Abstract:
:With the realization that the skin bleeding time is often an unreliable measure of platelet function, efforts have been made to identify ways to assess qualitative platelet dysfunction. Currently available techniques measure platelet adhesion, platelet aggregation, the ability of platelets to retard or stop flow through fibers, and the contribution of platelets to in vitro clot formation. Glass bead adhesion, which continues to be performed in some laboratories, is gradually being replaced by measures of platelet adhesion to filters composed of glass fibers, Dacron fibers, or collagen. In each instance, anticoagulated platelet-rich plasma or whole blood flows through the filter under a regulated pressure gradient. The amount of blood flowing through the filter versus time and/or the time to filter occlusion are measured. Recent developments in platelet aggregation have focused on whole blood and stagnation point flow aggregation techniques. Whole blood aggregation does not require blood sample processing and accommodates blood obtained from citrated vacutainer tubes. Stagnation point flow measures both platelet adhesion and aggregation and may be able to detect pathologically-enhanced platelet function. Global measures of hemostasis attempt to simultaneously evaluate the adequacy of fluid phase coagulation and platelet function. Currently available techniques include Thromboelastography, SonoClot Analyzer, Hemodyne Hemostasis Analyzer, PITT, and Hemostatometry. Although each of these technologies have been shown to provide interesting data in the research setting, the ability of any of these techniques to detect abnormal or clinical inadequate platelet function remains to be established.
journal_name
Transfus Med Revjournal_title
Transfusion medicine reviewsauthors
Carr ME Jrdoi
10.1053/tm.1997.0110106subject
Has Abstractpub_date
1997-04-01 00:00:00pages
106-15issue
2eissn
0887-7963issn
1532-9496pii
S0887-7963(97)80066-1journal_volume
11pub_type
杂志文章,评审abstract::Over the last 20 years, the Canadian Blood Services' (CBS) Donor Health Assessment Questionnaire (DHAQ), used to screen prospective blood donors to determine their eligibility, has grown in complexity and length. Its growth is inextricably linked to the evolution of the environment within which CBS operates from unreg...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2007.03.002
更新日期:2007-07-01 00:00:00
abstract::The development and expansion of the CTS in Pittsburgh shows the feasibility of this transfusion medicine delivery system. Few of the changes driven by health care reform both improve patient care and reduce costs. When properly implemented, a CTS achieves these objectives, benefits the community as a whole, and enhan...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/s0887-7963(05)80051-3
更新日期:1995-04-01 00:00:00
abstract::Thrombocytopenia affects approximately one fourth of neonates admitted to neonatal intensive care units, and prophylactic platelet transfusions are commonly administered to reduce bleeding risk. However, there are few evidence-based guidelines to inform clinicians' decision-making process. Developmental differences in...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2016.05.009
更新日期:2016-10-01 00:00:00
abstract::Roger Irving Lee (1881-1964) played significant scientific and leadership roles in overcoming the clinical impediments to blood transfusion in the 1910s. He developed the first successful anticoagulant system, paraffinized glass, and the first sterile system for indirect transfusion without defibrination, the Lee-Vinc...
journal_title:Transfusion medicine reviews
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.tmrv.2004.09.003
更新日期:2005-01-01 00:00:00
abstract::Quality patient care entails more than simply biomedical interventions. Respect for the wishes, values, and preferences of patients are important elements of quality care. Unique aspects of the beliefs of Jehovah's Witnesses may present physicians with ethical and clinical conflicts. Witnesses believe that allogeneic ...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2003.12.004
更新日期:2004-04-01 00:00:00
abstract::The crossmatch (XM) is an important part of routine pretransfusion testing. It is used to detect ABO incompatibility and other clinically significant antibodies. The XM has been modified many times and, in recent years, has been abbreviated. The 2 common types of XM currently being done are the immediate spin XM for a...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2005.08.007
更新日期:2006-01-01 00:00:00
abstract::The use of blood products to support patients undergoing the large variety of medical and surgical interventions requiring such support has continued to escalate very significantly over time. Relevantly, significant practice variation in the use of blood products exists among practitioners and institutions, largely be...
journal_title:Transfusion medicine reviews
pub_type:
doi:10.1016/j.tmrv.2010.05.002
更新日期:2010-10-01 00:00:00
abstract::The administration of blood products is a common, resource-intensive, and potentially problem-prone area that may place patients at elevated risk in the clinical setting. Much of the emphasis in transfusion safety has been targeted toward quality control measures in laboratory settings where blood products are prepare...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2006.08.007
更新日期:2007-01-01 00:00:00
abstract::Intravenous iron therapy is increasingly used in patients with iron deficiency anemia, although concerns of hypophosphatemia have been recently raised. The aim of this study was to evaluate different intravenous iron formulations for the risk of hypophosphatemia. Medline, Scopus, Cochrane Central Register of Controlle...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2020.07.002
更新日期:2020-07-01 00:00:00
abstract::Autoantibodies against red cells optimally reacting at 0 degree C, ie, CA, are normally found with low titers in the serum of human adults. High-titer CA may be induced by certain infectious agents, including M pneumoniae, EBV, CMV, and rubella virus, or may develop on the basis of chronic (malignant) B cell lymphopro...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/s0887-7963(89)70075-4
更新日期:1989-04-01 00:00:00
abstract::Reasons for variation in transfusion practice in orthopedic surgery are not well understood. This systematic review identified and appraised the quality of the literature in this area to assess the impact of factors associated with the use of allogeneic red blood cell (RBC) transfusion in orthopedic procedures. MEDLIN...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2011.04.003
更新日期:2011-10-01 00:00:00
abstract::There is difficulty in obtaining adequate supplies of blood components, as well as disappointing performance of stabilized or recombinant hemoglobins, limited indications of oxygen transporters (perfluorocarbons), and slow development of "universal" red blood cells (RBCs). There is, therefore, a need for complementary...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2006.11.004
更新日期:2007-04-01 00:00:00
abstract::Hybridoma technology has contributed to virtually all areas of biology and medicine and set the scene for important advances in cell biology and immunodiagnostics. Blood transfusion and transfusion medicine have benefited significantly from development in hybridoma technology, and this has resulted in the generation o...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1053/tmrv.2002.33436
更新日期:2002-07-01 00:00:00
abstract::Several public policy decisions in transfusion medicine require information on the long-term (> or =10-year) survival of transfused patients. This information is needed (1) to estimate the number of surviving transfusion recipients who have contracted a particular infection through transfusion, (2) to assess the cost-...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/s0887-7963(03)00019-1
更新日期:2003-07-01 00:00:00
abstract::Sickle cell disease (SCD) is the most common monogenic disorder in sub-Saharan Africa (SSA). Blood transfusion to increase the oxygen carrying capacity of blood is vital in the management of many patients with SCD. However, red blood cell (RBC) alloimmunization is a major challenge to transfusions in these patients. C...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,meta分析
doi:10.1016/j.tmrv.2019.06.003
更新日期:2019-07-01 00:00:00
abstract::Two complex protein defense systems-complement and coagulation-are based on amplifying enzyme cascades triggered by specific local stimuli. Excess systemic activation of either system is pathologic and is normally prevented by a family of regulatory proteins. The 2 systems are ancient biological processes which share ...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2019.08.004
更新日期:2019-10-01 00:00:00
abstract::Cardiac surgery affects both coagulation and platelet function. Revision of surgery due to bleeding has to be performed in 2% to 6% of patients undergoing cardiac surgery and is generally associated with a marked deterioration in prognosis. Factors contributing to acquired hemostatic abnormalities in cardiac surgery i...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2006.03.003
更新日期:2006-07-01 00:00:00
abstract::Immunization against human platelet alloantigens (HPAs) is associated with a number of clinical complications. The detection and identification of clinically relevant platelet antibodies are important for the diagnosis and management of patients affected with immune-mediated thrombocytopenias. Human platelet alloantig...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2016.12.001
更新日期:2017-04-01 00:00:00
abstract::In summary, it is impossible to reconcile the contradictory results of the studies of the association between previous blood transfusion and subsequent development of NHL (Figs 1 and 2). Most of the studies were of high quality, and the authors discussed the possible sources of bias that might have generated a spuriou...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1053/tm.20000.7395
更新日期:2000-07-01 00:00:00
abstract::Although the risk of infection by blood transfusion is relatively low, breakthrough infections still occur, Transfusion-related fatalities caused by infections continue to be reported, and blood is not tested for many potentially dangerous pathogens. The current paradigm for increasing the safety of the blood supply i...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2004.11.005
更新日期:2005-04-01 00:00:00
abstract::Millions of patients in the UK benefit from the use of both plasma derivatives and blood components that are seen as critical interventions in current medicine. Measures are in place to significantly reduce the risks associated with blood transfusion and plasma derivatives; however, these measures themselves are not r...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2011.09.003
更新日期:2012-07-01 00:00:00
abstract::To this day, immune thrombocytopenia (ITP) remains a clinical diagnosis made by exclusion of other causes for thrombocytopenia. Reliable detection of platelet autoantibodies would support the clinical diagnosis, but the lack of specificity and sensitivity of the available methods for platelet autoantibody testing limi...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2020.09.003
更新日期:2020-10-01 00:00:00
abstract::Controversial results exist regarding the clinical benefits of single- vs double-unit umbilical cord blood transplantation (UCBT) in patients with hematologic diseases. A systematic review was conducted to evaluate this issue. The PubMed, Embase, and Cochrane Library databases were searched up to May 2018. A total of ...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章
doi:10.1016/j.tmrv.2018.11.001
更新日期:2019-01-01 00:00:00
abstract::Metabolic studies have revealed a gradual impairment in platelet integrity during storage, a process termed the platelet storage lesion. Recent evidence shows that stored platelets also lose signaling responses to physiological agonists with impaired integrin activation, secretion, and aggregation of the cells. On the...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2007.05.004
更新日期:2007-10-01 00:00:00
abstract::The chromosomal locations of genes controlling the expression of some 200 antigens constituting the 23 established human blood group systems have been reviewed. Twenty-one of the these genes are located on 12 autosomes, and two are located on the X chromosome. Refined chromosomal positions, to a single cytogenetically...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/s0887-7963(98)80056-4
更新日期:1998-07-01 00:00:00
abstract::Allergic transfusion reactions (ATRs) are the most common adverse reactions occurring during transfusion of blood components. Although most reactions are mild and involve cutaneous manifestations, severe ATRs including life-threatening anaphylaxis may also occur. The mechanisms of ATRs are largely unknown because they...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2017.09.002
更新日期:2018-01-01 00:00:00
abstract::Knowledge of the molecular basis of the blood group systems has enabled the development of assays for blood group genotyping. At this time, polymerase chain reaction (PCR)-based assays validated on fetal material obtained by invasive means (chorionic villus sampling or amniocentesis) are available for all clinically r...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1053/tmrv.2003.50001
更新日期:2003-01-01 00:00:00
abstract::ABO is the most important blood group system for transfusion and solid organ transplantation, but it is only over the past 15 years that the techniques for studying its molecular basis became mainstream. Many of its common and rare alleles are now well characterized and by using various expression systems, their effec...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2005.02.003
更新日期:2005-07-01 00:00:00
abstract::Cardiac surgical patients are among the highest consumers of allogeneic red blood cells (RBCs) due to the prevalence of anemia and bleeding. Up until recently, there was a paucity of high-quality evidence informing transfusion decisions in this patient group which led to wide variability in transfusion decision making...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2017.06.001
更新日期:2017-10-01 00:00:00
abstract::Until recently, atypical hemolytic uremic syndrome (aHUS), conventionally defined in the pediatric literature as a syndrome of the triad of renal failure, microangiopathic hemolytic anemia, and thrombocytopenia without a prodrome of hemorrhagic diarrhea, has received little attention in adult practice because the pati...
journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2014.08.004
更新日期:2014-10-01 00:00:00