Abstract：
:Multicomponent viral systems face specific challenges when enduring population bottlenecks. These systems can lose coding information due to the lack of co-encapsidation of all the genetic information, at least in a proportion of the capsids in a population. Moreover, bottlenecks can also impact one of the main potential advantages of multicomponent systems: the regulation of gene expression through changes in gene copy frequencies at the population level. How these systems cope with population bottlenecks is far from being clear. Here, two non-exclusive scenarios are described. In the first scenario, population bottlenecks during host infection allow for the isolation of within-host populations with different gene frequencies, leaving the door opened for the selection of populations with adaptive gene frequencies. The second scenario postulates that viruses could influence bottleneck size, at least at certain steps of their life cycle, to limit random changes in gene frequencies. Examples of viral mechanism impacting bottleneck size at cell infection are available and, intriguingly, they can lead to either increases or reductions in bottleneck size. This situation opens the way for putative trade-offs on both gene frequencies and bottleneck sizes that could differ among multicomponent systems.
journal_name
Curr Opin Viroljournal_title
Current opinion in virologyauthors
Gutiérrez S,Zwart MPdoi
10.1016/j.coviro.2018.09.001subject
Has Abstractpub_date
2018-12-01 00:00:00pages
184-190eissn
1879-6257issn
1879-6265pii
S1879-6257(18)30026-9journal_volume
33pub_type
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
pub_type： 杂志文章,评审
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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journal_title：Current opinion in virology
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abstract：:Epicutaneous delivery of vaccinia virus (VacV) by scarification of the skin generates robust and durable protective immunity, which was ultimately responsible for eradicating smallpox from the human race. Therefore, infection of the skin with VacV is often used in experimental model systems to study the activation of ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.10.001
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