Abstract：
:Over the last 20 years, the Canadian Blood Services' (CBS) Donor Health Assessment Questionnaire (DHAQ), used to screen prospective blood donors to determine their eligibility, has grown in complexity and length. Its growth is inextricably linked to the evolution of the environment within which CBS operates from unregulated collection and distribution of labile blood products to a fully regulated environment and to the need to satisfy both Health Canada and US Food and Drug Administration (FDA) requirements. Within this context, the development of the CBS DHAQ has been characterized by addition of questions and items without any periodic reevaluation of the need for retaining existing questions and/or items. In this review, we apply principles from cognitive science relating to how people think when answering questionnaires to the situation of blood donors completing the DHAQ. We show that some items that were added at different times in separate questions, for reasons that were historically relevant, could be now asked more simply with a single question. The historical development of the DHAQ, resulting in the condensing of many items into lists, the use of complex wording, and the sheer number of items included in the questionnaire make accurate retrieval of information from the donor's memory difficult. Thus, we believe that redesigning the DHAQ will improve the quality and accuracy of the donors' answers to screening questions.
journal_name
Transfus Med Revjournal_title
Transfusion medicine reviewsauthors
O'Brien SF,Ram SS,Vamvakas EC,Goldman Mdoi
10.1016/j.tmrv.2007.03.002subject
Has Abstractpub_date
2007-07-01 00:00:00pages
205-22issue
3eissn
0887-7963issn
1532-9496pii
S0887-7963(07)00018-1journal_volume
21pub_type
杂志文章,评审abstract：:To this day, immune thrombocytopenia (ITP) remains a clinical diagnosis made by exclusion of other causes for thrombocytopenia. Reliable detection of platelet autoantibodies would support the clinical diagnosis, but the lack of specificity and sensitivity of the available methods for platelet autoantibody testing limi...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2020.09.003
更新日期：2020-10-01 00:00:00
abstract：:A number of molecules on the surface of red blood cells (RBCs) and platelets express antigenic activity. Various biochemical and molecular approaches have been used to determine the structure and possible function that these molecules have for their respective cell types. The existence of variant molecules and null ph...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2004.03.006
更新日期：2004-07-01 00:00:00
abstract：:The small number of studies done on the covalent modification of RBC with PEG, or PEG-derivatives, suggests that the immunocamouflage of intact cells significantly reduces the antigenicity and immunogenicity of the foreign cell. Importantly, this protective immunologic effect can be accomplished without adversely affe...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(00)80115-7
更新日期：2000-01-01 00:00:00
abstract：:The virucidal properties of photoactive phenothiazine dyes, such as methylene blue, have been known approximately 70 years. The mechanism of virus inactivation involves binding of the dye to nucleic acid, absorption of light, generation of reactive oxygen species, guanine oxidation in the viral genome. The first pract...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tmrv.2002.29405
更新日期：2002-01-01 00:00:00
abstract：:Thrombocytopenia affects approximately one fourth of neonates admitted to neonatal intensive care units, and prophylactic platelet transfusions are commonly administered to reduce bleeding risk. However, there are few evidence-based guidelines to inform clinicians' decision-making process. Developmental differences in...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2016.05.009
更新日期：2016-10-01 00:00:00
abstract：:Studies of human herpesvirus-8 (HHV-8) transmission through transfusion have produced contradictory results. In North America-a region with a low prevalence of HHV-8 infection-3 studies that tested specimens from linked positive-donor/negative-recipient pairs collected before the introduction of white blood cell (WBC)...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2009.09.001
更新日期：2010-01-01 00:00:00
abstract：:The regulation of complement at the surface of cells is mediated by both plasma and membrane proteins. These molecules act in concert to prevent the accelerated catabolism of complement proteins and the concomitant lysis of homologous blood cells. The deficiency of either a plasma or membrane protein predisposes to th...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(91)70199-5
更新日期：1991-04-01 00:00:00
abstract：:The limiting factor in platelet transfusion therapy is the development of alloimmunization. Although using HLA matched platelets may be effective in reducing the problem of alloimmune platelet transfusion refractoriness, relying solely upon HLA matching has its shortcomings. The selection of compatible platelet transf...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(90)70237-4
更新日期：1990-10-01 00:00:00
abstract：:Allergic transfusion reactions (ATRs) are the most common adverse reactions occurring during transfusion of blood components. Although most reactions are mild and involve cutaneous manifestations, severe ATRs including life-threatening anaphylaxis may also occur. The mechanisms of ATRs are largely unknown because they...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2017.09.002
更新日期：2018-01-01 00:00:00
abstract：:Prior preclinical and clinical studies support the use of platelet-derived products for the treatment of soft and hard tissue lesions. These regenerative effects are controlled by autocrine and paracrine biomolecules including growth factors and cytokines contained in platelet alpha granules. Each growth factor is inv...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2014.11.001
更新日期：2015-01-01 00:00:00
abstract：:There is difficulty in obtaining adequate supplies of blood components, as well as disappointing performance of stabilized or recombinant hemoglobins, limited indications of oxygen transporters (perfluorocarbons), and slow development of "universal" red blood cells (RBCs). There is, therefore, a need for complementary...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2006.11.004
更新日期：2007-04-01 00:00:00
abstract：:Millions of patients in the UK benefit from the use of both plasma derivatives and blood components that are seen as critical interventions in current medicine. Measures are in place to significantly reduce the risks associated with blood transfusion and plasma derivatives; however, these measures themselves are not r...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2011.09.003
更新日期：2012-07-01 00:00:00
abstract：:In the last half of this century, donor deferral registries have grown in size, scope, and importance for blood collection organizations and regulatory agencies. This has occurred despite the lack of direct evidence that, when used with all other methods, they contribute meaningfully to the safety of the blood supply....
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(93)70131-5
更新日期：1993-04-01 00:00:00
abstract：:Two complex protein defense systems-complement and coagulation-are based on amplifying enzyme cascades triggered by specific local stimuli. Excess systemic activation of either system is pathologic and is normally prevented by a family of regulatory proteins. The 2 systems are ancient biological processes which share ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2019.08.004
更新日期：2019-10-01 00:00:00
abstract：:The administration of blood products is a common, resource-intensive, and potentially problem-prone area that may place patients at elevated risk in the clinical setting. Much of the emphasis in transfusion safety has been targeted toward quality control measures in laboratory settings where blood products are prepare...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2006.08.007
更新日期：2007-01-01 00:00:00
abstract：:With the realization that the skin bleeding time is often an unreliable measure of platelet function, efforts have been made to identify ways to assess qualitative platelet dysfunction. Currently available techniques measure platelet adhesion, platelet aggregation, the ability of platelets to retard or stop flow throu...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tm.1997.0110106
更新日期：1997-04-01 00:00:00
abstract：:Sickle cell disease (SCD) is the most common monogenic disorder in sub-Saharan Africa (SSA). Blood transfusion to increase the oxygen carrying capacity of blood is vital in the management of many patients with SCD. However, red blood cell (RBC) alloimmunization is a major challenge to transfusions in these patients. C...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,meta分析
doi：10.1016/j.tmrv.2019.06.003
更新日期：2019-07-01 00:00:00
abstract：:Immunization against human platelet alloantigens (HPAs) is associated with a number of clinical complications. The detection and identification of clinically relevant platelet antibodies are important for the diagnosis and management of patients affected with immune-mediated thrombocytopenias. Human platelet alloantig...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2016.12.001
更新日期：2017-04-01 00:00:00
abstract：:Several public policy decisions in transfusion medicine require information on the long-term (> or =10-year) survival of transfused patients. This information is needed (1) to estimate the number of surviving transfusion recipients who have contracted a particular infection through transfusion, (2) to assess the cost-...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(03)00019-1
更新日期：2003-07-01 00:00:00
abstract：:Low levels of C1 inhibitor, the main inhibitor of the classic complement system, result in paroxysmal angioedema attacks that can be incapacitating or even life-threatening in affected individuals. Molecular defects in the gene for C1 inhibitor cause hereditary angioedema. In recent years, new insights in the pathways...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2019.08.002
更新日期：2019-10-01 00:00:00
abstract：:In summary, it is impossible to reconcile the contradictory results of the studies of the association between previous blood transfusion and subsequent development of NHL (Figs 1 and 2). Most of the studies were of high quality, and the authors discussed the possible sources of bias that might have generated a spuriou...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tm.20000.7395
更新日期：2000-07-01 00:00:00
abstract：:Knowledge of the molecular basis of the blood group systems has enabled the development of assays for blood group genotyping. At this time, polymerase chain reaction (PCR)-based assays validated on fetal material obtained by invasive means (chorionic villus sampling or amniocentesis) are available for all clinically r...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tmrv.2003.50001
更新日期：2003-01-01 00:00:00
abstract：:Quality patient care entails more than simply biomedical interventions. Respect for the wishes, values, and preferences of patients are important elements of quality care. Unique aspects of the beliefs of Jehovah's Witnesses may present physicians with ethical and clinical conflicts. Witnesses believe that allogeneic ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2003.12.004
更新日期：2004-04-01 00:00:00
abstract：:Blood services around the world face increasing challenges in recruiting voluntary blood donors. With increasing donor restrictions and ageing populations, it is essential to look for any existing restrictions that may be relaxed in the light of currently available evidence. We propose that one such restriction is the...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2010.03.005
更新日期：2010-07-01 00:00:00
abstract：:Although the role of platelets as central mediators of hemostasis and thrombosis has been the primary focus of research into platelet biology for more than a century, over the last decade, nonhemostatic functions of platelets have been increasingly defined. As such, a large body of experimental evidence now exists, wh...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2014.11.006
更新日期：2015-04-01 00:00:00
abstract：:Metabolic studies have revealed a gradual impairment in platelet integrity during storage, a process termed the platelet storage lesion. Recent evidence shows that stored platelets also lose signaling responses to physiological agonists with impaired integrin activation, secretion, and aggregation of the cells. On the...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2007.05.004
更新日期：2007-10-01 00:00:00
abstract：:The chromosomal locations of genes controlling the expression of some 200 antigens constituting the 23 established human blood group systems have been reviewed. Twenty-one of the these genes are located on 12 autosomes, and two are located on the X chromosome. Refined chromosomal positions, to a single cytogenetically...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(98)80056-4
更新日期：1998-07-01 00:00:00
abstract：:Hybridoma technology has contributed to virtually all areas of biology and medicine and set the scene for important advances in cell biology and immunodiagnostics. Blood transfusion and transfusion medicine have benefited significantly from development in hybridoma technology, and this has resulted in the generation o...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tmrv.2002.33436
更新日期：2002-07-01 00:00:00
abstract：:ABO is the most important blood group system for transfusion and solid organ transplantation, but it is only over the past 15 years that the techniques for studying its molecular basis became mainstream. Many of its common and rare alleles are now well characterized and by using various expression systems, their effec...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2005.02.003
更新日期：2005-07-01 00:00:00
abstract：:Autoantibodies against red cells optimally reacting at 0 degree C, ie, CA, are normally found with low titers in the serum of human adults. High-titer CA may be induced by certain infectious agents, including M pneumoniae, EBV, CMV, and rubella virus, or may develop on the basis of chronic (malignant) B cell lymphopro...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(89)70075-4
更新日期：1989-04-01 00:00:00
