ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line.

abstract：:The authors have previously shown that high alcohol preference rats (HAP) have a significantly higher sensitivity than low alcohol preference rats (LAP) for methamphetamine (MAP). In this study, changes in dopamine and serotonin release induced by MAP (1 mg/kg, intraperitoneally) after pre-treatment with D1 and D2 rec...

journal_title：Toxicology mechanisms and methods

authors： Nishiguchi M,Kinoshita H,Kasuda S,Takahashi M,Yamamura T,Matsui K,Ouchi H,Minami T,Hishida S,Nishio H

更新日期：2010-03-01 00:00:00

abstract：:The aim of this work was to characterize inner mitochondrial membrane channels permeable to calcium cations (Ca(++)). Mitochondrial membranes isolated from rat heart were incorporated into the bilayer lipid membrane, and single Ca(++) channel currents were measured. The observed channels were selective for Ca(++) and ...

journal_title：Toxicology mechanisms and methods

authors： Komínková V,Novotová M,Ondrias K,Ravingerová T,Szewczyk A

更新日期：2004-01-01 00:00:00

abstract：:Oral cocaine administration results in hepatic necrosis, increased plasma transaminase concentration, and decreased antioxidative capability, which is potentiated by lipopolysaccharide (LPS) in male CF-1 mice. Females administered the same treatment regimen display none of the hepatotoxic effects seen in their male co...

journal_title：Toxicology mechanisms and methods

authors： Visalli T,Turkall R,Abdel-Rahman MS

更新日期：2005-01-01 00:00:00

abstract：:Chronic hyperglycemia leads to the development of microvascular complications like diabetic nephropathy. The present study investigated the potential effects of the hydroalcoholic extract of Tribulus terrestris, a plant of Zygophyllaceae family, on the renal complications in streptozotocin (STZ)-induced diabetic rats....

journal_title：Toxicology mechanisms and methods

authors： Gandhi S,Srinivasan BP,Akarte AS

更新日期：2013-09-01 00:00:00

abstract：:ABSTRACT The present investigation was undertaken to examine the effects of chlorpyrifos (CP, an organophosphate) and deltamethrin (DM, a pyrethroid pesticide) treatments at low and high doses and their combination on lipid peroxidation and antioxidant enzyme activities such as SOD, GSH-Px, and CAT and also AChE activ...

journal_title：Toxicology mechanisms and methods

authors： Tüzmen MN,Candan N,Kaya E

更新日期：2007-01-01 00:00:00

abstract：:ABSTRACT This paper presents the results from an evaluation of the noncommercial, (quantitative) structure-activity relationship ([Q]SAR) models for the prediction of mutagenicity and carcinogenicity, carried out in a collaboration between the European Chemicals Bureau Group on Computational Toxicology and the Italian...

journal_title：Toxicology mechanisms and methods

authors： Benigni R,Bossa C

更新日期：2008-01-01 00:00:00

abstract：:Human exposure to copper oxide (CuO) nanoparticles (NPs) is rapidly increasing and for this reason reliable toxicity test systems are urgently needed. Recently, the acute cytotoxicity of CuO NPs using the new toxicity test based on human bone marrow mesenchymal stem cells (hBMMSCs) has been evaluated. It was shown tha...

journal_title：Toxicology mechanisms and methods

authors： Murgia A,Mancuso L,Manis C,Caboni P,Cao G

更新日期：2016-10-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of different doses of an adenosine A(1) selective agonist, phenylisopropyl adenosine (PIA), on metamidophos-induced cholinergic symptoms, mortality, diaphragm muscle necrosis, and brain oxidative stress. A LD(50) dose of metamidophos (20 mg/kg body weight, p.o.) was fo...

journal_title：Toxicology mechanisms and methods

authors： Kalkan S,Ozdemir D,Ergur BU,Hazardin NU,Akgun A,Topcu A,Kaplan YC,Hocaoglu N,Oransay K,Tuncok Y

更新日期：2009-02-01 00:00:00

abstract：:Histone deacetylase 2 (HDAC2), a prominent member of the class I HDAC family, plays crucial roles in inflammation and other pathological processes. Recent studies have found that the activity and expression of HDAC2 were altered under oxidative stress conditions. The aim of the current study was to elucidate the expre...

journal_title：Toxicology mechanisms and methods

authors： Lu H,Wan J,Jiang R,Xie J,Peng X,Zhang L

更新日期：2012-10-01 00:00:00

abstract：:Color and geometric characteristics of stained areas in histochemical slides are among the features pathologists assess to evaluate the severity of lesions. In this research, image processing techniques were used to perform objective quantification of these characteristics in images of H&E-stained spleen tissues. A se...

journal_title：Toxicology mechanisms and methods

authors： Liu X,Tan J,Hatem I,Smith BL

更新日期：2004-01-01 00:00:00

abstract：:In pregnancy, opioids may be used medically and also misused. We hypothesized that the umbilical cord (UC) could be a good screening tool for determining opioid exposure and improving medical care. One hundred and one UC, each with 50 associated ICD9/ICD10 codes were used. Using predictive pharmacokinetic analysis we ...

journal_title：Toxicology mechanisms and methods

authors： Knight SJ,Smith AD,Wright TE,Collier AC

更新日期：2019-01-01 00:00:00

abstract：:4-Methylimidazole (4-MeI) is a nitrogen-containing heterocyclic compound that is used in the manufacture of chemicals, dyes and pharmaceuticals and may be found in a variety of foods following formation during heating. The purpose of this study was to use two different in silico programs, CASE Ultra and Toxtree, to in...

journal_title：Toxicology mechanisms and methods

authors： Howard AS,Choksi N

更新日期：2020-05-01 00:00:00

abstract：:Plethysmograph measurement of respiratory phenotypes provides a highly sensitive means to study nicotine response in experimental model animals. We measured average respiratory frequency, tidal volume, minute volume and inspiratory time in C3H/HeJ and C57BL/6J mice subcutaneously administered 0.35 and 0.70 mg/kg nicot...

journal_title：Toxicology mechanisms and methods

authors： Bloom AJ

更新日期：2019-09-01 00:00:00

abstract：:Nicotine, an active substance present in tobacco has been identified as a major risk factor for lung related diseases. In the present study, we have evaluated the protective effect of curcumin on circulatory lipid peroxidation and antioxidants in nicotine administered Wistar rats. Lung toxicity was induced by subcutan...

journal_title：Toxicology mechanisms and methods

authors： Kalpana C,Menon VP

更新日期：2004-01-01 00:00:00

abstract：UNLABELLED:Cisplatin (CP) is an antineoplastic agent that induces nephrotoxicity and oxidative stress. It is unknown whether renal tight junction (TJ) proteins expression and localization are modified in CP-induced nephrotoxicity. OBJECTIVE:To study if the expression of the TJ proteins occludin, claudin-2, claudin-5 a...

journal_title：Toxicology mechanisms and methods

authors： Trujillo J,Molina-Jijón E,Medina-Campos ON,Rodríguez-Muñoz R,Reyes JL,Loredo ML,Tapia E,Sánchez-Lozada LG,Barrera-Oviedo D,Pedraza-Chaverri J

更新日期：2014-10-01 00:00:00

abstract：:Crotonaldehyde is a ubiquitous hazardous pollutant, present in cigarette smoke and automobile exhaust and is endogenously generated by lipid peroxidation. Most of the current studies focus on its lung toxicity. However, there have been few investigations on the cardiac and renal toxicity caused by crotonaldehyde expos...

journal_title：Toxicology mechanisms and methods

authors： Zhang B,Li S,Men J,Peng C,Shao H,Zhang Z

更新日期：2019-05-01 00:00:00

abstract：:Cadmium is one of the most toxic elements to which man can be exposed at work or in the environment. By far, the most salient toxicological property of Cd is its exceptionally long half-life in the human body. Once absorbed, Cd accumulates in the human body, particularly in the liver and other vital organs. The cellul...

journal_title：Toxicology mechanisms and methods

authors： Escobar Mdel C,Souza V,Bucio L,Hernández E,Gómez-Quiroz LE,Gutiérrez Ruiz MC

更新日期：2009-10-01 00:00:00

abstract：:Clinical use of doxorubicin continues to be challenged by its undesirable systematic toxicity, caused mainly by oxidative stress. The aim of this study was to investigate the effectiveness of fullerenol C(60)(OH)(24) polyanion nanoparticles, an antioxidant agent, against doxorubicin-induced nephro-, testicular, and pu...

journal_title：Toxicology mechanisms and methods

authors： Srdjenovic B,Milic-Torres V,Grujic N,Stankov K,Djordjevic A,Vasovic V

更新日期：2010-07-01 00:00:00

abstract：:Miniscrew implants are widely used nowadays in orthodontic treatments due to their good results in clinical practice. However, data regarding the biocompatibility of commercially available orthodontic miniscrews and temporary devices are very scarce, and their role as genotoxicity inducers has been not previously eval...

journal_title：Toxicology mechanisms and methods

authors： Martín-Cameán A,Puerto M,Jos Á,Azqueta A,Iglesias-Linares A,Solano E,Cameán AM

更新日期：2015-01-01 00:00:00

abstract：:Renal disease is a common complication of diabetes mellitus. The pathogenesis of diabetic nephropathy is not well understood, but hyperglycemia seems to be a crucial factor. Recent evidence indicates that the overproduction of reactive oxygen species, observed in both clinical and experimental diabetes, and mitochondr...

journal_title：Toxicology mechanisms and methods

authors： Seiça R,Santos DL,Palmeira CM,Moreno AJ,Sena C,Cunha MF,Santos MS

更新日期：2005-01-01 00:00:00

abstract：:The brain is a well-organized, yet highly complex, organ in the mammalian system. Most investigators use the whole brain, instead of a selected brain region(s), for biochemical analytes as toxicological endpoints. As a result, the obtained data is often of limited value, since their significance is compromised due to ...

journal_title：Toxicology mechanisms and methods

authors： Gupta RC

更新日期：2004-01-01 00:00:00

abstract：CONTEXT:Although the liver is the primary target organ in acetaminophen (APAP) toxicity, other organs are affected. Previous data suggested that chronic APAP abuse can be ototoxic and the mechanism involves APAP-induced oxidative stress and reactive metabolite (N-acetyl-p-benzoquinone imine, NAPQI)-induced endoplasmic ...

journal_title：Toxicology mechanisms and methods

authors： McGill MR,Kennon-McGill S,Durham D,Jaeschke H

更新日期：2016-02-01 00:00:00

abstract：:Silver and gold nanoparticles (Ag-AuNPs) are currently some of the most manufactured nanomaterials. Accordingly, the hazards associated with human exposure to Ag-AuNPs should be investigated to facilitate the risk assessment process. In particular, because pulmonary exposure to Ag-AuNPs occurs during handling of these...

journal_title：Toxicology mechanisms and methods

authors： Ávalos A,Haza AI,Mateo D,Morales P

更新日期：2015-01-01 00:00:00

abstract：:Crotonaldehyde is a hazardous pollutant present in cigarette smoke and automobile exhausts that is generated by lipid peroxidation, and harmful to reproductive organs. Although we are often exposed to low doses of crotonaldehyde daily, its adverse effects on the reproductive organs have not been fully elucidated. To e...

journal_title：Toxicology mechanisms and methods

authors： Zhang B,Wei P,Men J,Zhang S,Shao H,Zhang Z

更新日期：2020-01-01 00:00:00

abstract：:The epidemiological association between black cherry trees and mare reproductive loss syndrome has focused attention on cyanide and environmental cyanogens. This article describes the toxicokinetics of cyanide in horses and the relationships between blood cyanide concentrations and potentially adverse responses to cya...

journal_title：Toxicology mechanisms and methods

authors： Dirikolu L,Hughes C,Harkins D,Boyles J,Bosken J,Lehner F,Troppmann A,McDowell K,Tobin T,Sebastian MM,Harrison L,Crutchfield J,Baskin SI,Fitzgerald TD

更新日期：2003-01-01 00:00:00

abstract：:The titanium nitride coated titanium is a material intended for the fabrication of left ventricular assist device. As per International standards, a material is subjected to pre-clinical evaluation before fabrication of a device. Toxicity/biocompatibility studies such as acute systemic toxicity, intracutaneous irritat...

journal_title：Toxicology mechanisms and methods

authors： Geetha CS,Sabareeswaran A,Mohanan PV

更新日期：2012-02-01 00:00:00

abstract：:The metabolism of aromatic hydrocarbons by the organism forms products that cause cell death depending on the type of exposure. Benzene exposure has been linked to oxidative stress, hepatic damage, aplastic anemia, and hematopoietic cancer as lymphoid and myeloid leukemia. However, there are not fast methods to evalua...

journal_title：Toxicology mechanisms and methods

authors： Martínez-Rodríguez JL,Gutiérrez-Hernández R,Reyes-Estrada CA,Granados-López AJ,Arcos-Ortega T,López JA

更新日期：2018-07-01 00:00:00

abstract：:We investigated the prooxidant effects of bisphenol A (BPA) phenoxyl radicals in comparison with the phenoxyl radicals of 3-tert-butyl-4-hydroxyanisole (BHA), 2,6-di-tert-butyl-methylphenol (BHT) and 4-tert-butylphenol (TBP). The phenoxyl radicals, generated in situ by 1-electron oxidation of the corresponding phenol,...

journal_title：Toxicology mechanisms and methods

authors： Babu S,Uppu S,Claville MO,Uppu RM

更新日期：2013-05-01 00:00:00

abstract：:In this study, the preventive effects of NGF against colistin-induced autophagy and apoptosis in PC12 cells have been investigated. Fluorescence microscopy, real-time PCR, transmission electron microscopy (TEM), flow cytometery, and western blotting technique were used. The results showed that large amounts of autopha...

journal_title：Toxicology mechanisms and methods

authors： Tian E,Hu W,Miao Y,Muhammad I,Zhang L,Xia C,Ding L,Zhang Q,Li R,Chen C,Li J

更新日期：2019-03-01 00:00:00

abstract：:Xysmalobium undulatum (Uzara) is one of the most widely used indigenous traditional herbal remedies in Southern Africa. Commercially available Uzara plant material was used to prepare a crude aqueous extract, of which the toxicity potential was investigated in the hepatic HepG2/C3A cell line in both traditional two-di...

journal_title：Toxicology mechanisms and methods

authors： Calitz C,Hamman JH,Viljoen AM,Fey SJ,Wrzesinski K,Gouws C

更新日期：2018-11-01 00:00:00