Abstract：
:The fibrinolytic system, known for its ability to regulate the activation of the zymogen plasminogen into active plasmin, has been primarily associated with the removal of fibrin and blood clots. Tissue-type plasminogen activator, the most well-recognized plasminogen activator, was harnessed for therapeutic benefit against thromboembolic disorders more than 30 years ago, whereas inhibition of this system has been proven effective for certain bleeding disorders. However, in recent years, new and unexpected functional roles for this system have been identified mostly in relation to the central nervous system that are both unrelated and independent of fibrin degradation and clot removal. Hence, it seems reasonable to ask whether agents used to modify components or activities of the fibrinolytic system have any clinical consequences unrelated to their intended use in hemostasis. This review will provide an overview of these new features of the fibrinolytic system and will also focus on prospective considerations in the use of fibrinolytic and antifibrinolytic agents.
journal_name
Transfus Med Revjournal_title
Transfusion medicine reviewsauthors
Draxler DF,Medcalf RLdoi
10.1016/j.tmrv.2014.09.006subject
Has Abstractpub_date
2015-04-01 00:00:00pages
102-9issue
2eissn
0887-7963issn
1532-9496pii
S0887-7963(14)00099-6journal_volume
29pub_type
杂志文章,评审abstract：:Allergic transfusion reactions (ATRs) are the most common adverse reactions occurring during transfusion of blood components. Although most reactions are mild and involve cutaneous manifestations, severe ATRs including life-threatening anaphylaxis may also occur. The mechanisms of ATRs are largely unknown because they...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2017.09.002
更新日期：2018-01-01 00:00:00
abstract：:Although the role of platelets as central mediators of hemostasis and thrombosis has been the primary focus of research into platelet biology for more than a century, over the last decade, nonhemostatic functions of platelets have been increasingly defined. As such, a large body of experimental evidence now exists, wh...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2014.11.006
更新日期：2015-04-01 00:00:00
abstract：:Studies of human herpesvirus-8 (HHV-8) transmission through transfusion have produced contradictory results. In North America-a region with a low prevalence of HHV-8 infection-3 studies that tested specimens from linked positive-donor/negative-recipient pairs collected before the introduction of white blood cell (WBC)...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2009.09.001
更新日期：2010-01-01 00:00:00
abstract：:Cardiac surgery affects both coagulation and platelet function. Revision of surgery due to bleeding has to be performed in 2% to 6% of patients undergoing cardiac surgery and is generally associated with a marked deterioration in prognosis. Factors contributing to acquired hemostatic abnormalities in cardiac surgery i...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2006.03.003
更新日期：2006-07-01 00:00:00
abstract：:The use of prothrombin complex concentrates (PCCs) and fibrinogen concentrates (FIBCs) to achieve hemostasis in the perioperative setting as alternatives to allogeneic blood products remains controversial. To examine the efficacy and safety of PCCs and FIBCs, we conducted a systematic review-in accordance with the Pre...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2013.01.002
更新日期：2013-04-01 00:00:00
abstract：:Although the true risk of transmitting (classical) Creutzfeld-Jakob Disease (CJD) and variant CJD (vCJD) via transfusion is likely very minimal, a review of prions and the impact of these associated prion diseases is timely because of their current effect on safety policies in the blood-plasma industry. Various types ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tm.2001.25382
更新日期：2001-04-01 00:00:00
abstract：:Roger Irving Lee (1881-1964) played significant scientific and leadership roles in overcoming the clinical impediments to blood transfusion in the 1910s. He developed the first successful anticoagulant system, paraffinized glass, and the first sterile system for indirect transfusion without defibrination, the Lee-Vinc...
journal_title：Transfusion medicine reviews
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.tmrv.2004.09.003
更新日期：2005-01-01 00:00:00
abstract：:Blood services around the world face increasing challenges in recruiting voluntary blood donors. With increasing donor restrictions and ageing populations, it is essential to look for any existing restrictions that may be relaxed in the light of currently available evidence. We propose that one such restriction is the...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2010.03.005
更新日期：2010-07-01 00:00:00
abstract：:There is difficulty in obtaining adequate supplies of blood components, as well as disappointing performance of stabilized or recombinant hemoglobins, limited indications of oxygen transporters (perfluorocarbons), and slow development of "universal" red blood cells (RBCs). There is, therefore, a need for complementary...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2006.11.004
更新日期：2007-04-01 00:00:00
abstract：:Population-based investigations suggest that red blood cells (RBCs) are therapeutically effective when collected, processed, and stored for up to 42 days under validated conditions before transfusion. However, some retrospective clinical studies have shown worse patient outcomes when transfused RBCs have been stored f...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章
doi：10.1016/j.tmrv.2014.01.003
更新日期：2014-04-01 00:00:00
abstract：:The development and expansion of the CTS in Pittsburgh shows the feasibility of this transfusion medicine delivery system. Few of the changes driven by health care reform both improve patient care and reduce costs. When properly implemented, a CTS achieves these objectives, benefits the community as a whole, and enhan...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(05)80051-3
更新日期：1995-04-01 00:00:00
abstract：:Knowledge of the molecular basis of the blood group systems has enabled the development of assays for blood group genotyping. At this time, polymerase chain reaction (PCR)-based assays validated on fetal material obtained by invasive means (chorionic villus sampling or amniocentesis) are available for all clinically r...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tmrv.2003.50001
更新日期：2003-01-01 00:00:00
abstract：:Quality patient care entails more than simply biomedical interventions. Respect for the wishes, values, and preferences of patients are important elements of quality care. Unique aspects of the beliefs of Jehovah's Witnesses may present physicians with ethical and clinical conflicts. Witnesses believe that allogeneic ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2003.12.004
更新日期：2004-04-01 00:00:00
abstract：:Some have suggested that "blood is different," and the role for cost-effectiveness is thus circumscribed. In this article, the authors start by reviewing key concepts in health economics and economic analysis methods. Examples are drawn from published blood safety studies. After explaining the underlying reasoning beh...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2008.09.001
更新日期：2009-01-01 00:00:00
abstract：:The use of blood products to support patients undergoing the large variety of medical and surgical interventions requiring such support has continued to escalate very significantly over time. Relevantly, significant practice variation in the use of blood products exists among practitioners and institutions, largely be...
journal_title：Transfusion medicine reviews
pub_type：
doi：10.1016/j.tmrv.2010.05.002
更新日期：2010-10-01 00:00:00
abstract：:Hybridoma technology has contributed to virtually all areas of biology and medicine and set the scene for important advances in cell biology and immunodiagnostics. Blood transfusion and transfusion medicine have benefited significantly from development in hybridoma technology, and this has resulted in the generation o...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tmrv.2002.33436
更新日期：2002-07-01 00:00:00
abstract：:The regulation of complement at the surface of cells is mediated by both plasma and membrane proteins. These molecules act in concert to prevent the accelerated catabolism of complement proteins and the concomitant lysis of homologous blood cells. The deficiency of either a plasma or membrane protein predisposes to th...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(91)70199-5
更新日期：1991-04-01 00:00:00
abstract：:An international multidisciplinary panel of 15 experts reviewed 494 published articles and used the RAND/UCLA Appropriateness Method to determine the appropriateness of allogeneic red blood cell (RBC) transfusion based on its expected impact on outcomes of stable nonbleeding patients in 450 typical inpatient medical, ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,多中心研究,评审
doi：10.1016/j.tmrv.2011.02.001
更新日期：2011-07-01 00:00:00
abstract：:Low levels of C1 inhibitor, the main inhibitor of the classic complement system, result in paroxysmal angioedema attacks that can be incapacitating or even life-threatening in affected individuals. Molecular defects in the gene for C1 inhibitor cause hereditary angioedema. In recent years, new insights in the pathways...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2019.08.002
更新日期：2019-10-01 00:00:00
abstract：:The virucidal properties of photoactive phenothiazine dyes, such as methylene blue, have been known approximately 70 years. The mechanism of virus inactivation involves binding of the dye to nucleic acid, absorption of light, generation of reactive oxygen species, guanine oxidation in the viral genome. The first pract...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tmrv.2002.29405
更新日期：2002-01-01 00:00:00
abstract：:Autoantibodies against red cells optimally reacting at 0 degree C, ie, CA, are normally found with low titers in the serum of human adults. High-titer CA may be induced by certain infectious agents, including M pneumoniae, EBV, CMV, and rubella virus, or may develop on the basis of chronic (malignant) B cell lymphopro...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(89)70075-4
更新日期：1989-04-01 00:00:00
abstract：:Several public policy decisions in transfusion medicine require information on the long-term (> or =10-year) survival of transfused patients. This information is needed (1) to estimate the number of surviving transfusion recipients who have contracted a particular infection through transfusion, (2) to assess the cost-...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(03)00019-1
更新日期：2003-07-01 00:00:00
abstract：:Until recently, atypical hemolytic uremic syndrome (aHUS), conventionally defined in the pediatric literature as a syndrome of the triad of renal failure, microangiopathic hemolytic anemia, and thrombocytopenia without a prodrome of hemorrhagic diarrhea, has received little attention in adult practice because the pati...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2014.08.004
更新日期：2014-10-01 00:00:00
abstract：:Significant progress has been made in reducing the risk of pathogen transmission to transfusion recipients. Nonetheless, there remains a continuing risk of transmission of viruses, bacteria, protozoa, and prions to recipients. These include many of the viruses for which specific screening tests exist as well as pathog...
journal_title：Transfusion medicine reviews
pub_type： 共识发展会议,杂志文章,评审
doi：10.1016/j.tmrv.2007.09.001
更新日期：2008-01-01 00:00:00
abstract：:In the last half of this century, donor deferral registries have grown in size, scope, and importance for blood collection organizations and regulatory agencies. This has occurred despite the lack of direct evidence that, when used with all other methods, they contribute meaningfully to the safety of the blood supply....
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(93)70131-5
更新日期：1993-04-01 00:00:00
abstract：:Despite significant advancements in the production of platelet products, storage, and transfusion, transfusion refractoriness remains a significant clinical problem, affecting up to 14% of hematological patients receiving platelet transfusions. Human leukocyte antigen (HLA) alloimmunization is a major cause of immune ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2020.09.010
更新日期：2020-10-01 00:00:00
abstract：:This guideline for the use of immunoglobulin (IG) for sensitized patients undergoing solid organ transplantation (SOT) is an initiative of the Canadian Blood Services and the National Advisory Committee on Blood and Blood Products of Canada to (1) provide guidance for Canadian practitioners involved in the care of pat...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2009.09.010
更新日期：2010-01-01 00:00:00
abstract：:Controversial results exist regarding the clinical benefits of single- vs double-unit umbilical cord blood transplantation (UCBT) in patients with hematologic diseases. A systematic review was conducted to evaluate this issue. The PubMed, Embase, and Cochrane Library databases were searched up to May 2018. A total of ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章
doi：10.1016/j.tmrv.2018.11.001
更新日期：2019-01-01 00:00:00
abstract：:Although James Blundell is rightly acknowledged as the father of modern transfusion therapy, a review of the events surrounding the initial human-to-human transfusions in the first decades of the 19th century reveals substantial contributions by Blundell's collaborators. Bundell's uncle John Haighton provided substant...
journal_title：Transfusion medicine reviews
pub_type： 传,历史文章,杂志文章,评审
doi：10.1016/j.tmrv.2018.08.003
更新日期：2018-10-01 00:00:00
abstract：:Cardiac surgical patients are among the highest consumers of allogeneic red blood cells (RBCs) due to the prevalence of anemia and bleeding. Up until recently, there was a paucity of high-quality evidence informing transfusion decisions in this patient group which led to wide variability in transfusion decision making...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2017.06.001
更新日期：2017-10-01 00:00:00
