Evaluation of a new binary system of grading oral epithelial dysplasia for prediction of malignant transformation.


:The aim of this paper is to assess the reproducibility of a novel binary grading system (high/low risk) of oral epithelial dysplasia and to compare it with the WHO classification 2005. The accuracy of the new system for predicting malignant transformation was also assessed. Ninety-six consecutive oral epithelial dysplasia biopsies with known clinical outcomes were retrieved from the Oral Pathology archives. A pilot study was conducted on 28 cases to determine the process of classification. Four observers then reviewed the same set of H&E stained slides of 68 oral dysplastic lesions using the two grading systems blinded to the clinical outcomes. The overall inter-observer unweighted and weighted kappa agreements for the WHO grading system were Ks = 0.22 (95% CI: 0.11-0.35), Kw = 0.63 (95% CI: 0.42-0.78), respectively, versus K = 0.50 (95% CI: 0.35-0.67) for the new binary system. Interestingly, all pathologists showed satisfactory agreement on the distinction of mild dysplasia from severe dysplasia and from carcinoma in situ using the new WHO classification. However, assessment of moderate dysplasia remains problematic. The sensitivity and specificity of the new binary grading system for predicting malignant transformation in oral epithelial dysplasia were 85% and 80%, respectively and the accuracy was 82%. The new binary grading system complemented the WHO Classification 2005 and may have merit in helping clinicians to make critical clinical decisions particularly for the cases of moderate dysplasia. Histological grading of dysplasia using established criteria is a reproducible prognosticator in oral epithelial dysplasia. Furthermore, the present study showed that more consensus scoring on either the degree of dysplasia, assessment of risk or the presence of each morphological characteristic by a panel should be encouraged.


Oral Oncol


Oral oncology


Kujan O,Oliver RJ,Khattab A,Roberts SA,Thakker N,Sloan P




Has Abstract


2006-11-01 00:00:00














  • ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion!

    abstract::ICAM-5 (telencephalin) is an intercellular adhesion molecule reported to be expressed only in the somatodendritic membrane of telencephalic neurons. We recently identified high ICAM-5 expression in a cDNA array study of head and neck neoplasms with a propensity for perineural invasion. To determine the association of ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Maruya SI,Myers JN,Weber RS,Rosenthal DI,Lotan R,El-Naggar AK

    更新日期:2005-07-01 00:00:00

  • Serum C-reactive protein as a prognostic indicator in patients with oral squamous cell carcinoma.

    abstract::Preoperative elevation of serum C-reactive protein (CRP) has been demonstrated as a prognostic indicator in oesophageal, gastric and colorectal cancer. This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamou...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Khandavilli SD,Ceallaigh PO,Lloyd CJ,Whitaker R

    更新日期:2009-10-01 00:00:00

  • Risk of contralateral nodal failure following ipsilateral IMRT for node-positive tonsillar cancer.

    abstract:PURPOSE:To determine the risk of contralateral nodal failure following ipsilateral radiotherapy in a series of patients with node-positive tonsillar squamous cell carcinoma. METHODS:Retrospective review was used to identify 34 patients with well-lateralized node-positive tonsillar squamous cell carcinoma treated with ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Gottumukkala S,Pham NL,Sumer B,Myers L,Truelson J,Nedzi L,Khan S,Hughes R,Sher DJ

    更新日期:2017-12-01 00:00:00

  • Podoplanin expression in oral leukoplakia: tumorigenic role.

    abstract:OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelia...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: de Vicente JC,Rodrigo JP,Rodriguez-Santamarta T,Lequerica-Fernández P,Allonca E,García-Pedrero JM

    更新日期:2013-06-01 00:00:00

  • Oncological safety of submental island flap for reconstruction of pathologically node-negative and node-positive T1-2 oral squamous cell carcinoma-related defects: A retrospective study and comparison of outcomes.

    abstract:OBJECTIVES:To evaluate the oncological safety and reliability of the submental island flap (SIF) technique in patients with pathologically node-negative (pN0) and node-positive (pN+) T1-2 oral squamous cell carcinoma (OSCC) undergoing surgical tumor resection and concurrent SIF reconstruction. PATIENTS AND METHODS:Ret...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Wang J,Tan Y,Shen Y,Lv M,Li J,Sun J

    更新日期:2020-03-01 00:00:00

  • Cisplatin and oxaliplatin induce similar immunogenic changes in preclinical models of head and neck cancer.

    abstract:OBJECTIVES:Prior studies suggest that oxaliplatin is unique among platinum chemotherapy drugs in its ability to enhance anti-tumor immunity, but the immune mechanisms of different platinum chemotherapy drugs have not been previously compared in preclinical models of head and neck squamous cell carcinoma (HNSCC). MATER...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Park SJ,Ye W,Xiao R,Silvin C,Padget M,Hodge JW,Van Waes C,Schmitt NC

    更新日期:2019-08-01 00:00:00

  • Assessment of the total cfDNA and HPV16/18 detection in plasma samples of head and neck squamous cell carcinoma patients.

    abstract:OBJECTIVES:The advantages of the circulating cell-free DNA (cfDNA) methodology are quick results and the possibility of repeated analysis. The main aim of our study was to establish the relationship of the total cfDNA with patients' clinical characteristics and circulating HPV DNA detection in the blood of patients wit...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Mazurek AM,Rutkowski T,Fiszer-Kierzkowska A,Małusecka E,Składowski K

    更新日期:2016-03-01 00:00:00

  • Pediatric intraosseous hemangioma of the anterior mandible.

    abstract::Intraosseous hemangioma is a benign vascular neoplasm and seldom affects the mandible. The diagnosis is challenging owing to its unspecific clinical and radiographic findings. Treatment options in children should be elective based on their age, symptoms, and facial deformity. Herein a rare case of intraosseous hemangi...

    journal_title:Oral oncology

    pub_type: 信件


    authors: Madiraju GS

    更新日期:2020-09-01 00:00:00

  • Eosinophil ablation and tumor development.

    abstract::Tissue eosinophilia in squamous cell carcinoma has long been recognized; however, the role of eosinophils in tumor development remains unclear. Studies have reported both favorable and unfavorable prognoses for patients with tumors exhibiting tumor-associated tissue eosinophilia (TATE). This study seeks to elucidate t...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Wong DT,Bowen SM,Elovic A,Gallagher GT,Weller PF

    更新日期:1999-09-01 00:00:00

  • Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy.

    abstract::Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage. Previously, little was known about outcomes of this disease due to its rarity. In the past several years, much has been learned about salivary duct carcinoma after publication of outcomes from several ...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Schmitt NC,Kang H,Sharma A

    更新日期:2017-11-01 00:00:00

  • Biomechanical study of a unilocking T-plate system for prophylactic internal fixation of the radial osteocutaneous donor site using the sheep tibia model.

    abstract::Prophylactic internal fixation (PIF), with a bone plate in either the anterior (over the section defect) or posterior (on intact cortex) position, has substantially reduced the incidence of fracture at the donor site of the radial osteocutaneous free flap. This study uses the sheep tibia model to compare the effective...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Avery CM,Skidmore M,Peden A,Pan J

    更新日期:2011-04-01 00:00:00

  • Confocal laser endomicroscopy for non-invasive head and neck cancer imaging: a comprehensive review.

    abstract::Histological assessment is an essential tool in the diagnosis and guidance of the treatment of various diseases, in particular cancer, of the head and neck. Recent major advances in optical imaging techniques have made it possible to acquire high-resolution in vivo images at the cellular scale. Confocal endomicroscopy...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Abbaci M,Breuskin I,Casiraghi O,De Leeuw F,Ferchiou M,Temam S,Laplace-Builhé C

    更新日期:2014-08-01 00:00:00

  • Prognostic significance of tumor-related genes hypermethylation detected in cancer-free surgical margins of oral squamous cell carcinomas.

    abstract::Oral squamous cell carcinoma (OSCC) is characterized by high mortality rates. High incidence of local recurrences in the normal-appearing surgical margins of OSCC patients indicates the existence molecular alterations, including DNA methylation, which could not be detectable by histopathologic analysis. The objective ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Supic G,Kozomara R,Jovic N,Zeljic K,Magic Z

    更新日期:2011-08-01 00:00:00

  • Clear cell odontogenic carcinoma.

    abstract::Clear cell tumours, in the head and neck region, are usually derived from salivary or odontogenic tissues, or may be metastatic. A few clear cells may be present in odontogenic cysts, while, odontogenic neoplasms composed predominantly of clear cells are quite rare. They include calcifying epithelial odontogenic tumou...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Iezzi G,Rubini C,Fioroni M,Piattelli A

    更新日期:2002-02-01 00:00:00

  • Efficacy of super-selective neck dissection following chemoradiation for advanced head and neck cancer.

    abstract:BACKGROUND:Hypothesizing that neck-level specific locations of residual lymph node metastases following chemoradiation for head and neck cancer are highly predictable, the efficacy of the more targeted lymphadenectomy procedure called super-selective neck dissection (SSND) was evaluated. METHODS:A retrospective analys...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究


    authors: Robbins KT,Dhiwakar M,Vieira F,Rao K,Malone J

    更新日期:2012-11-01 00:00:00

  • Quality insurance in head and neck cancer multidisciplinary team meetings: A watchful eye on real-life experience.

    abstract:INTRODUCTION:Although Multidisciplinary Team Management (MDT) is integrated in most international head and neck cancer treatment guidelines, its applications and proceedings were rarely described. The present study explores a 6-year real-life experience in a French Comprehensive Cancer Care Center. METHODS:Patients, t...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Guy JB,Benna M,Xia Y,Daguenet E,Ben Mrad M,Jmour O,Vial N,Lelonge Y,Fournel P,Prades JM,Vallard A,Magné N

    更新日期:2019-04-01 00:00:00

  • Psychological distress in patients and caregivers over the course of radiotherapy for head and neck cancer.

    abstract:OBJECTIVES:Head and neck cancer patients and their caregivers report high rates of psychological distress. High rates of physical symptom burden and the increased need for family members to provide caregiving during treatment may contribute to this distress. METHODS:This study examined trajectories of patient and care...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Badr H,Gupta V,Sikora A,Posner M

    更新日期:2014-10-01 00:00:00

  • Current attitudes of head and neck oncologists in the United Kingdom to induction chemotherapy for locally advanced head and neck cancer: a survey of centres participating in a national randomised controlled trial.

    abstract:OBJECTIVES:Induction chemotherapy (IC) followed by chemoradiation (CRT) for locally advanced squamous cell head and neck cancer (SCCHN) remains controversial in the absence of clear evidence to define its role. As part of a prospective, randomised, multicentre study of CRT for stage III/IV laryngeal/hypopharyngeal canc...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究


    authors: Gujral DM,Piercy D,Morden JP,Emson M,Hall E,Miah AB,Bhide SA,Newbold KL,Harrington KJ,Nutting CM

    更新日期:2014-02-01 00:00:00

  • Impact of histological Oral Tongue Cancer margins on locoregional recurrence: A multi-centre retrospective analysis.

    abstract:OBJECTIVES:To assess the effect of the histological margins (HM) upon locoregional failure (LRF) and overall survival (OS) for oral tongue squamous cell carcinoma (OTSCC). MATERIALS AND METHODS:We undertook a retrospective review of 258 patients, across two institutions, treated for OTSCC between 2007 and 2016. A Cox-...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Daniell J,Udovicich C,Rowe D,McDowell L,Vital D,Bressel M,Magarey MJR,Iseli TA,Wong T,Lekgabe E,Cavanagh K,Fua T,Rischin D,Wiesenfeld D

    更新日期:2020-12-01 00:00:00

  • Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene.

    abstract:OBJECTIVE:Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and charac...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kujiraoka S,Tsunematsu T,Sato Y,Yoshida M,Ishikawa A,Tohyama R,Tanaka M,Kobayashi Y,Kondo T,Ushio A,Otsuka K,Kurosawa M,Saito M,Yamada A,Arakaki R,Nagai H,Nikai H,Takeuchi K,Nagao T,Miyamoto Y,Ishimaru N,Kudo Y

    更新日期:2017-06-01 00:00:00

  • Traumatic eosinophilic granuloma of the oral mucosa: a CD30+(Ki-1) lymphoproliferative disorder?

    abstract::Traumatic eosinophilic granuloma of the oral mucosa, also known as eosinophilic ulcer, is considered to be a reactive lesion of unknown aetiology. It usually presents as a tongue ulcer and injury has been considered to play a role in its cause. We present a 72-year-old man who had suffered multiple episodes of recurre...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ficarra G,Prignano F,Romagnoli P

    更新日期:1997-09-01 00:00:00

  • Glutathione S-transferase M1 or T1 null genotype as a risk factor for developing multiple primary neoplasms in the upper aero-digestive tract, in Indian males using tobacco.

    abstract::In this study conducted amongst Indian male tobacco users with upper aero-digestive tract (UADT) squamous carcinoma, 30 patients with multiple primary neoplasms (MPN) were compared with 28 age and sex matched patients with a single primary neoplasm (SPN) for various environmental factors (form of tobacco use, alcohol,...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Jhavar S,Sarin R,Mulherkar R,Benner A,Agarwal JP,Dinshaw K

    更新日期:2004-01-01 00:00:00

  • Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt.

    abstract::Hematogenous metastasis is one of the most important factors determining the outcome of the patients with salivary adenoid cystic carcinoma (SACC). In the present study, we examined expression profile of genes in SACC cell lines to look for molecules responsible for its unique metastatic trait. A transcriptomic microa...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Hu K,Li SL,Gan YH,Wang CY,Yu GY

    更新日期:2009-02-01 00:00:00

  • Influence of tumor and microenvironment characteristics on diffusion-weighted imaging in oropharyngeal carcinoma: A pilot study.

    abstract:OBJECTIVES:Diffusion weighted imaging (DWI) is a frequently performed MRI sequence in cancer patients. While previous studies have shown the clinical value of the apparent diffusion coefficient (ADC) for response prediction and response monitoring, less is known about the biological background of ADC. In the tumor micr...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Swartz JE,Driessen JP,van Kempen PMW,de Bree R,Janssen LM,Pameijer FA,Terhaard CHJ,Philippens MEP,Willems S

    更新日期:2018-02-01 00:00:00

  • The submental island flap for reconstruction of intraoral defects in oral cancer patients.

    abstract::The submental artery island flap (SIF) is gaining acceptance as a simple and reliable option in selected oral oncologic reconstructions. The present study aims to assess the usefulness of submental artery flap in oral reconstruction with respect to flap reliability, cosmesis, function, donor site morbidity and oncolog...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Sebastian P,Thomas S,Varghese BT,Iype EM,Balagopal PG,Mathew PC

    更新日期:2008-11-01 00:00:00

  • Understanding the impact of survival and human papillomavirus tumor status on timing of recurrence in oropharyngeal squamous cell carcinoma.

    abstract:OBJECTIVES:Human papillomavirus (HPV)-positive tumor status is associated with improved prognosis after disease recurrence in oropharyngeal squamous cell carcinoma (OPSCC). In this study the potential role of survival bias in the relationship between HPV tumor status and the timing of recurrence was evaluated, given co...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Guo T,Rettig E,Fakhry C

    更新日期:2016-01-01 00:00:00

  • Actinic cheilitis: epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2.

    abstract::Cyclooxygenase-2 (COX-2) is overexpressed in various types of human malignancies, including oral cancers. Recent studies have shown that mast cell-derived protease tryptase can induce COX-2 expression by the cleavage of proteinase-activated receptor-2 (PAR-2). Actinic cheilitis (AC) is a premalignant form of lip cance...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Rojas IG,Martínez A,Brethauer U,Grez P,Yefi R,Luza S,Marchesani FJ

    更新日期:2009-03-01 00:00:00

  • Effects of metformin on head and neck cancer: a systematic review.

    abstract::Conventional therapeutic approaches for head and neck squamous cell carcinoma (HNSCC) are associated with many adverse effects that reduce quality of life. Therefore, identification of new less cytotoxic treatments is highly important. Metformin, which is commonly used for type 2 diabetes, may reduce cancer risk. A fe...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Rêgo DF,Pavan LM,Elias ST,De Luca Canto G,Guerra EN

    更新日期:2015-05-01 00:00:00

  • Chest radiography or chest CT plus head and neck CT versus 18F-FDG PET/CT for detection of distant metastasis and synchronous cancer in patients with head and neck cancer.

    abstract:OBJECTIVES:Current guidelines recommend chest computed tomography (CT) with locoregional CT/magnetic resonance imaging for patients with head and neck squamous cell carcinoma (HNSCC), and 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/CT is suggested for stage III-IV patients. However, whole body scree...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kim Y,Roh JL,Kim JS,Lee JH,Choi SH,Nam SY,Kim SY

    更新日期:2019-01-01 00:00:00

  • Analysis of amelogenin gene (AMGX, AMGY) expression in ameloblastoma.

    abstract::Although the amelogenin gene is expressed in ameloblastoma, the precise expression pattern of X and Y amelogenin genes (AMGX, AMGY) in this tumor has not yet been identified. In this study, we analyzed amelogenin gene expression in 19 samples (9 male, 10 female) of oral ameloblastomas by RT-PCR and detect the chromoso...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Tsujigiwa H,Nagatsuka H,Han PP,Gunduz M,Siar CH,Oida S,Nagai N

    更新日期:2005-09-01 00:00:00