听力与言语-语言病理学

行为科学

医学伦理学

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  • UPR signaling at the nexus of plant viral, bacterial, and fungal defenses.

    abstract::In recent years there have been significant advances in our understanding of the ER stress responses in plants that are associated with virus infection, as well as bacterial and fungal diseases. In plants, ER stress induced by virus infection includes several signaling pathways that include the unfolded protein respon...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2020.11.001

    authors: Verchot J,Pajerowska-Mukhtar KM

    更新日期:2020-12-21 00:00:00

  • Structural and dynamic asymmetry in icosahedrally symmetric virus capsids.

    abstract::A common characteristic of virus capsids is icosahedral symmetry, yet these highly symmetric structures can display asymmetric features within their virions and undergo asymmetric dynamics. The fields of structural and computational biology have entered a new realm in the investigation of virus infection mechanisms, w...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2020.06.002

    authors: Jana AK,May ER

    更新日期:2020-12-01 00:00:00

  • Structures of the tailed bacteriophages that infect Gram-positive bacteria.

    abstract::Productive virus infection depends upon delivery of viral genomic material into the host cell cytoplasm. The tails of bacteriophages recognize host cells and mediate host cell wall and membrane penetration. Recent cryo-electron microscopy studies have revealed near atomic-resolutions structures of the entire or almost...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2020.09.002

    authors: Huang L,Xiang Y

    更新日期:2020-12-01 00:00:00

  • Reverse genetics approaches for the development of bunyavirus vaccines.

    abstract::The Bunyavirales order is the largest group of RNA viruses, which includes important human and animal pathogens, that cause serious diseases. Licensed vaccines are often not available for many of these pathogens. The establishment of bunyavirus reverse genetics systems has facilitated the generation of recombinant inf...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2020.05.004

    authors: Tercero B,Makino S

    更新日期:2020-10-01 00:00:00

  • Rhabdoviruses as vectors for vaccines and therapeutics.

    abstract::Appropriate choice of vaccine vector is crucial for effective vaccine development. Rhabdoviral vectors, such as rabies virus and vesicular stomatitis virus, have been used in a variety of vaccine strategies. These viruses have small, easily manipulated genomes that can stably express foreign glycoproteins due to a wel...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2020.09.003

    authors: Scher G,Schnell MJ

    更新日期:2020-10-01 00:00:00

  • Reverse genetic approaches for the development of Zika vaccines and therapeutics.

    abstract::In 2015-2016, the little known Zika virus (ZIKV) caused an epidemic, in which it became recognized as a unique human pathogen associated with a range of devastating congenital abnormalities collectively categorized as congenital Zika syndrome (CZS). In adults, the virus can trigger the autoimmune disorder Guillain-Bar...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2020.05.002

    authors: Fontes-Garfias CR,Baker CK,Shi PY

    更新日期:2020-10-01 00:00:00

  • Cytotoxicity in Epstein Barr virus specific immune control.

    abstract::Epstein Barr virus (EBV) is the most common human tumor virus, persistently infecting more than 95% of the human adult population and readily transforming human B cell in culture. Fortunately, only a small minority of EBV carriers develops virus associated malignancies. The majority controls persistent EBV infection w...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2020.07.011

    authors: Münz C

    更新日期:2020-08-06 00:00:00

  • Historical discourse on the development of the live attenuated tetravalent dengue vaccine candidate TV003/TV005.

    abstract::Dengue is the most important arboviral disease world-wide with an estimated 400 million annual infections. Dengvaxia™ is a live attenuated tetravalent vaccine recently licensed for dengue seropositive individuals aged 9-45 years. There is great need for a dengue vaccine that could be given to dengue-naïve individuals ...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2020.09.005

    authors: Durbin AP

    更新日期:2020-08-01 00:00:00

  • Measles Resurgence and Drug Development.

    abstract::Measles caused an estimated minimum of one million fatalities annually before vaccination. Outstanding progress towards controlling the virus has been made since the measles vaccine was introduced, but reduction of measles case-fatalities has stalled at around 100,000 annually for the last decade and a 2019 resurgence...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2020.02.007

    authors: Plemper RK

    更新日期:2020-04-01 00:00:00

  • Rapid diagnostic tests to address challenges for global measles surveillance.

    abstract::Recently, a lateral flow rapid diagnostic test (RDT) with good accuracy has been described. This test enables measles specific IgM antibody detection in serum, capillary blood and oral fluid. RDTs have the potential to transform measles surveillance by allowing real-time case confirmation outside of central/regional l...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2020.05.007

    authors: Brown DW,Warrener L,Scobie HM,Donadel M,Waku-Kouomou D,Mulders MN,Rota PA

    更新日期:2020-04-01 00:00:00

  • Altered microRNA processing proteins in HPV-induced cancers.

    abstract::High-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are s...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2019.07.002

    authors: Snoek BC,Babion I,Koppers-Lalic D,Pegtel DM,Steenbergen RD

    更新日期:2019-12-01 00:00:00

  • Detecting viral sequences in NGS data.

    abstract::Next generation sequencing (NGS) technologies provide an increasingly important avenue for detecting known viruses, and for discovering novel viruses present in clinical or environmental samples. Several computational pipelines capable of identifying and classifying viral sequences in NGS data have been developed and ...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2019.07.010

    authors: Cantalupo PG,Pipas JM

    更新日期:2019-12-01 00:00:00

  • HIV-1 persistence in the central nervous system: viral and host determinants during antiretroviral therapy.

    abstract::Despite remarkable therapeutic advances in the past two decades, the elimination of human immunodeficiency virus type 1 (HIV-1) from latent reservoirs constitutes a major barrier to eradication and preventing neurological disease associated with HIV/AIDS. Invasion of the central nervous system (CNS) by HIV-1 occurs ea...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2019.06.004

    authors: Balcom EF,Roda WC,Cohen EA,Li MY,Power C

    更新日期:2019-10-01 00:00:00

  • Assessment of antiviral therapeutics in animal models of Lassa fever.

    abstract::Lassa virus (LASV) is an emerging zoonotic virus endemic in West Africa that can cause severe haemorrhagic Lassa fever (LF) in humans. LF recently gained international attention as a prominent infectious disease, leading to increasingly severe outbreaks in Nigeria over the past three years. Morbidity and mortality ass...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2019.06.010

    authors: Warner BM,Siragam V,Stein DR

    更新日期:2019-08-01 00:00:00

  • Taming a beast: lessons from the domestication of hepatitis C virus.

    abstract::"What I cannot create, I do not understand." Richard Feynman may have championed reasoning from first principles in his famous blackboard missive, but he could just as well have been referring to the plight of a molecular virologist. What cannot be grown in a controlled laboratory setting, we cannot fully understand. ...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2019.02.008

    authors: Luna JM,Saeed M,Rice CM

    更新日期:2019-04-01 00:00:00

  • VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design.

    abstract::Broadly neutralizing antibodies (bnAbs) are potential therapeutic molecules and valuable tools for studying conserved viral targets for vaccine and drug design. Interestingly, antibody responses to conserved epitopes can be highly convergent at the molecular level. Human antibodies targeting a number of viral antigens...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2019.02.004

    authors: Chen F,Tzarum N,Wilson IA,Law M

    更新日期:2019-02-01 00:00:00

  • Broadly protective influenza vaccines: design and production platforms.

    abstract::Effective vaccines are the cornerstone of our defenses against acute influenza virus infections that result in ∼500 000 annual deaths worldwide. For decades, an on-going concerted effort has been to develop a universal influenza vaccine to combat the looming threat of potentially pandemic emerging and re-emerging infl...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2018.11.005

    authors: Elbahesh H,Saletti G,Gerlach T,Rimmelzwaan GF

    更新日期:2019-02-01 00:00:00

  • Evolution of plant-virus interactions: host range and virus emergence.

    abstract::Changes in host range are central to virus emergence. Host range, together with its evolution, is determined by virus intrinsic factors, such as genetic traits determining its fitness in different hosts. Experimental analyses have shown the relevance in host range evolution of across-host fitness trade-offs. Host rang...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2018.12.003

    authors: McLeish MJ,Fraile A,García-Arenal F

    更新日期:2019-02-01 00:00:00

  • Population bottlenecks in multicomponent viruses: first forays into the uncharted territory of genome-formula drift.

    abstract::Multicomponent viral systems face specific challenges when enduring population bottlenecks. These systems can lose coding information due to the lack of co-encapsidation of all the genetic information, at least in a proportion of the capsids in a population. Moreover, bottlenecks can also impact one of the main potent...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2018.09.001

    authors: Gutiérrez S,Zwart MP

    更新日期:2018-12-01 00:00:00

  • The depths of virus exaptation.

    abstract::Viruses are ubiquitous parasites of cellular life forms and the most abundant biological entities on earth. The relationships between viruses and their hosts involve the continuous arms race but are by no account limited to it. Growing evidence shows that, in the course of evolution, viruses and their components are r...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2018.07.011

    authors: Koonin EV,Krupovic M

    更新日期:2018-08-01 00:00:00

  • Norovirus assembly and stability.

    abstract::Noroviruses are rapidly evolving RNA viruses and are generally known as the main cause of viral gastroenteritis worldwide. Particle stability is of special interest as transmission occurs via the faecal-oral route and virions are able to persist in the environment. Studies on norovirus capsid assembly and disassembly ...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2018.05.003

    authors: Pogan R,Dülfer J,Uetrecht C

    更新日期:2018-08-01 00:00:00

  • New advances in CNS immunity against viral infection.

    abstract::The central nervous system (CNS) is an immunologically specialized organ where restrictive barrier structures protect the parenchyma from inflammation and infection. This protection is important in preventing damage to non-renewable resident cell populations, such as neurons, responsible for functions ranging from exe...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2017.12.003

    authors: Manglani M,McGavern DB

    更新日期:2018-02-01 00:00:00

  • Formation and function of tissue-resident memory T cells during viral infection.

    abstract::Memory T cells are an important component of the adaptive immune response. Tissue-resident memory T cells (TRM) are a recently described subset of memory T cells that reside in peripheral tissues and are maintained independently of circulating subsets of memory T cells. Importantly, TRM are frequently found in barrier...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2017.11.001

    authors: Shin H

    更新日期:2018-02-01 00:00:00

  • Activation and trafficking of CD8+ T cells during viral skin infection: immunological lessons learned from vaccinia virus.

    abstract::Epicutaneous delivery of vaccinia virus (VacV) by scarification of the skin generates robust and durable protective immunity, which was ultimately responsible for eradicating smallpox from the human race. Therefore, infection of the skin with VacV is often used in experimental model systems to study the activation of ...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2017.10.001

    authors: Hobbs SJ,Osborn JF,Nolz JC

    更新日期:2018-02-01 00:00:00

  • Vertical transmission of positive-sense single-stranded RNA viruses in plants as a model for arboviral induced teratogenesis.

    abstract::Teratogenic viruses have increased public health importance with the emergence of Zika virus and a recent decline in rubella virus vaccination. Of the seven viruses known to cause birth defects in humans, three are mosquito-borne pathogens. Ethical oversight, compliance, rising costs, and the need for specialized trai...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2017.11.010

    authors: Barr KL

    更新日期:2017-12-01 00:00:00

  • Epstein-Barr virus: a master epigenetic manipulator.

    abstract::Like all herpesviruses, the ability of Epstein-Barr virus (EBV) to establish life-long persistent infections is related to a biphasic viral lifecycle that involves latency and reactivation/lytic replication. Memory B cells serve as the EBV latency compartment where silencing of viral gene expression allows maintenance...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2017.07.017

    authors: Scott RS

    更新日期:2017-10-01 00:00:00

  • Cis-drivers and trans-drivers of bovine leukemia virus oncogenesis.

    abstract::The bovine leukemia virus (BLV) is a retrovirus inducing an asymptomatic and persistent infection in ruminants and leading in a minority of cases to the accumulation of B-lymphocytes (lymphocytosis, leukemia or lymphoma). Although the mechanisms of oncogenesis are still largely unknown, there is clear experimental evi...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2017.06.012

    authors: Safari R,Hamaidia M,de Brogniez A,Gillet N,Willems L

    更新日期:2017-10-01 00:00:00

  • Origin of the retroviruses: when, where, and how?

    abstract::Retroviruses are a virus family of considerable medical and veterinary importance. Additionally, it is now clear that endogenous retroviruses (ERVs) comprise significant portions of vertebrate genomes. Until recently, very little was known about the deep evolutionary origins of retroviruses. However, advances in genom...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2017.06.006

    authors: Hayward A

    更新日期:2017-08-01 00:00:00

  • Biochemical principles and inhibitors to interfere with viral capping pathways.

    abstract::Messenger RNAs are decorated by a cap structure, which is essential for their translation into proteins. Many viruses have developed strategies in order to cap their mRNAs. The cap is either synthetized by a subset of viral or cellular enzymes, or stolen from capped cellular mRNAs by viral endonucleases ('cap-snatchin...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2017.04.003

    authors: Decroly E,Canard B

    更新日期:2017-06-01 00:00:00

  • Within host RNA virus persistence: mechanisms and consequences.

    abstract::In a prototypical response to an acute viral infection it would be expected that the adaptive immune response would eliminate all virally infected cells within a few weeks of infection. However many (non-retrovirus) RNA viruses can establish 'within host' persistent infections that occasionally lead to chronic or reac...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2017.03.001

    authors: Randall RE,Griffin DE

    更新日期:2017-04-01 00:00:00

  • Immunomonitoring of human responses to the rVSV-ZEBOV Ebola vaccine.

    abstract::The rVSV-ZEBOV vaccine is currently the only Ebola vaccine with demonstrated clinical efficacy in a ring-vaccination clinical trial. It has been shown to be reactogenic but immunogenic and safe in several Phase I clinical studies. However, its mechanisms of protection are unknown and available immunogenicity data are ...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2017.03.008

    authors: Medaglini D,Siegrist CA

    更新日期:2017-04-01 00:00:00

  • Protect this house: cytosolic sensing of viruses.

    abstract::The ability to recognize invading viral pathogens and to distinguish their components from those of the host cell is critical to initiate the innate immune response. The efficiency of this detection is an important factor in determining the susceptibility of the cell to viral infection. Innate sensing of viruses is, t...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2016.11.012

    authors: McFadden MJ,Gokhale NS,Horner SM

    更新日期:2017-02-01 00:00:00

  • The role of CD27 in anti-viral T-cell immunity.

    abstract::CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, seconda...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2016.12.001

    authors: Grant EJ,Nüssing S,Sant S,Clemens EB,Kedzierska K

    更新日期:2017-02-01 00:00:00

  • Dynamics of West Nile virus evolution in mosquito vectors.

    abstract::West Nile virus remains the most common cause of arboviral encephalitis in North America. Since it was introduced, it has undergone adaptive genetic change as it spread throughout the continent. The WNV transmission cycle is relatively tractable in the laboratory. Thus the virus serves as a convenient model system for...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2016.09.007

    authors: Grubaugh ND,Ebel GD

    更新日期:2016-12-01 00:00:00

  • Adeno-associated virus and lentivirus vectors: a refined toolkit for the central nervous system.

    abstract::The last two decades have witnessed the increasing instrumentalization of viruses, which have progressively evolved into highly potent gene transfer vehicles for a wide spectrum of applications. In the context of the central nervous system (CNS), their unique gene delivery features and targeting specificities have bee...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2016.08.004

    authors: Blessing D,Déglon N

    更新日期:2016-12-01 00:00:00

  • Human papillomavirus infection and induction of neoplasia: a matter of fitness.

    abstract::The aetiologic association between infection with certain human papillomavirus (HPV) types, high-grade squamous neoplasia, and cancer at different epithelial sites is well established. In this review we briefly discuss recent breakthroughs in the regulation of squamous epithelia in homeostasis and disease, and provide...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2016.08.011

    authors: Kranjec C,Doorbar J

    更新日期:2016-10-01 00:00:00

  • Discovery of novel targets for antivirals: learning from flies.

    abstract::Developing antiviral drugs is challenging due to the small number of targets in viruses, and the rapid evolution of viral genes. Animals have evolved a number of efficient antiviral defence mechanisms, which can serve as a source of inspiration for novel therapies. The genetically tractable insect Drosophila belongs t...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2016.09.005

    authors: Martins N,Imler JL,Meignin C

    更新日期:2016-10-01 00:00:00

  • Impacts of poultry vaccination on viruses of wild bird.

    abstract::Spillover of viruses from farmed poultry into wild birds is a relatively new area of study at the livestock-wildlife interface. These transmission events can threaten the health of wild birds. There is growing evidence of transmission of vaccine viruses from poultry to wild birds, including attenuated vaccine strains ...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2016.06.007

    authors: Devlin JM,Vaz PK,Coppo MJ,Browning GF

    更新日期:2016-08-01 00:00:00

  • Virus particle dynamics derived from CryoEM studies.

    abstract::The direct electron detector has revolutionized electron cryo-microscopy (CryoEM). Icosahedral virus structures are routinely produced at 4Å resolution or better and the approach has largely displaced virus crystallography, as it requires less material, less purity and often produces a structure more rapidly. Largely ...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2016.02.011

    authors: Doerschuk PC,Gong Y,Xu N,Domitrovic T,Johnson JE

    更新日期:2016-06-01 00:00:00

  • The battle for survival between viruses and their host plants.

    abstract::Evolution has equipped plants with defense mechanisms to counterattack virus infections. However, some viruses have acquired the capacity to escape these defense barriers. In their combats, plants use mechanisms such as antiviral RNA silencing that viruses fight against using silencing-repressors. Plants could also re...

    journal_title:Current opinion in virology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coviro.2015.12.001

    authors: Boualem A,Dogimont C,Bendahmane A

    更新日期:2016-04-01 00:00:00

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