Hemostatic and signaling functions of transfused platelets.

Abstract:

:Metabolic studies have revealed a gradual impairment in platelet integrity during storage, a process termed the platelet storage lesion. Recent evidence shows that stored platelets also lose signaling responses to physiological agonists with impaired integrin activation, secretion, and aggregation of the cells. On the other hand, storage leads to a gain in platelet activation properties, such as release of microparticles and appearance of surface epitopes for their clearance by macrophages. New techniques for measuring flow-induced thrombus formation and platelet-dependent coagulation provide evidence that the hemostatic activity of platelets decreases during storage. Besides pharmacological inhibition, novel storage strategies, like metabolic suppression, should be considered to better preserve platelet functionality while limiting the expression of clearance markers. Understanding the changes that occur in association with the platelet storage lesion and the use of updated storage methods will help to generate platelets for transfusion with optimal hemostatic function and a long circulation time after transfusion.

journal_name

Transfus Med Rev

authors

Cauwenberghs S,van Pampus E,Curvers J,Akkerman JW,Heemskerk JW

doi

10.1016/j.tmrv.2007.05.004

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

287-94

issue

4

eissn

0887-7963

issn

1532-9496

pii

S0887-7963(07)00043-0

journal_volume

21

pub_type

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