Translational research in nasopharyngeal carcinoma.

abstract：:The relationship between basic fibroblast growth factor (bFGF), receptors for bFGF and neoangiogenesis was investigated in 51 patients with squamous cell carcinoma of the tongue, 26 of whom had metastatic disease in cervical lymph nodes. Vessels were demonstrated by immunocytochemical labelling for CD34 and expressed ...

journal_title：Oral oncology

authors： Forootan SS,Ke Y,Jones AS,Helliwell TR

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:Loss of Von Hippel-Lindau (VHL) gene expression has been implicated in the development of human cancers. However, its function in oral squamous cell carcinoma (OSCC) remains undefined. The aim of this study was to clarify the VHL expression in OSCC and to explore the underlying mechanisms of VHL in modulating...

journal_title：Oral oncology

authors： Zhang S,Zhou X,Wang B,Zhang K,Liu S,Yue K,Zhang L,Wang X

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:To evaluate the new American Joint Committee on Cancer (AJCC) cancer staging manual (8th edition) in an independent cohort of patients surgically treated for oral squamous cell carcinoma in order to determine whether the upstaging of pT and pN classification was indicative of a worse prognosis. METHODS:A co...

journal_title：Oral oncology

authors： Matos LL,Dedivitis RA,Kulcsar MAV,de Mello ES,Alves VAF,Cernea CR

更新日期：2017-08-01 00:00:00

abstract：:Oral cancer models have attempted to demonstrate inhibition of oral carcinogenesis. These models used synthetic carcinogens, lacked a specific mechanism of activity or used non-physiologic doses for carcinogen or inhibitor. To correct these problems the tobacco and environmental carcinogen, dibenzo[a,l]pyrene (DB[a,l]...

journal_title：Oral oncology

authors： Schwartz J,Baker V,Larios E,Desai D,Amin S

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:The immune system is crucial in the evolution of head and neck cancer. Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic cells and immune cells in the tumor microenvironment. The main aim of this study was to apply univariate/multivariate analysis to investigate the p...

journal_title：Oral oncology

authors： Alessandrini L,Franz L,Ottaviano G,Ghi MG,Lanza C,Blandamura S,Marioni G

更新日期：2020-09-01 00:00:00

abstract：:Maté is a beverage regularly consumed by Latin American populations. Upper aerodigestive tract (UADT) cancers are frequent in this region and are suspected to be associated with maté consumption. The aim of this systematic review and meta-analysis was to answer a focused question: "Is there an association between maté...

journal_title：Oral oncology

authors： Mello FW,Scotti FM,Melo G,Warnakulasuriya S,Guerra ENS,Rivero ERC

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Depth of invasion (DOI) has been introduced into the latest TNM classification of oral squamous cell carcinoma (OSCC). Despite its primarily pathological definition (pDOI), a preoperative evaluation of a radiological DOI (rDOI) would be useful but a standard and practical definition is lacking. The primary a...

journal_title：Oral oncology

authors： Locatello LG,Bruno C,Pietragalla M,Taverna C,Novelli L,Nardi C,Bonasera L,Cannavicci A,Maggiore G,Gallo O

更新日期：2020-08-01 00:00:00

abstract：:Hepatoma-derived growth factor (HDGF) participates in oncogenic progression and represents a prognostic factor in several types of cancer. This study aimed to elucidate the role of HDGF during oral carcinogenesis. HDGF expression and the tumorigenic behaviors in human oral cell lines were investigated by immunoblottin...

journal_title：Oral oncology

authors： Lin YW,Li CF,Chen HY,Yen CY,Lin LC,Huang CC,Huang HY,Wu PC,Chen CH,Chen SC,Tai MH

更新日期：2012-07-01 00:00:00

abstract：:Head and neck cancers during pregnancy are rising in incidence. Clinicians need to be aware of the principles of managing these cases. This paper is a review of the literature of head and neck cancers during pregnancy with a short case series of six non-thyroid pregnancy-associated cancers treated by a head and neck o...

journal_title：Oral oncology

authors： Atabo A,Bradley PJ

更新日期：2008-03-01 00:00:00

abstract：:In our previous study, we established an in vitro cellular carcinogenesis model of oral squamous cell carcinoma (OSCC), including a human immortalized oral epithelial cell (HIOEC) and a cancerous cell line (HB96). Microarray analysis showed that the gene encoding Yes-associated protein (YAP) was significantly increase...

journal_title：Oral oncology

authors： Zhang L,Ye DX,Pan HY,Wei KJ,Wang LZ,Wang XD,Shen GF,Zhang ZY

更新日期：2011-08-01 00:00:00

abstract：:The Wnt pathway is involved in carcinogenesis and three regulatory genes of the Wnt pathway, APC (adenomatous polyposis coli), beta-catenin and Axin are frequently mutated in some primary human cancers. This study was conducted to clarify the relation of beta-catenin accumulation and the mutation of the CTNNB1 (beta-c...

journal_title：Oral oncology

authors： Siriwardena BS,Kudo Y,Ogawa I,Tilakaratne WM,Takata T

更新日期：2009-02-01 00:00:00

abstract：:Oral carcinoma (OSCC) is one of the most important causes of cancer death worldwide. OSCC cell lines and preclinical rodent models are crucial to addressing the mechanisms of OSCC and helping the development of new therapeutic strategies and interventions. The establishment of murine OSCC cell lines and syngeneic mode...

journal_title：Oral oncology

authors： Chen YF,Chang KW,Yang IT,Tu HF,Lin SC

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:We assess the incremental cost-effectiveness ratio (ICER) of the oral cancer (OC) screening program in Taiwan. MATERIALS AND METHODS:We interlinked the Cancer Registry, Mortality Registry, National Vital Statistics, reimbursement database of National Health Insurance, and the National Oral Cancer Screening ...

journal_title：Oral oncology

authors： Huang CC,Lin CN,Chung CH,Hwang JS,Tsai ST,Wang JD

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transf...

journal_title：Oral oncology

authors： Yagyuu T,Hatakeyama K,Imada M,Kurihara M,Matsusue Y,Yamamoto K,Obayashi C,Kirita T

更新日期：2017-05-01 00:00:00

abstract：:ICAM-5 (telencephalin) is an intercellular adhesion molecule reported to be expressed only in the somatodendritic membrane of telencephalic neurons. We recently identified high ICAM-5 expression in a cDNA array study of head and neck neoplasms with a propensity for perineural invasion. To determine the association of ...

journal_title：Oral oncology

authors： Maruya SI,Myers JN,Weber RS,Rosenthal DI,Lotan R,El-Naggar AK

更新日期：2005-07-01 00:00:00

abstract：:Oral cancer (OC), which is the most common form of head and neck cancers, has one of the lowest (~50%) overall 5-year survival rates. The main reasons for this high mortality rate are diagnosis of OC in advanced stages in most patients and spread to distant organs via lymph node metastasis. Many studies have shown tha...

journal_title：Oral oncology

authors： Barlak N,Capik O,Sanli F,Karatas OF

更新日期：2020-08-19 00:00:00

abstract：:Lip cancer is the most frequent malignant neoplasm of the oral cavity; however, there is no information available on the incidence of this type of cancer in Mexico. This study provides information about the clinico-pathological features of lip cancer patients admitted at a cancer hospital in Mexico City during an 11-y...

journal_title：Oral oncology

authors： Luna-Ortiz K,Güemes-Meza A,Villavicencio-Valencia V,Mosqueda-Taylor A

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To assess the relationship between tumor-specific growth rate (TSGR) and oropharyngeal cancer (OPC) outcomes in the HPV era. METHODS/MATERIALS:Primary tumor volume differences between a diagnostic and secondary scan separated ⩾7days without interval treatment were used to estimate TSGR, defined as percent volu...

journal_title：Oral oncology

authors： Murphy CT,Devarajan K,Wang LS,Mehra R,Ridge JA,Fundakowski C,Galloway TJ

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:Head and neck radiotherapy can cause several toxicities, and its management has important treatment implications. Proper information about treatment is crucial to assist patients by preparing them and enhancing their ability to manage their illness. Thus, this study aimed to verify the impact of an education...

journal_title：Oral oncology

authors： Fernandes DT,Prado-Ribeiro AC,Markman RL,Morais K,Moutinho K,Tonaki JO,Brandão TB,Rivera C,Santos-Silva AR,Lopes MA

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:The long-term results of RTOG 91-11 suggested increased deaths not attributed to larynx cancer after concomitant chemoradiotherapy (CRT) despite no apparent increase in late effects. Because the timing of events was not reported by RTOG 91-11, one possibility is that severe late dysphagia (SLD) develops beyond ...

journal_title：Oral oncology

authors： Ward MC,Adelstein DJ,Bhateja P,Nwizu TI,Scharpf J,Houston N,Lamarre ED,Lorenz R,Burkey BB,Greskovich JF,Koyfman SA

更新日期：2016-06-01 00:00:00

abstract：:We have investigated whether Ginkgo biloba extract (EGb 761) induces apoptosis of oral cavity cancer cells and attempted to characterize the apoptotic pathway activated by EGb 761. The inhibition of SCC 1483 oral cavity cancer cells proliferation was noted from 250 micro/ml of EGb 761. Apoptosis was observed after 24 ...

journal_title：Oral oncology

authors： Kim KS,Rhee KH,Yoon JH,Lee JG,Lee JH,Yoo JB

更新日期：2005-04-01 00:00:00

abstract：:Spindle-cell lipoma (SCL) is a distinct histological variant of lipoma. Clinically, it appears as a solitary, subcutaneous, circumscribed lesion. SCL accounts for about 1.5% of all adipocytic tumours. Only nine cases of intraoral SCL were found in the literature. Microscopically, mature adipocytes and spindle cells ar...

journal_title：Oral oncology

authors： Piattelli A,Rubini C,Fioroni M,Iezzi G

更新日期：2000-09-01 00:00:00

abstract：:Immunoreactivity of proliferating cell nuclear antigen (PCNA) was assessed in formalin-fixed, paraffin-embedded sections from human normal parotid gland (N; n = 12), chronic sialadenitis (CS; n = 8), Warthin's tumour (W; n = 10), benign pleomorphic adenoma (BPA; n = 11), mucoepidermoid carcinoma (MEC; n = 14), carcino...

journal_title：Oral oncology

authors： Zhu Q,White FH,Tipoe GL

更新日期：1997-01-01 00:00:00

abstract：:It has been reported that cyclooxygenase-2 (COX-2) plays roles in cell proliferation, tumor invasion and inhibition of apoptosis. We reported COX-2 expression in salivary adenoma and its involvement in inhibition of apoptosis. COX-2 is known to induce a number of cytokines and growth factors. On the other hand, hepato...

journal_title：Oral oncology

authors： Aoki T,Tsukinoki K,Kurabayashi H,Sasaki M,Yasuda M,Ota Y,Watanabe Y,Kaneko A

更新日期：2006-01-01 00:00:00

abstract：:It is well known that cellular DNA alterations can lead to the formation of cancer, and there has been much discovery in the pathways involved in the development of head and neck squamous cell carcinoma (HNSCC). With novel genome-wide molecular assays, our ability to detect these abnormalities has increased. We now ha...

journal_title：Oral oncology

authors： Ha PK,Chang SS,Glazer CA,Califano JA,Sidransky D

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:The present study aimed to clarify the role of Moesin in oral squamous cell carcinoma (OSCC) progression, especially in regulation of cell motility. MATERIALS AND METHODS:Immunohistochemistry and western blotting were used to investigate the expression of Moesin, E-cadherin, p120-catenin and MT1-MMP in norma...

journal_title：Oral oncology

authors： Li YY,Zhou CX,Gao Y

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:Current guidelines recommend chest computed tomography (CT) with locoregional CT/magnetic resonance imaging for patients with head and neck squamous cell carcinoma (HNSCC), and 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/CT is suggested for stage III-IV patients. However, whole body scree...

journal_title：Oral oncology

authors： Kim Y,Roh JL,Kim JS,Lee JH,Choi SH,Nam SY,Kim SY

更新日期：2019-01-01 00:00:00

abstract：:Betel quid (BQ) and matrix metalloproteinase-8 (MMP-8) play roles in oral diseases. Here, we analyzed the regulation of MMP-8 by BQ and its effect on cell migration. We found that BQ extract (BQE) increased the secretion of an 85kDa caseinolytic proteinase, specifically precipitated by an anti-MMP-8 antibody, in the c...

journal_title：Oral oncology

authors： Liu SY,Liu YC,Huang WT,Huang GC,Chen TC,Lin MH

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVES:Secretory leukocyte protease inhibitor (SLPI) is an innate-immunity protein displaying antimicrobial and anti-inflammatory properties that is found in high concentrations in saliva. The role of extracellular salivary SLPI in head and neck squamous cell carcinoma (HNSCC) remains unclear. Thus, we aimed to eva...

journal_title：Oral oncology

authors： Pierce Campbell CM,Giuliano AR,Torres BN,O'Keefe MT,Ingles DJ,Anderson RL,Teras LR,Gapstur SM

更新日期：2016-04-01 00:00:00

abstract：:Head-and-neck (H&N) tumor re-growth is clinically observed after arrest of anti-EGFR therapies. In the present study, we compared, for a similar dose exposure to anti-EGFR therapies, constant (CS) with tapered (TS) schedules (i.e. progressive dose reduction) for cetuximab, a mAb, and gefitinib, a TKI. Mice bearing CAL...

journal_title：Oral oncology

authors： Bozec A,Formento P,Fischel JL,Etienne-Grimaldi MC,Milano G

更新日期：2010-03-01 00:00:00