Abstract:
:Pathogens such as the human immunodeficiency virus (HIV), the hepatitis B and C virus (HBV, HCV) and certain strains of the rodent lymphocytic choriomeningitis virus (LCMV) establish a state of persisting viral replication. This occurs besides strong adoptive immune responses and the induction of large numbers of activated pathogen-specific T-cells. The failure of the immune system to clear these viruses is typically attributed to a loss of effector T-cell function-a phenomenon referred to as T-cell exhaustion. Though largely accepted, this loss of function concept is being more and more challenged by comprehensive clinical and experimental observations which highlight that T-cells in chronic infections are more functional than previously considered. Here, we highlight examples that demonstrate that such T-cells mediate a profound form of immune-surveillance. We also briefly discuss the opportunities and limitations of employing 'exhausted' T-cells for therapeutic purposes.
journal_name
Curr Opin Viroljournal_title
Current opinion in virologyauthors
Zehn D,Utzschneider DT,Thimme Rdoi
10.1016/j.coviro.2016.01.002subject
Has Abstractpub_date
2016-02-01 00:00:00pages
49-54eissn
1879-6257issn
1879-6265pii
S1879-6257(16)00005-5journal_volume
16pub_type
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2013.08.013
更新日期:2013-12-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2015.12.001
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2016.06.007
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2011.12.005
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2015.06.006
更新日期:2015-08-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2018.11.005
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
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更新日期:2019-12-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2015.08.010
更新日期:2015-10-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2014.09.012
更新日期:2014-12-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2013.06.003
更新日期:2013-08-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2015.08.001
更新日期:2015-12-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2011.10.016
更新日期:2011-12-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2012.02.017
更新日期:2012-06-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章
doi:10.1016/j.coviro.2011.10.026
更新日期:2011-12-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2013.06.015
更新日期:2013-08-01 00:00:00
abstract::In recent years there have been significant advances in our understanding of the ER stress responses in plants that are associated with virus infection, as well as bacterial and fungal diseases. In plants, ER stress induced by virus infection includes several signaling pathways that include the unfolded protein respon...
journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2020.11.001
更新日期:2020-12-21 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2017.11.010
更新日期:2017-12-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2016.09.007
更新日期:2016-12-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2020.02.007
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2012.06.004
更新日期:2012-08-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2016.08.011
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abstract::Dengue is a potentially fatal viral disease for which treatment is limited to supportive care, and prevention and control are based on mosquito vector control programs. It is the fastest growing arboviral infection and is currently endemic in more than 100 tropical and subtropical countries, placing over 40% of the wo...
journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2013.05.014
更新日期:2013-06-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2012.04.005
更新日期:2012-08-01 00:00:00
abstract::The last two decades have witnessed the increasing instrumentalization of viruses, which have progressively evolved into highly potent gene transfer vehicles for a wide spectrum of applications. In the context of the central nervous system (CNS), their unique gene delivery features and targeting specificities have bee...
journal_title:Current opinion in virology
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
abstract::Viruses can suffer 'life-history' trade-offs that prevent simultaneous improvement in fitness traits, such as improved intrahost reproduction at the expense of reduced extrahost survival. Here we examine reproduction-survival trade-offs and other trait compromises, highlighting that experimental evolution can reveal t...
journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2014.07.005
更新日期:2014-10-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
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abstract::The bovine leukemia virus (BLV) is a retrovirus inducing an asymptomatic and persistent infection in ruminants and leading in a minority of cases to the accumulation of B-lymphocytes (lymphocytosis, leukemia or lymphoma). Although the mechanisms of oncogenesis are still largely unknown, there is clear experimental evi...
journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2017.06.012
更新日期:2017-10-01 00:00:00
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2016.09.005
更新日期:2016-10-01 00:00:00