Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential.

Abstract:

:Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be involved in tumorigenesis. Like other human polyomaviruses, MCPyV is highly prevalent in the healthy population, yet the MCPyV-associated Merkel cell carcinoma (MCC) is a very rare disease. Although in vitro and in vivo models have provided significant details regarding molecular functions of viral oncoproteins during cellular transformation, many open questions about the natural life cycle of the virus, its mechanisms of persistence and the precise role of MCPyV during MCC pathogenesis remain. This review will carve out the specifics of MCPyV biology and discuss unresolved issues to help the reader gain a better understanding of what may differentiate MCPyV from other polyomaviruses.

journal_name

Curr Opin Virol

authors

Grundhoff A,Fischer N

doi

10.1016/j.coviro.2015.08.010

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

129-37

eissn

1879-6257

issn

1879-6265

pii

S1879-6257(15)00129-7

journal_volume

14

pub_type

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