当前位置： SCI文献检索 > ORAL ONCOLOGY期刊下所有文献 > Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer.

Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer.

Abstract：

OBJECTIVES:To describe the natural course of distant metastases (DMs) following radiotherapy (RT) or chemoradiotherapy (CRT) in HPV(+) oropharyngeal carcinoma (OPC). METHODS:OPC treated with RT/CRT from 1/1/2000 to 5/31/2010 were reviewed. The natural course of DM were compared between HPV(+) and HPV(-) cohorts. RESULTS:Median follow-up was 3.9 years. The DM rate were similar (11% vs. 15% at 3-years, p=0.25) between the HPV(+) (n=457) vs. the HPV(-) (n=167) cases. While almost all (24/25) HPV(-) DM occurred within 2-years following RT (1 was at 2.1 years), 7/54 (13%) of HPV(+) DM were detected beyond 3 years (up to 5.3 years). Disseminating to >2 organs occurred in 18 (33%) HPV(+) vs. none in HPV(-). Post-DM survival rates were 11% vs. 4% at 2-years (p=0.02) for the HPV(+) vs. HPV(-) cases respectively. 5/6 HPV(+) with lung oligo-metastasis were still alive with stable disease beyond 2-years after salvage procedures for DM (chemotherapy: 3; surgical resection: 2; radiotherapy: 1). CONCLUSIONS:Although DM rates are similar, the natural course of HPV(+) DM differs from that of HPV(-) patients: it may occur after a longer interval, often with a "disseminating" phenotype, and a small number may have prolonged survival after salvage for DM.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Huang SH,Perez-Ordonez B,Weinreb I,Hope A,Massey C,Waldron JN,Kim J,Bayley AJ,Cummings B,Cho BC,Ringash J,Dawson LA,Siu LL,Chen E,Irish J,Gullane P,Hui A,Liu FF,Shen X,Xu W,O'Sullivan B

doi

10.1016/j.oraloncology.2012.07.015

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

79-85

issue

1

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(12)00243-6

journal_volume

49

pub_type

杂志文章

相关文献

ORAL ONCOLOGY文献大全
  • Potential role of HDAC inhibitors in cancer therapy: insights into oral squamous cell carcinoma.

    abstract：:Histone deacetylases (HDACs) are enzymes that are involved in the remodeling of chromatin and play a key role in the epigenetic regulation of gene expression. In addition, the activity of non-histone proteins can be regulated through HDAC-mediated hypoacetylation. In recent years, inhibition of HDACs has emerged as a ...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.oraloncology.2010.01.009

    authors： Iglesias-Linares A,Yañez-Vico RM,González-Moles MA

    更新日期：2010-05-01 00:00:00

  • A clinicopathologic study of head and neck rhabdomyosarcomas showing FOXO1 fusion-positive alveolar and MYOD1-mutant sclerosing are associated with unfavorable outcome.

    abstract：BACKGROUND:Based on their distinctive histologic and genetic features, the latest WHO classification of soft tissue tumors includes four pathologic variants of rhabdomyosarcoma (RMS): embryonal (ERMS), alveolar (ARMS), spindle cell-sclerosing (SRMS-ScRMS) and pleomorphic RMS. The aim of this study focused on a detailed...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2016.08.017

    authors： Owosho AA B Ch D,Huang SC Md,Chen S Mbbs,Kashikar S Dds,Estilo CL Dmd,Wolden SL Md,Wexler LH Md,Huryn JM Dds,Antonescu CR Md

    更新日期：2016-10-01 00:00:00

  • The efficacy and safety of PD-1/PD-L1 inhibitors in patients with recurrent or metastatic nasopharyngeal carcinoma: A systematic review and meta-analysis.

    abstract：OBJECTIVES:There is currently no effective salvage therapeutic modality that improves the survival outcomes of patients with recurrent or metastatic nasopharyngeal carcinoma. However, the programmed cell death protein 1 (PD-1) and its ligand (PD-L1) inhibitors may provide clinical benefit for these advanced patients. ...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2020.104640

    authors： Wang BC,Cao RB,Fu C,Chen WB,Li PD,Lin GH,Qian XJ,Li YT,Liu Q

    更新日期：2020-05-01 00:00:00

  • Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene.

    abstract：OBJECTIVE:Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and charac...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2017.04.003

    authors： Kujiraoka S,Tsunematsu T,Sato Y,Yoshida M,Ishikawa A,Tohyama R,Tanaka M,Kobayashi Y,Kondo T,Ushio A,Otsuka K,Kurosawa M,Saito M,Yamada A,Arakaki R,Nagai H,Nikai H,Takeuchi K,Nagao T,Miyamoto Y,Ishimaru N,Kudo Y

    更新日期：2017-06-01 00:00:00

  • The impact of surgery for oral cancer on quality of life as measured by the Medical Outcomes Short Form 36.

    abstract：:Quality of life evaluation is an important measure of outcome following the treatment of head and neck cancer. The aim of this study was to evaluate the quality of life of patients undergoing primary surgery for oral and oropharyngeal squamous cell carcinoma. 50 consecutive patients with previously untreated oral canc...

    journal_title：Oral oncology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s1368-8375(97)00069-9

    authors： Rogers SN,Humphris G,Lowe D,Brown JS,Vaughan ED

    更新日期：1998-05-01 00:00:00

  • Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay.

    abstract：OBJECTIVE:A standardized assay to determine the HPV status of head and neck squamous cell carcinoma (HNSCC) specimens has not yet been established, particularly for cytologic samples. The goal of this study was to determine whether the hybrid capture-2 (HC-2) assay, already widely used for the detection of high risk HP...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2014.02.011

    authors： Smith DF,Maleki Z,Coughlan D,Gooi Z,Akpeng B,Ogawa T,Bishop JA,Frick KD,Agrawal N,Gourin CG,Ha PK,Koch WM,Richmon JD,Westra WH,Pai SI

    更新日期：2014-06-01 00:00:00

  • Potential role of autofluorescence imaging in determining biopsy of oral potentially malignant disorders: A large prospective diagnostic study.

    abstract：:Autofluorescence examination of oral tissues using the VELscope has been suggested as an adjunctive tool for cancer detection and diagnosis. This study aimed to determine the diagnostic value of VELscope in a large prospective study of 517 patients with oral potentially malignant disorders (OPMD). For the outcome asse...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2019.08.006

    authors： Shi L,Li C,Shen X,Zhou Z,Liu W,Tang G

    更新日期：2019-11-01 00:00:00

  • Influence of tumor and microenvironment characteristics on diffusion-weighted imaging in oropharyngeal carcinoma: A pilot study.

    abstract：OBJECTIVES:Diffusion weighted imaging (DWI) is a frequently performed MRI sequence in cancer patients. While previous studies have shown the clinical value of the apparent diffusion coefficient (ADC) for response prediction and response monitoring, less is known about the biological background of ADC. In the tumor micr...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2017.12.001

    authors： Swartz JE,Driessen JP,van Kempen PMW,de Bree R,Janssen LM,Pameijer FA,Terhaard CHJ,Philippens MEP,Willems S

    更新日期：2018-02-01 00:00:00

  • Mucositis: The impact, biology and therapeutic opportunities of oral mucositis.

    abstract：:The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinici...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.oraloncology.2009.08.006

    authors： Sonis ST

    更新日期：2009-12-01 00:00:00

  • Hepatocyte growth factor expression correlates with cyclooxygenase-2 pathway in human salivary gland tumors.

    abstract：:It has been reported that cyclooxygenase-2 (COX-2) plays roles in cell proliferation, tumor invasion and inhibition of apoptosis. We reported COX-2 expression in salivary adenoma and its involvement in inhibition of apoptosis. COX-2 is known to induce a number of cytokines and growth factors. On the other hand, hepato...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2005.06.012

    authors： Aoki T,Tsukinoki K,Kurabayashi H,Sasaki M,Yasuda M,Ota Y,Watanabe Y,Kaneko A

    更新日期：2006-01-01 00:00:00

  • Large cell neuroendocrine carcinoma of the head and neck.

    abstract：:Large cell neuroendocrine carcinoma is a poorly differentiated neuroendocrine carcinoma that usually occurs in the lung. Although rare in the head and neck, salivary and mucosal subtypes are recognized. This article describes their characteristic light microscopic and immunohistochemical features and highlights the im...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.oraloncology.2011.09.016

    authors： Kusafuka K,Ferlito A,Lewis JS Jr,Woolgar JA,Rinaldo A,Slootweg PJ,Gnepp DR,Devaney KO,Travis WD,Barnes L

    更新日期：2012-03-01 00:00:00

  • Aberrant beta-catenin expression and adenomatous polyposis coli gene mutation in ameloblastoma and odontogenic carcinoma.

    abstract：:The Wnt pathway is involved in carcinogenesis and three regulatory genes of the Wnt pathway, APC (adenomatous polyposis coli), beta-catenin and Axin are frequently mutated in some primary human cancers. This study was conducted to clarify the relation of beta-catenin accumulation and the mutation of the CTNNB1 (beta-c...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2008.03.008

    authors： Siriwardena BS,Kudo Y,Ogawa I,Tilakaratne WM,Takata T

    更新日期：2009-02-01 00:00:00

  • Osteoprotegerin (OPG) binds with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): suppression of TRAIL-induced apoptosis in ameloblastomas.

    abstract：:Osteoprotegerin (OPG) is a useful receptor in inhibiting Receptor Activator of NFkappaB Ligand (RANKL) in inducing osteoclastogenesis. Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) is a potent apoptosis-inducing ligand in ameloblastomas. Since OPG has been reported to bind to TRAIL as well, the...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2005.09.009

    authors： Sandra F,Hendarmin L,Nakamura S

    更新日期：2006-04-01 00:00:00

  • The roles of excision repair cross-complementation group1 in objective response after cisplatin-based concurrent chemoradiotherapy and survival in head and neck cancers: a systematic review and meta-analysis.

    abstract：:Our aim of the study was to investigate the precise relationship of repair cross-complementation group 1 (ERCC1) expression and the survival as well as objective response rate to cisplatin-based concurrent chemoradiotherapy (CCRT) and a meta-analysis was conducted to analysis ERCC1's prognostic roles in head and neck ...

    journal_title：Oral oncology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.oraloncology.2015.03.009

    authors： Gao Y,Liu D

    更新日期：2015-06-01 00:00:00

  • Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias.

    abstract：:Oral leukoplakia is the most prevalent and potentially malignant disorder of the oral mucosa. Previous studies have demonstrated that molecular changes of the WWOX gene (WW-domain containing oxidoreductase), a candidate tumor suppressor gene located at 16q23.3-24.1 that spans FRA16D, the second most common fragile sit...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2007.08.019

    authors： Pimenta FJ,Cordeiro GT,Pimenta LG,Viana MB,Lopes J,Gomez MV,Aldaz CM,De Marco L,Gomez RS

    更新日期：2008-08-01 00:00:00

  • Scintigraphic evaluation of mandibular bone turnover in patients with solid tumors receiving zoledronic acid.

    abstract：:Bisphosphonates (BP) have been associated with the occurrence of osteonecrosis of the jaw (ONJ), possibly by causing an excessive bone turnover inhibition. However, little in vivo evidence exists to support this theory. The (99m)Tc-medronate scintigrams of patients with skeletal metastases and BP use (n=40) were indiv...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2010.01.001

    authors： Van den Wyngaert T,Huizing MT,Fossion E,Vermorken JB

    更新日期：2010-03-01 00:00:00

  • Neoantigens in immunotherapy and personalized vaccines: Implications for head and neck squamous cell carcinoma.

    abstract：:The recent success of immunotherapies has demonstrated the potency of tumor-specific immune cells in mediating tumor rejection and generating durable tumor immunity. Our understanding of the scientific basis of these responses results from the confluence of a better comprehension of the cancer immunoediting process an...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.oraloncology.2016.09.010

    authors： Zolkind P,Dunn GP,Lin T,Griffith M,Griffith OL,Uppaluri R

    更新日期：2017-08-01 00:00:00

  • Implications of understanding cancer stem cell (CSC) biology in head and neck squamous cell cancer.

    abstract：:Head and neck squamous cell cancer (HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of this disease. Efforts are ongoing throughout the world to improve early detection and prevention of H...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.oraloncology.2011.02.009

    authors： Sayed SI,Dwivedi RC,Katna R,Garg A,Pathak KA,Nutting CM,Rhys-Evans P,Harrington KJ,Kazi R

    更新日期：2011-04-01 00:00:00

  • Feasibility of transoral lateral oropharyngectomy using a robotic surgical system for tonsillar cancer.

    abstract：:Conventional surgical approaches for tonsillar carcinomas have a great risk for developing treatment-related morbidity. To minimize this morbidity, transoral lateral oropharyngectomy (TLO) using the robotic surgical system was performed, and the efficacy and feasibility of this procedure was evaluated. TLO was perform...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2009.02.012

    authors： Park YM,Lee JG,Lee WS,Choi EC,Chung SM,Kim SH

    更新日期：2009-08-01 00:00:00

  • Association between oral leukoplakia and upper gastrointestinal cancers: a 28-year follow-up study in the Linxian General Population Trial.

    abstract：BACKGROUND:Oral leukoplakia is a precancerous disorder that is common among residents in Linxian. However, the associations between oral leukoplakia and upper gastrointestinal cancers have not been reported. We investigated the relationships between oral leukoplakia and upper gastrointestinal cancers in the Linxian Gen...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2014.07.009

    authors： Fan JH,Wang JB,Qu CX,Zhang YQ,Taylor PR,Abnet CC,Dawsey SM,Qiao YL

    更新日期：2014-10-01 00:00:00

  • Translational research in nasopharyngeal carcinoma.

    abstract：:Nasopharyngeal carcinoma is well known to be a viral driven malignancy. Despite high loco-regional control rate with modern radiotherapy, distant metastasis remains as a major threat to the patients highlighting the importance of effective systemic therapy. Recent advances in the understanding of tumor biology, host c...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.oraloncology.2013.11.005

    authors： Chiang AK,Mak NK,Ng WT

    更新日期：2014-05-01 00:00:00

  • Orbital outcomes after orbit-sparing surgery and free flap reconstruction.

    abstract：OBJECTIVE:To identify functional outcome and orbital complication rate of the preserved orbit and to identify predictors of orbital impairment in periorbital free flap reconstruction. MATERIALS AND METHODS:A retrospective review was conducted on patients undergoing orbit-sparing surgery with periorbital free flap reco...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2019.09.023

    authors： Philips R,Topf MC,Graf A,Krein H,Heffelfinger R,Luginbuhl A,Curry J

    更新日期：2019-11-01 00:00:00

  • Tubulopapillary hidradenoma-like tumor of the mandible: Two case reports of an underrecognized entity.

    abstract：:Tubulopapillary hidradenoma-like tumor of the mandible is extremely rare, with only 3 cases published in the English-language literature. The clinicopathological characteristics and histogenesis of this tumor are unclear. Few pathologists and perhaps fewer clinicians are familiar with this entity, and it is likely und...

    journal_title：Oral oncology

    pub_type： 信件

    doi：10.1016/j.oraloncology.2019.104448

    authors： Zeng M,Guo X,Chen X,Yang S

    更新日期：2020-01-01 00:00:00

  • Knowledge and behaviors of primary care physicians on oral cancer in Italy.

    abstract：:We investigated the knowledge and behaviors of a random sample of 500 primary care physicians (PCPs) regarding oral cancer in Calabria (Italy). 87.6% and 64% indicated tobacco and alcohol use as risk factors, only 31.5% and 2.8% having a prior oral cancer lesion and older age. 60.9% knew that squamous-cell carcinoma i...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2003.10.001

    authors： Nicotera G,Di Stasio SM,Angelillo IF

    更新日期：2004-05-01 00:00:00

  • A phase I study of cabazitaxel in combination with platinum and 5-fluorouracil (PF) in locally advanced squamous cell carcinoma of head and neck (LA-SCCHN).

    abstract：BACKGROUND:There is a clinical need to improve outcomes for patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN), especially in Human Papilloma Virus (HPV) negative and HPV positive subtypes with a significant history of tobacco use. In animal models bearing SCCHN, Cabazitaxel showed a...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2017.05.008

    authors： Camille N,Rozehnal J,Roy E,Uczkowski D,Olson A,Genden E,Teng M,Bakst R,Gupta V,Posner M,Misiukiewicz K

    更新日期：2017-08-01 00:00:00

  • Podoplanin expression in oral leukoplakia: tumorigenic role.

    abstract：OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelia...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2013.02.008

    authors： de Vicente JC,Rodrigo JP,Rodriguez-Santamarta T,Lequerica-Fernández P,Allonca E,García-Pedrero JM

    更新日期：2013-06-01 00:00:00

  • Anticancer activity and mechanism of action of retinoids in oral and pharyngeal cancer.

    abstract：:Retinoids are the natural and synthetic derivatives of vitamin A. Epidemiological studies indicate that a low intake of vitamin A is associated with an increased risk of squamous cancer. In vitro studies on cancer cells show that exposure to retinoids results in the inhibition of growth, by blocking the cell cycle or ...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/s1368-8375(01)00118-x

    authors： Klaassen I,Braakhuis BJ

    更新日期：2002-09-01 00:00:00

  • Verruciform xanthoma of the oral mucosa. Report of four cases and a review of the literature.

    abstract：:We present four new cases of verruciform xanthoma (VX) in the oral mucosa and review the literature. Clinical, histological, and immunohistochemical features of four new cases of VX were analysed together with cases found in a review of the literature. Expression of CD-68 was studied by immunohistochemistry. Only 162 ...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/s1368-8375(00)00068-3

    authors： Oliveira PT,Jaeger RG,Cabral LA,Carvalho YR,Costa AL,Jaeger MM

    更新日期：2001-04-01 00:00:00

  • Nivolumab in patients with rare head and neck carcinomas: A single center's experience.

    abstract：:Immunotherapy (IO) with anti-PD1 inhibitors is available for the treatment of recurrent/metastatic squamous cell carcinomas of the head and neck (SCCHD) since 2016. Both nivolumab and pembrolizumab were tested in phase 3 randomized trials in adults progressing on or after platinum-based therapy and were found to confe...

    journal_title：Oral oncology

    pub_type： 信件

    doi：10.1016/j.oraloncology.2019.07.002

    authors： Kokkali S,Ntokou A,Drizou M,Perdikari K,Makaronis P,Katsarou E,Koufopoulos N,Tzovaras A,Ardavanis A

    更新日期：2020-02-01 00:00:00

  • Role of AMP-18 in oral mucositis.

    abstract：:Oral mucositis (OM) is a devasting toxicity associated with cytotoxic cancer therapy. Antrum mucosal protein (AMP)-18 and a synthetic peptide surrogate, exhibit cell protective and mitogenic properties in in vitro and in vivo models of gastrointestinal epithelial cell injury. The mucosal barrier-protective effects may...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2011.06.012

    authors： Chen P,Lingen M,Sonis ST,Walsh-Reitz MM,Toback FG

    更新日期：2011-09-01 00:00:00