Abstract：
:Human alphaherpesviruses (αHHV) - herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV) - infect mucosal epithelial cells, establish a lifelong latent infection of sensory neurons, and reactivate intermittingly to cause recrudescent disease. Although chronic αHHV infections co-exist with brisk T-cell responses, T-cell immune suppression is associated with worsened recurrent infection. Induction of αHHV-specific T-cell immunity is complex and results in poly-specific CD4 and CD8 T-cell responses in peripheral blood. Specific T-cells are localized to ganglia during the chronic phase of HSV infection and to several infected areas during recurrences, and persist long after viral clearance. These recent advances hold promise in the design of new vaccine candidates.
journal_name
Curr Opin Viroljournal_title
Current opinion in virologyauthors
Ouwendijk WJ,Laing KJ,Verjans GM,Koelle DMdoi
10.1016/j.coviro.2013.04.004subject
Has Abstractpub_date
2013-08-01 00:00:00pages
452-60issue
4eissn
1879-6257issn
1879-6265pii
S1879-6257(13)00056-4journal_volume
3pub_type
杂志文章,评审abstract：:Memory T cells are an important component of the adaptive immune response. Tissue-resident memory T cells (TRM) are a recently described subset of memory T cells that reside in peripheral tissues and are maintained independently of circulating subsets of memory T cells. Importantly, TRM are frequently found in barrier...
journal_title：Current opinion in virology
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.10.001
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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更新日期：2014-10-01 00:00:00
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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abstract：:The central nervous system (CNS) is an immunologically specialized organ where restrictive barrier structures protect the parenchyma from inflammation and infection. This protection is important in preventing damage to non-renewable resident cell populations, such as neurons, responsible for functions ranging from exe...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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abstract：:Evolution has equipped plants with defense mechanisms to counterattack virus infections. However, some viruses have acquired the capacity to escape these defense barriers. In their combats, plants use mechanisms such as antiviral RNA silencing that viruses fight against using silencing-repressors. Plants could also re...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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abstract：:Model systems show that papillomavirus DNA can persist after lesion-regression, and be maintained in a subset of epithelial basal cells. These are very likely long-lived 'stem-cells' or 'stem-like cells', with latency arising via at least two distinct mechanisms. The first involves low-titre virus infection and the re...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2013.06.003
更新日期：2013-08-01 00:00:00
