Origin of the retroviruses: when, where, and how?

Abstract:

:Retroviruses are a virus family of considerable medical and veterinary importance. Additionally, it is now clear that endogenous retroviruses (ERVs) comprise significant portions of vertebrate genomes. Until recently, very little was known about the deep evolutionary origins of retroviruses. However, advances in genomics and bioinformatics have opened the way for great strides in understanding. Recent research employing a wide variety of bioinformatic approaches has demonstrated that retroviruses evolved during the early Palaeozoic Era, between 460 and 550 million years ago, providing the oldest inferred date estimate for any virus group. This finding presents an important framework to investigate the evolutionary transitions that led to the emergence of the retroviruses, offering potential insights into the infectious origins of a major group of pathogenic viruses.

journal_name

Curr Opin Virol

authors

Hayward A

doi

10.1016/j.coviro.2017.06.006

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

23-27

eissn

1879-6257

issn

1879-6265

pii

S1879-6257(17)30041-X

journal_volume

25

pub_type

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