Abstract:
:Lymphatic malformations, traditionally called lymphangiomas, are diseases caused by development errors of the lymphatic system. About 90% of the cases occur within 2years of age, except a few cases which occur in adulthood, and approximately 75% of the lesions are located in the head and neck region. The lesions can grow rapidly with infection, trauma or bleeding, resulting in disfigurement as well as severe impairment of respiration, swallow and speech. Although lymphatic malformations are benign lesions, they rarely resolve spontaneously, their infiltrating nature coupled with the difficulty in distinguishing involved vital structures of head and neck from adjacent normal tissues makes complete surgical resection even more difficult. The likelihood of postsurgical recurrence and complications is thus higher than other vascular lesions. Surgical resection, sclerotherapy and laser therapy are currently the main treatment modes of lymphatic malformations. Various treatment options have their advantages and disadvantages, the selection of treatment modalities should depend on the patient's individual status and available technology and expertise. The treatment protocol should be individualized, comprehensive as well as sequential in order to obtain the best treatment outcome. Based on published literatures and clinical experiences, we devised the treatment guideline for management of head and neck lymphatic malformations. This protocol will be reviewed and updated periodically to include cutting edge knowledge to provide the best treatment options to benefit our patients.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Zhou Q,Zheng JW,Mai HM,Luo QF,Fan XD,Su LX,Wang YA,Qin ZPdoi
10.1016/j.oraloncology.2011.08.001subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1105-9issue
12eissn
1368-8375issn
1879-0593pii
S1368-8375(11)00776-7journal_volume
47pub_type
杂志文章,评审相关文献
ORAL ONCOLOGY文献大全abstract::Laryngeal cancer is a rare type of neoplasia, constituting approximately 2% of all human cancers. Mutations of the ras gene family is one of the main activating mechanisms in human cancer. Their involvement in head and neck cancer has been mainly demonstrated at the level of the overexpression whereas ras mutations in...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(99)00032-9
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVES:In shared decision making it is important to adequately, timely and actively involve patients in treatment decisions. Sharing prognostic information can be of key importance. This study describes whether and how prognostic information on life expectancy is included during communication on diagnosis and treat...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2018.07.014
更新日期:2018-09-01 00:00:00
abstract::Several reports have indicated that nuclear factor-kappa B (NF-κB) is constitutively activated in a variety of cancer cells including human oral squamous carcinoma cells, and play a key role in their growth and survival. Recent studies report that NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), inhibits proli...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2011.03.001
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:The incidence of nasopharyngeal carcinoma (NPC) is higher in Chinese than in Caucasian populations. Genetic, viral, and lifestyle factors may explain these ethnic differences in the incidence of NPC. In the present study, we examined the familial aggregation, heritability, and relative risks (RRs) of NPC usi...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2017.07.020
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Adenoid cystic carcinomas (ACC) are characterized by high rate of local recurrence and late distant metastasis. Chromosomal changes in the evolution from primary tumors to metastatic disease of ACC have not been appointed. Here we investigated the chromosomal alterations of 53 primary tumors from...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.104615
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:There is a clinical need to improve outcomes for patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN), especially in Human Papilloma Virus (HPV) negative and HPV positive subtypes with a significant history of tobacco use. In animal models bearing SCCHN, Cabazitaxel showed a...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2017.05.008
更新日期:2017-08-01 00:00:00
abstract::Metallothioneins (MTs) are a family of low molecular weight, cysteine-rich, inducible, intracellular proteins that bind heavy metals with high affinity. MT-1 is known as a stress-inducible protein and functions as an antioxidant enzyme. Areca quid chewing is a major risk factor in the development and further progressi...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2007.01.019
更新日期:2008-02-01 00:00:00
abstract::Nasopharyngeal carcinoma is well known to be a viral driven malignancy. Despite high loco-regional control rate with modern radiotherapy, distant metastasis remains as a major threat to the patients highlighting the importance of effective systemic therapy. Recent advances in the understanding of tumor biology, host c...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2013.11.005
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:The need to improve chemotherapeutic efficacy against head and neck squamous cell carcinomas (HNSCC) is well recognized. In this study, we investigated the potential of targeting the established tumor vasculature in combination with chemotherapy in head and neck cancer. METHODS:Experimental studies were carrie...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2013.06.011
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelia...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2013.02.008
更新日期:2013-06-01 00:00:00
abstract::The presence of distant metastasis after the initial treatment of head and neck squamous cell carcinoma is not considered a common event and is associated with a poor outcome. The objective of this study was to investigate the prevalence and risk factors associated with the diagnosis of distant metastasis in oral and ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2005.01.012
更新日期:2005-05-01 00:00:00
abstract::The hormonal regulation of Na+,K(+)-ATPase enzyme activities and induction of the alpha subunit protein of the enzyme in the human submandibular gland (HSG) were studied by use of cultured HSG cells. We treated HSG cells with thyroid hormone, androgen, mineralocorticoid, and glucocorticoid, singly or in combination. 3...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00124-9
更新日期:1999-07-01 00:00:00
abstract::The inactivation of tumor suppressor gene (TSG) is important during multistage carcinogenesis. The p53 TSG is frequently mutated in oral squamous cell carcinomas. These mutations can serve as very specific markers for the presence of tumor cells in a background of normal cells. In this study, 10 oral squamous cell car...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(00)00005-1
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Histopathological grading of adenoid cystic carcinoma (ACC) is a controversial issue. It is generally agreed that solid type ACC has a relatively poor prognosis. However, the amount of solid regions within this often mixed type tumor that predicts a poor prognosis is not firmly established. Some authors stip...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2014.10.007
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:The evaluation of neck lymph node metastasis is critical for predicting survival after head and neck cancer treatment. However, traditional pathological N staging does not completely correlate with survival; the total number of lymph nodes resected during surgery affects staging, and a minimal number of node...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.105146
更新日期:2021-01-16 00:00:00
abstract::Human beta-defensins (hBDs) are small, cationic antimicrobial peptides produced by oral and other mucosal epithelia. More recently, hBDs have been shown to regulate adaptive immunity. In this study, we provide new information about the potential role of hBD-3 in the progression of oral cancer. In normal human oral epi...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2008.10.016
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Oral mucositis is a major event increasing treatment costs of head and neck squamous cell carcinoma (HNSCC) patients treated with chemoradiation (CRT). This study was designed to estimate the cost-effectiveness of low-level laser therapy (LLLT) to prevent oral mucositis in HNSCC patients receiving CRT. METH...
journal_title:Oral oncology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.oraloncology.2015.10.022
更新日期:2016-01-01 00:00:00
abstract::This hospital-based cohort study evaluated the efficacy of three Epstein-Barr virus (EBV) - associated assays for nasopharyngeal carcinoma (NPC) primary screening and monitoring treatment outcome. Five hundred and seventeen consecutive subjects, including 156 NPC patients, 264 healthy volunteers and 97 patients with h...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2007.10.003
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:Comorbid conditions impact outcome for patients treated for oropharyngeal squamous cell carcinoma (OPSCC) and serve as competing risk factors for death. The purpose of this study was to examine differences in comorbidities in patients with OPSCC and known HPV-DNA. MATERIAL AND METHODS:We included patients d...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2019.06.035
更新日期:2019-09-01 00:00:00
abstract::The high frequency of second or third primary tumors was first explained by Slaughter et al. with the concept of field cancerisation. Another theory postulates micrometastatic lesions as a reason for this phenomenon. The micronuclei (MN)-assay was evaluated to provide evidence for the concept of field cancerisation an...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(00)00051-8
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVES:To establish the concept that the antigenicity/immunogenicity of ALDH(high) human head and neck squamous cell carcinoma (HNSCC) cancer stem cells (CSC) is distinct from that of ALDH(low) non-CSCs. METHODS:We generated CSC-loaded dendritic cells (DCs) to sensitize autologous peripheral blood T, B lymphocytes...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2016.05.013
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVES:Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transf...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2017.03.006
更新日期:2017-05-01 00:00:00
abstract::Emerging evidence suggests the existence of a tumorigenic population of cancer cells that demonstrate stem cell-like properties such as self-renewal and multipotency. These cells, termed cancer stem cells (CSC), are able to both initiate and maintain tumor formation and progression. Studies have shown that CSC are res...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2013.05.013
更新日期:2013-09-01 00:00:00
abstract::We have established four cell lines from a human malignant fibrous histiocytoma. Each cell line had human aneuploid karyotype and DNA aneuploidy. Cells in all lines expressed CD13, CD68 and vimentin but lacked CD11, CD14, CD15, CD16, CD45, HLA class II and other mesenchymal and epithelial markers such as desmin, alpha...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(01)00004-5
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:To analyse the survival and late toxicities of elderly nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiotherapy (IMRT) with the high-total- and fractionated-dose simultaneous modulated accelerated radiation therapy (SMART) boost technique and to identify the effect of concurrent ch...
journal_title:Oral oncology
pub_type: 已发布勘误
doi:10.1016/j.oraloncology.2019.01.005
更新日期:2019-03-01 00:00:00
abstract::Head and neck cancers during pregnancy are rising in incidence. Clinicians need to be aware of the principles of managing these cases. This paper is a review of the literature of head and neck cancers during pregnancy with a short case series of six non-thyroid pregnancy-associated cancers treated by a head and neck o...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2007.02.003
更新日期:2008-03-01 00:00:00
abstract::We evaluated the prognostic significance of p34cdc2 expression in 50 tongue squamous cell carcinomas (SCC) using immunohistochemical methods. The p34cdc2 protein was expressed in 33 cases of 50 tumor tissues (66.0%), compared with 15 cases of 42 controlled epithelia (35.7%). The expression of p34cdc2 was significantly...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(03)00146-5
更新日期:2004-02-01 00:00:00
abstract:INTRODUCTION:Although Multidisciplinary Team Management (MDT) is integrated in most international head and neck cancer treatment guidelines, its applications and proceedings were rarely described. The present study explores a 6-year real-life experience in a French Comprehensive Cancer Care Center. METHODS:Patients, t...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2019.02.020
更新日期:2019-04-01 00:00:00
abstract::Oral and pharyngeal cancer (OC) mortality is very low in Greece, especially among men, compared to other European countries. We conducted a case-control study of OC in Athens, and obtained information on tobacco, alcohol use and other potential risk factors and confounding variables for 110 incident cases and 115 hosp...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(00)00060-9
更新日期:2001-01-01 00:00:00
abstract::Oral cancer has become one of the most aggressive types of cancer, killing 140,000 people worldwide every year. Current treatments for oral cancer include surgery and radiation therapies. These procedures can be very effective; however, they can also drastically decrease the quality of life for survivors. New chemothe...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2018.01.011
更新日期:2018-03-01 00:00:00