abstract：:In recent years there have been significant advances in our understanding of the ER stress responses in plants that are associated with virus infection, as well as bacterial and fungal diseases. In plants, ER stress induced by virus infection includes several signaling pathways that include the unfolded protein respon...

journal_title：Current opinion in virology

authors： Verchot J,Pajerowska-Mukhtar KM

更新日期：2020-12-21 00:00:00

abstract：:Productive virus infection depends upon delivery of viral genomic material into the host cell cytoplasm. The tails of bacteriophages recognize host cells and mediate host cell wall and membrane penetration. Recent cryo-electron microscopy studies have revealed near atomic-resolutions structures of the entire or almost...

journal_title：Current opinion in virology

authors： Huang L,Xiang Y

更新日期：2020-12-01 00:00:00

abstract：:A common characteristic of virus capsids is icosahedral symmetry, yet these highly symmetric structures can display asymmetric features within their virions and undergo asymmetric dynamics. The fields of structural and computational biology have entered a new realm in the investigation of virus infection mechanisms, w...

journal_title：Current opinion in virology

authors： Jana AK,May ER

更新日期：2020-12-01 00:00:00

abstract：:Appropriate choice of vaccine vector is crucial for effective vaccine development. Rhabdoviral vectors, such as rabies virus and vesicular stomatitis virus, have been used in a variety of vaccine strategies. These viruses have small, easily manipulated genomes that can stably express foreign glycoproteins due to a wel...

journal_title：Current opinion in virology

authors： Scher G,Schnell MJ

更新日期：2020-10-01 00:00:00

abstract：:The Bunyavirales order is the largest group of RNA viruses, which includes important human and animal pathogens, that cause serious diseases. Licensed vaccines are often not available for many of these pathogens. The establishment of bunyavirus reverse genetics systems has facilitated the generation of recombinant inf...

journal_title：Current opinion in virology

authors： Tercero B,Makino S

更新日期：2020-10-01 00:00:00

abstract：:In 2015-2016, the little known Zika virus (ZIKV) caused an epidemic, in which it became recognized as a unique human pathogen associated with a range of devastating congenital abnormalities collectively categorized as congenital Zika syndrome (CZS). In adults, the virus can trigger the autoimmune disorder Guillain-Bar...

journal_title：Current opinion in virology

authors： Fontes-Garfias CR,Baker CK,Shi PY

更新日期：2020-10-01 00:00:00

abstract：:Epstein Barr virus (EBV) is the most common human tumor virus, persistently infecting more than 95% of the human adult population and readily transforming human B cell in culture. Fortunately, only a small minority of EBV carriers develops virus associated malignancies. The majority controls persistent EBV infection w...

journal_title：Current opinion in virology

authors： Münz C

更新日期：2020-08-06 00:00:00

abstract：:Dengue is the most important arboviral disease world-wide with an estimated 400 million annual infections. Dengvaxia™ is a live attenuated tetravalent vaccine recently licensed for dengue seropositive individuals aged 9-45 years. There is great need for a dengue vaccine that could be given to dengue-naïve individuals ...

journal_title：Current opinion in virology

authors： Durbin AP

更新日期：2020-08-01 00:00:00

abstract：:Recently, a lateral flow rapid diagnostic test (RDT) with good accuracy has been described. This test enables measles specific IgM antibody detection in serum, capillary blood and oral fluid. RDTs have the potential to transform measles surveillance by allowing real-time case confirmation outside of central/regional l...

journal_title：Current opinion in virology

authors： Brown DW,Warrener L,Scobie HM,Donadel M,Waku-Kouomou D,Mulders MN,Rota PA

更新日期：2020-04-01 00:00:00

abstract：:Measles caused an estimated minimum of one million fatalities annually before vaccination. Outstanding progress towards controlling the virus has been made since the measles vaccine was introduced, but reduction of measles case-fatalities has stalled at around 100,000 annually for the last decade and a 2019 resurgence...

journal_title：Current opinion in virology

authors： Plemper RK

更新日期：2020-04-01 00:00:00

abstract：:Next generation sequencing (NGS) technologies provide an increasingly important avenue for detecting known viruses, and for discovering novel viruses present in clinical or environmental samples. Several computational pipelines capable of identifying and classifying viral sequences in NGS data have been developed and ...

journal_title：Current opinion in virology

authors： Cantalupo PG,Pipas JM

更新日期：2019-12-01 00:00:00

abstract：:High-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are s...

journal_title：Current opinion in virology

authors： Snoek BC,Babion I,Koppers-Lalic D,Pegtel DM,Steenbergen RD

更新日期：2019-12-01 00:00:00

abstract：:Despite remarkable therapeutic advances in the past two decades, the elimination of human immunodeficiency virus type 1 (HIV-1) from latent reservoirs constitutes a major barrier to eradication and preventing neurological disease associated with HIV/AIDS. Invasion of the central nervous system (CNS) by HIV-1 occurs ea...

journal_title：Current opinion in virology

authors： Balcom EF,Roda WC,Cohen EA,Li MY,Power C

更新日期：2019-10-01 00:00:00

abstract：:Lassa virus (LASV) is an emerging zoonotic virus endemic in West Africa that can cause severe haemorrhagic Lassa fever (LF) in humans. LF recently gained international attention as a prominent infectious disease, leading to increasingly severe outbreaks in Nigeria over the past three years. Morbidity and mortality ass...

journal_title：Current opinion in virology

authors： Warner BM,Siragam V,Stein DR

更新日期：2019-08-01 00:00:00

abstract：:"What I cannot create, I do not understand." Richard Feynman may have championed reasoning from first principles in his famous blackboard missive, but he could just as well have been referring to the plight of a molecular virologist. What cannot be grown in a controlled laboratory setting, we cannot fully understand. ...

journal_title：Current opinion in virology

authors： Luna JM,Saeed M,Rice CM

更新日期：2019-04-01 00:00:00

abstract：:Broadly neutralizing antibodies (bnAbs) are potential therapeutic molecules and valuable tools for studying conserved viral targets for vaccine and drug design. Interestingly, antibody responses to conserved epitopes can be highly convergent at the molecular level. Human antibodies targeting a number of viral antigens...

journal_title：Current opinion in virology

authors： Chen F,Tzarum N,Wilson IA,Law M

更新日期：2019-02-01 00:00:00

abstract：:Changes in host range are central to virus emergence. Host range, together with its evolution, is determined by virus intrinsic factors, such as genetic traits determining its fitness in different hosts. Experimental analyses have shown the relevance in host range evolution of across-host fitness trade-offs. Host rang...

journal_title：Current opinion in virology

authors： McLeish MJ,Fraile A,García-Arenal F

更新日期：2019-02-01 00:00:00

abstract：:Effective vaccines are the cornerstone of our defenses against acute influenza virus infections that result in ∼500 000 annual deaths worldwide. For decades, an on-going concerted effort has been to develop a universal influenza vaccine to combat the looming threat of potentially pandemic emerging and re-emerging infl...

journal_title：Current opinion in virology

authors： Elbahesh H,Saletti G,Gerlach T,Rimmelzwaan GF

更新日期：2019-02-01 00:00:00

abstract：:Multicomponent viral systems face specific challenges when enduring population bottlenecks. These systems can lose coding information due to the lack of co-encapsidation of all the genetic information, at least in a proportion of the capsids in a population. Moreover, bottlenecks can also impact one of the main potent...

journal_title：Current opinion in virology

authors： Gutiérrez S,Zwart MP

更新日期：2018-12-01 00:00:00

abstract：:Viruses are ubiquitous parasites of cellular life forms and the most abundant biological entities on earth. The relationships between viruses and their hosts involve the continuous arms race but are by no account limited to it. Growing evidence shows that, in the course of evolution, viruses and their components are r...

journal_title：Current opinion in virology

authors： Koonin EV,Krupovic M

更新日期：2018-08-01 00:00:00

abstract：:Noroviruses are rapidly evolving RNA viruses and are generally known as the main cause of viral gastroenteritis worldwide. Particle stability is of special interest as transmission occurs via the faecal-oral route and virions are able to persist in the environment. Studies on norovirus capsid assembly and disassembly ...

journal_title：Current opinion in virology

authors： Pogan R,Dülfer J,Uetrecht C

更新日期：2018-08-01 00:00:00

abstract：:The central nervous system (CNS) is an immunologically specialized organ where restrictive barrier structures protect the parenchyma from inflammation and infection. This protection is important in preventing damage to non-renewable resident cell populations, such as neurons, responsible for functions ranging from exe...

journal_title：Current opinion in virology

authors： Manglani M,McGavern DB

更新日期：2018-02-01 00:00:00

abstract：:Memory T cells are an important component of the adaptive immune response. Tissue-resident memory T cells (TRM) are a recently described subset of memory T cells that reside in peripheral tissues and are maintained independently of circulating subsets of memory T cells. Importantly, TRM are frequently found in barrier...

journal_title：Current opinion in virology

authors： Shin H

更新日期：2018-02-01 00:00:00

abstract：:Epicutaneous delivery of vaccinia virus (VacV) by scarification of the skin generates robust and durable protective immunity, which was ultimately responsible for eradicating smallpox from the human race. Therefore, infection of the skin with VacV is often used in experimental model systems to study the activation of ...

journal_title：Current opinion in virology

authors： Hobbs SJ,Osborn JF,Nolz JC

更新日期：2018-02-01 00:00:00

abstract：:Teratogenic viruses have increased public health importance with the emergence of Zika virus and a recent decline in rubella virus vaccination. Of the seven viruses known to cause birth defects in humans, three are mosquito-borne pathogens. Ethical oversight, compliance, rising costs, and the need for specialized trai...

journal_title：Current opinion in virology

authors： Barr KL

更新日期：2017-12-01 00:00:00

abstract：:Like all herpesviruses, the ability of Epstein-Barr virus (EBV) to establish life-long persistent infections is related to a biphasic viral lifecycle that involves latency and reactivation/lytic replication. Memory B cells serve as the EBV latency compartment where silencing of viral gene expression allows maintenance...

journal_title：Current opinion in virology

authors： Scott RS

更新日期：2017-10-01 00:00:00

abstract：:The bovine leukemia virus (BLV) is a retrovirus inducing an asymptomatic and persistent infection in ruminants and leading in a minority of cases to the accumulation of B-lymphocytes (lymphocytosis, leukemia or lymphoma). Although the mechanisms of oncogenesis are still largely unknown, there is clear experimental evi...

journal_title：Current opinion in virology

authors： Safari R,Hamaidia M,de Brogniez A,Gillet N,Willems L

更新日期：2017-10-01 00:00:00

abstract：:Retroviruses are a virus family of considerable medical and veterinary importance. Additionally, it is now clear that endogenous retroviruses (ERVs) comprise significant portions of vertebrate genomes. Until recently, very little was known about the deep evolutionary origins of retroviruses. However, advances in genom...

journal_title：Current opinion in virology

authors： Hayward A

更新日期：2017-08-01 00:00:00

abstract：:Messenger RNAs are decorated by a cap structure, which is essential for their translation into proteins. Many viruses have developed strategies in order to cap their mRNAs. The cap is either synthetized by a subset of viral or cellular enzymes, or stolen from capped cellular mRNAs by viral endonucleases ('cap-snatchin...

journal_title：Current opinion in virology

authors： Decroly E,Canard B

更新日期：2017-06-01 00:00:00

abstract：:The rVSV-ZEBOV vaccine is currently the only Ebola vaccine with demonstrated clinical efficacy in a ring-vaccination clinical trial. It has been shown to be reactogenic but immunogenic and safe in several Phase I clinical studies. However, its mechanisms of protection are unknown and available immunogenicity data are ...

journal_title：Current opinion in virology

authors： Medaglini D,Siegrist CA

更新日期：2017-04-01 00:00:00

abstract：:In a prototypical response to an acute viral infection it would be expected that the adaptive immune response would eliminate all virally infected cells within a few weeks of infection. However many (non-retrovirus) RNA viruses can establish 'within host' persistent infections that occasionally lead to chronic or reac...

journal_title：Current opinion in virology

authors： Randall RE,Griffin DE

更新日期：2017-04-01 00:00:00

abstract：:CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, seconda...

journal_title：Current opinion in virology

authors： Grant EJ,Nüssing S,Sant S,Clemens EB,Kedzierska K

更新日期：2017-02-01 00:00:00

abstract：:The ability to recognize invading viral pathogens and to distinguish their components from those of the host cell is critical to initiate the innate immune response. The efficiency of this detection is an important factor in determining the susceptibility of the cell to viral infection. Innate sensing of viruses is, t...

journal_title：Current opinion in virology

authors： McFadden MJ,Gokhale NS,Horner SM

更新日期：2017-02-01 00:00:00

abstract：:West Nile virus remains the most common cause of arboviral encephalitis in North America. Since it was introduced, it has undergone adaptive genetic change as it spread throughout the continent. The WNV transmission cycle is relatively tractable in the laboratory. Thus the virus serves as a convenient model system for...

journal_title：Current opinion in virology

authors： Grubaugh ND,Ebel GD

更新日期：2016-12-01 00:00:00

abstract：:The last two decades have witnessed the increasing instrumentalization of viruses, which have progressively evolved into highly potent gene transfer vehicles for a wide spectrum of applications. In the context of the central nervous system (CNS), their unique gene delivery features and targeting specificities have bee...

journal_title：Current opinion in virology

authors： Blessing D,Déglon N

更新日期：2016-12-01 00:00:00

abstract：:Developing antiviral drugs is challenging due to the small number of targets in viruses, and the rapid evolution of viral genes. Animals have evolved a number of efficient antiviral defence mechanisms, which can serve as a source of inspiration for novel therapies. The genetically tractable insect Drosophila belongs t...

journal_title：Current opinion in virology

authors： Martins N,Imler JL,Meignin C

更新日期：2016-10-01 00:00:00

abstract：:The aetiologic association between infection with certain human papillomavirus (HPV) types, high-grade squamous neoplasia, and cancer at different epithelial sites is well established. In this review we briefly discuss recent breakthroughs in the regulation of squamous epithelia in homeostasis and disease, and provide...

journal_title：Current opinion in virology

authors： Kranjec C,Doorbar J

更新日期：2016-10-01 00:00:00

abstract：:Spillover of viruses from farmed poultry into wild birds is a relatively new area of study at the livestock-wildlife interface. These transmission events can threaten the health of wild birds. There is growing evidence of transmission of vaccine viruses from poultry to wild birds, including attenuated vaccine strains ...

journal_title：Current opinion in virology

authors： Devlin JM,Vaz PK,Coppo MJ,Browning GF

更新日期：2016-08-01 00:00:00

abstract：:The direct electron detector has revolutionized electron cryo-microscopy (CryoEM). Icosahedral virus structures are routinely produced at 4Å resolution or better and the approach has largely displaced virus crystallography, as it requires less material, less purity and often produces a structure more rapidly. Largely ...

journal_title：Current opinion in virology

authors： Doerschuk PC,Gong Y,Xu N,Domitrovic T,Johnson JE

更新日期：2016-06-01 00:00:00

abstract：:Evolution has equipped plants with defense mechanisms to counterattack virus infections. However, some viruses have acquired the capacity to escape these defense barriers. In their combats, plants use mechanisms such as antiviral RNA silencing that viruses fight against using silencing-repressors. Plants could also re...

journal_title：Current opinion in virology

authors： Boualem A,Dogimont C,Bendahmane A

更新日期：2016-04-01 00:00:00