prognosis. Epidemiological information has scarcely been reported in the literature over the past 40 years. Analyzing the Cancer Incidence in Five Continents volume IX (CI5-IX) database we found a total of 124,436 ...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究


    authors: Sortino-Rachou AM,Cancela Mde C,Voti L,Curado MP

    更新日期:2009-03-01 00:00:00

  • Transforming growth factor-β and epithelial-mesenchymal transition are associated with pulmonary metastasis in adenoid cystic carcinoma.

    abstract:OBJECTIVES:Adenoid cystic carcinoma (ACC) is one of the most common malignancies of salivary glands, characterized by poor prognosis, particularly due to pulmonary metastasis. We previously reported that transforming growth factor (TGF)-β1 promoted ACC cell migration and invasion via the Smad pathway in vitro. The aim ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Dong L,Ge XY,Wang YX,Yang LQ,Li SL,Yu GY,Gao Y,Fu J

    更新日期:2013-11-01 00:00:00

  • Gender disparities in head and neck cancer chemotherapy clinical trials participation and treatment.

    abstract:OBJECTIVES:To characterize the representation of women in clinical trials directing the National Comprehensive Cancer Network (NCCN) guidelines for chemotherapy use in head and neck squamous cell carcinoma (HNSCC), as well as the relationship between gender and chemotherapy administration in the definitive treatment of...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Benchetrit L,Torabi SJ,Tate JP,Mehra S,Osborn HA,Young MR,Burtness B,Judson BL

    更新日期:2019-07-01 00:00:00

  • Impact of histological Oral Tongue Cancer margins on locoregional recurrence: A multi-centre retrospective analysis.

    abstract:OBJECTIVES:To assess the effect of the histological margins (HM) upon locoregional failure (LRF) and overall survival (OS) for oral tongue squamous cell carcinoma (OTSCC). MATERIALS AND METHODS:We undertook a retrospective review of 258 patients, across two institutions, treated for OTSCC between 2007 and 2016. A Cox-...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Daniell J,Udovicich C,Rowe D,McDowell L,Vital D,Bressel M,Magarey MJR,Iseli TA,Wong T,Lekgabe E,Cavanagh K,Fua T,Rischin D,Wiesenfeld D

    更新日期:2020-12-01 00:00:00

  • Mucositis: The impact, biology and therapeutic opportunities of oral mucositis.

    abstract::The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinici...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Sonis ST

    更新日期:2009-12-01 00:00:00

  • Pioglitazone and oral cancer risk in patients with type 2 diabetes.

    abstract:BACKGROUND:Pioglitazone has shown an inhibitory effect on the growth of cell lines derived from human salivary gland and human oral squamous cell carcinoma. However, whether this effect can be applied to patients with type 2 diabetes mellitus who use pioglitazone for glycemic control remains unanswered. METHODS:The re...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Tseng CH

    更新日期:2014-02-01 00:00:00

  • Depth of invasion, size and number of metastatic nodes predicts extracapsular spread in early oral cancers with occult metastases.

    abstract:OBJECTIVE:Presence of extracapsular spread (ECS) significantly decreases survival in oral cancer patients. Considering its prognostic impact, we have studied the incidence and factors predicting ECS in clinically node negative early oral cancers. MATERIALS AND METHODS:We performed a retrospective chart review of 354 t...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Mair MD,Shetty R,Nair D,Mathur Y,Nair S,Deshmukh A,Thiagarajan S,Pantvaidya G,Lashkar S,Prabhash K,Chaukar D,Pai P,Cruz AD,Chaturvedi P

    更新日期:2018-06-01 00:00:00

  • Susceptibility to Melaleuca alternifolia (tea tree) oil of yeasts isolated from the mouths of patients with advanced cancer.

    abstract::Yeasts that are resistant to azole antifungal drugs are increasingly isolated from the mouths of cancer patients suffering from oral fungal infections. Tea tree oil is an agent possessing antimicrobial properties that may prove useful in the prevention and management of infections caused by these organisms. In this st...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究


    authors: Bagg J,Jackson MS,Petrina Sweeney M,Ramage G,Davies AN

    更新日期:2006-05-01 00:00:00

  • N-acetylcysteine (NAC) inhibits cell growth by mediating the EGFR/Akt/HMG box-containing protein 1 (HBP1) signaling pathway in invasive oral cancer.

    abstract:OBJECTIVES:Overexpression of the epidermal growth factor (EGF) receptor (EGFR) gene in the squamous cell carcinomas of the head and neck (SCCHN) is often associated with inauspicious prognosis and poor survival. N-acetylcysteine (NAC), a compound from some vegetables and allium species, appears anti-tumorigenesis, but ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Lee MF,Chan CY,Hung HC,Chou IT,Yee AS,Huang CY

    更新日期:2013-02-01 00:00:00

  • Prognostic biomarkers in oral squamous cell carcinoma: A systematic review.

    abstract::Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/Pu...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Rivera C,Oliveira AK,Costa RAP,De Rossi T,Paes Leme AF

    更新日期:2017-09-01 00:00:00

  • Orbital outcomes after orbit-sparing surgery and free flap reconstruction.

    abstract:OBJECTIVE:To identify functional outcome and orbital complication rate of the preserved orbit and to identify predictors of orbital impairment in periorbital free flap reconstruction. MATERIALS AND METHODS:A retrospective review was conducted on patients undergoing orbit-sparing surgery with periorbital free flap reco...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Philips R,Topf MC,Graf A,Krein H,Heffelfinger R,Luginbuhl A,Curry J

    更新日期:2019-11-01 00:00:00

  • Intravenous myofibroblastic pseudotumour of the buccal mucosa.

    abstract::An intravenous pseudotumour at a traumatised site of the buccal mucosa of a 68-year-old woman is described. The lesion was composed of reactive spindle cell proliferation, merging of haphazard bizarre cells and inflammatory elements. Cellular morphology and immunohistochemical profile of proliferating cells reflected ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ide F,Shimoyama T,Horie N

    更新日期:1998-05-01 00:00:00

  • Gene expression profiling by DNA microarrays and its application to dental research.

    abstract:UNLABELLED:DNA microarray technology has been used for genome-wide gene expression studies that incorporate molecular genetics and computer science skills on massive levels. The technology permits the simultaneous analysis of tens of thousands of genes for the purposes of gene discovery, disease diagnosis. improved dru...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Kuo WP,Whipple ME,Sonis ST,Ohno-Machado L,Jenssen TK

    更新日期:2002-10-01 00:00:00

  • Relationship between the expressions of PD-L1 and tumor-infiltrating lymphocytes in oral squamous cell carcinoma.

    abstract::Tumor-infiltrating lymphocytes (TILs) are considered to represent immune reactions of the host to a malignant tumor. Programmed death receptor ligand-1 (PD-L1) is a surface protein that blocks the function of T lymphocytes and is expressed on cancer cells. Tumor-associated fibroblasts (TAFs), which influence tumor gro...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Cho YA,Yoon HJ,Lee JI,Hong SP,Hong SD

    更新日期:2011-12-01 00:00:00

  • MicroRNAs as prognostic molecular signatures in human head and neck squamous cell carcinoma: a systematic review and meta-analysis.

    abstract::The aim of this study was to systematically review the articles investigating the prognostic value of different microRNAs (miRs) in human head and neck squamous cell carcinoma (HNSCC). Following the guidelines of the Meta-analysis of Observational Studies in Epidemiology group (MOOSE), we performed a broad and sensiti...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Jamali Z,Asl Aminabadi N,Attaran R,Pournagiazar F,Ghertasi Oskouei S,Ahmadpour F

    更新日期:2015-04-01 00:00:00

  • Translational research in nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma is well known to be a viral driven malignancy. Despite high loco-regional control rate with modern radiotherapy, distant metastasis remains as a major threat to the patients highlighting the importance of effective systemic therapy. Recent advances in the understanding of tumor biology, host c...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Chiang AK,Mak NK,Ng WT

    更新日期:2014-05-01 00:00:00

  • The submental island flap for reconstruction of intraoral defects in oral cancer patients.

    abstract::The submental artery island flap (SIF) is gaining acceptance as a simple and reliable option in selected oral oncologic reconstructions. The present study aims to assess the usefulness of submental artery flap in oral reconstruction with respect to flap reliability, cosmesis, function, donor site morbidity and oncolog...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Sebastian P,Thomas S,Varghese BT,Iype EM,Balagopal PG,Mathew PC

    更新日期:2008-11-01 00:00:00