Abstract：
:Recently, a lateral flow rapid diagnostic test (RDT) with good accuracy has been described. This test enables measles specific IgM antibody detection in serum, capillary blood and oral fluid. RDTs have the potential to transform measles surveillance by allowing real-time case confirmation outside of central/regional laboratories and by facilitating a timely public health response. Measles virus genes can also be amplified and sequenced consistently from dried IgM-positive RDTs stored outside of cold chain, which will enable more complete virologic surveillance. Critical questions remain regarding operational use of RDTs as part of global measles surveillance. Projects to evaluate RDT use as part of national surveillance programs and to commercialize the RDT are underway.
journal_name
Curr Opin Viroljournal_title
Current opinion in virologyauthors
Brown DW,Warrener L,Scobie HM,Donadel M,Waku-Kouomou D,Mulders MN,Rota PAdoi
10.1016/j.coviro.2020.05.007subject
Has Abstractpub_date
2020-04-01 00:00:00pages
77-84eissn
1879-6257issn
1879-6265pii
S1879-6257(20)30028-6journal_volume
41pub_type
杂志文章,评审abstract：:Noroviruses are a leading cause of gastroenteritis outbreaks globally. Several lines of evidence indicate that noroviruses can antagonize or evade host immune responses, including the absence of long-lasting immunity elicited during a primary norovirus exposure and the ability of noroviruses to establish prolonged inf...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.11.005
更新日期：2016-02-01 00:00:00
abstract：:The rate of new virus discovery is increasing dramatically with improvements in sequencing and other molecular diagnostic platforms, and investments in sample collection and analysis. However, progress has been more limited in identification and implication of infectious agents that pose threats to human health and we...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2011.10.010
更新日期：2011-12-01 00:00:00
abstract：:Genetic recombination facilitates the transfer of genetic information in a parasexual reproduction manner even between distantly related species. Within the Geminiviridae family, a group of plant-infecting viruses that severely constrain cropping systems worldwide, it is highly suspected that recombination was pivotal...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.12.005
更新日期：2015-02-01 00:00:00
abstract：:Measles caused an estimated minimum of one million fatalities annually before vaccination. Outstanding progress towards controlling the virus has been made since the measles vaccine was introduced, but reduction of measles case-fatalities has stalled at around 100,000 annually for the last decade and a 2019 resurgence...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.02.007
更新日期：2020-04-01 00:00:00
abstract：:All known gammaherpesviruses encode at least one conserved tegument protein that contains sequence homology to the cellular purine biosynthesis enzyme: phosphoribosylformylglycineamide amidotransferase (FGARAT, or PFAS). While no enzymatic activity have been found on these viral FGARAT-homology proteins (vFGARAT), the...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.07.008
更新日期：2015-10-01 00:00:00
abstract：:Once considered an inevitable consequence of HIV treatment, drug resistance is declining. This decline supports the hypothesis that antiretroviral therapy can arrest replication and prevent the evolution of resistance. Further support comes from excellent clinical outcomes, the failure of treatment intensification to ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2013.08.007
更新日期：2013-10-01 00:00:00
abstract：:Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be involved in tumorigenesis. Like other human polyomaviruses, MCPyV is highly prevalent in the healthy population, yet the MCPyV-associated Merkel cell carcinoma (MCC) is a very rare disease. Although in vitro and in vivo models have provided si...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.08.010
更新日期：2015-10-01 00:00:00
abstract：:Dengue is the most important arboviral disease world-wide with an estimated 400 million annual infections. Dengvaxia™ is a live attenuated tetravalent vaccine recently licensed for dengue seropositive individuals aged 9-45 years. There is great need for a dengue vaccine that could be given to dengue-naïve individuals ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.09.005
更新日期：2020-08-01 00:00:00
abstract：:Noroviruses are rapidly evolving RNA viruses and are generally known as the main cause of viral gastroenteritis worldwide. Particle stability is of special interest as transmission occurs via the faecal-oral route and virions are able to persist in the environment. Studies on norovirus capsid assembly and disassembly ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2018.05.003
更新日期：2018-08-01 00:00:00
abstract：:The ability to recognize invading viral pathogens and to distinguish their components from those of the host cell is critical to initiate the innate immune response. The efficiency of this detection is an important factor in determining the susceptibility of the cell to viral infection. Innate sensing of viruses is, t...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.11.012
更新日期：2017-02-01 00:00:00
abstract：:Productive virus infection depends upon delivery of viral genomic material into the host cell cytoplasm. The tails of bacteriophages recognize host cells and mediate host cell wall and membrane penetration. Recent cryo-electron microscopy studies have revealed near atomic-resolutions structures of the entire or almost...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.09.002
更新日期：2020-12-01 00:00:00
abstract：:The direct electron detector has revolutionized electron cryo-microscopy (CryoEM). Icosahedral virus structures are routinely produced at 4Å resolution or better and the approach has largely displaced virus crystallography, as it requires less material, less purity and often produces a structure more rapidly. Largely ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.02.011
更新日期：2016-06-01 00:00:00
abstract：:Recent technological advances have led to an explosion in the system-wide profiling of biological processes in the study of herpesvirus biology, herein referred to as '-omics'. In many cases these approaches have revealed novel virus-induced changes to host cell biology that can be targeted with new antiviral therapeu...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.09.021
更新日期：2014-12-01 00:00:00
abstract：:The bovine leukemia virus (BLV) is a retrovirus inducing an asymptomatic and persistent infection in ruminants and leading in a minority of cases to the accumulation of B-lymphocytes (lymphocytosis, leukemia or lymphoma). Although the mechanisms of oncogenesis are still largely unknown, there is clear experimental evi...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.06.012
更新日期：2017-10-01 00:00:00
abstract：:Pathogens such as the human immunodeficiency virus (HIV), the hepatitis B and C virus (HBV, HCV) and certain strains of the rodent lymphocytic choriomeningitis virus (LCMV) establish a state of persisting viral replication. This occurs besides strong adoptive immune responses and the induction of large numbers of acti...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2016.01.002
更新日期：2016-02-01 00:00:00
abstract：:We compare the design, mechanism of action, and clinical efficacy of two recently licensed paradigm shifting vaccines. Zostavax is the first vaccine licensed to prevent disease in patients already infected with a pathogen, and is contrasted with Gardasil and Cervarix, the first vaccines designed and licensed specifica...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2011.07.007
更新日期：2011-10-01 00:00:00
abstract：:Teratogenic viruses have increased public health importance with the emergence of Zika virus and a recent decline in rubella virus vaccination. Of the seven viruses known to cause birth defects in humans, three are mosquito-borne pathogens. Ethical oversight, compliance, rising costs, and the need for specialized trai...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.11.010
更新日期：2017-12-01 00:00:00
abstract：:In a prototypical response to an acute viral infection it would be expected that the adaptive immune response would eliminate all virally infected cells within a few weeks of infection. However many (non-retrovirus) RNA viruses can establish 'within host' persistent infections that occasionally lead to chronic or reac...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.03.001
更新日期：2017-04-01 00:00:00
abstract：:Viral proteins have enabled the design of selective and efficacious treatments for viral diseases. While focus in this area has been on viral enzymes, it appears that multifunctional viral proteins may be even more susceptible to small molecule interference. As exemplified by HIV capsid, small molecule inhibitors can ...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.02.002
更新日期：2014-04-01 00:00:00
abstract：:A model is described that predicts patterns of polyomavirus SV40 infections and associated cancers in humans. The model proposes that SV40 infections were established in humans primarily by exposure to contaminated oral poliovaccines and that infections persist today in geographic regions where poor sanitation or livi...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2012.06.004
更新日期：2012-08-01 00:00:00
abstract：:Model systems show that papillomavirus DNA can persist after lesion-regression, and be maintained in a subset of epithelial basal cells. These are very likely long-lived 'stem-cells' or 'stem-like cells', with latency arising via at least two distinct mechanisms. The first involves low-titre virus infection and the re...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2013.06.003
更新日期：2013-08-01 00:00:00
abstract：:High-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are s...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2019.07.002
更新日期：2019-12-01 00:00:00
abstract：:A number of new vaccines are being developed against microbial pathogens that might be used as bioweapons. For some of these vaccines, because of the lack of endemic disease and the lethal nature of the disease, human efficacy studies would not be ethical or feasible to conduct. In such cases, a regulation, known as t...
journal_title：Current opinion in virology
pub_type： 杂志文章
doi：10.1016/j.coviro.2012.01.004
更新日期：2012-06-01 00:00:00
abstract：:Evolution has equipped plants with defense mechanisms to counterattack virus infections. However, some viruses have acquired the capacity to escape these defense barriers. In their combats, plants use mechanisms such as antiviral RNA silencing that viruses fight against using silencing-repressors. Plants could also re...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2015.12.001
更新日期：2016-04-01 00:00:00
abstract：:The evolution of virulence has been studied from a number of theoretical perspectives, and a few experimental systems. Although there is no consensus on an overarching framework that covers all situations, the 'trade-off' hypothesis is a useful framework for examining the nature of symbiotic relationships between viru...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2012.06.010
更新日期：2012-10-01 00:00:00
abstract：:The central nervous system (CNS) is an immunologically specialized organ where restrictive barrier structures protect the parenchyma from inflammation and infection. This protection is important in preventing damage to non-renewable resident cell populations, such as neurons, responsible for functions ranging from exe...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2017.12.003
更新日期：2018-02-01 00:00:00
abstract：:The human roseoloviruses, human herpesviruses 6A (HHV-6A), HHV-6B, and HHV-7, are highly prevalent viruses that typically cause fever/rash illnesses such as roseola during early life primary infections. They also cause significant neurologic disease and complications following stem cell and solid organ transplantation...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：:Despite remarkable therapeutic advances in the past two decades, the elimination of human immunodeficiency virus type 1 (HIV-1) from latent reservoirs constitutes a major barrier to eradication and preventing neurological disease associated with HIV/AIDS. Invasion of the central nervous system (CNS) by HIV-1 occurs ea...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2019.06.004
更新日期：2019-10-01 00:00:00
abstract：:Appropriate choice of vaccine vector is crucial for effective vaccine development. Rhabdoviral vectors, such as rabies virus and vesicular stomatitis virus, have been used in a variety of vaccine strategies. These viruses have small, easily manipulated genomes that can stably express foreign glycoproteins due to a wel...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.09.003
更新日期：2020-10-01 00:00:00
abstract：:The Bunyavirales order is the largest group of RNA viruses, which includes important human and animal pathogens, that cause serious diseases. Licensed vaccines are often not available for many of these pathogens. The establishment of bunyavirus reverse genetics systems has facilitated the generation of recombinant inf...
journal_title：Current opinion in virology
pub_type： 杂志文章,评审
doi：10.1016/j.coviro.2020.05.004
更新日期：2020-10-01 00:00:00
