Abstract：
:Effective vaccines are the cornerstone of our defenses against acute influenza virus infections that result in ∼500 000 annual deaths worldwide. For decades, an on-going concerted effort has been to develop a universal influenza vaccine to combat the looming threat of potentially pandemic emerging and re-emerging influenza viruses. To address the need for rapid efficacious vaccines that could mitigate the impact of seasonal and future pandemics, multiple platforms are under development and/or investigation. What is clear is that any universal vaccine must provide long-lasting cross-protective immunity that can induce both B and T cell responses. This review will explore some of the universal influenza vaccine platforms in the contexts of their ability to induce long-lasting and cross-protective T cell immunity.
journal_name
Curr Opin Viroljournal_title
Current opinion in virologyauthors
Elbahesh H,Saletti G,Gerlach T,Rimmelzwaan GFdoi
10.1016/j.coviro.2018.11.005subject
Has Abstractpub_date
2019-02-01 00:00:00pages
1-9eissn
1879-6257issn
1879-6265pii
S1879-6257(18)30113-5journal_volume
34pub_type
杂志文章,评审abstract：:Dengue is a potentially fatal viral disease for which treatment is limited to supportive care, and prevention and control are based on mosquito vector control programs. It is the fastest growing arboviral infection and is currently endemic in more than 100 tropical and subtropical countries, placing over 40% of the wo...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2013.05.014
更新日期：2013-06-01 00:00:00
abstract：:Multicomponent viral systems face specific challenges when enduring population bottlenecks. These systems can lose coding information due to the lack of co-encapsidation of all the genetic information, at least in a proportion of the capsids in a population. Moreover, bottlenecks can also impact one of the main potent...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2018.09.001
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abstract：:All known gammaherpesviruses encode at least one conserved tegument protein that contains sequence homology to the cellular purine biosynthesis enzyme: phosphoribosylformylglycineamide amidotransferase (FGARAT, or PFAS). While no enzymatic activity have been found on these viral FGARAT-homology proteins (vFGARAT), the...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.07.008
更新日期：2015-10-01 00:00:00
abstract：:Pathogens such as the human immunodeficiency virus (HIV), the hepatitis B and C virus (HBV, HCV) and certain strains of the rodent lymphocytic choriomeningitis virus (LCMV) establish a state of persisting viral replication. This occurs besides strong adoptive immune responses and the induction of large numbers of acti...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.01.002
更新日期：2016-02-01 00:00:00
abstract：:Vaccines are the gold standard for the control and prevention of infectious diseases, but a number of important human diseases remain challenging targets for vaccine development. An influenza vaccine that confers broad spectrum, long-term protection remains elusive. Several broadly neutralizing antibodies have been id...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2012.02.005
更新日期：2012-04-01 00:00:00
abstract：:Recently, a lateral flow rapid diagnostic test (RDT) with good accuracy has been described. This test enables measles specific IgM antibody detection in serum, capillary blood and oral fluid. RDTs have the potential to transform measles surveillance by allowing real-time case confirmation outside of central/regional l...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.05.007
更新日期：2020-04-01 00:00:00
abstract：:The generation of humanized mouse models in which immune deficient mice are engrafted with human tissues allows for the direct in vivo investigation of human-restricted viruses. These humanized mouse models have been developed and improved over the past 30 years. It is now possible to achieve high levels of human cell...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.06.006
更新日期：2015-08-01 00:00:00
abstract：:In recent years there have been significant advances in our understanding of the ER stress responses in plants that are associated with virus infection, as well as bacterial and fungal diseases. In plants, ER stress induced by virus infection includes several signaling pathways that include the unfolded protein respon...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.11.001
更新日期：2020-12-21 00:00:00
abstract：:In 2015-2016, the little known Zika virus (ZIKV) caused an epidemic, in which it became recognized as a unique human pathogen associated with a range of devastating congenital abnormalities collectively categorized as congenital Zika syndrome (CZS). In adults, the virus can trigger the autoimmune disorder Guillain-Bar...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.05.002
更新日期：2020-10-01 00:00:00
abstract：:Productive virus infection depends upon delivery of viral genomic material into the host cell cytoplasm. The tails of bacteriophages recognize host cells and mediate host cell wall and membrane penetration. Recent cryo-electron microscopy studies have revealed near atomic-resolutions structures of the entire or almost...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.09.002
更新日期：2020-12-01 00:00:00
abstract：:The three types of interferon (IFNs) are essential for immunity against at least some viruses in the mouse model of experimental infections, type I IFNs displaying the broadest and strongest anti-viral activity. Consistently, human genetic studies have shown that type II IFN is largely redundant for immunity against v...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2011.10.016
更新日期：2011-12-01 00:00:00
abstract：:Biological invasions occur when plants, animals, or microbes are introduced to a new geographic region, then spread and have negative consequences for the local ecosystem. Across both plant and animal hosts, viruses can play diverse roles in biological invasions. First, viruses can either decrease or increase the impa...
journal_title：Current opinion in virology
pub_type： 杂志文章
doi：10.1016/j.coviro.2011.05.018
更新日期：2011-07-01 00:00:00
abstract：:Like all herpesviruses, the ability of Epstein-Barr virus (EBV) to establish life-long persistent infections is related to a biphasic viral lifecycle that involves latency and reactivation/lytic replication. Memory B cells serve as the EBV latency compartment where silencing of viral gene expression allows maintenance...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.07.017
更新日期：2017-10-01 00:00:00
abstract：:DNA is potently immunostimulatory, and self-DNA is packaged in the nucleus or mitochondria allowing it to remain silent to cell-intrinsic sensors. However, damaged or mislocalised self-DNA is sensed by our innate immune systems, resulting in the production of type I interferons (IFNI), chemokines and inflammatory cyto...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.08.001
更新日期：2015-12-01 00:00:00
abstract：:Canine distemper virus (CDV) is an animal morbillivirus with a worldwide circulation that infects carnivores, including domestic dogs and an assortment of wildlife hosts. The development of reverse genetics systems for wild-type strains of CDV and the use of the resulting recombinant (r) viruses to infect ferrets by a...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2013.11.001
更新日期：2014-02-01 00:00:00
abstract：:Viruses are ubiquitous parasites of cellular life forms and the most abundant biological entities on earth. The relationships between viruses and their hosts involve the continuous arms race but are by no account limited to it. Growing evidence shows that, in the course of evolution, viruses and their components are r...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2018.07.011
更新日期：2018-08-01 00:00:00
abstract：:The evolution of virulence has been studied from a number of theoretical perspectives, and a few experimental systems. Although there is no consensus on an overarching framework that covers all situations, the 'trade-off' hypothesis is a useful framework for examining the nature of symbiotic relationships between viru...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2012.06.010
更新日期：2012-10-01 00:00:00
abstract：:Retroviruses are a virus family of considerable medical and veterinary importance. Additionally, it is now clear that endogenous retroviruses (ERVs) comprise significant portions of vertebrate genomes. Until recently, very little was known about the deep evolutionary origins of retroviruses. However, advances in genom...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.06.006
更新日期：2017-08-01 00:00:00
abstract：:Positive strand RNA viruses cause membrane modifications which are microenvironments or larger intracellular compartments, also called 'viroplasms'. These compartments serve to concentrate virus and host factors needed to produce new genomes. Forming these replication sites often involves virus induced membrane synthe...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2011.09.009
更新日期：2011-11-01 00:00:00
abstract：:The central nervous system (CNS) is an immunologically specialized organ where restrictive barrier structures protect the parenchyma from inflammation and infection. This protection is important in preventing damage to non-renewable resident cell populations, such as neurons, responsible for functions ranging from exe...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.12.003
更新日期：2018-02-01 00:00:00
abstract：:Structural information can inform our understanding of virus origins and evolution. The herpesviruses and tailed bacteriophages constitute two large families of dsDNA viruses which infect vertebrates and prokaryotes respectively. A relationship between these disparate groups was initially suggested by similarities in ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.02.003
更新日期：2014-04-01 00:00:00
abstract：:Coronaviruses are positive stranded RNA viruses that cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses impeded the development of coronavirus specific therapeutics. However, the...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.06.002
更新日期：2014-10-01 00:00:00
abstract：:Memory T cells are an important component of the adaptive immune response. Tissue-resident memory T cells (TRM) are a recently described subset of memory T cells that reside in peripheral tissues and are maintained independently of circulating subsets of memory T cells. Importantly, TRM are frequently found in barrier...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.11.001
更新日期：2018-02-01 00:00:00
abstract：:A common characteristic of virus capsids is icosahedral symmetry, yet these highly symmetric structures can display asymmetric features within their virions and undergo asymmetric dynamics. The fields of structural and computational biology have entered a new realm in the investigation of virus infection mechanisms, w...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.06.002
更新日期：2020-12-01 00:00:00
abstract：:We compare the design, mechanism of action, and clinical efficacy of two recently licensed paradigm shifting vaccines. Zostavax is the first vaccine licensed to prevent disease in patients already infected with a pathogen, and is contrasted with Gardasil and Cervarix, the first vaccines designed and licensed specifica...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2011.07.007
更新日期：2011-10-01 00:00:00
abstract：:Three integrase strand transfer inhibitors have now been approved for the treatment of HIV infection, raltegravir, cobicistat-boosted elvitegravir, and dolutegravir. Each of these agents selects for unique signature mutations; however, there can be significant cross resistance among all three drugs when multiple mutat...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.07.006
更新日期：2014-10-01 00:00:00
abstract：:Epicutaneous delivery of vaccinia virus (VacV) by scarification of the skin generates robust and durable protective immunity, which was ultimately responsible for eradicating smallpox from the human race. Therefore, infection of the skin with VacV is often used in experimental model systems to study the activation of ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.10.001
更新日期：2018-02-01 00:00:00
abstract：:Evolution has equipped plants with defense mechanisms to counterattack virus infections. However, some viruses have acquired the capacity to escape these defense barriers. In their combats, plants use mechanisms such as antiviral RNA silencing that viruses fight against using silencing-repressors. Plants could also re...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.12.001
更新日期：2016-04-01 00:00:00
abstract：:Messenger RNAs are decorated by a cap structure, which is essential for their translation into proteins. Many viruses have developed strategies in order to cap their mRNAs. The cap is either synthetized by a subset of viral or cellular enzymes, or stolen from capped cellular mRNAs by viral endonucleases ('cap-snatchin...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.04.003
更新日期：2017-06-01 00:00:00
abstract：:Developing antiviral drugs is challenging due to the small number of targets in viruses, and the rapid evolution of viral genes. Animals have evolved a number of efficient antiviral defence mechanisms, which can serve as a source of inspiration for novel therapies. The genetically tractable insect Drosophila belongs t...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.09.005
更新日期：2016-10-01 00:00:00
