abstract：:To this day, immune thrombocytopenia (ITP) remains a clinical diagnosis made by exclusion of other causes for thrombocytopenia. Reliable detection of platelet autoantibodies would support the clinical diagnosis, but the lack of specificity and sensitivity of the available methods for platelet autoantibody testing limi...

journal_title：Transfusion medicine reviews

authors： Porcelijn L,Schmidt DE,Oldert G,Hofstede-van Egmond S,Kapur R,Zwaginga JJ,de Haas M

更新日期：2020-10-01 00:00:00

abstract：:Despite significant advancements in the production of platelet products, storage, and transfusion, transfusion refractoriness remains a significant clinical problem, affecting up to 14% of hematological patients receiving platelet transfusions. Human leukocyte antigen (HLA) alloimmunization is a major cause of immune ...

journal_title：Transfusion medicine reviews

authors： Saris A,Pavenski K

更新日期：2020-10-01 00:00:00

abstract：:Intravenous iron therapy is increasingly used in patients with iron deficiency anemia, although concerns of hypophosphatemia have been recently raised. The aim of this study was to evaluate different intravenous iron formulations for the risk of hypophosphatemia. Medline, Scopus, Cochrane Central Register of Controlle...

journal_title：Transfusion medicine reviews

authors： Bellos I,Frountzas M,Pergialiotis V

更新日期：2020-07-01 00:00:00

abstract：:Passenger lymphocyte syndrome (PLS) is caused by the transfer of B-lymphocytes present in the donor graft into the recipient circulation following solid organ or hematopoietic stem cell transplantation. These cells may produce antibodies against the recipient's red blood cells, thereby triggering antibody dependent cy...

journal_title：Transfusion medicine reviews

authors： Moosavi MM,Duncan A,Stowell SR,Roback JD,Sullivan HC

更新日期：2020-07-01 00:00:00

abstract：:Two complex protein defense systems-complement and coagulation-are based on amplifying enzyme cascades triggered by specific local stimuli. Excess systemic activation of either system is pathologic and is normally prevented by a family of regulatory proteins. The 2 systems are ancient biological processes which share ...

journal_title：Transfusion medicine reviews

authors： Dzik S

更新日期：2019-10-01 00:00:00

abstract：:Low levels of C1 inhibitor, the main inhibitor of the classic complement system, result in paroxysmal angioedema attacks that can be incapacitating or even life-threatening in affected individuals. Molecular defects in the gene for C1 inhibitor cause hereditary angioedema. In recent years, new insights in the pathways...

journal_title：Transfusion medicine reviews

authors： Levi M,Cohn DM

更新日期：2019-10-01 00:00:00

abstract：:Sickle cell disease (SCD) is the most common monogenic disorder in sub-Saharan Africa (SSA). Blood transfusion to increase the oxygen carrying capacity of blood is vital in the management of many patients with SCD. However, red blood cell (RBC) alloimmunization is a major challenge to transfusions in these patients. C...

journal_title：Transfusion medicine reviews

authors： Boateng LA,Ngoma AM,Bates I,Schonewille H

更新日期：2019-07-01 00:00:00

abstract：:Controversial results exist regarding the clinical benefits of single- vs double-unit umbilical cord blood transplantation (UCBT) in patients with hematologic diseases. A systematic review was conducted to evaluate this issue. The PubMed, Embase, and Cochrane Library databases were searched up to May 2018. A total of ...

journal_title：Transfusion medicine reviews

authors： Wang L,Gu ZY,Liu SF,Ma DX,Zhang C,Liu CJ,Gao R,Guan LX,Zhu CY,Wang FY,Gao CJ,Wei HP

更新日期：2019-01-01 00:00:00

abstract：:Although James Blundell is rightly acknowledged as the father of modern transfusion therapy, a review of the events surrounding the initial human-to-human transfusions in the first decades of the 19th century reveals substantial contributions by Blundell's collaborators. Bundell's uncle John Haighton provided substant...

journal_title：Transfusion medicine reviews

authors： Dzik S

更新日期：2018-10-01 00:00:00

abstract：:Allergic transfusion reactions (ATRs) are the most common adverse reactions occurring during transfusion of blood components. Although most reactions are mild and involve cutaneous manifestations, severe ATRs including life-threatening anaphylaxis may also occur. The mechanisms of ATRs are largely unknown because they...

journal_title：Transfusion medicine reviews

authors： Hirayama F,Yasui K,Matsuyama N,Okamura-Shiki I

更新日期：2018-01-01 00:00:00

abstract：:Cardiac surgical patients are among the highest consumers of allogeneic red blood cells (RBCs) due to the prevalence of anemia and bleeding. Up until recently, there was a paucity of high-quality evidence informing transfusion decisions in this patient group which led to wide variability in transfusion decision making...

journal_title：Transfusion medicine reviews

authors： Patel NN,Murphy GJ

更新日期：2017-10-01 00:00:00

abstract：:Immunization against human platelet alloantigens (HPAs) is associated with a number of clinical complications. The detection and identification of clinically relevant platelet antibodies are important for the diagnosis and management of patients affected with immune-mediated thrombocytopenias. Human platelet alloantig...

journal_title：Transfusion medicine reviews

authors： Wu G,Zhou Y,Li L,Zhong Z,Li H,Li H,Yu M,Shen W,Ni H

更新日期：2017-04-01 00:00:00

abstract：:Thrombocytopenia affects approximately one fourth of neonates admitted to neonatal intensive care units, and prophylactic platelet transfusions are commonly administered to reduce bleeding risk. However, there are few evidence-based guidelines to inform clinicians' decision-making process. Developmental differences in...

journal_title：Transfusion medicine reviews

authors： Sola-Visner M,Bercovitz RS

更新日期：2016-10-01 00:00:00

abstract：:The fibrinolytic system, known for its ability to regulate the activation of the zymogen plasminogen into active plasmin, has been primarily associated with the removal of fibrin and blood clots. Tissue-type plasminogen activator, the most well-recognized plasminogen activator, was harnessed for therapeutic benefit ag...

journal_title：Transfusion medicine reviews

authors： Draxler DF,Medcalf RL

更新日期：2015-04-01 00:00:00

abstract：:Although the role of platelets as central mediators of hemostasis and thrombosis has been the primary focus of research into platelet biology for more than a century, over the last decade, nonhemostatic functions of platelets have been increasingly defined. As such, a large body of experimental evidence now exists, wh...

journal_title：Transfusion medicine reviews

authors： McFadyen JD,Kaplan ZS

更新日期：2015-04-01 00:00:00

abstract：:Prior preclinical and clinical studies support the use of platelet-derived products for the treatment of soft and hard tissue lesions. These regenerative effects are controlled by autocrine and paracrine biomolecules including growth factors and cytokines contained in platelet alpha granules. Each growth factor is inv...

journal_title：Transfusion medicine reviews

authors： De Pascale MR,Sommese L,Casamassimi A,Napoli C

更新日期：2015-01-01 00:00:00

abstract：:Until recently, atypical hemolytic uremic syndrome (aHUS), conventionally defined in the pediatric literature as a syndrome of the triad of renal failure, microangiopathic hemolytic anemia, and thrombocytopenia without a prodrome of hemorrhagic diarrhea, has received little attention in adult practice because the pati...

journal_title：Transfusion medicine reviews

authors： Tsai HM

更新日期：2014-10-01 00:00:00

abstract：:Population-based investigations suggest that red blood cells (RBCs) are therapeutically effective when collected, processed, and stored for up to 42 days under validated conditions before transfusion. However, some retrospective clinical studies have shown worse patient outcomes when transfused RBCs have been stored f...

journal_title：Transfusion medicine reviews

authors： Roback JD,Josephson CD,Waller EK,Newman JL,Karatela S,Uppal K,Jones DP,Zimring JC,Dumont LJ

更新日期：2014-04-01 00:00:00

abstract：:The use of prothrombin complex concentrates (PCCs) and fibrinogen concentrates (FIBCs) to achieve hemostasis in the perioperative setting as alternatives to allogeneic blood products remains controversial. To examine the efficacy and safety of PCCs and FIBCs, we conducted a systematic review-in accordance with the Pre...

journal_title：Transfusion medicine reviews

authors： Lin DM,Murphy LS,Tran MH

更新日期：2013-04-01 00:00:00

abstract：:Millions of patients in the UK benefit from the use of both plasma derivatives and blood components that are seen as critical interventions in current medicine. Measures are in place to significantly reduce the risks associated with blood transfusion and plasma derivatives; however, these measures themselves are not r...

journal_title：Transfusion medicine reviews

authors： Watkins NA,Dobra S,Bennett P,Cairns J,Turner ML

更新日期：2012-07-01 00:00:00

abstract：:Reasons for variation in transfusion practice in orthopedic surgery are not well understood. This systematic review identified and appraised the quality of the literature in this area to assess the impact of factors associated with the use of allogeneic red blood cell (RBC) transfusion in orthopedic procedures. MEDLIN...

journal_title：Transfusion medicine reviews

authors： Barr PJ,Donnelly M,Cardwell C,Alam SS,Morris K,Parker M,Bailie KE

更新日期：2011-10-01 00:00:00

abstract：:An international multidisciplinary panel of 15 experts reviewed 494 published articles and used the RAND/UCLA Appropriateness Method to determine the appropriateness of allogeneic red blood cell (RBC) transfusion based on its expected impact on outcomes of stable nonbleeding patients in 450 typical inpatient medical, ...

journal_title：Transfusion medicine reviews

authors： Shander A,Fink A,Javidroozi M,Erhard J,Farmer SL,Corwin H,Goodnough LT,Hofmann A,Isbister J,Ozawa S,Spahn DR,International Consensus Conference on Transfusion Outcomes Group.

更新日期：2011-07-01 00:00:00

abstract：:The use of blood products to support patients undergoing the large variety of medical and surgical interventions requiring such support has continued to escalate very significantly over time. Relevantly, significant practice variation in the use of blood products exists among practitioners and institutions, largely be...

journal_title：Transfusion medicine reviews

authors： Blajchman MA,Glynn SA,Josephson CD,Kleinman SH,State-of-the Science Symposium Transfusion Medicine Committee.

更新日期：2010-10-01 00:00:00

abstract：:Blood services around the world face increasing challenges in recruiting voluntary blood donors. With increasing donor restrictions and ageing populations, it is essential to look for any existing restrictions that may be relaxed in the light of currently available evidence. We propose that one such restriction is the...

journal_title：Transfusion medicine reviews

authors： Yang H,Lee J,Seed CR,Keller AJ

更新日期：2010-07-01 00:00:00

abstract：:Studies of human herpesvirus-8 (HHV-8) transmission through transfusion have produced contradictory results. In North America-a region with a low prevalence of HHV-8 infection-3 studies that tested specimens from linked positive-donor/negative-recipient pairs collected before the introduction of white blood cell (WBC)...

journal_title：Transfusion medicine reviews

authors： Vamvakas EC

更新日期：2010-01-01 00:00:00

abstract：:This guideline for the use of immunoglobulin (IG) for sensitized patients undergoing solid organ transplantation (SOT) is an initiative of the Canadian Blood Services and the National Advisory Committee on Blood and Blood Products of Canada to (1) provide guidance for Canadian practitioners involved in the care of pat...

journal_title：Transfusion medicine reviews

authors： Shehata N,Palda VA,Meyer RM,Blydt-Hansen TD,Campbell P,Cardella C,Martin S,Nickerson P,Peltekian K,Ross H,Waddell TK,West L,Anderson D,Freedman J,Hume H

更新日期：2010-01-01 00:00:00

abstract：:Some have suggested that "blood is different," and the role for cost-effectiveness is thus circumscribed. In this article, the authors start by reviewing key concepts in health economics and economic analysis methods. Examples are drawn from published blood safety studies. After explaining the underlying reasoning beh...

journal_title：Transfusion medicine reviews

authors： Custer B,Hoch JS

更新日期：2009-01-01 00:00:00

abstract：:Although remarkable advances have been made in the prevention of the major transfusion-transmitted diseases, long intervals have transpired between the first recognition of transfusion risk and the implementation of a preventive strategy. For hepatitis B virus, that interval was 30 years; for non-A, non-B/hepatitis C ...

journal_title：Transfusion medicine reviews

authors： Alter HJ

更新日期：2008-04-01 00:00:00

abstract：:Significant progress has been made in reducing the risk of pathogen transmission to transfusion recipients. Nonetheless, there remains a continuing risk of transmission of viruses, bacteria, protozoa, and prions to recipients. These include many of the viruses for which specific screening tests exist as well as pathog...

journal_title：Transfusion medicine reviews

authors： Webert KE,Cserti CM,Hannon J,Lin Y,Pavenski K,Pendergrast JM,Blajchman MA

更新日期：2008-01-01 00:00:00

abstract：:Metabolic studies have revealed a gradual impairment in platelet integrity during storage, a process termed the platelet storage lesion. Recent evidence shows that stored platelets also lose signaling responses to physiological agonists with impaired integrin activation, secretion, and aggregation of the cells. On the...

journal_title：Transfusion medicine reviews

authors： Cauwenberghs S,van Pampus E,Curvers J,Akkerman JW,Heemskerk JW

更新日期：2007-10-01 00:00:00

abstract：:Over the last 20 years, the Canadian Blood Services' (CBS) Donor Health Assessment Questionnaire (DHAQ), used to screen prospective blood donors to determine their eligibility, has grown in complexity and length. Its growth is inextricably linked to the evolution of the environment within which CBS operates from unreg...

journal_title：Transfusion medicine reviews

authors： O'Brien SF,Ram SS,Vamvakas EC,Goldman M

更新日期：2007-07-01 00:00:00

abstract：:There is difficulty in obtaining adequate supplies of blood components, as well as disappointing performance of stabilized or recombinant hemoglobins, limited indications of oxygen transporters (perfluorocarbons), and slow development of "universal" red blood cells (RBCs). There is, therefore, a need for complementary...

journal_title：Transfusion medicine reviews

authors： Douay L,Andreu G

更新日期：2007-04-01 00:00:00

abstract：:The administration of blood products is a common, resource-intensive, and potentially problem-prone area that may place patients at elevated risk in the clinical setting. Much of the emphasis in transfusion safety has been targeted toward quality control measures in laboratory settings where blood products are prepare...

journal_title：Transfusion medicine reviews

authors： Henneman EA,Avrunin GS,Clarke LA,Osterweil LJ,Andrzejewski C Jr,Merrigan K,Cobleigh R,Frederick K,Katz-Bassett E,Henneman PL

更新日期：2007-01-01 00:00:00

abstract：:Cardiac surgery affects both coagulation and platelet function. Revision of surgery due to bleeding has to be performed in 2% to 6% of patients undergoing cardiac surgery and is generally associated with a marked deterioration in prognosis. Factors contributing to acquired hemostatic abnormalities in cardiac surgery i...

journal_title：Transfusion medicine reviews

authors： Hartmann M,Sucker C,Boehm O,Koch A,Loer S,Zacharowski K

更新日期：2006-07-01 00:00:00

abstract：:The crossmatch (XM) is an important part of routine pretransfusion testing. It is used to detect ABO incompatibility and other clinically significant antibodies. The XM has been modified many times and, in recent years, has been abbreviated. The 2 common types of XM currently being done are the immediate spin XM for a...

journal_title：Transfusion medicine reviews

authors： Arslan O

更新日期：2006-01-01 00:00:00

abstract：:ABO is the most important blood group system for transfusion and solid organ transplantation, but it is only over the past 15 years that the techniques for studying its molecular basis became mainstream. Many of its common and rare alleles are now well characterized and by using various expression systems, their effec...

journal_title：Transfusion medicine reviews

authors： Yazer MH

更新日期：2005-07-01 00:00:00

abstract：:Although the risk of infection by blood transfusion is relatively low, breakthrough infections still occur, Transfusion-related fatalities caused by infections continue to be reported, and blood is not tested for many potentially dangerous pathogens. The current paradigm for increasing the safety of the blood supply i...

journal_title：Transfusion medicine reviews

authors： Allain JP,Bianco C,Blajchman MA,Brecher ME,Busch M,Leiby D,Lin L,Stramer S

更新日期：2005-04-01 00:00:00

abstract：:Roger Irving Lee (1881-1964) played significant scientific and leadership roles in overcoming the clinical impediments to blood transfusion in the 1910s. He developed the first successful anticoagulant system, paraffinized glass, and the first sterile system for indirect transfusion without defibrination, the Lee-Vinc...

journal_title：Transfusion medicine reviews

authors： Stansbury LG,Hess JR

更新日期：2005-01-01 00:00:00

abstract：:A number of molecules on the surface of red blood cells (RBCs) and platelets express antigenic activity. Various biochemical and molecular approaches have been used to determine the structure and possible function that these molecules have for their respective cell types. The existence of variant molecules and null ph...

journal_title：Transfusion medicine reviews

authors： Denomme GA

更新日期：2004-07-01 00:00:00

abstract：:Quality patient care entails more than simply biomedical interventions. Respect for the wishes, values, and preferences of patients are important elements of quality care. Unique aspects of the beliefs of Jehovah's Witnesses may present physicians with ethical and clinical conflicts. Witnesses believe that allogeneic ...

journal_title：Transfusion medicine reviews

authors： Bodnaruk ZM,Wong CJ,Thomas MJ

更新日期：2004-04-01 00:00:00