Abstract：
:Broadly neutralizing antibodies (bnAbs) are potential therapeutic molecules and valuable tools for studying conserved viral targets for vaccine and drug design. Interestingly, antibody responses to conserved epitopes can be highly convergent at the molecular level. Human antibodies targeting a number of viral antigens have often been found to utilize a restricted set of immunoglobulin germline genes in different individuals. Here we review recent knowledge on VH1-69-encoded antibodies in antiviral responses to influenza virus, HCV, and HIV-1. These antibodies share common genetic and structural features, and often develop neutralizing activity against a broad spectrum of viral strains. Understanding the genetic and structural characteristics of such antibodies and the target epitopes should help advance novel strategies to elicit bnAbs through vaccination.
journal_name
Curr Opin Viroljournal_title
Current opinion in virologyauthors
Chen F,Tzarum N,Wilson IA,Law Mdoi
10.1016/j.coviro.2019.02.004subject
Has Abstractpub_date
2019-02-01 00:00:00pages
149-159eissn
1879-6257issn
1879-6265pii
S1879-6257(18)30102-0journal_volume
34pub_type
杂志文章,评审abstract：:The generation of humanized mouse models in which immune deficient mice are engrafted with human tissues allows for the direct in vivo investigation of human-restricted viruses. These humanized mouse models have been developed and improved over the past 30 years. It is now possible to achieve high levels of human cell...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.06.006
更新日期：2015-08-01 00:00:00
abstract：:A number of new vaccines are being developed against microbial pathogens that might be used as bioweapons. For some of these vaccines, because of the lack of endemic disease and the lethal nature of the disease, human efficacy studies would not be ethical or feasible to conduct. In such cases, a regulation, known as t...
journal_title：Current opinion in virology
pub_type： 杂志文章
doi：10.1016/j.coviro.2012.01.004
更新日期：2012-06-01 00:00:00
abstract：:High-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are s...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2019.07.002
更新日期：2019-12-01 00:00:00
abstract：:Viruses can suffer 'life-history' trade-offs that prevent simultaneous improvement in fitness traits, such as improved intrahost reproduction at the expense of reduced extrahost survival. Here we examine reproduction-survival trade-offs and other trait compromises, highlighting that experimental evolution can reveal t...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.07.005
更新日期：2014-10-01 00:00:00
abstract：:Biological invasions occur when plants, animals, or microbes are introduced to a new geographic region, then spread and have negative consequences for the local ecosystem. Across both plant and animal hosts, viruses can play diverse roles in biological invasions. First, viruses can either decrease or increase the impa...
journal_title：Current opinion in virology
pub_type： 杂志文章
doi：10.1016/j.coviro.2011.05.018
更新日期：2011-07-01 00:00:00
abstract：:Latent HIV reservoirs are the greatest challenge facing an HIV cure. Here, we review recent evidence supporting an important role for the host immune response, in particular HLA class I-restricted CD8+ T lymphocytes, in modulating HIV reservoirs during natural infection. These observations indicate that factors govern...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2012.08.003
更新日期：2012-10-01 00:00:00
abstract：:Developing antiviral drugs is challenging due to the small number of targets in viruses, and the rapid evolution of viral genes. Animals have evolved a number of efficient antiviral defence mechanisms, which can serve as a source of inspiration for novel therapies. The genetically tractable insect Drosophila belongs t...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.09.005
更新日期：2016-10-01 00:00:00
abstract：:Progress in the identification of suitable animal models for human herpesvirus (HHV)-6A and HHV-6B infections has been slow. Recently, new models have been established, mainly for HHV-6A, which reproduce some pathological features seen in humans. Neuroinflammatory signs were observed in infected marmosets and CD46-tra...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.09.012
更新日期：2014-12-01 00:00:00
abstract：:West Nile virus remains the most common cause of arboviral encephalitis in North America. Since it was introduced, it has undergone adaptive genetic change as it spread throughout the continent. The WNV transmission cycle is relatively tractable in the laboratory. Thus the virus serves as a convenient model system for...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.09.007
更新日期：2016-12-01 00:00:00
abstract：:Changes in host range are central to virus emergence. Host range, together with its evolution, is determined by virus intrinsic factors, such as genetic traits determining its fitness in different hosts. Experimental analyses have shown the relevance in host range evolution of across-host fitness trade-offs. Host rang...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2018.12.003
更新日期：2019-02-01 00:00:00
abstract：:Next generation sequencing (NGS) technologies provide an increasingly important avenue for detecting known viruses, and for discovering novel viruses present in clinical or environmental samples. Several computational pipelines capable of identifying and classifying viral sequences in NGS data have been developed and ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2019.07.010
更新日期：2019-12-01 00:00:00
abstract：:A model is described that predicts patterns of polyomavirus SV40 infections and associated cancers in humans. The model proposes that SV40 infections were established in humans primarily by exposure to contaminated oral poliovaccines and that infections persist today in geographic regions where poor sanitation or livi...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2012.06.004
更新日期：2012-08-01 00:00:00
abstract：:The aetiologic association between infection with certain human papillomavirus (HPV) types, high-grade squamous neoplasia, and cancer at different epithelial sites is well established. In this review we briefly discuss recent breakthroughs in the regulation of squamous epithelia in homeostasis and disease, and provide...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.08.011
更新日期：2016-10-01 00:00:00
abstract：:The Bunyavirales order is the largest group of RNA viruses, which includes important human and animal pathogens, that cause serious diseases. Licensed vaccines are often not available for many of these pathogens. The establishment of bunyavirus reverse genetics systems has facilitated the generation of recombinant inf...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.05.004
更新日期：2020-10-01 00:00:00
abstract：:A common characteristic of virus capsids is icosahedral symmetry, yet these highly symmetric structures can display asymmetric features within their virions and undergo asymmetric dynamics. The fields of structural and computational biology have entered a new realm in the investigation of virus infection mechanisms, w...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.06.002
更新日期：2020-12-01 00:00:00
abstract：:The rVSV-ZEBOV vaccine is currently the only Ebola vaccine with demonstrated clinical efficacy in a ring-vaccination clinical trial. It has been shown to be reactogenic but immunogenic and safe in several Phase I clinical studies. However, its mechanisms of protection are unknown and available immunogenicity data are ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.03.008
更新日期：2017-04-01 00:00:00
abstract：:The ability to recognize invading viral pathogens and to distinguish their components from those of the host cell is critical to initiate the innate immune response. The efficiency of this detection is an important factor in determining the susceptibility of the cell to viral infection. Innate sensing of viruses is, t...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.11.012
更新日期：2017-02-01 00:00:00
abstract：:Productive virus infection depends upon delivery of viral genomic material into the host cell cytoplasm. The tails of bacteriophages recognize host cells and mediate host cell wall and membrane penetration. Recent cryo-electron microscopy studies have revealed near atomic-resolutions structures of the entire or almost...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.09.002
更新日期：2020-12-01 00:00:00
abstract：:Viruses are ubiquitous parasites of cellular life forms and the most abundant biological entities on earth. The relationships between viruses and their hosts involve the continuous arms race but are by no account limited to it. Growing evidence shows that, in the course of evolution, viruses and their components are r...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2018.07.011
更新日期：2018-08-01 00:00:00
abstract：:Dengue virus is the causative agent of dengue virus fever. It infects about 400 million people per year and leads to about 21,000 deaths annually. There is available neither a fully successful vaccine nor a successful drug therapy. Some dengue virus serotypes undergo a temperature dependent conformational change from ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.04.006
更新日期：2015-06-01 00:00:00
abstract：:Noroviruses are a leading cause of gastroenteritis outbreaks globally. Several lines of evidence indicate that noroviruses can antagonize or evade host immune responses, including the absence of long-lasting immunity elicited during a primary norovirus exposure and the ability of noroviruses to establish prolonged inf...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.11.005
更新日期：2016-02-01 00:00:00
abstract：:In 2015-2016, the little known Zika virus (ZIKV) caused an epidemic, in which it became recognized as a unique human pathogen associated with a range of devastating congenital abnormalities collectively categorized as congenital Zika syndrome (CZS). In adults, the virus can trigger the autoimmune disorder Guillain-Bar...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.05.002
更新日期：2020-10-01 00:00:00
abstract：:Structural information can inform our understanding of virus origins and evolution. The herpesviruses and tailed bacteriophages constitute two large families of dsDNA viruses which infect vertebrates and prokaryotes respectively. A relationship between these disparate groups was initially suggested by similarities in ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.02.003
更新日期：2014-04-01 00:00:00
abstract：:In a prototypical response to an acute viral infection it would be expected that the adaptive immune response would eliminate all virally infected cells within a few weeks of infection. However many (non-retrovirus) RNA viruses can establish 'within host' persistent infections that occasionally lead to chronic or reac...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.03.001
更新日期：2017-04-01 00:00:00
abstract：:Model systems show that papillomavirus DNA can persist after lesion-regression, and be maintained in a subset of epithelial basal cells. These are very likely long-lived 'stem-cells' or 'stem-like cells', with latency arising via at least two distinct mechanisms. The first involves low-titre virus infection and the re...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2013.06.003
更新日期：2013-08-01 00:00:00
abstract：:We compare the design, mechanism of action, and clinical efficacy of two recently licensed paradigm shifting vaccines. Zostavax is the first vaccine licensed to prevent disease in patients already infected with a pathogen, and is contrasted with Gardasil and Cervarix, the first vaccines designed and licensed specifica...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2011.07.007
更新日期：2011-10-01 00:00:00
abstract：:Teratogenic viruses have increased public health importance with the emergence of Zika virus and a recent decline in rubella virus vaccination. Of the seven viruses known to cause birth defects in humans, three are mosquito-borne pathogens. Ethical oversight, compliance, rising costs, and the need for specialized trai...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.11.010
更新日期：2017-12-01 00:00:00
abstract：:Morbilliviruses are pathogens of humans and other animals. Live attenuated morbillivirus vaccines have been used to end endemic transmission of measles virus (MV) in many parts of the developed world and to eradicate rinderpest virus. Entry is mediated by two different receptors which govern virus lymphotropism and ep...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.01.019
更新日期：2016-02-01 00:00:00
abstract：:DNA is potently immunostimulatory, and self-DNA is packaged in the nucleus or mitochondria allowing it to remain silent to cell-intrinsic sensors. However, damaged or mislocalised self-DNA is sensed by our innate immune systems, resulting in the production of type I interferons (IFNI), chemokines and inflammatory cyto...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.08.001
更新日期：2015-12-01 00:00:00
abstract：:Dengue is the most important arboviral disease world-wide with an estimated 400 million annual infections. Dengvaxia™ is a live attenuated tetravalent vaccine recently licensed for dengue seropositive individuals aged 9-45 years. There is great need for a dengue vaccine that could be given to dengue-naïve individuals ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.09.005
更新日期：2020-08-01 00:00:00
