听力与言语-语言病理学

行为科学

医学伦理学

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  • Toxicological analyses: analytical method validation for prevention or diagnosis.

    abstract::The need for reliable results in Toxicological Analysis is recognized and required worldwide. The analytical validation ensures that a method will provide trustworthy information about a particular sample when applied in accordance with a predefined protocol, being able to determine a specific analyte at a distinct co...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2020.1839612

    authors: Abrão LCC,Silveira AT,de Faria HD,Machado SC,Mendes TV,Plácido RV,Marciano LPA,Martins I

    更新日期:2021-01-01 00:00:00

  • Cytotoxicity profiles of multi-walled carbon nanotubes with different physico-chemical properties.

    abstract::Multi-walled carbon nanotubes (MWCNTs) have industrial applications in the nanotechnology field. The physico-chemical properties of MWCNTs vary greatly depending on MWCNT manufacture and application. It has been pointed out that their needle shape and high durability are important factors that determine the biopersist...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2020.1761920

    authors: Fujita K,Obara S,Maru J,Endoh S

    更新日期:2020-09-01 00:00:00

  • Paraben concentrations found in human body fluids do not exert steroidogenic effects in human granulosa primary cell cultures.

    abstract::In cosmetics and food products, parabens are widely used as antimicrobial agents. Reports have suggested that parabens may be linked to infertility, owing to their effects on basal steroidogenesis properties or their capacity to inflict mitochondrial damage. Despite growing concerns about parabens as endocrine disrupt...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2020.1741052

    authors: Herrera-Cogco E,López-Bayghen B,Hernández-Melchor D,López-Luna A,Palafox-Gómez C,Ramírez-Martínez L,López-Bello E,Albores A,López-Bayghen E

    更新日期:2020-06-01 00:00:00

  • Morin supplementation modulates PERK branch of UPR and mitigates 1,2-dimethylhydrazine-induced angiogenesis and oxidative stress in the colon of experimental rats.

    abstract::Angiogenesis, disturbance in redox homeostasis, and deregulated redox signaling are considered as common hallmarks of cancer progression and chemo resistance. In this context, PERK (protein kinase PKR-like ER kinase) branch of the unfolded protein response (UPR), an adaptive mechanism triggered by endoplasmic reticulu...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2020.1727596

    authors: Sharma SH,Suresh Kumar J,Madhavan S,Nagarajan S

    更新日期:2020-05-01 00:00:00

  • Evaluation of two in silico programs for predicting mutagenicity and carcinogenicity potential for 4-methylimidazole (4-MeI) and known metabolites.

    abstract::4-Methylimidazole (4-MeI) is a nitrogen-containing heterocyclic compound that is used in the manufacture of chemicals, dyes and pharmaceuticals and may be found in a variety of foods following formation during heating. The purpose of this study was to use two different in silico programs, CASE Ultra and Toxtree, to in...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2019.1709237

    authors: Howard AS,Choksi N

    更新日期:2020-05-01 00:00:00

  • Identification of structural fingerprints for in vivo toxicity by using Monte Carlo based QSTR modeling of nitroaromatics.

    abstract::Monte Carlo based method by using either SMILES based or combination of SMILES and Graph-based descriptors is an important strategy to build the QSAR/QSTR model for prediction of different biological endpoints. In this study, Monte Carlo based QSTR approach was applied to the dataset of 90 nitroaromatic compounds rela...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2019.1709238

    authors: Mondal D,Ghosh K,Baidya ATK,Gantait AM,Gayen S

    更新日期:2020-05-01 00:00:00

  • Vitamin E supplementation ameliorates the hepatotoxicity induced by Tramadol: toxicological, histological and immunohistochemical study.

    abstract::Several deleterious effects of Tramadol including deaths were reported especially when used in large doses. Being metabolized mainly in the liver, Tramadol have serious hepatotoxic effects. This study investigates the effect of vitamin E on Tramadol-induced hepatotoxicity in rats by evaluating the antioxidant biochemi...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2019.1681043

    authors: Ibrahim MA,Ibrahim HM,Mohamed AA,Tammam HG

    更新日期:2020-03-01 00:00:00

  • Mitochondria-dependent apoptosis in triptolide-induced hepatotoxicity is associated with the Drp1 activation.

    abstract::How triptolide is associated with mitochondrial dysfunction and apoptosis in connection with its hepatotoxicity remains unclear. The objective of our study was to find out the link between mitochondrial dynamics and cell death in triptolide induced hepatotoxicity. We treated L02 cells with 25 nM concentration of tript...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2019.1669247

    authors: Hasnat M,Yuan Z,Ullah A,Naveed M,Raza F,Baig MMFA,Khan A,Xu D,Su Y,Sun L,Zhang L,Jiang Z

    更新日期:2020-02-01 00:00:00

  • Crotonaldehyde-induced alterations in testicular enzyme function and hormone levels, and apoptosis in the testes of male Wistar rats are associated with oxidative damage.

    abstract::Crotonaldehyde is a hazardous pollutant present in cigarette smoke and automobile exhausts that is generated by lipid peroxidation, and harmful to reproductive organs. Although we are often exposed to low doses of crotonaldehyde daily, its adverse effects on the reproductive organs have not been fully elucidated. To e...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2019.1646369

    authors: Zhang B,Wei P,Men J,Zhang S,Shao H,Zhang Z

    更新日期:2020-01-01 00:00:00

  • Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.

    abstract::The present study investigated the protective effect of hesperidin on carbohydrate metabolizing enzymes in streptozotocin-induced diabetic rats. Hesperidin was administered to streptozotocin-induced (40 mg/kg b.w.) diabetic rats at different dosages of (25, 50, 100 mg/kg b.w.) respectively for 30 days to evaluate its ...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2019.1646370

    authors: Sundaram R,Nandhakumar E,Haseena Banu H

    更新日期:2019-11-01 00:00:00

  • Toxic effects of chlorine gas and potential treatments: a literature review.

    abstract::Chlorine gas is one of the highly produced chemicals in the USA and around the world. Chlorine gas has several uses in water purification, sanitation, and industrial applications; however, it is a toxic inhalation hazard agent. Inhalation of chlorine gas, based on the concentration and duration of the exposure, causes...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2019.1669244

    authors: Achanta S,Jordt SE

    更新日期:2019-10-01 00:00:00

  • Mouse strain-specific acute respiratory effects of nicotine unrelated to nicotine metabolism.

    abstract::Plethysmograph measurement of respiratory phenotypes provides a highly sensitive means to study nicotine response in experimental model animals. We measured average respiratory frequency, tidal volume, minute volume and inspiratory time in C3H/HeJ and C57BL/6J mice subcutaneously administered 0.35 and 0.70 mg/kg nicot...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2019.1628141

    authors: Bloom AJ

    更新日期:2019-09-01 00:00:00

  • Qualitative identification of imidacloprid in postmortem animal tissue by gas chromatography-tandem mass spectrometry.

    abstract::During an avian mass mortality event investigation at the National Fish and Wildlife Forensic Laboratory in Ashland, OR, imidacloprid became an insecticide of concern. A qualitative analytical toxicology screen of seeds, plucks (tongue, esophagus, and trachea), and ventricular contents was requested. A method for the ...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2019.1616344

    authors: Buchweitz JP,Viner TC,Lehner AF

    更新日期:2019-09-01 00:00:00

  • Long-term exposure to crotonaldehyde causes heart and kidney dysfunction through induction of inflammatory and oxidative damage in male Wistar rats.

    abstract::Crotonaldehyde is a ubiquitous hazardous pollutant, present in cigarette smoke and automobile exhaust and is endogenously generated by lipid peroxidation. Most of the current studies focus on its lung toxicity. However, there have been few investigations on the cardiac and renal toxicity caused by crotonaldehyde expos...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2018.1542474

    authors: Zhang B,Li S,Men J,Peng C,Shao H,Zhang Z

    更新日期:2019-05-01 00:00:00

  • Effect of polyethylene glycol surface charge functionalization of SWCNT on the in vitro and in vivo nanotoxicity and biodistribution monitored noninvasively using MRI.

    abstract::The current study evaluated in vitro and in vivo toxicity of carboxyl or amine polyethylene glycol (PEG) surface functionalization of single-walled carbon nanotubes (SWCNTs). Assessments of cytotoxicity, genotoxicity, immunotoxicity, and oxidative stress were performed in vitro and in vivo (in a 1-month follow-up stud...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2018.1540674

    authors: Shaik AS,Shaik AP,Bammidi VK,Al Faraj A

    更新日期:2019-05-01 00:00:00

  • Preventive effects of nerve growth factor against colistin-induced autophagy and apoptosis in PC12 cells.

    abstract::In this study, the preventive effects of NGF against colistin-induced autophagy and apoptosis in PC12 cells have been investigated. Fluorescence microscopy, real-time PCR, transmission electron microscopy (TEM), flow cytometery, and western blotting technique were used. The results showed that large amounts of autopha...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2018.1534298

    authors: Tian E,Hu W,Miao Y,Muhammad I,Zhang L,Xia C,Ding L,Zhang Q,Li R,Chen C,Li J

    更新日期:2019-03-01 00:00:00

  • Effects of timolol on Ca2+ handling and viability in human prostate cancer cells.

    abstract::Timolol is a medication used widely to treat glaucoma. Regarding Ca2+ signaling, timolol was shown to modulate Ca2+-related physiology in various cell types, however, the effect of timolol on Ca2+ homeostasis and cell viability has not been explored in human prostate cancer cells. The aim of this study was to explore ...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2018.1540024

    authors: Wang JL,Chou CT,Liang WZ,Wu CJ,Kuo CC,Hao LJ,Shieh P,Jan CR

    更新日期:2019-02-01 00:00:00

  • Detection of opioids in umbilical cord lysates: an antibody-based rapid screening approach.

    abstract::In pregnancy, opioids may be used medically and also misused. We hypothesized that the umbilical cord (UC) could be a good screening tool for determining opioid exposure and improving medical care. One hundred and one UC, each with 50 associated ICD9/ICD10 codes were used. Using predictive pharmacokinetic analysis we ...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2018.1506850

    authors: Knight SJ,Smith AD,Wright TE,Collier AC

    更新日期:2019-01-01 00:00:00

  • Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short-term exposure to two-dimensional and three-dimensional spheroid cell cultures.

    abstract::Xysmalobium undulatum (Uzara) is one of the most widely used indigenous traditional herbal remedies in Southern Africa. Commercially available Uzara plant material was used to prepare a crude aqueous extract, of which the toxicity potential was investigated in the hepatic HepG2/C3A cell line in both traditional two-di...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2018.1485805

    authors: Calitz C,Hamman JH,Viljoen AM,Fey SJ,Wrzesinski K,Gouws C

    更新日期:2018-11-01 00:00:00

  • Metformin protects PC12 cells against oxygen-glucose deprivation/reperfusion injury.

    abstract::Oxidative stress has a causative role in ischemic reperfusion-induced cell death. Evidence has shown that metformin is capable to reduce ischemic reperfusion injuries. The current study investigated the effect of metformin on ischemia/reperfusion-induced apoptosis in PC12 cells by evaluation of Bcl-2 family proteins e...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2018.1486495

    authors: Mohammad Alizadeh E,Mahdavi M,Jenani Fard F,Chamani S,Farajdokht F,Karimi P

    更新日期:2018-10-01 00:00:00

  • Toxicity of silver nanoparticles, multiwalled carbon nanotubes, and dendrimers assessed with multicellular organism Caenorhabditis elegans.

    abstract::Nematode Caenorhabditis elegans (C. elegans) was used to investigate the impact of silver nanoparticles (SNP), multiwalled carbon nanotubes (MWCNT), and polyamidoamine dendrimers (PAMAM) used in concentration of 1010 particle/mL. Population-based observations and gene expression analysis were employed in this study. S...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2018.1449277

    authors: Walczynska M,Jakubowski W,Wasiak T,Kadziola K,Bartoszek N,Kotarba S,Siatkowska M,Komorowski P,Walkowiak B

    更新日期:2018-07-01 00:00:00

  • Arsenic induces cardiac rhythm dysfunction and acylcarnitines metabolism perturbation in rats.

    abstract:BACKGROUND:Arsenic has been shown to cause various diseases (such as blackfoot disease, cardiovascular diseases, bladder cancer and skin cancer) in many areas of the world. However, the effects of arsenic on cardiac rhythm functions still lack investigation. METHODS:In this study, different concentrations of arsenic w...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2018.1440679

    authors: Phan NN,Li KL,Lin YC

    更新日期:2018-07-01 00:00:00

  • Quantitative measurement of oxidative damage in erythrocytes as indicator in benzene intoxications.

    abstract::The metabolism of aromatic hydrocarbons by the organism forms products that cause cell death depending on the type of exposure. Benzene exposure has been linked to oxidative stress, hepatic damage, aplastic anemia, and hematopoietic cancer as lymphoid and myeloid leukemia. However, there are not fast methods to evalua...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2018.1455786

    authors: Martínez-Rodríguez JL,Gutiérrez-Hernández R,Reyes-Estrada CA,Granados-López AJ,Arcos-Ortega T,López JA

    更新日期:2018-07-01 00:00:00

  • T-2 toxin induces apoptosis via the Bax-dependent caspase-3 activation in mouse primary Leydig cells.

    abstract::To explore the toxic effect of T-2 toxin on mouse Leydig cells and its underlying molecular mechanisms, we isolated Leydig cells from mature mice, set-up Leydig cells culture, treated cells with T-2 toxin, evaluated cell proliferation, detected the caspase-3 activity, mitochondrial activity and apoptosis rate, and mea...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2017.1354413

    authors: Zhang YF,Su PK,Wang LJ,Zheng HQ,Bai XF,Li P,Meng XP,Yang JY

    更新日期:2018-01-01 00:00:00

  • Detrimental effects of nicotine on thioacetamide-induced liver injury in mice.

    abstract:AIM:Nicotine exerts a number of physiological effects. The purpose of this study was to determine the effects of nicotine on thioacetamide (TAA)-induced liver fibrosis in mice. MATERIALS AND METHODS:For in vivo experiments, hepatic fibrosis was induced by TAA (0.25 g/kg, i.p.) three times a week for 6 weeks. Mice of T...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2017.1323256

    authors: Zhou Z,Park S,Kim JW,Zhao J,Lee MY,Choi KC,Lim CW,Kim B

    更新日期:2017-09-01 00:00:00

  • Evaluation of methylglyoxal toxicity in human erythrocytes, leukocytes and platelets.

    abstract::Methylglyoxal (MG) is a reactive dicarbonyl metabolite originated mainly from glucose degradation pathway that plays an important role in the pathogenesis of diabetes mellitus (DM). Reactions of MG with biological macromolecules (proteins, DNA and lipids) can induce cytotoxicity and apoptosis. Here, human erythrocytes...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2017.1285971

    authors: Prestes AS,Dos Santos MM,Ecker A,Zanini D,Schetinger MR,Rosemberg DB,da Rocha JB,Barbosa NV

    更新日期:2017-05-01 00:00:00

  • Antioxidant and anti-inflammatory effects of Nasturtium officinale involved in attenuation of gentamicin-induced nephrotoxicity.

    abstract:BACKGROUND AND PURPOSE:Gentamicin (GM) is used against bacterial infections. The aim of our investigation was to evaluate the role of inflammation and also oxidative damage in nephrotoxic potential of GM and protective effects of Nasturtium officinale (watercress) against GM-induced nephrotoxicity in Wistar rats. MATE...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2016.1258748

    authors: Shahani S,Behzadfar F,Jahani D,Ghasemi M,Shaki F

    更新日期:2017-02-01 00:00:00

  • Molecular interactions of dioxins and DLCs with the ketosteroid receptors: an in silico risk assessment approach.

    abstract::Dioxins and dioxin-like compounds (DLCs) are the ones with poor water solubility and low volatility, resistant to physical, chemical and biological processes, persistent in the environment even under extreme conditions. Due to lipophilic nature, they get adhered to the fatty material and concentrate through biomagnifi...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2016.1273423

    authors: Khan MF,Alam MM,Verma G,Akhtar W,Rizvi MA,Ali A,Akhter M,Shaquiquzzaman M

    更新日期:2017-02-01 00:00:00

  • Protective effects of lemongrass essential oil against benzo(a)pyrene-induced oxidative stress and DNA damage in human embryonic lung fibroblast cells.

    abstract::Benzo(a)pyrene (BaP) was a well-known environmental pollutant, numerous studies had implicated BaP as a causative agent in human cancer, particularly lung cancer. The lemongrass essential oil (LEO) possessed various pharmacological activities, especially the anti-oxidative stress and cancer prevention. In the current ...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2016.1266541

    authors: Jiang J,Xu H,Wang H,Zhang Y,Ya P,Yang C,Li F

    更新日期:2017-02-01 00:00:00

  • GC-MS metabolomics analysis of mesenchymal stem cells treated with copper oxide nanoparticles.

    abstract::Human exposure to copper oxide (CuO) nanoparticles (NPs) is rapidly increasing and for this reason reliable toxicity test systems are urgently needed. Recently, the acute cytotoxicity of CuO NPs using the new toxicity test based on human bone marrow mesenchymal stem cells (hBMMSCs) has been evaluated. It was shown tha...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.1080/15376516.2016.1220654

    authors: Murgia A,Mancuso L,Manis C,Caboni P,Cao G

    更新日期:2016-10-01 00:00:00

  • Mast cell accumulation precedes tissue fibrosis induced by intravenously administered amorphous silica nanoparticles.

    abstract::Despite the increasing use of amorphous silica nanoparticles (SNPs) in biomedical applications, their toxicity after intravenous administration remains a major concern. We investigated the effects of single 7 mg/kg intravenous infusions of 13 nm SNPs on hemodynamic parameters in rats. Hematological and biochemical par...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.3109/15376516.2016.1169341

    authors: Zhuravskii S,Yukina G,Kulikova O,Panevin A,Tomson V,Korolev D,Galagudza M

    更新日期:2016-05-01 00:00:00

  • Effect of aliskiren and carvedilol on expression of Ca(2+)/calmodulin-dependent protein kinase II δ-subunit isoforms in cardiac hypertrophy rat model.

    abstract:CONTEXT:The critical role of CaMKIIδ isoforms in cardiac hypertrophy is well documented. OBJECTIVE:This study was aimed to investigate the possible inhibitory effects of aliskiren (ALS) and/or carvedilol (CAV) on CaMKIIδ isoforms expression in experimental cardiac hypertrophy. MATERIALS AND METHODS:Male Wistar albino...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.3109/15376516.2015.1128035

    authors: Bin-Dayel AF,Abdel Baky NA,Fadda LM,Mohammad RA,Al-Mohanna F

    更新日期:2016-02-01 00:00:00

  • Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study.

    abstract:CONTEXT:Although the liver is the primary target organ in acetaminophen (APAP) toxicity, other organs are affected. Previous data suggested that chronic APAP abuse can be ototoxic and the mechanism involves APAP-induced oxidative stress and reactive metabolite (N-acetyl-p-benzoquinone imine, NAPQI)-induced endoplasmic ...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.3109/15376516.2015.1122136

    authors: McGill MR,Kennon-McGill S,Durham D,Jaeschke H

    更新日期:2016-02-01 00:00:00

  • Effects of maternal exposure to aflatoxin B1 during pregnancy on fertility output of dams and developmental, behavioral and reproductive consequences in female offspring using a rat model.

    abstract::A suboptimal in utero environment can have detrimental effects on the pregnancy and long-term adverse "programing" effects on the offspring. Aflatoxin B1 is one of the potent reproductive toxicants and currently detected in both milk and tissues. This article focuses on the effects of prenatal exposure to graded doses...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.3109/15376516.2016.1151967

    authors: Supriya Ch,Akhila B,Pratap Reddy K,Girish BP,Sreenivasula Reddy P

    更新日期:2016-01-01 00:00:00

  • ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line.

    abstract::The study aims at evaluating the combination of the quinocetone and the ML-7 in preclinical hepatocellular carcinoma models. To this end, the effect of quinocetone and ML-7 on apoptosis induction and signaling pathways was analyzed on HepG2 cell lines. Here, we report that ML-7, in a nontoxic concentration, sensitized...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.3109/15376516.2015.1090513

    authors: Zhou Y,Zhang S,Deng S,Dai C,Tang S,Yang X,Li D,Zhao K,Xiao X

    更新日期:2016-01-01 00:00:00

  • Carfilzomib-induced cardiotoxicity mitigated by dexrazoxane through inhibition of hypertrophic gene expression and oxidative stress in rats.

    abstract::Carfilzomib (CFZ) is an inhibitor of proteasome that is generally used in the treatment of multiple myeloma but due to its cardiotoxicity clinical use may be limited. Dexrazoxane (DZR), an inhibitor of topoisomerase-II, prevents cardiac damage by reducing the formation of reactive oxygen species and hypertrophic gene ...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.3109/15376516.2016.1143071

    authors: Al-Harbi NO

    更新日期:2016-01-01 00:00:00

  • Down-regulation of poly (ADP-ribose) polymerase 1 leads to change of hydroquinone cytotoxicity in TK6 cells.

    abstract::Hydroquinone (HQ), one of the most important metabolites derived from benzene, is known to be associated with acute myelogenous leukemia risk; however, its carcinogenic mechanism remains unclear. In a previous study, we found that low-level of benzene exposure down-regulated the expression of poly(ADP-ribose)polymeras...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.3109/15376516.2015.1070222

    authors: Sha Y,Zhou W,Yang Z,Zhu X,Yang X,Li TD,Zhu D

    更新日期:2015-01-01 00:00:00

  • Electrophysiological and molecular mechanisms of protection by iron sucrose against phosphine-induced cardiotoxicity: a time course study.

    abstract::The present study was designed for determining the exact mechanism of cytotoxic action of aluminum phosphide (AlP) in the presence of iron sucrose as the proposed antidote. Rats received AlP (12 mg/kg) and iron sucrose (5-30 mg/kg) in various sets and were connected to cardiovascular monitoring device. After identific...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.3109/15376516.2015.1015086

    authors: Solgi R,Baghaei A,Golaghaei A,Hasani S,Baeeri M,Navaei M,Ostad SN,Hosseini R,Abdollahi M

    更新日期:2015-01-01 00:00:00

  • Different regulation of aryl hydrocarbon receptor-regulated genes in response to dioxin in undifferentiated and neuronally differentiated human neuroblastoma SH-SY5Y cells.

    abstract::Some environmental pollutants derived from industrial processes have been suggested to be responsible for neurological impairment in children, especially in heavily polluted areas. Since these compounds are usually activators of aryl hydrocarbon receptor (AhR), it would be important to better understand the molecular ...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.3109/15376516.2015.1070227

    authors: Imran S,Ferretti P,Vrzal R

    更新日期:2015-01-01 00:00:00

  • The molecular mechanisms of liver and islets of Langerhans toxicity by benzene and its metabolite hydroquinone in vivo and in vitro.

    abstract::Benzene (C6H6) is one of the most commonly used industrial chemicals causing environmental pollution. This study aimed to examine the effect of benzene and its metabolite hydroquinone on glucose regulating organs, liver and pancreas, and to reveal the involved toxic mechanisms, in rats. In the in vivo part, benzene wa...

    journal_title:Toxicology mechanisms and methods

    pub_type: 杂志文章

    doi:10.3109/15376516.2015.1053650

    authors: Bahadar H,Maqbool F,Mostafalou S,Baeeri M,Gholami M,Ghafour-Boroujerdi E,Abdollahi M

    更新日期:2015-01-01 00:00:00

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