Abstract：
:Quality patient care entails more than simply biomedical interventions. Respect for the wishes, values, and preferences of patients are important elements of quality care. Unique aspects of the beliefs of Jehovah's Witnesses may present physicians with ethical and clinical conflicts. Witnesses believe that allogeneic blood transfusion (ie, whole blood, red blood cells, white cells, platelets, and plasma) and preoperative autologous blood deposit (PAD) are prohibited by several Biblical passages. This article reviews the Witness position on medical care, blood components, and fractions, placing these and related interventions into categories that may help physicians to individualize clinical management plans and meet the challenge of caring for patients who are Jehovah's Witnesses. It includes an overview of cost, safety, efficacy, and medicolegal issues related to patient care using transfusion-alternative strategies.
journal_name
Transfus Med Revjournal_title
Transfusion medicine reviewsauthors
Bodnaruk ZM,Wong CJ,Thomas MJdoi
10.1016/j.tmrv.2003.12.004subject
Has Abstractpub_date
2004-04-01 00:00:00pages
105-16issue
2eissn
0887-7963issn
1532-9496pii
S0887796303000889journal_volume
18pub_type
杂志文章,评审abstract：:In the last half of this century, donor deferral registries have grown in size, scope, and importance for blood collection organizations and regulatory agencies. This has occurred despite the lack of direct evidence that, when used with all other methods, they contribute meaningfully to the safety of the blood supply....
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(93)70131-5
更新日期：1993-04-01 00:00:00
abstract：:The use of blood products to support patients undergoing the large variety of medical and surgical interventions requiring such support has continued to escalate very significantly over time. Relevantly, significant practice variation in the use of blood products exists among practitioners and institutions, largely be...
journal_title：Transfusion medicine reviews
pub_type：
doi：10.1016/j.tmrv.2010.05.002
更新日期：2010-10-01 00:00:00
abstract：:Although remarkable advances have been made in the prevention of the major transfusion-transmitted diseases, long intervals have transpired between the first recognition of transfusion risk and the implementation of a preventive strategy. For hepatitis B virus, that interval was 30 years; for non-A, non-B/hepatitis C ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章
doi：10.1016/j.tmrv.2008.01.001
更新日期：2008-04-01 00:00:00
abstract：:Although the true risk of transmitting (classical) Creutzfeld-Jakob Disease (CJD) and variant CJD (vCJD) via transfusion is likely very minimal, a review of prions and the impact of these associated prion diseases is timely because of their current effect on safety policies in the blood-plasma industry. Various types ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tm.2001.25382
更新日期：2001-04-01 00:00:00
abstract：:Knowledge of the molecular basis of the blood group systems has enabled the development of assays for blood group genotyping. At this time, polymerase chain reaction (PCR)-based assays validated on fetal material obtained by invasive means (chorionic villus sampling or amniocentesis) are available for all clinically r...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tmrv.2003.50001
更新日期：2003-01-01 00:00:00
abstract：:Thrombocytopenia affects approximately one fourth of neonates admitted to neonatal intensive care units, and prophylactic platelet transfusions are commonly administered to reduce bleeding risk. However, there are few evidence-based guidelines to inform clinicians' decision-making process. Developmental differences in...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2016.05.009
更新日期：2016-10-01 00:00:00
abstract：:Population-based investigations suggest that red blood cells (RBCs) are therapeutically effective when collected, processed, and stored for up to 42 days under validated conditions before transfusion. However, some retrospective clinical studies have shown worse patient outcomes when transfused RBCs have been stored f...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章
doi：10.1016/j.tmrv.2014.01.003
更新日期：2014-04-01 00:00:00
abstract：:The administration of blood products is a common, resource-intensive, and potentially problem-prone area that may place patients at elevated risk in the clinical setting. Much of the emphasis in transfusion safety has been targeted toward quality control measures in laboratory settings where blood products are prepare...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2006.08.007
更新日期：2007-01-01 00:00:00
abstract：:With the realization that the skin bleeding time is often an unreliable measure of platelet function, efforts have been made to identify ways to assess qualitative platelet dysfunction. Currently available techniques measure platelet adhesion, platelet aggregation, the ability of platelets to retard or stop flow throu...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tm.1997.0110106
更新日期：1997-04-01 00:00:00
abstract：:Millions of patients in the UK benefit from the use of both plasma derivatives and blood components that are seen as critical interventions in current medicine. Measures are in place to significantly reduce the risks associated with blood transfusion and plasma derivatives; however, these measures themselves are not r...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2011.09.003
更新日期：2012-07-01 00:00:00
abstract：:The limiting factor in platelet transfusion therapy is the development of alloimmunization. Although using HLA matched platelets may be effective in reducing the problem of alloimmune platelet transfusion refractoriness, relying solely upon HLA matching has its shortcomings. The selection of compatible platelet transf...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(90)70237-4
更新日期：1990-10-01 00:00:00
abstract：:Controversial results exist regarding the clinical benefits of single- vs double-unit umbilical cord blood transplantation (UCBT) in patients with hematologic diseases. A systematic review was conducted to evaluate this issue. The PubMed, Embase, and Cochrane Library databases were searched up to May 2018. A total of ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章
doi：10.1016/j.tmrv.2018.11.001
更新日期：2019-01-01 00:00:00
abstract：:Although James Blundell is rightly acknowledged as the father of modern transfusion therapy, a review of the events surrounding the initial human-to-human transfusions in the first decades of the 19th century reveals substantial contributions by Blundell's collaborators. Bundell's uncle John Haighton provided substant...
journal_title：Transfusion medicine reviews
pub_type： 传,历史文章,杂志文章,评审
doi：10.1016/j.tmrv.2018.08.003
更新日期：2018-10-01 00:00:00
abstract：:The development and expansion of the CTS in Pittsburgh shows the feasibility of this transfusion medicine delivery system. Few of the changes driven by health care reform both improve patient care and reduce costs. When properly implemented, a CTS achieves these objectives, benefits the community as a whole, and enhan...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(05)80051-3
更新日期：1995-04-01 00:00:00
abstract：:ABO is the most important blood group system for transfusion and solid organ transplantation, but it is only over the past 15 years that the techniques for studying its molecular basis became mainstream. Many of its common and rare alleles are now well characterized and by using various expression systems, their effec...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2005.02.003
更新日期：2005-07-01 00:00:00
abstract：:Two complex protein defense systems-complement and coagulation-are based on amplifying enzyme cascades triggered by specific local stimuli. Excess systemic activation of either system is pathologic and is normally prevented by a family of regulatory proteins. The 2 systems are ancient biological processes which share ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2019.08.004
更新日期：2019-10-01 00:00:00
abstract：:Several public policy decisions in transfusion medicine require information on the long-term (> or =10-year) survival of transfused patients. This information is needed (1) to estimate the number of surviving transfusion recipients who have contracted a particular infection through transfusion, (2) to assess the cost-...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(03)00019-1
更新日期：2003-07-01 00:00:00
abstract：:Over the last 20 years, the Canadian Blood Services' (CBS) Donor Health Assessment Questionnaire (DHAQ), used to screen prospective blood donors to determine their eligibility, has grown in complexity and length. Its growth is inextricably linked to the evolution of the environment within which CBS operates from unreg...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2007.03.002
更新日期：2007-07-01 00:00:00
abstract：:Sickle cell disease (SCD) is the most common monogenic disorder in sub-Saharan Africa (SSA). Blood transfusion to increase the oxygen carrying capacity of blood is vital in the management of many patients with SCD. However, red blood cell (RBC) alloimmunization is a major challenge to transfusions in these patients. C...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,meta分析
doi：10.1016/j.tmrv.2019.06.003
更新日期：2019-07-01 00:00:00
abstract：:Some have suggested that "blood is different," and the role for cost-effectiveness is thus circumscribed. In this article, the authors start by reviewing key concepts in health economics and economic analysis methods. Examples are drawn from published blood safety studies. After explaining the underlying reasoning beh...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2008.09.001
更新日期：2009-01-01 00:00:00
abstract：:Autoantibodies against red cells optimally reacting at 0 degree C, ie, CA, are normally found with low titers in the serum of human adults. High-titer CA may be induced by certain infectious agents, including M pneumoniae, EBV, CMV, and rubella virus, or may develop on the basis of chronic (malignant) B cell lymphopro...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(89)70075-4
更新日期：1989-04-01 00:00:00
abstract：:Intravenous iron therapy is increasingly used in patients with iron deficiency anemia, although concerns of hypophosphatemia have been recently raised. The aim of this study was to evaluate different intravenous iron formulations for the risk of hypophosphatemia. Medline, Scopus, Cochrane Central Register of Controlle...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2020.07.002
更新日期：2020-07-01 00:00:00
abstract：:Cardiac surgery affects both coagulation and platelet function. Revision of surgery due to bleeding has to be performed in 2% to 6% of patients undergoing cardiac surgery and is generally associated with a marked deterioration in prognosis. Factors contributing to acquired hemostatic abnormalities in cardiac surgery i...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2006.03.003
更新日期：2006-07-01 00:00:00
abstract：:The regulation of complement at the surface of cells is mediated by both plasma and membrane proteins. These molecules act in concert to prevent the accelerated catabolism of complement proteins and the concomitant lysis of homologous blood cells. The deficiency of either a plasma or membrane protein predisposes to th...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(91)70199-5
更新日期：1991-04-01 00:00:00
abstract：:Low levels of C1 inhibitor, the main inhibitor of the classic complement system, result in paroxysmal angioedema attacks that can be incapacitating or even life-threatening in affected individuals. Molecular defects in the gene for C1 inhibitor cause hereditary angioedema. In recent years, new insights in the pathways...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2019.08.002
更新日期：2019-10-01 00:00:00
abstract：:Roger Irving Lee (1881-1964) played significant scientific and leadership roles in overcoming the clinical impediments to blood transfusion in the 1910s. He developed the first successful anticoagulant system, paraffinized glass, and the first sterile system for indirect transfusion without defibrination, the Lee-Vinc...
journal_title：Transfusion medicine reviews
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.tmrv.2004.09.003
更新日期：2005-01-01 00:00:00
abstract：:A number of molecules on the surface of red blood cells (RBCs) and platelets express antigenic activity. Various biochemical and molecular approaches have been used to determine the structure and possible function that these molecules have for their respective cell types. The existence of variant molecules and null ph...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2004.03.006
更新日期：2004-07-01 00:00:00
abstract：:The small number of studies done on the covalent modification of RBC with PEG, or PEG-derivatives, suggests that the immunocamouflage of intact cells significantly reduces the antigenicity and immunogenicity of the foreign cell. Importantly, this protective immunologic effect can be accomplished without adversely affe...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(00)80115-7
更新日期：2000-01-01 00:00:00
abstract：:In summary, it is impossible to reconcile the contradictory results of the studies of the association between previous blood transfusion and subsequent development of NHL (Figs 1 and 2). Most of the studies were of high quality, and the authors discussed the possible sources of bias that might have generated a spuriou...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tm.20000.7395
更新日期：2000-07-01 00:00:00
abstract：:Immunization against human platelet alloantigens (HPAs) is associated with a number of clinical complications. The detection and identification of clinically relevant platelet antibodies are important for the diagnosis and management of patients affected with immune-mediated thrombocytopenias. Human platelet alloantig...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2016.12.001
更新日期：2017-04-01 00:00:00
