Abstract：
:DNA is potently immunostimulatory, and self-DNA is packaged in the nucleus or mitochondria allowing it to remain silent to cell-intrinsic sensors. However, damaged or mislocalised self-DNA is sensed by our innate immune systems, resulting in the production of type I interferons (IFNI), chemokines and inflammatory cytokines. During DNA virus infection the detection of viral DNA genomes by pattern recognition receptors (PRRs) is essential for the initiation of IFNI responses and host defence against these pathogens. It is intriguing that a number of molecular mechanisms have been found to be common to both of these DNA-induced stress responses and this has potentially important consequences for both sides of the host/pathogen arms race.
journal_name
Curr Opin Viroljournal_title
Current opinion in virologyauthors
Trigg BJ,Ferguson BJdoi
10.1016/j.coviro.2015.08.001subject
Has Abstractpub_date
2015-12-01 00:00:00pages
56-62eissn
1879-6257issn
1879-6265pii
S1879-6257(15)00111-Xjournal_volume
15pub_type
杂志文章,评审abstract：:Latent HIV reservoirs are the greatest challenge facing an HIV cure. Here, we review recent evidence supporting an important role for the host immune response, in particular HLA class I-restricted CD8+ T lymphocytes, in modulating HIV reservoirs during natural infection. These observations indicate that factors govern...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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abstract：:Human alphaherpesviruses (αHHV) - herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV) - infect mucosal epithelial cells, establish a lifelong latent infection of sensory neurons, and reactivate intermittingly to cause recrudescent disease. Although chronic αHHV infections co-exist with brisk T...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
pub_type： 杂志文章
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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更新日期：2012-04-01 00:00:00
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2013.08.013
更新日期：2013-12-01 00:00:00
abstract：:A model is described that predicts patterns of polyomavirus SV40 infections and associated cancers in humans. The model proposes that SV40 infections were established in humans primarily by exposure to contaminated oral poliovaccines and that infections persist today in geographic regions where poor sanitation or livi...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2012.06.004
更新日期：2012-08-01 00:00:00
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.06.012
更新日期：2017-10-01 00:00:00
abstract：:Structural information can inform our understanding of virus origins and evolution. The herpesviruses and tailed bacteriophages constitute two large families of dsDNA viruses which infect vertebrates and prokaryotes respectively. A relationship between these disparate groups was initially suggested by similarities in ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.02.003
更新日期：2014-04-01 00:00:00
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.03.008
更新日期：2017-04-01 00:00:00
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.07.008
更新日期：2015-10-01 00:00:00
abstract：:Retroviruses are a virus family of considerable medical and veterinary importance. Additionally, it is now clear that endogenous retroviruses (ERVs) comprise significant portions of vertebrate genomes. Until recently, very little was known about the deep evolutionary origins of retroviruses. However, advances in genom...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.06.006
更新日期：2017-08-01 00:00:00
abstract：:Coronaviruses are positive stranded RNA viruses that cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses impeded the development of coronavirus specific therapeutics. However, the...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.06.002
更新日期：2014-10-01 00:00:00
abstract：:Like all herpesviruses, the ability of Epstein-Barr virus (EBV) to establish life-long persistent infections is related to a biphasic viral lifecycle that involves latency and reactivation/lytic replication. Memory B cells serve as the EBV latency compartment where silencing of viral gene expression allows maintenance...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.07.017
更新日期：2017-10-01 00:00:00
abstract：:CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, seconda...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.12.001
更新日期：2017-02-01 00:00:00
abstract：:Progress in the identification of suitable animal models for human herpesvirus (HHV)-6A and HHV-6B infections has been slow. Recently, new models have been established, mainly for HHV-6A, which reproduce some pathological features seen in humans. Neuroinflammatory signs were observed in infected marmosets and CD46-tra...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.09.012
更新日期：2014-12-01 00:00:00
abstract：:Three integrase strand transfer inhibitors have now been approved for the treatment of HIV infection, raltegravir, cobicistat-boosted elvitegravir, and dolutegravir. Each of these agents selects for unique signature mutations; however, there can be significant cross resistance among all three drugs when multiple mutat...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.07.006
更新日期：2014-10-01 00:00:00
abstract：:Next generation sequencing (NGS) technologies provide an increasingly important avenue for detecting known viruses, and for discovering novel viruses present in clinical or environmental samples. Several computational pipelines capable of identifying and classifying viral sequences in NGS data have been developed and ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2019.07.010
更新日期：2019-12-01 00:00:00
abstract：:The rate of new virus discovery is increasing dramatically with improvements in sequencing and other molecular diagnostic platforms, and investments in sample collection and analysis. However, progress has been more limited in identification and implication of infectious agents that pose threats to human health and we...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2011.10.010
更新日期：2011-12-01 00:00:00
abstract：:Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be involved in tumorigenesis. Like other human polyomaviruses, MCPyV is highly prevalent in the healthy population, yet the MCPyV-associated Merkel cell carcinoma (MCC) is a very rare disease. Although in vitro and in vivo models have provided si...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.08.010
更新日期：2015-10-01 00:00:00
abstract：:The evolution of virulence has been studied from a number of theoretical perspectives, and a few experimental systems. Although there is no consensus on an overarching framework that covers all situations, the 'trade-off' hypothesis is a useful framework for examining the nature of symbiotic relationships between viru...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2012.06.010
更新日期：2012-10-01 00:00:00
abstract：:Positive strand RNA viruses cause membrane modifications which are microenvironments or larger intracellular compartments, also called 'viroplasms'. These compartments serve to concentrate virus and host factors needed to produce new genomes. Forming these replication sites often involves virus induced membrane synthe...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2011.09.009
更新日期：2011-11-01 00:00:00
abstract：:Multicomponent viral systems face specific challenges when enduring population bottlenecks. These systems can lose coding information due to the lack of co-encapsidation of all the genetic information, at least in a proportion of the capsids in a population. Moreover, bottlenecks can also impact one of the main potent...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2018.09.001
更新日期：2018-12-01 00:00:00
abstract：:The generation of humanized mouse models in which immune deficient mice are engrafted with human tissues allows for the direct in vivo investigation of human-restricted viruses. These humanized mouse models have been developed and improved over the past 30 years. It is now possible to achieve high levels of human cell...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.06.006
更新日期：2015-08-01 00:00:00
abstract：:Rotaviruses are members of the Reoviridae family of non-enveloped viruses and important etiologic agents of acute gastroenteritis in infants and young children. In recent years, high-resolution structures of triple-layered rotavirus virions and the constituent proteins have provided valuable insights into functions. O...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2012.04.005
更新日期：2012-08-01 00:00:00
abstract：:Rotavirus, a cause of pediatric gastroenteritis, has a genome consisting of 11 segments of double-stranded (ds)RNA surrounded by a triple-layered protein capsid. The rotavirus RNA-dependent RNA polymerase, VP1, synthesizes both dsRNA and plus-strand RNA (+RNA) within subviral particles. Structural analyses of the rota...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.08.008
更新日期：2014-12-01 00:00:00
abstract：:Viruses are ubiquitous parasites of cellular life forms and the most abundant biological entities on earth. The relationships between viruses and their hosts involve the continuous arms race but are by no account limited to it. Growing evidence shows that, in the course of evolution, viruses and their components are r...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2018.07.011
更新日期：2018-08-01 00:00:00
abstract：:Dengue is the most important arboviral disease world-wide with an estimated 400 million annual infections. Dengvaxia™ is a live attenuated tetravalent vaccine recently licensed for dengue seropositive individuals aged 9-45 years. There is great need for a dengue vaccine that could be given to dengue-naïve individuals ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.09.005
更新日期：2020-08-01 00:00:00
abstract：:Messenger RNAs are decorated by a cap structure, which is essential for their translation into proteins. Many viruses have developed strategies in order to cap their mRNAs. The cap is either synthetized by a subset of viral or cellular enzymes, or stolen from capped cellular mRNAs by viral endonucleases ('cap-snatchin...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.04.003
更新日期：2017-06-01 00:00:00
abstract：:Memory T cells are an important component of the adaptive immune response. Tissue-resident memory T cells (TRM) are a recently described subset of memory T cells that reside in peripheral tissues and are maintained independently of circulating subsets of memory T cells. Importantly, TRM are frequently found in barrier...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.11.001
更新日期：2018-02-01 00:00:00
abstract：:The direct electron detector has revolutionized electron cryo-microscopy (CryoEM). Icosahedral virus structures are routinely produced at 4Å resolution or better and the approach has largely displaced virus crystallography, as it requires less material, less purity and often produces a structure more rapidly. Largely ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.02.011
更新日期：2016-06-01 00:00:00
