Single- Versus Double-Unit Umbilical Cord Blood Transplantation for Hematologic Diseases: A Systematic Review.

Abstract:

:Controversial results exist regarding the clinical benefits of single- vs double-unit umbilical cord blood transplantation (UCBT) in patients with hematologic diseases. A systematic review was conducted to evaluate this issue. The PubMed, Embase, and Cochrane Library databases were searched up to May 2018. A total of 25 studies including 6571 recipients were identified. Although double-unit UCB contained higher doses of total nucleated cells and CD34+ cells, it offered no advantages over single-unit UCB in terms of hematologic recovery, including the rate and speed of neutrophil and platelet engraftment. Double-unit UCBT was associated with higher incidences of grades II-IV acute and extensive chronic graft-vs-host disease, accompanied by a lower relapse incidence, which may be attributed to a graft-vs-graft effect induced by double-unit UCB. However, transplant-related mortality, disease-free survival, and overall survival were comparable between single- and double-unit UCBT. Although double-unit UCBT confers no clinical advantages over single-unit UCBT, certain patients, such as those at high risk of relapse, might benefit from double-unit UCBT, a possibility that needs to be clarified in future randomized trials.

journal_name

Transfus Med Rev

authors

Wang L,Gu ZY,Liu SF,Ma DX,Zhang C,Liu CJ,Gao R,Guan LX,Zhu CY,Wang FY,Gao CJ,Wei HP

doi

10.1016/j.tmrv.2018.11.001

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

51-60

issue

1

eissn

0887-7963

issn

1532-9496

pii

S0887-7963(18)30093-2

journal_volume

33

pub_type

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