Functions of DNA damage machinery in the innate immune response to DNA virus infection.

Abstract:

:DNA is potently immunostimulatory, and self-DNA is packaged in the nucleus or mitochondria allowing it to remain silent to cell-intrinsic sensors. However, damaged or mislocalised self-DNA is sensed by our innate immune systems, resulting in the production of type I interferons (IFNI), chemokines and inflammatory cytokines. During DNA virus infection the detection of viral DNA genomes by pattern recognition receptors (PRRs) is essential for the initiation of IFNI responses and host defence against these pathogens. It is intriguing that a number of molecular mechanisms have been found to be common to both of these DNA-induced stress responses and this has potentially important consequences for both sides of the host/pathogen arms race.

journal_name

Curr Opin Virol

authors

Trigg BJ,Ferguson BJ

doi

10.1016/j.coviro.2015.08.001

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

56-62

eissn

1879-6257

issn

1879-6265

pii

S1879-6257(15)00111-X

journal_volume

15

pub_type

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