abstract：:This manuscript explores the ethics of human inoculation experiments in young healthy adults with wild-type severe acute respiratory sydrome coronavirus 2 (SARS-CoV-2) as a tool to evaluate vaccine efficacy in the context of the Nuremberg Code, the Declaration of Helsinki, and the Belmont Report, and in the context of...

journal_title：Open forum infectious diseases

authors： Spinola SM,Broderick C,Zimet GD,Ott MA

更新日期：2020-12-28 00:00:00

abstract：Background:Dengue and Chikungunya viruses can cause large-scale epidemics, with attack rates of up to 80%. In Tanzania, there have been repeated outbreaks of dengue fever, the most recent in 2018 and 2019, mostly affecting the coastal areas. Despite the importance of these viruses, there is limited knowledge on the epi...

journal_title：Open forum infectious diseases

authors： Chipwaza B,Sumaye RD,Weisser M,Gingo W,Yeo NK,Amrun SN,Okumu FO,Ng LFP

更新日期：2020-12-26 00:00:00

abstract：Background:Staphylococcus aureus is the most common cause of native septic arthritis. Few studies have characterized this disease during the US opioid epidemic. The role of methicillin-resistant Staphylococcus aureus (MRSA) nasal screening in this disease has not been elucidated. We sought to identify risk factors and ...

journal_title：Open forum infectious diseases

authors： Gobao VC,Alfishawy M,Smith C,Byers KE,Yassin M,Urish KL,Shah NB

更新日期：2020-12-18 00:00:00

abstract：:The Democratic Republic of the Congo (DRC) has begun implementing HIV self-testing to boost the first "95" of the UNAIDS 95-95-95 targets by 2025. This study aims to assess the performance and usability of the Exacto Test HIV (Biosynex, Strasbourg, France) self-test in the lab and in the field. The Exacto Test HIV sel...

journal_title：Open forum infectious diseases

authors： Tonen-Wolyec S,Muwonga Masidi J,Kamanga Lukusa LF,Nsiku Dikumbwa G,Sarassoro A,Bélec L

更新日期：2020-11-29 00:00:00

abstract：:Peritoneal dialysis (PD)-associated peritonitis constitutes a major complication associated with the procedure. PD-associated peritonitis caused by nontuberculous mycobacteria, usually as a result of an infection related to the PD catheter, has been reported in adults and is associated with significant complications a...

journal_title：Open forum infectious diseases

authors： Imam O,Al-Zubaidi K,Janahi M,Imam A,Leghrouz B,Dobson S,Sundararaju S,Tsui KM,Hasan MR,Perez-Lopez A

更新日期：2020-11-27 00:00:00

abstract：Background:Cryptococcal meningitis is a major cause of death among people with human immunodeficiency virus (PWH). Cryptococcal antigen (CrAg) testing of asymptomatic patients is an important public health measure to reduce mortality in high-incidence areas. However, limited data exist on CrAg prevalence in Central Ame...

journal_title：Open forum infectious diseases

authors： Zuniga-Moya JC,Romero-Reyes LE,Saavedra EB,Montoya S,Varela D,Borjas M,Cerna A,Bejarano S,Martinez P,Lujan K,Erazo K,Lainez I,Pineda L,Yanes D,O'Halloran JA,Spec A

更新日期：2020-11-13 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an increasingly recognized cause of acute respiratory infection (ARI) in adults. We compared the crude in-hospital mortality of patients with RSV infection alone with that of patients with RSV-bacterial coinfection. Overall, 12 144 hospitalized patients with ARI were screened for R...

journal_title：Open forum infectious diseases

authors： Godefroy R,Giraud-Gatineau A,Jimeno MT,Edouard S,Meddeb L,Zandotti C,Chaudet H,Colson P,Raoult D,Cassir N

更新日期：2020-11-12 00:00:00

abstract：Background:Bacterial and fungal infections (BFIs) are frequent in patients with cirrhosis and often trigger acute-on-chronic liver failure (ACLF). This prospective observational study aims to describe the interactions between BFI and ACLF in terms of mortality and related risk factors. Methods:We performed a 2-center ...

journal_title：Open forum infectious diseases

authors： Bartoletti M,Baldassarre M,Domenicali M,Lewis RE,Giannella M,Antognoli A,Rinaldi M,Zaccherini G,Verucchi G,Marconi L,Tamè M,Berardi S,Napoli L,Siniscalchi A,Fabbri A,Biselli M,Tufoni M,Pavarin RM,Trevisani F,Viale P

更新日期：2020-11-04 00:00:00

abstract：:We investigated the microbial burden on the operating room environment when patients on contact precautions for a multidrug-resistant pathogen received surgery. Our study demonstrated that the perioperative environment was contaminated with aerobic bacteria and methicillin-resistant Staphylococcus aureus (MRSA) after ...

journal_title：Open forum infectious diseases

authors： Kanamori H,Rutala WA,Gergen MF,Weber DJ

更新日期：2020-10-27 00:00:00

abstract：:The role of empirical and even directed antimicrobial management of patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is problematic; antibiotics are used frequently among these patients to treat confirmed or suspected coinfection or just the symptoms. In the rapidly cha...

journal_title：Open forum infectious diseases

authors： Goldstein EJC,Tillotson G,Redell M

更新日期：2020-10-26 00:00:00

abstract：Background:Rates of hepatitis C virus (HCV) among women of childbearing age have increased as a result of the opioid epidemic, especially in the nonurban white population. Recently updated US Preventative Services Task Force and Centers for Disease Control and Prevention guidance have recommended universal HCV screenin...

journal_title：Open forum infectious diseases

authors： Kushner T,Park C,Masand D,Wagner B,Grace M,Rosenbluth E,Rodriquez-Rivas C,de la Cruz H,Overbey J,Sperling R

更新日期：2020-10-23 00:00:00

abstract：Background:Nosocomial spread of coronavirus disease 2019 (COVID-19) causes clusters of infection among high-risk individuals. Controlling this spread is critical to reducing COVID-19 morbidity and mortality. We describe an outbreak of COVID-19 in Keio University Hospital, Japan, and its control and propose effective co...

journal_title：Open forum infectious diseases

authors： Harada S,Uno S,Ando T,Iida M,Takano Y,Ishibashi Y,Uwamino Y,Nishimura T,Takeda A,Uchida S,Hirata A,Sata M,Matsumoto M,Takeuchi A,Obara H,Yokoyama H,Fukunaga K,Amagai M,Kitagawa Y,Takebayashi T,Hasegawa N

更新日期：2020-10-22 00:00:00

abstract：Background:Cutaneous leishmaniasis (CL) caused by L. braziliensis is characterized by 1 or multiple well-limited ulcerated lesions. Diabetes mellitus (DM) impairs neutrophil and monocyte function, and there is a report of vegetative lesions in a patient with both diseases in Morocco. Here we evaluate the influence of D...

journal_title：Open forum infectious diseases

authors： Lago AS,Lima FR,Carvalho AM,Sampaio C,Lago N,Guimarães LH,Lago J,Machado PRL,Carvalho LP,Arruda S,Carvalho EM

更新日期：2020-10-19 00:00:00

abstract：:The potential for transmission of severe acute respiratory syndrome coronavirus 2 shed in stool via fecal microbiota transplantation is not yet known, and the effectiveness of various testing strategies to prevent fecal microbiota transplantation-based transmission has also not yet been quantified. In this study, we u...

journal_title：Open forum infectious diseases

authors： Olesen SW,Zaman A,Osman M,Ramakrishna B

更新日期：2020-10-19 00:00:00

abstract：:We present a case of a 20-year-old male who had ambiguous HIV test results after entering new provider care and whose status was later complicated by undetectable viral RNA off antiretroviral therapy (ART). Verifying HIV infection status may occasionally require sensitive DNA testing that might need to be considered i...

journal_title：Open forum infectious diseases

authors： Springer SA,Masciotra S,Johnson JA,Campbell S

更新日期：2020-10-10 00:00:00

abstract：:We report a case of acute weight gain after switching from emtricitabine/tenofovir disoproxil to emtricitabine/tenofovir alafenamide for human immunodeficiency virus pre-exposure prophylaxis. ...

journal_title：Open forum infectious diseases

authors： Selvaraj SV,Bares SH,Havens JP

更新日期：2020-09-24 00:00:00

abstract：Background:From an isolated epidemic, coronavirus disease 2019 has now emerged as a global pandemic. The availability of genomes in the public domain after the epidemic provides a unique opportunity to understand the evolution and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus across the g...

journal_title：Open forum infectious diseases

authors： Banu S,Jolly B,Mukherjee P,Singh P,Khan S,Zaveri L,Shambhavi S,Gaur N,Reddy S,Kaveri K,Srinivasan S,Gopal DR,Siva AB,Thangaraj K,Tallapaka KB,Mishra RK,Scaria V,Sowpati DT

更新日期：2020-09-18 00:00:00

abstract：Background:Oncological patients have several additional risk factors for developing a cardiac implantable electronic device (CIED)-related infection. Therefore, we evaluated the clinical impact of our comprehensive bundle approach that includes the novel minocycline and rifampin antimicrobial mesh (TYRX) for the preven...

journal_title：Open forum infectious diseases

authors： Khalil M,Karimzad K,Durand JB,Malek AE,Raad II,Viola GM

更新日期：2020-09-13 00:00:00

abstract：Background:Short-term recurrence of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) polymerase chain reaction (PCR) in discharged coronavirus disease 2019 (COVID-19) patients attracts the public's concern. This study aimed to determine the clinical and epidemiological result...

journal_title：Open forum infectious diseases

authors： Chen SL,Xu H,Feng HY,Sun JF,Li X,Zhou L,Song WL,Huang SS,He JL,Deng YY,Wang RJ,Fang M

更新日期：2020-09-13 00:00:00

abstract：Background:Residual monocyte activation may contribute to increased risk for endothelial dysfunction and subsequent atherosclerotic cardiovascular diseases (CVDs) among people with HIV (PWH) on antiretroviral therapy (ART). We examined the relationship between monocyte activation and endothelial activation in PWH in Ke...

journal_title：Open forum infectious diseases

authors： Temu TM,Polyak SJ,Zifodya JS,Wanjalla CN,Koethe JR,Masyuko S,Nyabiage J,Kinuthia J,Gervassi AL,Oyugi J,Page S,Farquhar C

更新日期：2020-09-12 00:00:00

abstract：Background:To determine the effectiveness of implementing a locally developed clinical practice guideline (CPG) for antibiotic treatment in adults with community-acquired cellulitis at Siriraj Hospital in Bangkok, Thailand. Methods:The CPG for antibiotic treatment of community-acquired cellulitis was developed based o...

journal_title：Open forum infectious diseases

authors： Sirijatuphat R,Nookeu P,Thamlikitkul V

更新日期：2020-09-07 00:00:00

abstract：:Proper disinfection using adequate disinfecting agents will be necessary for infection control strategies against coronavirus disease 2019 (COVID-19). However, limited guidance exists on effective surface disinfectants or best practices for their use against severe acute respiratory coronavirus 2. We outlined a proces...

journal_title：Open forum infectious diseases

authors： Tyan K,Levin A,Avalos-Pacheco A,Plana D,Rand EA,Yang H,Maliszewski LE,Chylek LA,Atta L,Tye MA,Carmack MM,Oglesby NS,Burgin S,Yu SH,LeBoeuf NR,Kemp JM

更新日期：2020-08-31 00:00:00

abstract：:Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and int...

journal_title：Open forum infectious diseases

authors： Cai CW,Pinyakorn S,Kroon E,de Souza M,Colby DJ,Pankam T,Pattanachaiwit S,Ubolyam S,Rupert A,Lallemand P,Dewar R,Highbarger HC,Ananworanich J,Vasan S,Sereti I

更新日期：2020-08-26 00:00:00

abstract：Background:Few studies have compared the yield of reverse transcription polymerase chain reaction (RT-PCR) assays in nasopharyngeal swabs, oropharyngeal swabs, and sputum for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection. Methods:We conducted an observational study in Beijing Ditan Hospital, C...

journal_title：Open forum infectious diseases

authors： Zhang H,Chen M,Zhang Y,Wen J,Wang Y,Wang L,Guo J,Liu C,Li D,Wang Y,Bai J,Gao G,Wang S,Yang D,Yu F,Yan L,Wan G,Zhang F

更新日期：2020-08-26 00:00:00

abstract：:We assessed the impact of a rapid molecular assay for influenza detection whether outsourced or performed onsite 24/7 in a University Hospital in Paris, France. Shorter median time-to-results (16.8 vs 2.3 hours, P < .05) and an increased rate of adequate prescription of oseltamivir (76.6% vs 95.3%, P < .05) were obser...

journal_title：Open forum infectious diseases

authors： Jacquier H,Péan de Ponfilly G,Chauvin A,Amarsy R,Benmansour H,Hoang-Nguyen DT,Lecorché E,Mesnil C,Mougari F,Munier AL,Salmona M,Berçot B,Le Goff J,Cambau E

更新日期：2020-08-25 00:00:00

abstract：Background:Health departments utilize HIV surveillance data to identify people with HIV (PWH) who need re-linkage to HIV care as part of an approach known as Data to Care (D2C.) The most accurate, effective, and efficient method of identifying PWH for re-linkage is unknown. Methods:We evaluated referral and care conti...

journal_title：Open forum infectious diseases

authors： Sachdev DD,Mara E,Hughes AJ,Antunez E,Kohn R,Cohen S,Scheer S

更新日期：2020-08-21 00:00:00

abstract：:Fast microbiological diagnostics (MDx) are needed to ensure early targeted antimicrobial treatment in sepsis. This systematic review focuses on the impact on antimicrobial management and patient outcomes of MDx for pathogen and resistance gene identification compared with blood cultures. PubMed was searched for clinic...

journal_title：Open forum infectious diseases

authors： D'Onofrio V,Salimans L,Bedenić B,Cartuyvels R,Barišić I,Gyssens IC

更新日期：2020-08-13 00:00:00

abstract：:Among a cohort of men who have sex with men in a pre-exposure prophylaxis (PrEP) adherence trial, syphilis requiring treatment was associated with white coat dosing (increased PrEP adherence immediately preceding study visits) when compared with participants with optimal drug concentrations. The findings highlight the...

journal_title：Open forum infectious diseases

authors： Blair CS,Beymer MR,Kofron RM,Bolan RK,Jordan WC,Haubrich RH,Wohl AR,Landovitz RJ

更新日期：2020-08-07 00:00:00

abstract：Background:The US Food and Drug Administration issued an Emergency Use Authorization for remdesivir use in patients with severe COVID-19. Methods:We utilized data from 2 quaternary acute care hospitals. The outcomes of interest were the impact of remdesivir on in-hospital death by day 28 and time to recovery, clinical...

journal_title：Open forum infectious diseases

authors： Kalligeros M,Tashima KT,Mylona EK,Rybak N,Flanigan TP,Farmakiotis D,Beckwith CG,Sanchez M,Neill M,Johnson JE,Garland JM,Aung S,Byrd KM,O'Brien T,Pandita A,Aridi J,Macias Gil R,Larkin J,Shehadeh F,Mylonakis E

更新日期：2020-08-06 00:00:00

abstract：Background:In December 2018, a large, tertiary, university-affiliated hospital in the Philippines discovered that their legitimate supply chain was infiltrated with counterfeit rabies vaccines. Methods:All vials suspected to be counterfeit were quarantined and surrendered to the Philippine Food and Drug Administration...

journal_title：Open forum infectious diseases

authors： Henson KER,Santiago AAC,Namqui SS

更新日期：2020-07-22 00:00:00

abstract：:This study evaluated health outcomes among people who inject drugs who are infected with hepatitis C virus using an artificial intelligence platform. Mean (SD) cumulative adherence (visual confirmation of administration) was 91.3% (10.5%). Most subjects (88.2%) achieved ≥80% adherence to treatment, and 88.2% (15 of 17...

journal_title：Open forum infectious diseases

authors： Litwin AH,Shafner L,Norton B,Akiyama MJ,Agyemang L,Guzman M,Vera T,Heo M

更新日期：2020-07-20 00:00:00

abstract：Background:We recently reported that the levels of activation, exhaustion, and terminal differentiation within the peripheral T-cell compartment were increased in men who have sex with men (MSM) compared with blood bank donors. During activation and differentiation, T cells undergo metabolic changes to maintain their e...

journal_title：Open forum infectious diseases

authors： Kruize Z,Maurer I,van Dort KA,van den Elshout MAM,Hoornenborg E,Booiman T,Prins M,Kootstra NA

更新日期：2020-07-05 00:00:00

abstract：:Both dengue virus (DENV) and hepatitis C virus (HCV) belong to the Flaviviridae family and could induce hepatitis. We aimed to investigate the interference between them. In total, 515 patients confirmed with dengue fever (DF) were enrolled. Thirty-two patients (6.21%) were seropositive for anti-HCV; 12 of 32 anti-HCV-...

journal_title：Open forum infectious diseases

authors： Liang PC,Chen KY,Huang CH,Chang K,Lu PL,Yeh ML,Huang CF,Huang CI,Hsieh MH,Dai CY,Lin ZY,Chen SC,Chuang WL,Chen YH,Huang JF,Yu ML

更新日期：2020-07-03 00:00:00

abstract：Background:Klebsiella pneumoniae is a bacterial pathogen with increasing rates of resistance to carbapenem antibiotics, but the population structure and genetic drivers of carbapenem-resistant K pneumoniae (CRKP) remain underexplored in developing countries. Carbapenem-resistant K pneumoniae were recently introduced in...

journal_title：Open forum infectious diseases

authors： Roach D,Waalkes A,Abanto J,Zunt J,Cucho C,Soria J,Salipante SJ

更新日期：2020-07-02 00:00:00

abstract：Background:Preventing severe complications of influenza such as hospitalization is a public health priority; however, estimates of influenza vaccine effectiveness (VE) against influenza-associated acute lower respiratory tract infection (LRTI) hospitalizations are limited. We examined influenza VE against influenza-ass...

journal_title：Open forum infectious diseases

authors： Chow EJ,Rolfes MA,Carrico RL,Furmanek S,Ramirez JA,Ferdinands JM,Fry AM,Patel MM

更新日期：2020-06-30 00:00:00

abstract：Background:Plasma gelsolin (pGSN) is an abundant circulating protein quickly consumed by extensive tissue damage. Marked depletion is associated with later poor outcomes in diverse clinical circumstances. Repletion with recombinant human (rhu)-pGSN in animal models of inflammation lessens mortality and morbidity. Meth...

journal_title：Open forum infectious diseases

authors： DiNubile MJ,Levinson SL,Stossel TP,Lawrenz MB,Warawa JM

更新日期：2020-06-19 00:00:00

abstract：Background:Antibiotic stewardship programs (ASPs) are required at every hospital regardless of size. We conducted a qualitative study across different hospital settings to examine perspectives of physician and pharmacist stewards about the dynamics within their team and contextual factors that facilitate the success of...

journal_title：Open forum infectious diseases

authors： Barlam TF,Childs E,Zieminski SA,Meshesha TM,Jones KE,Butler JM,Damschroder LJ,Goetz MB,Madaras-Kelly K,Reardon CM,Samore MH,Shen J,Stenehjem E,Zhang Y,Drainoni ML

更新日期：2020-06-15 00:00:00

abstract：Background:US hematopoietic cell transplantation (HCT) recipients have a low prevalence of latent tuberculosis infection (LTBI), but if latently infected they are at risk for progression to active tuberculosis. At our center, all HCT recipients underwent LTBI testing pretransplant by tuberculin skin testing (TST) until...

journal_title：Open forum infectious diseases

authors： Sosa-Moreno A,Narita M,Spitters C,Swetky M,Podczervinski S,Lind ML,Holmberg L,Liu C,Edelstein R,Pergam SA

更新日期：2020-06-10 00:00:00

abstract：Background:The Affordable Care Act's (ACA's) major reforms started in 2014. In addition to assessing HIV clinicians' ACA knowledge and attitudes, this study aims to evaluate HIV clinicians' perspectives on whether the ACA has impacted the quality of HIV care and whether it addresses the main barriers to HIV care. Meth...

journal_title：Open forum infectious diseases

authors： McManus KA,Ferey J,Farrell E,Dillingham R

更新日期：2020-06-10 00:00:00

abstract：:Suspicion of an infection without localizing signs or symptoms is a common problem. A chest x-ray (CXR) is often performed to rule out pneumonia. Our prospective cross-sectional study suggests that a CXR has no diagnostic value in patients without respiratory signs or symptoms, if a reliable medical history can be obt...

journal_title：Open forum infectious diseases

authors： de Stoppelaar SF,Pereverzeva L,Hafkamp B,Lips N,Tielbeke F,Rustenburg L,Hoogerheide-Wiegerinck C,de Heer K

更新日期：2020-06-08 00:00:00