Abstract：
:Oral leukoplakia is a potentially malignant disorder that will develop into oral cancer at an estimated rate of 1-2% per year. Aim of the present study is to assess the possible predictive value of DNA ploidy for malignant progression of oral leukoplakia. A cohort of 62 leukoplakia patients was studied and their biopsy was examined with standard histopathology and DNA image cytometry. Cox regression analysis was performed to establish the relationship between progression-free survival and the DNA ploidy status. During the follow-up time (median of 69 months) 13 patients developed an oral squamous cell carcinoma (OSCC). DNA aneuploidy was observed in 27 (44%) patients and was significantly associated with a shorter progression-free survival [Hazard ratio of 3.7, 95% confidence intervals (CI) of 1.1 and 13.0 and a p-value of 0.04]. Sensitivity and specificity scores were 54% and 60%, respectively. Aneuploidy was not correlated with dysplasia grading (chi-square analysis). DNA aneuploidy in oral leukoplakia is associated with an increased risk of progression to OSCC. However, for the individual leukoplakia patient, DNA ploidy status as single biomarker has limited value to predict progression to cancer.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Bremmer JF,Brakenhoff RH,Broeckaert MA,Beliën JA,Leemans CR,Bloemena E,van der Waal I,Braakhuis BJdoi
10.1016/j.oraloncology.2011.07.025subject
Has Abstractpub_date
2011-10-01 00:00:00pages
956-60issue
10eissn
1368-8375issn
1879-0593pii
S1368-8375(11)00766-4journal_volume
47pub_type
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