Abstract:
:Low levels of C1 inhibitor, the main inhibitor of the classic complement system, result in paroxysmal angioedema attacks that can be incapacitating or even life-threatening in affected individuals. Molecular defects in the gene for C1 inhibitor cause hereditary angioedema. In recent years, new insights in the pathways leading to angioedema due to a deficiency of C1 inhibitor have been gathered. Bradykinin, which is formed upon activation of the kallikrein-kinin system under insufficient regulation by C1 inhibitor, plays a crucial role. Whereas C1 inhibitor also occupies a central mediatory role in other plasma systems, such as the contact activation system of coagulation and the fibrinolytic plasminogen-plasmin system, a C1 inhibitor deficiency may also cause enhanced activation of these pathways. Novel therapeutic modalities for treatment and prevention of hereditary angioedema are now available, such as different forms of C1 inhibitor concentrate and novel agents that interfere in the kallikrein-kinin system.
journal_name
Transfus Med Revjournal_title
Transfusion medicine reviewsauthors
Levi M,Cohn DMdoi
10.1016/j.tmrv.2019.08.002subject
Has Abstractpub_date
2019-10-01 00:00:00pages
243-247issue
4eissn
0887-7963issn
1532-9496pii
S0887-7963(19)30104-Xjournal_volume
33pub_type
杂志文章,评审abstract::The regulation of complement at the surface of cells is mediated by both plasma and membrane proteins. These molecules act in concert to prevent the accelerated catabolism of complement proteins and the concomitant lysis of homologous blood cells. The deficiency of either a plasma or membrane protein predisposes to th...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/s0887-7963(91)70199-5
更新日期:1991-04-01 00:00:00
abstract::Hybridoma technology has contributed to virtually all areas of biology and medicine and set the scene for important advances in cell biology and immunodiagnostics. Blood transfusion and transfusion medicine have benefited significantly from development in hybridoma technology, and this has resulted in the generation o...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1053/tmrv.2002.33436
更新日期:2002-07-01 00:00:00
abstract::To this day, immune thrombocytopenia (ITP) remains a clinical diagnosis made by exclusion of other causes for thrombocytopenia. Reliable detection of platelet autoantibodies would support the clinical diagnosis, but the lack of specificity and sensitivity of the available methods for platelet autoantibody testing limi...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2020.09.003
更新日期:2020-10-01 00:00:00
abstract::Significant progress has been made in reducing the risk of pathogen transmission to transfusion recipients. Nonetheless, there remains a continuing risk of transmission of viruses, bacteria, protozoa, and prions to recipients. These include many of the viruses for which specific screening tests exist as well as pathog...
journal_title:Transfusion medicine reviews
pub_type: 共识发展会议,杂志文章,评审
doi:10.1016/j.tmrv.2007.09.001
更新日期:2008-01-01 00:00:00
abstract::In the last half of this century, donor deferral registries have grown in size, scope, and importance for blood collection organizations and regulatory agencies. This has occurred despite the lack of direct evidence that, when used with all other methods, they contribute meaningfully to the safety of the blood supply....
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/s0887-7963(93)70131-5
更新日期:1993-04-01 00:00:00
abstract::Although James Blundell is rightly acknowledged as the father of modern transfusion therapy, a review of the events surrounding the initial human-to-human transfusions in the first decades of the 19th century reveals substantial contributions by Blundell's collaborators. Bundell's uncle John Haighton provided substant...
journal_title:Transfusion medicine reviews
pub_type: 传,历史文章,杂志文章,评审
doi:10.1016/j.tmrv.2018.08.003
更新日期:2018-10-01 00:00:00
abstract::Prior preclinical and clinical studies support the use of platelet-derived products for the treatment of soft and hard tissue lesions. These regenerative effects are controlled by autocrine and paracrine biomolecules including growth factors and cytokines contained in platelet alpha granules. Each growth factor is inv...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2014.11.001
更新日期:2015-01-01 00:00:00
abstract::In summary, it is impossible to reconcile the contradictory results of the studies of the association between previous blood transfusion and subsequent development of NHL (Figs 1 and 2). Most of the studies were of high quality, and the authors discussed the possible sources of bias that might have generated a spuriou...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1053/tm.20000.7395
更新日期:2000-07-01 00:00:00
abstract::There is difficulty in obtaining adequate supplies of blood components, as well as disappointing performance of stabilized or recombinant hemoglobins, limited indications of oxygen transporters (perfluorocarbons), and slow development of "universal" red blood cells (RBCs). There is, therefore, a need for complementary...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2006.11.004
更新日期:2007-04-01 00:00:00
abstract::Thrombocytopenia affects approximately one fourth of neonates admitted to neonatal intensive care units, and prophylactic platelet transfusions are commonly administered to reduce bleeding risk. However, there are few evidence-based guidelines to inform clinicians' decision-making process. Developmental differences in...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2016.05.009
更新日期:2016-10-01 00:00:00
abstract::Roger Irving Lee (1881-1964) played significant scientific and leadership roles in overcoming the clinical impediments to blood transfusion in the 1910s. He developed the first successful anticoagulant system, paraffinized glass, and the first sterile system for indirect transfusion without defibrination, the Lee-Vinc...
journal_title:Transfusion medicine reviews
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.tmrv.2004.09.003
更新日期:2005-01-01 00:00:00
abstract::Although the true risk of transmitting (classical) Creutzfeld-Jakob Disease (CJD) and variant CJD (vCJD) via transfusion is likely very minimal, a review of prions and the impact of these associated prion diseases is timely because of their current effect on safety policies in the blood-plasma industry. Various types ...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1053/tm.2001.25382
更新日期:2001-04-01 00:00:00
abstract::Reasons for variation in transfusion practice in orthopedic surgery are not well understood. This systematic review identified and appraised the quality of the literature in this area to assess the impact of factors associated with the use of allogeneic red blood cell (RBC) transfusion in orthopedic procedures. MEDLIN...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2011.04.003
更新日期:2011-10-01 00:00:00
abstract::Sickle cell disease (SCD) is the most common monogenic disorder in sub-Saharan Africa (SSA). Blood transfusion to increase the oxygen carrying capacity of blood is vital in the management of many patients with SCD. However, red blood cell (RBC) alloimmunization is a major challenge to transfusions in these patients. C...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,meta分析
doi:10.1016/j.tmrv.2019.06.003
更新日期:2019-07-01 00:00:00
abstract::The chromosomal locations of genes controlling the expression of some 200 antigens constituting the 23 established human blood group systems have been reviewed. Twenty-one of the these genes are located on 12 autosomes, and two are located on the X chromosome. Refined chromosomal positions, to a single cytogenetically...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/s0887-7963(98)80056-4
更新日期:1998-07-01 00:00:00
abstract::ABO is the most important blood group system for transfusion and solid organ transplantation, but it is only over the past 15 years that the techniques for studying its molecular basis became mainstream. Many of its common and rare alleles are now well characterized and by using various expression systems, their effec...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2005.02.003
更新日期:2005-07-01 00:00:00
abstract::A number of molecules on the surface of red blood cells (RBCs) and platelets express antigenic activity. Various biochemical and molecular approaches have been used to determine the structure and possible function that these molecules have for their respective cell types. The existence of variant molecules and null ph...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2004.03.006
更新日期:2004-07-01 00:00:00
abstract::The use of prothrombin complex concentrates (PCCs) and fibrinogen concentrates (FIBCs) to achieve hemostasis in the perioperative setting as alternatives to allogeneic blood products remains controversial. To examine the efficacy and safety of PCCs and FIBCs, we conducted a systematic review-in accordance with the Pre...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2013.01.002
更新日期:2013-04-01 00:00:00
abstract::Millions of patients in the UK benefit from the use of both plasma derivatives and blood components that are seen as critical interventions in current medicine. Measures are in place to significantly reduce the risks associated with blood transfusion and plasma derivatives; however, these measures themselves are not r...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2011.09.003
更新日期:2012-07-01 00:00:00
abstract::Until recently, atypical hemolytic uremic syndrome (aHUS), conventionally defined in the pediatric literature as a syndrome of the triad of renal failure, microangiopathic hemolytic anemia, and thrombocytopenia without a prodrome of hemorrhagic diarrhea, has received little attention in adult practice because the pati...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2014.08.004
更新日期:2014-10-01 00:00:00
abstract::Cardiac surgery affects both coagulation and platelet function. Revision of surgery due to bleeding has to be performed in 2% to 6% of patients undergoing cardiac surgery and is generally associated with a marked deterioration in prognosis. Factors contributing to acquired hemostatic abnormalities in cardiac surgery i...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2006.03.003
更新日期:2006-07-01 00:00:00
abstract::The fibrinolytic system, known for its ability to regulate the activation of the zymogen plasminogen into active plasmin, has been primarily associated with the removal of fibrin and blood clots. Tissue-type plasminogen activator, the most well-recognized plasminogen activator, was harnessed for therapeutic benefit ag...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2014.09.006
更新日期:2015-04-01 00:00:00
abstract::Cardiac surgical patients are among the highest consumers of allogeneic red blood cells (RBCs) due to the prevalence of anemia and bleeding. Up until recently, there was a paucity of high-quality evidence informing transfusion decisions in this patient group which led to wide variability in transfusion decision making...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2017.06.001
更新日期:2017-10-01 00:00:00
abstract::Quality patient care entails more than simply biomedical interventions. Respect for the wishes, values, and preferences of patients are important elements of quality care. Unique aspects of the beliefs of Jehovah's Witnesses may present physicians with ethical and clinical conflicts. Witnesses believe that allogeneic ...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2003.12.004
更新日期:2004-04-01 00:00:00
abstract::The crossmatch (XM) is an important part of routine pretransfusion testing. It is used to detect ABO incompatibility and other clinically significant antibodies. The XM has been modified many times and, in recent years, has been abbreviated. The 2 common types of XM currently being done are the immediate spin XM for a...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2005.08.007
更新日期:2006-01-01 00:00:00
abstract::The use of blood products to support patients undergoing the large variety of medical and surgical interventions requiring such support has continued to escalate very significantly over time. Relevantly, significant practice variation in the use of blood products exists among practitioners and institutions, largely be...
journal_title:Transfusion medicine reviews
pub_type:
doi:10.1016/j.tmrv.2010.05.002
更新日期:2010-10-01 00:00:00
abstract::Two complex protein defense systems-complement and coagulation-are based on amplifying enzyme cascades triggered by specific local stimuli. Excess systemic activation of either system is pathologic and is normally prevented by a family of regulatory proteins. The 2 systems are ancient biological processes which share ...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2019.08.004
更新日期:2019-10-01 00:00:00
abstract::The small number of studies done on the covalent modification of RBC with PEG, or PEG-derivatives, suggests that the immunocamouflage of intact cells significantly reduces the antigenicity and immunogenicity of the foreign cell. Importantly, this protective immunologic effect can be accomplished without adversely affe...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/s0887-7963(00)80115-7
更新日期:2000-01-01 00:00:00
abstract::An international multidisciplinary panel of 15 experts reviewed 494 published articles and used the RAND/UCLA Appropriateness Method to determine the appropriateness of allogeneic red blood cell (RBC) transfusion based on its expected impact on outcomes of stable nonbleeding patients in 450 typical inpatient medical, ...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,多中心研究,评审
doi:10.1016/j.tmrv.2011.02.001
更新日期:2011-07-01 00:00:00
abstract::Studies of human herpesvirus-8 (HHV-8) transmission through transfusion have produced contradictory results. In North America-a region with a low prevalence of HHV-8 infection-3 studies that tested specimens from linked positive-donor/negative-recipient pairs collected before the introduction of white blood cell (WBC)...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2009.09.001
更新日期:2010-01-01 00:00:00