Abstract:
:Progress in the identification of suitable animal models for human herpesvirus (HHV)-6A and HHV-6B infections has been slow. Recently, new models have been established, mainly for HHV-6A, which reproduce some pathological features seen in humans. Neuroinflammatory signs were observed in infected marmosets and CD46-transgenic mice; although viral replication was not prominent, persistence of viral DNA and specific immunologic responses were detected, suggesting an immune-mediated pathogenic mechanism. Pig-tailed macaques showed robust viral replication concomitant with acute-phase symptoms, and provided a model to study the effects of HHV-6A on AIDS progression. In humanized mice, viral replication was less evident, but infection led to T-cell alterations. Altogether, these recent developments have opened new perspectives for studying the pathogenic role of HHV-6A in humans.
journal_name
Curr Opin Viroljournal_title
Current opinion in virologyauthors
Horvat B,Berges BK,Lusso Pdoi
10.1016/j.coviro.2014.09.012subject
Has Abstractpub_date
2014-12-01 00:00:00pages
97-103eissn
1879-6257issn
1879-6265pii
S1879-6257(14)00192-8journal_volume
9pub_type
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journal_title:Current opinion in virology
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abstract::Effective vaccines are the cornerstone of our defenses against acute influenza virus infections that result in ∼500 000 annual deaths worldwide. For decades, an on-going concerted effort has been to develop a universal influenza vaccine to combat the looming threat of potentially pandemic emerging and re-emerging infl...
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