Abstract:
:An international multidisciplinary panel of 15 experts reviewed 494 published articles and used the RAND/UCLA Appropriateness Method to determine the appropriateness of allogeneic red blood cell (RBC) transfusion based on its expected impact on outcomes of stable nonbleeding patients in 450 typical inpatient medical, surgical, or trauma scenarios. Panelists rated allogeneic RBC transfusion as appropriate in 53 of the scenarios (11.8%), inappropriate in 267 (59.3%), and uncertain in 130 (28.9%). Red blood cell transfusion was most often rated appropriate (81%) in scenarios featuring patients with hemoglobin (Hb) level 7.9 g/dL or less, associated comorbidities, and age older than 65 years. Red blood cell transfusion was rated inappropriate in all scenarios featuring patients with Hb level 10 g/dL or more and in 71.3% of scenarios featuring patients with Hb level 8 to 9.9 g/dL. Conversely, no scenario with patient's Hb level of 8 g/dL or more was rated as appropriate. Nearly one third of all scenarios were rated uncertain, indicating the need for more research. The observation that allogeneic RBC transfusions were rated as either inappropriate or uncertain in most scenarios in this study supports a more judicious transfusion strategy. In addition, the large number of scenarios in which RBC transfusions were rated as uncertain can serve as a road map to identify areas in need of further investigation.
journal_name
Transfus Med Revjournal_title
Transfusion medicine reviewsauthors
Shander A,Fink A,Javidroozi M,Erhard J,Farmer SL,Corwin H,Goodnough LT,Hofmann A,Isbister J,Ozawa S,Spahn DR,International Consensus Conference on Transfusion Outcomes Group.doi
10.1016/j.tmrv.2011.02.001subject
Has Abstractpub_date
2011-07-01 00:00:00pages
232-246.e53issue
3eissn
0887-7963issn
1532-9496pii
S0887-7963(11)00009-5journal_volume
25pub_type
杂志文章,多中心研究,评审abstract::The virucidal properties of photoactive phenothiazine dyes, such as methylene blue, have been known approximately 70 years. The mechanism of virus inactivation involves binding of the dye to nucleic acid, absorption of light, generation of reactive oxygen species, guanine oxidation in the viral genome. The first pract...
journal_title:Transfusion medicine reviews
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doi:10.1053/tmrv.2002.29405
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journal_title:Transfusion medicine reviews
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/s0887-7963(91)70199-5
更新日期:1991-04-01 00:00:00
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journal_title:Transfusion medicine reviews
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journal_title:Transfusion medicine reviews
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2007.05.004
更新日期:2007-10-01 00:00:00
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journal_title:Transfusion medicine reviews
pub_type: 传,历史文章,杂志文章
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journal_title:Transfusion medicine reviews
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2014.09.006
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1053/tm.20000.7395
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章
doi:10.1016/j.tmrv.2014.01.003
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journal_title:Transfusion medicine reviews
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Transfusion medicine reviews
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journal_title:Transfusion medicine reviews
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journal_title:Transfusion medicine reviews
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,meta分析
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.tmrv.2006.03.003
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journal_title:Transfusion medicine reviews
pub_type: 共识发展会议,杂志文章,评审
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journal_title:Transfusion medicine reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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