The challenge of platelet alloimmunization: management and prevention.


:The limiting factor in platelet transfusion therapy is the development of alloimmunization. Although using HLA matched platelets may be effective in reducing the problem of alloimmune platelet transfusion refractoriness, relying solely upon HLA matching has its shortcomings. The selection of compatible platelet transfusions can be improved by compatibility testing. Despite these maneuvers, compatible platelets may not be found for some patients. When faced with these difficult patients there are few effective alternatives. The preventive measures of leukocyte depletion or ultraviolet irradiation of platelets promise to reduce or prevent alloimmunization.


Transfus Med Rev


Kickler TS




Has Abstract


1990-10-01 00:00:00




4 Suppl 1








  • Does hybridoma technology still have a place in transfusion medicine?

    abstract::Hybridoma technology has contributed to virtually all areas of biology and medicine and set the scene for important advances in cell biology and immunodiagnostics. Blood transfusion and transfusion medicine have benefited significantly from development in hybridoma technology, and this has resulted in the generation o...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Yuan FF,Watt JM,Geczy AF

    更新日期:2002-07-01 00:00:00

  • The Role of Complement in Hereditary Angioedema.

    abstract::Low levels of C1 inhibitor, the main inhibitor of the classic complement system, result in paroxysmal angioedema attacks that can be incapacitating or even life-threatening in affected individuals. Molecular defects in the gene for C1 inhibitor cause hereditary angioedema. In recent years, new insights in the pathways...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Levi M,Cohn DM

    更新日期:2019-10-01 00:00:00

  • Effects of cardiac surgery on hemostasis.

    abstract::Cardiac surgery affects both coagulation and platelet function. Revision of surgery due to bleeding has to be performed in 2% to 6% of patients undergoing cardiac surgery and is generally associated with a marked deterioration in prognosis. Factors contributing to acquired hemostatic abnormalities in cardiac surgery i...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Hartmann M,Sucker C,Boehm O,Koch A,Loer S,Zacharowski K

    更新日期:2006-07-01 00:00:00

  • Human Leukocyte Antigen Alloimmunization and Alloimmune Platelet Refractoriness.

    abstract::Despite significant advancements in the production of platelet products, storage, and transfusion, transfusion refractoriness remains a significant clinical problem, affecting up to 14% of hematological patients receiving platelet transfusions. Human leukocyte antigen (HLA) alloimmunization is a major cause of immune ...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Saris A,Pavenski K

    更新日期:2020-10-01 00:00:00

  • Evidence-Based Red Blood Cell Transfusion Practices in Cardiac Surgery.

    abstract::Cardiac surgical patients are among the highest consumers of allogeneic red blood cells (RBCs) due to the prevalence of anemia and bleeding. Up until recently, there was a paucity of high-quality evidence informing transfusion decisions in this patient group which led to wide variability in transfusion decision making...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Patel NN,Murphy GJ

    更新日期:2017-10-01 00:00:00

  • Platelet derivatives in regenerative medicine: an update.

    abstract::Prior preclinical and clinical studies support the use of platelet-derived products for the treatment of soft and hard tissue lesions. These regenerative effects are controlled by autocrine and paracrine biomolecules including growth factors and cytokines contained in platelet alpha granules. Each growth factor is inv...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: De Pascale MR,Sommese L,Casamassimi A,Napoli C

    更新日期:2015-01-01 00:00:00

  • Donor deferral registries.

    abstract::In the last half of this century, donor deferral registries have grown in size, scope, and importance for blood collection organizations and regulatory agencies. This has occurred despite the lack of direct evidence that, when used with all other methods, they contribute meaningfully to the safety of the blood supply....

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Sherwood WC

    更新日期:1993-04-01 00:00:00

  • The impact of Creutzfeldt-Jakob disease and variant Creutzfeldt-Jakob disease on plasma safety.

    abstract::Although the true risk of transmitting (classical) Creutzfeld-Jakob Disease (CJD) and variant CJD (vCJD) via transfusion is likely very minimal, a review of prions and the impact of these associated prion diseases is timely because of their current effect on safety policies in the blood-plasma industry. Various types ...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Hoots WK,Abrams C,Tankersleydagger D

    更新日期:2001-04-01 00:00:00

  • Evolution and Utility of Antiplatelet Autoantibody Testing in Patients with Immune Thrombocytopenia.

    abstract::To this day, immune thrombocytopenia (ITP) remains a clinical diagnosis made by exclusion of other causes for thrombocytopenia. Reliable detection of platelet autoantibodies would support the clinical diagnosis, but the lack of specificity and sensitivity of the available methods for platelet autoantibody testing limi...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Porcelijn L,Schmidt DE,Oldert G,Hofstede-van Egmond S,Kapur R,Zwaginga JJ,de Haas M

    更新日期:2020-10-01 00:00:00

  • Comparative Risk of Hypophosphatemia Following the Administration of Intravenous Iron Formulations: A Network Meta-Analysis.

    abstract::Intravenous iron therapy is increasingly used in patients with iron deficiency anemia, although concerns of hypophosphatemia have been recently raised. The aim of this study was to evaluate different intravenous iron formulations for the risk of hypophosphatemia. Medline, Scopus, Cochrane Central Register of Controlle...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Bellos I,Frountzas M,Pergialiotis V

    更新日期:2020-07-01 00:00:00

  • Hemostatic and signaling functions of transfused platelets.

    abstract::Metabolic studies have revealed a gradual impairment in platelet integrity during storage, a process termed the platelet storage lesion. Recent evidence shows that stored platelets also lose signaling responses to physiological agonists with impaired integrin activation, secretion, and aggregation of the cells. On the...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Cauwenberghs S,van Pampus E,Curvers J,Akkerman JW,Heemskerk JW

    更新日期:2007-10-01 00:00:00

  • Metabolomics of ADSOL (AS-1) red blood cell storage.

    abstract::Population-based investigations suggest that red blood cells (RBCs) are therapeutically effective when collected, processed, and stored for up to 42 days under validated conditions before transfusion. However, some retrospective clinical studies have shown worse patient outcomes when transfused RBCs have been stored f...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章


    authors: Roback JD,Josephson CD,Waller EK,Newman JL,Karatela S,Uppal K,Jones DP,Zimring JC,Dumont LJ

    更新日期:2014-04-01 00:00:00

  • Platelet Immunology in China: Research and Clinical Applications.

    abstract::Immunization against human platelet alloantigens (HPAs) is associated with a number of clinical complications. The detection and identification of clinically relevant platelet antibodies are important for the diagnosis and management of patients affected with immune-mediated thrombocytopenias. Human platelet alloantig...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Wu G,Zhou Y,Li L,Zhong Z,Li H,Li H,Yu M,Shen W,Ni H

    更新日期:2017-04-01 00:00:00

  • Is human herpesvirus-8 transmitted by transfusion?

    abstract::Studies of human herpesvirus-8 (HHV-8) transmission through transfusion have produced contradictory results. In North America-a region with a low prevalence of HHV-8 infection-3 studies that tested specimens from linked positive-donor/negative-recipient pairs collected before the introduction of white blood cell (WBC)...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Vamvakas EC

    更新日期:2010-01-01 00:00:00

  • James Blundell, Obstetrical Hemorrhage, and the Origins of Transfusion Medicine.

    abstract::Although James Blundell is rightly acknowledged as the father of modern transfusion therapy, a review of the events surrounding the initial human-to-human transfusions in the first decades of the 19th century reveals substantial contributions by Blundell's collaborators. Bundell's uncle John Haighton provided substant...

    journal_title:Transfusion medicine reviews

    pub_type: 传,历史文章,杂志文章,评审


    authors: Dzik S

    更新日期:2018-10-01 00:00:00

  • The use of immunoglobulin therapy for patients undergoing solid organ transplantation: an evidence-based practice guideline.

    abstract::This guideline for the use of immunoglobulin (IG) for sensitized patients undergoing solid organ transplantation (SOT) is an initiative of the Canadian Blood Services and the National Advisory Committee on Blood and Blood Products of Canada to (1) provide guidance for Canadian practitioners involved in the care of pat...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Shehata N,Palda VA,Meyer RM,Blydt-Hansen TD,Campbell P,Cardella C,Martin S,Nickerson P,Peltekian K,Ross H,Waddell TK,West L,Anderson D,Freedman J,Hume H

    更新日期:2010-01-01 00:00:00

  • Drivers of transfusion decision making and quality of the evidence in orthopedic surgery: a systematic review of the literature.

    abstract::Reasons for variation in transfusion practice in orthopedic surgery are not well understood. This systematic review identified and appraised the quality of the literature in this area to assess the impact of factors associated with the use of allogeneic red blood cell (RBC) transfusion in orthopedic procedures. MEDLIN...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Barr PJ,Donnelly M,Cardwell C,Alam SS,Morris K,Parker M,Bailie KE

    更新日期:2011-10-01 00:00:00

  • Neonatal Platelet Transfusions and Future Areas of Research.

    abstract::Thrombocytopenia affects approximately one fourth of neonates admitted to neonatal intensive care units, and prophylactic platelet transfusions are commonly administered to reduce bleeding risk. However, there are few evidence-based guidelines to inform clinicians' decision-making process. Developmental differences in...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Sola-Visner M,Bercovitz RS

    更新日期:2016-10-01 00:00:00

  • The fibrinolytic system-more than fibrinolysis?

    abstract::The fibrinolytic system, known for its ability to regulate the activation of the zymogen plasminogen into active plasmin, has been primarily associated with the removal of fibrin and blood clots. Tissue-type plasminogen activator, the most well-recognized plasminogen activator, was harnessed for therapeutic benefit ag...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Draxler DF,Medcalf RL

    更新日期:2015-04-01 00:00:00

  • Virus inactivation in blood components by photoactive phenothiazine dyes.

    abstract::The virucidal properties of photoactive phenothiazine dyes, such as methylene blue, have been known approximately 70 years. The mechanism of virus inactivation involves binding of the dye to nucleic acid, absorption of light, generation of reactive oxygen species, guanine oxidation in the viral genome. The first pract...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Wagner SJ

    更新日期:2002-01-01 00:00:00

  • Ex vivo production of human red blood cells from hematopoietic stem cells: what is the future in transfusion?

    abstract::There is difficulty in obtaining adequate supplies of blood components, as well as disappointing performance of stabilized or recombinant hemoglobins, limited indications of oxygen transporters (perfluorocarbons), and slow development of "universal" red blood cells (RBCs). There is, therefore, a need for complementary...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Douay L,Andreu G

    更新日期:2007-04-01 00:00:00

  • Camouflaged blood cells: low-technology bioengineering for transfusion medicine?

    abstract::The small number of studies done on the covalent modification of RBC with PEG, or PEG-derivatives, suggests that the immunocamouflage of intact cells significantly reduces the antigenicity and immunogenicity of the foreign cell. Importantly, this protective immunologic effect can be accomplished without adversely affe...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Scott MD,Bradley AJ,Murad KL

    更新日期:2000-01-01 00:00:00

  • Prenatal typing of Rh and Kell blood group system antigens: the edge of a watershed.

    abstract::Knowledge of the molecular basis of the blood group systems has enabled the development of assays for blood group genotyping. At this time, polymerase chain reaction (PCR)-based assays validated on fetal material obtained by invasive means (chorionic villus sampling or amniocentesis) are available for all clinically r...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: van der Schoot CE,Tax GH,Rijnders RJ,de Haas M,Christiaens GC

    更新日期:2003-01-01 00:00:00

  • Single- Versus Double-Unit Umbilical Cord Blood Transplantation for Hematologic Diseases: A Systematic Review.

    abstract::Controversial results exist regarding the clinical benefits of single- vs double-unit umbilical cord blood transplantation (UCBT) in patients with hematologic diseases. A systematic review was conducted to evaluate this issue. The PubMed, Embase, and Cochrane Library databases were searched up to May 2018. A total of ...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章


    authors: Wang L,Gu ZY,Liu SF,Ma DX,Zhang C,Liu CJ,Gao R,Guan LX,Zhu CY,Wang FY,Gao CJ,Wei HP

    更新日期:2019-01-01 00:00:00

  • Meeting the clinical challenge of care for Jehovah's Witnesses.

    abstract::Quality patient care entails more than simply biomedical interventions. Respect for the wishes, values, and preferences of patients are important elements of quality care. Unique aspects of the beliefs of Jehovah's Witnesses may present physicians with ethical and clinical conflicts. Witnesses believe that allogeneic ...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Bodnaruk ZM,Wong CJ,Thomas MJ

    更新日期:2004-04-01 00:00:00

  • Allogeneic blood transfusion as a risk factor for the subsequent development of non-Hodgkin's lymphoma.

    abstract::In summary, it is impossible to reconcile the contradictory results of the studies of the association between previous blood transfusion and subsequent development of NHL (Figs 1 and 2). Most of the studies were of high quality, and the authors discussed the possible sources of bias that might have generated a spuriou...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Vamvakas EC

    更新日期:2000-07-01 00:00:00

  • Chromosome location of genes encoding human blood groups.

    abstract::The chromosomal locations of genes controlling the expression of some 200 antigens constituting the 23 established human blood group systems have been reviewed. Twenty-one of the these genes are located on 12 autosomes, and two are located on the X chromosome. Refined chromosomal positions, to a single cytogenetically...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Reid ME,McManus K,Zelinski T

    更新日期:1998-07-01 00:00:00

  • Putting the pieces together: Roger I. Lee and modern transfusion medicine.

    abstract::Roger Irving Lee (1881-1964) played significant scientific and leadership roles in overcoming the clinical impediments to blood transfusion in the 1910s. He developed the first successful anticoagulant system, paraffinized glass, and the first sterile system for indirect transfusion without defibrination, the Lee-Vinc...

    journal_title:Transfusion medicine reviews

    pub_type: 传,历史文章,杂志文章


    authors: Stansbury LG,Hess JR

    更新日期:2005-01-01 00:00:00

  • Uses and sources of data on long-term survival after blood transfusion.

    abstract::Several public policy decisions in transfusion medicine require information on the long-term (> or =10-year) survival of transfused patients. This information is needed (1) to estimate the number of surviving transfusion recipients who have contracted a particular infection through transfusion, (2) to assess the cost-...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Vamvakas EC

    更新日期:2003-07-01 00:00:00

  • Can blood tranfusion transmit cancer? A literature review.

    abstract::Blood services around the world face increasing challenges in recruiting voluntary blood donors. With increasing donor restrictions and ageing populations, it is essential to look for any existing restrictions that may be relaxed in the light of currently available evidence. We propose that one such restriction is the...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Yang H,Lee J,Seed CR,Keller AJ

    更新日期:2010-07-01 00:00:00