Abstract：
:Autoantibodies against red cells optimally reacting at 0 degree C, ie, CA, are normally found with low titers in the serum of human adults. High-titer CA may be induced by certain infectious agents, including M pneumoniae, EBV, CMV, and rubella virus, or may develop on the basis of chronic (malignant) B cell lymphoproliferation. The main clinical manifestation of cold agglutination is AIHA. Antigens and antibodies of cold agglutination are the best characterized reaction partners of a human autoimmune process. CA may recognize I and i antigens, which are lipid- and protein-linked branched and linear N-acetyl-lactosamine chains, respectively. They are precursors of the ABH blood group antigens and are converted into H by fucosylation. An alternative substitution by sialylation creates Gd, Fl, and probably Vo/Li antigens. CA with anti-Pr and anti-Sa specificities recognize 0-glycans with immunodominant sialyl groups on glycophorins. Several Pr subspecificities can be identified by chemically modified sialyl groups on glycophorins. Because CA in chronic lymphoproliferation are monoclonal antibodies, structure-specificity-interrelations of the antibodies could be identified by primary structure analyses of the N-terminal variable regions of H and L chains and by studies on CA idiotypes. Interrelations between distinct CA specificities and particular infectious agents could explain cold agglutination as a response to receptors for the agents or to the binding sites of antibodies against the agents. Interrelations also existing between certain CA isotypes (Ig classes and L chain types) and CA specificities could be a basis for the elucidation of the enigmatic etiology of chronic (malignant) monoclonal cold agglutination.
journal_name
Transfus Med Revjournal_title
Transfusion medicine reviewsauthors
Roelcke Ddoi
10.1016/s0887-7963(89)70075-4subject
Has Abstractpub_date
1989-04-01 00:00:00pages
140-66issue
2eissn
0887-7963issn
1532-9496journal_volume
3pub_type
杂志文章,评审abstract：:To this day, immune thrombocytopenia (ITP) remains a clinical diagnosis made by exclusion of other causes for thrombocytopenia. Reliable detection of platelet autoantibodies would support the clinical diagnosis, but the lack of specificity and sensitivity of the available methods for platelet autoantibody testing limi...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2020.09.003
更新日期：2020-10-01 00:00:00
abstract：:The chromosomal locations of genes controlling the expression of some 200 antigens constituting the 23 established human blood group systems have been reviewed. Twenty-one of the these genes are located on 12 autosomes, and two are located on the X chromosome. Refined chromosomal positions, to a single cytogenetically...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(98)80056-4
更新日期：1998-07-01 00:00:00
abstract：:The use of blood products to support patients undergoing the large variety of medical and surgical interventions requiring such support has continued to escalate very significantly over time. Relevantly, significant practice variation in the use of blood products exists among practitioners and institutions, largely be...
journal_title：Transfusion medicine reviews
pub_type：
doi：10.1016/j.tmrv.2010.05.002
更新日期：2010-10-01 00:00:00
abstract：:Some have suggested that "blood is different," and the role for cost-effectiveness is thus circumscribed. In this article, the authors start by reviewing key concepts in health economics and economic analysis methods. Examples are drawn from published blood safety studies. After explaining the underlying reasoning beh...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2008.09.001
更新日期：2009-01-01 00:00:00
abstract：:The use of prothrombin complex concentrates (PCCs) and fibrinogen concentrates (FIBCs) to achieve hemostasis in the perioperative setting as alternatives to allogeneic blood products remains controversial. To examine the efficacy and safety of PCCs and FIBCs, we conducted a systematic review-in accordance with the Pre...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2013.01.002
更新日期：2013-04-01 00:00:00
abstract：:Although the true risk of transmitting (classical) Creutzfeld-Jakob Disease (CJD) and variant CJD (vCJD) via transfusion is likely very minimal, a review of prions and the impact of these associated prion diseases is timely because of their current effect on safety policies in the blood-plasma industry. Various types ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tm.2001.25382
更新日期：2001-04-01 00:00:00
abstract：:Despite significant advancements in the production of platelet products, storage, and transfusion, transfusion refractoriness remains a significant clinical problem, affecting up to 14% of hematological patients receiving platelet transfusions. Human leukocyte antigen (HLA) alloimmunization is a major cause of immune ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2020.09.010
更新日期：2020-10-01 00:00:00
abstract：:Several public policy decisions in transfusion medicine require information on the long-term (> or =10-year) survival of transfused patients. This information is needed (1) to estimate the number of surviving transfusion recipients who have contracted a particular infection through transfusion, (2) to assess the cost-...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(03)00019-1
更新日期：2003-07-01 00:00:00
abstract：:Cardiac surgery affects both coagulation and platelet function. Revision of surgery due to bleeding has to be performed in 2% to 6% of patients undergoing cardiac surgery and is generally associated with a marked deterioration in prognosis. Factors contributing to acquired hemostatic abnormalities in cardiac surgery i...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2006.03.003
更新日期：2006-07-01 00:00:00
abstract：:Blood services around the world face increasing challenges in recruiting voluntary blood donors. With increasing donor restrictions and ageing populations, it is essential to look for any existing restrictions that may be relaxed in the light of currently available evidence. We propose that one such restriction is the...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2010.03.005
更新日期：2010-07-01 00:00:00
abstract：:Intravenous iron therapy is increasingly used in patients with iron deficiency anemia, although concerns of hypophosphatemia have been recently raised. The aim of this study was to evaluate different intravenous iron formulations for the risk of hypophosphatemia. Medline, Scopus, Cochrane Central Register of Controlle...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2020.07.002
更新日期：2020-07-01 00:00:00
abstract：:The virucidal properties of photoactive phenothiazine dyes, such as methylene blue, have been known approximately 70 years. The mechanism of virus inactivation involves binding of the dye to nucleic acid, absorption of light, generation of reactive oxygen species, guanine oxidation in the viral genome. The first pract...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tmrv.2002.29405
更新日期：2002-01-01 00:00:00
abstract：:Population-based investigations suggest that red blood cells (RBCs) are therapeutically effective when collected, processed, and stored for up to 42 days under validated conditions before transfusion. However, some retrospective clinical studies have shown worse patient outcomes when transfused RBCs have been stored f...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章
doi：10.1016/j.tmrv.2014.01.003
更新日期：2014-04-01 00:00:00
abstract：:Prior preclinical and clinical studies support the use of platelet-derived products for the treatment of soft and hard tissue lesions. These regenerative effects are controlled by autocrine and paracrine biomolecules including growth factors and cytokines contained in platelet alpha granules. Each growth factor is inv...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2014.11.001
更新日期：2015-01-01 00:00:00
abstract：:The fibrinolytic system, known for its ability to regulate the activation of the zymogen plasminogen into active plasmin, has been primarily associated with the removal of fibrin and blood clots. Tissue-type plasminogen activator, the most well-recognized plasminogen activator, was harnessed for therapeutic benefit ag...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2014.09.006
更新日期：2015-04-01 00:00:00
abstract：:Immunization against human platelet alloantigens (HPAs) is associated with a number of clinical complications. The detection and identification of clinically relevant platelet antibodies are important for the diagnosis and management of patients affected with immune-mediated thrombocytopenias. Human platelet alloantig...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2016.12.001
更新日期：2017-04-01 00:00:00
abstract：:The regulation of complement at the surface of cells is mediated by both plasma and membrane proteins. These molecules act in concert to prevent the accelerated catabolism of complement proteins and the concomitant lysis of homologous blood cells. The deficiency of either a plasma or membrane protein predisposes to th...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(91)70199-5
更新日期：1991-04-01 00:00:00
abstract：:Passenger lymphocyte syndrome (PLS) is caused by the transfer of B-lymphocytes present in the donor graft into the recipient circulation following solid organ or hematopoietic stem cell transplantation. These cells may produce antibodies against the recipient's red blood cells, thereby triggering antibody dependent cy...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2020.06.004
更新日期：2020-07-01 00:00:00
abstract：:This guideline for the use of immunoglobulin (IG) for sensitized patients undergoing solid organ transplantation (SOT) is an initiative of the Canadian Blood Services and the National Advisory Committee on Blood and Blood Products of Canada to (1) provide guidance for Canadian practitioners involved in the care of pat...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2009.09.010
更新日期：2010-01-01 00:00:00
abstract：:The administration of blood products is a common, resource-intensive, and potentially problem-prone area that may place patients at elevated risk in the clinical setting. Much of the emphasis in transfusion safety has been targeted toward quality control measures in laboratory settings where blood products are prepare...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2006.08.007
更新日期：2007-01-01 00:00:00
abstract：:Roger Irving Lee (1881-1964) played significant scientific and leadership roles in overcoming the clinical impediments to blood transfusion in the 1910s. He developed the first successful anticoagulant system, paraffinized glass, and the first sterile system for indirect transfusion without defibrination, the Lee-Vinc...
journal_title：Transfusion medicine reviews
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.tmrv.2004.09.003
更新日期：2005-01-01 00:00:00
abstract：:Allergic transfusion reactions (ATRs) are the most common adverse reactions occurring during transfusion of blood components. Although most reactions are mild and involve cutaneous manifestations, severe ATRs including life-threatening anaphylaxis may also occur. The mechanisms of ATRs are largely unknown because they...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2017.09.002
更新日期：2018-01-01 00:00:00
abstract：:In summary, it is impossible to reconcile the contradictory results of the studies of the association between previous blood transfusion and subsequent development of NHL (Figs 1 and 2). Most of the studies were of high quality, and the authors discussed the possible sources of bias that might have generated a spuriou...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/tm.20000.7395
更新日期：2000-07-01 00:00:00
abstract：:A number of molecules on the surface of red blood cells (RBCs) and platelets express antigenic activity. Various biochemical and molecular approaches have been used to determine the structure and possible function that these molecules have for their respective cell types. The existence of variant molecules and null ph...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2004.03.006
更新日期：2004-07-01 00:00:00
abstract：:The development and expansion of the CTS in Pittsburgh shows the feasibility of this transfusion medicine delivery system. Few of the changes driven by health care reform both improve patient care and reduce costs. When properly implemented, a CTS achieves these objectives, benefits the community as a whole, and enhan...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s0887-7963(05)80051-3
更新日期：1995-04-01 00:00:00
abstract：:Over the last 20 years, the Canadian Blood Services' (CBS) Donor Health Assessment Questionnaire (DHAQ), used to screen prospective blood donors to determine their eligibility, has grown in complexity and length. Its growth is inextricably linked to the evolution of the environment within which CBS operates from unreg...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2007.03.002
更新日期：2007-07-01 00:00:00
abstract：:Two complex protein defense systems-complement and coagulation-are based on amplifying enzyme cascades triggered by specific local stimuli. Excess systemic activation of either system is pathologic and is normally prevented by a family of regulatory proteins. The 2 systems are ancient biological processes which share ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2019.08.004
更新日期：2019-10-01 00:00:00
abstract：:Cardiac surgical patients are among the highest consumers of allogeneic red blood cells (RBCs) due to the prevalence of anemia and bleeding. Up until recently, there was a paucity of high-quality evidence informing transfusion decisions in this patient group which led to wide variability in transfusion decision making...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2017.06.001
更新日期：2017-10-01 00:00:00
abstract：:Controversial results exist regarding the clinical benefits of single- vs double-unit umbilical cord blood transplantation (UCBT) in patients with hematologic diseases. A systematic review was conducted to evaluate this issue. The PubMed, Embase, and Cochrane Library databases were searched up to May 2018. A total of ...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章
doi：10.1016/j.tmrv.2018.11.001
更新日期：2019-01-01 00:00:00
abstract：:There is difficulty in obtaining adequate supplies of blood components, as well as disappointing performance of stabilized or recombinant hemoglobins, limited indications of oxygen transporters (perfluorocarbons), and slow development of "universal" red blood cells (RBCs). There is, therefore, a need for complementary...
journal_title：Transfusion medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.tmrv.2006.11.004
更新日期：2007-04-01 00:00:00
