Mouse strain-specific acute respiratory effects of nicotine unrelated to nicotine metabolism.

abstract：:Owing to their structure and function, low-density lipoproteins (LDLs) are particularly susceptible to the oxidative modifications. To prevent against oxidative modification of LDL, L-carnitine, with endogenous small water-soluble quaternary amine possessing antioxidative properties, was used. The aim of this paper wa...

journal_title：Toxicology mechanisms and methods

authors： Augustyniak A,Stankiewicz A,Skrzydlewska E

更新日期：2008-07-01 00:00:00

abstract：:Color and geometric characteristics of stained areas in histochemical slides are among the features pathologists assess to evaluate the severity of lesions. In this research, image processing techniques were used to perform objective quantification of these characteristics in images of H&E-stained spleen tissues. A se...

journal_title：Toxicology mechanisms and methods

authors： Liu X,Tan J,Hatem I,Smith BL

更新日期：2004-01-01 00:00:00

abstract：:In the present investigation acetylcholinesterase (AChE) was estimated in erythrocytes from blood samples exposed to four commonly used organophosphorus pesticides in vitro. The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitor...

journal_title：Toxicology mechanisms and methods

authors： Das GP,Jamil K,Rahman MF

更新日期：2006-01-01 00:00:00

abstract：:In this study, 162 samples were analysed for monomer styrene content with using high performance liquid chromatography (HPLC) method in hot tea, milk, cocoa milk. The monomer styrene content, expressed in microg/l of drink and the level of migration of styrene monomer were varied from 0.61 to 8.15 for hot tea, from 0....

journal_title：Toxicology mechanisms and methods

authors： Khaksar MR,Ghazi-Khansari M

更新日期：2009-03-01 00:00:00

abstract：:Timolol is a medication used widely to treat glaucoma. Regarding Ca2+ signaling, timolol was shown to modulate Ca2+-related physiology in various cell types, however, the effect of timolol on Ca2+ homeostasis and cell viability has not been explored in human prostate cancer cells. The aim of this study was to explore ...

journal_title：Toxicology mechanisms and methods

authors： Wang JL,Chou CT,Liang WZ,Wu CJ,Kuo CC,Hao LJ,Shieh P,Jan CR

更新日期：2019-02-01 00:00:00

abstract：:Benzo(a)pyrene (BaP) was a well-known environmental pollutant, numerous studies had implicated BaP as a causative agent in human cancer, particularly lung cancer. The lemongrass essential oil (LEO) possessed various pharmacological activities, especially the anti-oxidative stress and cancer prevention. In the current ...

journal_title：Toxicology mechanisms and methods

authors： Jiang J,Xu H,Wang H,Zhang Y,Ya P,Yang C,Li F

更新日期：2017-02-01 00:00:00

abstract：:A potency of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) to reactivate cyclosarin-inhibited acetylcholinesterase and to reduce cyclosarin-induced acute toxic effects was evaluated in this study. In vivo determined percentage of reactivation of cyclosarin-inhibited blood and tissue ac...

journal_title：Toxicology mechanisms and methods

authors： Kassa J,Karasova JZ,Musilek K,Kuca K

更新日期：2009-06-01 00:00:00

abstract：:ABSTRACT The purpose of this study, carried out in Wistar rats, was to evaluate the protective effect of dietary restriction (performed by intermittent fasting) against oxidative stress induced by a low concentration of nickel chloride in kidney, liver, uterus, and ovary. Lipid peroxidation (TBARS), catalase activity,...

journal_title：Toxicology mechanisms and methods

authors： Hfaiedh N,Allagui MS,Carreau S,Zourgui L,Feki A,Croute F

更新日期：2008-01-01 00:00:00

abstract：:Reported myocardial pathology resulting from increased levels of catecholamines in vivo has led us to investigate the effect of adrenalin on the gap junction proteins connexin 40 (Cx40) and Cx43 and the possible relationship to vascular toxicity. Adrenalin and its known metabolites, adrenochrome and adrenolutin, were ...

journal_title：Toxicology mechanisms and methods

authors： Moreau V,Novak MJ,Moore LK

更新日期：2006-01-01 00:00:00

abstract：:Despite the increasing use of amorphous silica nanoparticles (SNPs) in biomedical applications, their toxicity after intravenous administration remains a major concern. We investigated the effects of single 7 mg/kg intravenous infusions of 13 nm SNPs on hemodynamic parameters in rats. Hematological and biochemical par...

journal_title：Toxicology mechanisms and methods

authors： Zhuravskii S,Yukina G,Kulikova O,Panevin A,Tomson V,Korolev D,Galagudza M

更新日期：2016-05-01 00:00:00

abstract：:Concern over the influence of carbon nanotubes (CNTs) on human health has arisen due to advances; however, little is known about the potential toxicity of CNTs. In this study, impurity-free single-wall carbon nanotubes (SWCNTs), with different physical properties in cell culture medium, were prepared by a novel disper...

journal_title：Toxicology mechanisms and methods

authors： Fujita K,Fukuda M,Endoh S,Kato H,Maru J,Nakamura A,Uchino K,Shinohara N,Obara S,Nagano R,Horie M,Kinugasa S,Hashimoto H,Kishimoto A

更新日期：2013-10-01 00:00:00

abstract：:Chlorpyrifos (CPF) is one of the organophosphorus pesticides widely used around the world, especially in China. Acetylcholinesterase inhibition is the main effect of organophosphorus insecticides exposure. Studies showed that CPF may also interfere with the metabolism of monoamine transmitters. To investigate the effe...

journal_title：Toxicology mechanisms and methods

authors： Xu F,Chang X,Lou D,Wu Q,Zhou Z

更新日期：2012-05-01 00:00:00

abstract：:The study aims at evaluating the combination of the quinocetone and the ML-7 in preclinical hepatocellular carcinoma models. To this end, the effect of quinocetone and ML-7 on apoptosis induction and signaling pathways was analyzed on HepG2 cell lines. Here, we report that ML-7, in a nontoxic concentration, sensitized...

journal_title：Toxicology mechanisms and methods

authors： Zhou Y,Zhang S,Deng S,Dai C,Tang S,Yang X,Li D,Zhao K,Xiao X

更新日期：2016-01-01 00:00:00

abstract：:Allergic rhinitis (also known as hay fever) is the most commonly occurring immunological disorder, and it affects 40 million men, women, and children in the United States. Symptomatically, it is an inflammation and irritation of the mucous membranes that line the nose. Allergy is defined as a state of hypersensitivity...

journal_title：Toxicology mechanisms and methods

authors： Amit A,Saxena VS,Pratibha N,Bagchi M,Bagchi D,Stohs SJ

更新日期：2003-01-01 00:00:00

abstract：:Nicotine, an active substance present in tobacco has been identified as a major risk factor for lung related diseases. In the present study, we have evaluated the protective effect of curcumin on circulatory lipid peroxidation and antioxidants in nicotine administered Wistar rats. Lung toxicity was induced by subcutan...

journal_title：Toxicology mechanisms and methods

authors： Kalpana C,Menon VP

更新日期：2004-01-01 00:00:00

abstract：:To explore the toxic effect of T-2 toxin on mouse Leydig cells and its underlying molecular mechanisms, we isolated Leydig cells from mature mice, set-up Leydig cells culture, treated cells with T-2 toxin, evaluated cell proliferation, detected the caspase-3 activity, mitochondrial activity and apoptosis rate, and mea...

journal_title：Toxicology mechanisms and methods

authors： Zhang YF,Su PK,Wang LJ,Zheng HQ,Bai XF,Li P,Meng XP,Yang JY

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Arsenic has been shown to cause various diseases (such as blackfoot disease, cardiovascular diseases, bladder cancer and skin cancer) in many areas of the world. However, the effects of arsenic on cardiac rhythm functions still lack investigation. METHODS:In this study, different concentrations of arsenic w...

journal_title：Toxicology mechanisms and methods

authors： Phan NN,Li KL,Lin YC

更新日期：2018-07-01 00:00:00

abstract：:ABSTRACT Male Wistar rats with streptozotocin-induced diabetes received a control diet and a pyridoxine-deficient diet. The animals were divided at random into four groups: control rats (CR), control diabetic rats (CDR), diabetic rats receiving a pyridoxine-free diet (DRB6), and diabetic rats receiving saline solution...

journal_title：Toxicology mechanisms and methods

authors： Jordao AA,Dos Santos FL,Marchini JS,Vannucchi H

更新日期：2007-01-01 00:00:00

abstract：:Oral cocaine administration results in hepatic necrosis, increased plasma transaminase concentration, and decreased antioxidative capability, which is potentiated by lipopolysaccharide (LPS) in male CF-1 mice. Females administered the same treatment regimen display none of the hepatotoxic effects seen in their male co...

journal_title：Toxicology mechanisms and methods

authors： Visalli T,Turkall R,Abdel-Rahman MS

更新日期：2005-01-01 00:00:00

abstract：:During an avian mass mortality event investigation at the National Fish and Wildlife Forensic Laboratory in Ashland, OR, imidacloprid became an insecticide of concern. A qualitative analytical toxicology screen of seeds, plucks (tongue, esophagus, and trachea), and ventricular contents was requested. A method for the ...

journal_title：Toxicology mechanisms and methods

authors： Buchweitz JP,Viner TC,Lehner AF

更新日期：2019-09-01 00:00:00

abstract：:The objective of this study was to examine the toxicity of 1-(4-morpholinophenyl)-3-(4-fluorophenyl)-propenone (A) and 1-(4-morpholinophenyl)-3-(3-fluorophenyl)-propenone (B) on Spodoptera frugiperda (Sf9) cells and the mechanism of the toxicity. By cell-based thiazolyl blue tetrazolium bromide (MTT) assay, we found t...

journal_title：Toxicology mechanisms and methods

authors： Zhang X,Tao K,Hou T

更新日期：2012-05-01 00:00:00

abstract：:Angiogenesis, disturbance in redox homeostasis, and deregulated redox signaling are considered as common hallmarks of cancer progression and chemo resistance. In this context, PERK (protein kinase PKR-like ER kinase) branch of the unfolded protein response (UPR), an adaptive mechanism triggered by endoplasmic reticulu...

journal_title：Toxicology mechanisms and methods

authors： Sharma SH,Suresh Kumar J,Madhavan S,Nagarajan S

更新日期：2020-05-01 00:00:00

abstract：:In pregnancy, opioids may be used medically and also misused. We hypothesized that the umbilical cord (UC) could be a good screening tool for determining opioid exposure and improving medical care. One hundred and one UC, each with 50 associated ICD9/ICD10 codes were used. Using predictive pharmacokinetic analysis we ...

journal_title：Toxicology mechanisms and methods

authors： Knight SJ,Smith AD,Wright TE,Collier AC

更新日期：2019-01-01 00:00:00

abstract：CONTEXT:Over expression of renin-angiotensin system (RAS) and nuclear factor-kappaB (NF-κB) has a major role in many cancers. It has been suggested that some angiotensin receptor blockers (ARBs) could reduce the proliferation of cancer cells. The role of NF-κB pathway has been documented in cell proliferation. OBJECTI...

journal_title：Toxicology mechanisms and methods

authors： Bakhtiari E,Hosseini A,Boroushaki MT,Mousavi SH

更新日期：2015-01-01 00:00:00

abstract：:The metabolism of aromatic hydrocarbons by the organism forms products that cause cell death depending on the type of exposure. Benzene exposure has been linked to oxidative stress, hepatic damage, aplastic anemia, and hematopoietic cancer as lymphoid and myeloid leukemia. However, there are not fast methods to evalua...

journal_title：Toxicology mechanisms and methods

authors： Martínez-Rodríguez JL,Gutiérrez-Hernández R,Reyes-Estrada CA,Granados-López AJ,Arcos-Ortega T,López JA

更新日期：2018-07-01 00:00:00

abstract：:The need for reliable results in Toxicological Analysis is recognized and required worldwide. The analytical validation ensures that a method will provide trustworthy information about a particular sample when applied in accordance with a predefined protocol, being able to determine a specific analyte at a distinct co...

journal_title：Toxicology mechanisms and methods

authors： Abrão LCC,Silveira AT,de Faria HD,Machado SC,Mendes TV,Plácido RV,Marciano LPA,Martins I

更新日期：2021-01-01 00:00:00

abstract：:The present study was designed to investigate the effects of aqueous Azadirchta Indica leaf extract (AAILE) on serum glycoprotein contents and tumor incidence rate in colon of rats subjected to Dimethylhydrazine (DMH) treatment. Forty rats were divided equally and randomly into four groups viz., Group I (normal contro...

journal_title：Toxicology mechanisms and methods

authors： Ramzanighara A,Ezzatighadi F,Rai DV,Dhawan DK

更新日期：2009-05-01 00:00:00

abstract：CONTEXT:The critical role of CaMKIIδ isoforms in cardiac hypertrophy is well documented. OBJECTIVE:This study was aimed to investigate the possible inhibitory effects of aliskiren (ALS) and/or carvedilol (CAV) on CaMKIIδ isoforms expression in experimental cardiac hypertrophy. MATERIALS AND METHODS:Male Wistar albino...

journal_title：Toxicology mechanisms and methods

authors： Bin-Dayel AF,Abdel Baky NA,Fadda LM,Mohammad RA,Al-Mohanna F

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Gentamicin (GM) is used against bacterial infections. The aim of our investigation was to evaluate the role of inflammation and also oxidative damage in nephrotoxic potential of GM and protective effects of Nasturtium officinale (watercress) against GM-induced nephrotoxicity in Wistar rats. MATE...

journal_title：Toxicology mechanisms and methods

authors： Shahani S,Behzadfar F,Jahani D,Ghasemi M,Shaki F

更新日期：2017-02-01 00:00:00

abstract：:The β-glucans (β-G) are polysaccharides produced by various organisms, and sulfation of β-G renders them more soluble. With the objective to assess the effects of sulfated and non-sulfated β-G extracted from Agaricus brasiliensis in MCF-7 cells, assays were used to evaluate cytotoxicity, genotoxicity, cell proliferati...

journal_title：Toxicology mechanisms and methods

authors： Baranoski A,Tempesta Oliveira M,Semprebon SC,Niwa AM,Ribeiro LR,Mantovani MS

更新日期：2015-01-01 00:00:00