Rhabdoviruses as vectors for vaccines and therapeutics.

Abstract:

:Appropriate choice of vaccine vector is crucial for effective vaccine development. Rhabdoviral vectors, such as rabies virus and vesicular stomatitis virus, have been used in a variety of vaccine strategies. These viruses have small, easily manipulated genomes that can stably express foreign glycoproteins due to a well-established reverse genetics system for virus recovery. Both viruses have well-described safety profiles and have been demonstrated to be effective vaccine vectors. This review will describe how these Rhabdoviruses can be manipulated for use as vectors, their various applications as vaccines or therapeutics, and the advantages and disadvantages of their use.

journal_name

Curr Opin Virol

authors

Scher G,Schnell MJ

doi

10.1016/j.coviro.2020.09.003

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

169-182

eissn

1879-6257

issn

1879-6265

pii

S1879-6257(20)30093-6

journal_volume

44

pub_type

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