Antimicrobial Management of Respiratory Infections in Severe Acute Respiratory Syndrome Coronavirus 2 Patients: Clinical and Antimicrobial Stewardship Programs Conundrums.

abstract：Background:Bacterial and fungal infections (BFIs) are frequent in patients with cirrhosis and often trigger acute-on-chronic liver failure (ACLF). This prospective observational study aims to describe the interactions between BFI and ACLF in terms of mortality and related risk factors. Methods:We performed a 2-center ...

journal_title：Open forum infectious diseases

authors： Bartoletti M,Baldassarre M,Domenicali M,Lewis RE,Giannella M,Antognoli A,Rinaldi M,Zaccherini G,Verucchi G,Marconi L,Tamè M,Berardi S,Napoli L,Siniscalchi A,Fabbri A,Biselli M,Tufoni M,Pavarin RM,Trevisani F,Viale P

更新日期：2020-11-04 00:00:00

abstract：:A patient with multiple sclerosis presented with seronegative C. burnetii endocarditis diagnosed using C. burnetii-specific polymerase chain reaction and fluorescence in situ hybridization on cardiovascular biopsy. This case supports the necessity of a systematic polymerase chain reaction testing of removed cardiac va...

journal_title：Open forum infectious diseases

authors： Melenotte C,Loukil A,Rico A,Lepidi H,Raoult D

更新日期：2019-10-04 00:00:00

abstract：Background:Needle and syringe sharing among people who inject drugs (PWID) can result in a rapid regional spread of a human immunodeficiency virus (HIV) variant. Such outbreaks have been identified recently in several countries and have raised public health attention because of an association with new psychoactive subs...

journal_title：Open forum infectious diseases

authors： Hanke K,Fiedler S,Grumann C,Ratmann O,Hauser A,Klink P,Meixenberger K,Altmann B,Zimmermann R,Marcus U,Bremer V,Auwärter V,Bannert N

更新日期：2020-05-27 00:00:00

abstract：Background:The 13-valent pneumococcal conjugate vaccine (PCV13) and the 23-valent pneumococcal polysaccharide vaccine (PPSV23) were both recommended to adults aged ≥65 years. The study examines adults ≥65 years for risk of adverse events (AEs) requiring medical attention following vaccination with PCV13 as compared wit...

journal_title：Open forum infectious diseases

authors： Tseng HF,Sy LS,Qian L,Liu IA,Mercado C,Lewin B,Tartof SY,Nelson J,Jackson LA,Daley MF,Weintraub E,Klein NP,Belongia E,Liles EG,Jacobsen SJ

更新日期：2018-05-02 00:00:00

abstract：Background:Cytomegalovirus retinitis is a treatable cause of blindness in people with human immunodeficiency virus (HIV) typically with CD4 counts <50 cells/mm3. Diagnosis is with indirect fundoscopy, and treatment is with intravitreal ganciclovir injections or systemic therapy. However, diagnosis and treatment are not...

journal_title：Open forum infectious diseases

authors： Ocieczek P,Barnacle JR,Gumulira J,Phiri S,Heller T,Grabska-Liberek I

更新日期：2019-11-06 00:00:00

abstract：Background:Health departments utilize HIV surveillance data to identify people with HIV (PWH) who need re-linkage to HIV care as part of an approach known as Data to Care (D2C.) The most accurate, effective, and efficient method of identifying PWH for re-linkage is unknown. Methods:We evaluated referral and care conti...

journal_title：Open forum infectious diseases

authors： Sachdev DD,Mara E,Hughes AJ,Antunez E,Kohn R,Cohen S,Scheer S

更新日期：2020-08-21 00:00:00

abstract：:Background.  The majority of Lyme disease cases in the United States are acquired on the east coast between northern Virginia and New England. In recent years the geographic extent of Lyme disease has been expanding, raising the prospect of Lyme disease becoming endemic in the southeast. Methods.  We collected confirm...

journal_title：Open forum infectious diseases

authors： Lantos PM,Nigrovic LE,Auwaerter PG,Fowler VG Jr,Ruffin F,Brinkerhoff RJ,Reber J,Williams C,Broyhill J,Pan WK,Gaines DN

更新日期：2015-09-27 00:00:00

abstract：BACKGROUND:Immune activation persists despite suppressive antiretroviral therapy (ART) in human immunodeficiency virus (HIV) infection and predicts non-Acquired Immune Deficiency Syndrome (AIDS) comorbidities including cardiovascular disease. Activated platelets play a key role in atherothrombosis and inflammation, and...

journal_title：Open forum infectious diseases

authors： O'Brien MP,Hunt PW,Kitch DW,Klingman K,Stein JH,Funderburg NT,Berger JS,Tebas P,Clagett B,Moisi D,Utay NS,Aweeka F,Aberg JA

更新日期：2017-01-19 00:00:00

abstract：Background:Human babesiosis is a common zoonosis caused by Babesia and is attracting an increasing concern worldwide. The natural course of babesiosis infection and how the human immune system changes during the course of babesiosis infection are not clear. Methods:We followed up 1 case infected with Babesia venatorum...

journal_title：Open forum infectious diseases

authors： Zhao L,Jiang R,Jia N,Ning N,Zheng Y,Huo Q,Sun Y,Yuan T,Jiang B,Li T,Liu H,Liu X,Chu Y,Wei R,Bian C,Wang H,Song J,Wang H,Jiang J,Cao W

更新日期：2020-02-18 00:00:00

abstract：Background:Tryptophan catabolism, measured by the kynurenine:tryptophan (kyn/trp) ratio, is associated with gut microbiota alterations in people with HIV (PWH). We examined the association of the kyn/trp ratio with liver fibrosis in women with/without HIV infection. Methods:The plasma kyn/trp ratio was measured in 137...

journal_title：Open forum infectious diseases

authors： Kardashian A,Ma Y,Yin MT,Scherzer R,Nolan O,Aweeka F,Tien PC,Price JC

更新日期：2019-06-11 00:00:00

abstract：Background:Irritable bowel syndrome (IBS) is a chronic and debilitating functional gastrointestinal disorder affecting 9%-23% of the population across the world. The relative efficacy of fecal microbiota transplantation (FMT) on IBS symptoms was demonstrated in a double-blind, randomized study. Methods:We describe the...

journal_title：Open forum infectious diseases

authors： Hocquart M,Pham T,Kuete E,Tomei E,Lagier JC,Raoult D

更新日期：2019-10-14 00:00:00

abstract：BACKGROUND:Ombitasvir, paritaprevir with ritonavir, and dasabuvir (OBV/PTV/r ± DSV) ±ribavirin (RBV) are approved to treat hepatitis C virus (HCV) genotype 1 and 4 infection. Here, we investigate the safety and efficacy of OBV/PTV/r + DSV ±RBV for HCV genotype 1, and OBV/PTV/r + RBV for HCV genotype 4, in human immunod...

journal_title：Open forum infectious diseases

authors： Rockstroh JK,Orkin C,Viani RM,Wyles D,Luetkemeyer AF,Lazzarin A,Soto-Malave R,Nelson MR,Bhagani SR,Klinker HHF,Rizzardini G,Girard PM,Tural C,Shulman NS,Mobashery N,Hu YB,Fredrick LM,Pilot-Matias T,Trinh R,Gane E

更新日期：2017-07-22 00:00:00

abstract：:We investigated the microbial burden on the operating room environment when patients on contact precautions for a multidrug-resistant pathogen received surgery. Our study demonstrated that the perioperative environment was contaminated with aerobic bacteria and methicillin-resistant Staphylococcus aureus (MRSA) after ...

journal_title：Open forum infectious diseases

authors： Kanamori H,Rutala WA,Gergen MF,Weber DJ

更新日期：2020-10-27 00:00:00

abstract：:Background.  The efficacy of live, attenuated live attenuated influenza vaccine(LAIV) and inactivated influenza vaccine(IIV) is poorly explained by either single or composite immune responses to vaccination. Protective biomarkers were therefore studied in response to LAIV or IIV followed by LAIV challenge in children....

journal_title：Open forum infectious diseases

authors： Wright PF,Hoen AG,Ilyushina NA,Brown EP,Ackerman ME,Wieland-Alter W,Connor RI,Jegaskanda S,Rosenberg-Hasson Y,Haynes BC,Luke CJ,Subbarao K,Treanor JJ

更新日期：2016-05-23 00:00:00

abstract：Background:Patients with chronic hepatitis C virus (HCV) infection and active or previous hepatitis B virus (HBV) are at risk of HBV reactivation (HBV-R) during direct-acting antiviral (DAA) therapy. Recent reports suggest that HBV-R may even occur several months after completion of DAA therapy. The aim of this study w...

journal_title：Open forum infectious diseases

authors： Mücke MM,Mücke VT,Peiffer KH,Sarrazin C,Zeuzem S,Berger A,Vermehren J

更新日期：2018-12-15 00:00:00

abstract：:We present a case of an unvaccinated traveler who traveled from New York to Peru and contracted yellow fever. He likely acquired the infection while visiting the Amazon River, with a point of exit of Lima, Peru. Our case illustrates the dramatic course that yellow fever may take, as well as the importance of pretravel...

journal_title：Open forum infectious diseases

authors： Winnicka L,Abdullah A,Yang T,Norville K,Irizarry-Acosta M

更新日期：2017-12-20 00:00:00

abstract：Background:Recent mumps outbreaks among 2-dose measles mumps rubella (MMR) vaccine recipients have raised questions regarding the potential benefits of a third dose of vaccine (MMR3). If MMR3 provides a sustained elevation in mumps antibody, it may be beneficial for certain at-risk groups or as an outbreak control meas...

journal_title：Open forum infectious diseases

authors： Latner DR,Parker Fiebelkorn A,McGrew M,Williams NJ,Coleman LA,McLean HQ,Rubin S,Hickman CJ

更新日期：2017-12-08 00:00:00

abstract：Background:In the outpatient setting, the majority of antibiotic prescriptions are for acute respiratory infections (ARIs), but most of these infections are viral and antibiotics are unnecessary. We analyzed provider-specific antibiotic prescribing in a group of outpatient clinics affiliated with an academic medical ce...

journal_title：Open forum infectious diseases

authors： Jung S,Sexton ME,Owens S,Spell N,Fridkin S

更新日期：2019-01-18 00:00:00

abstract：:Among a cohort of men who have sex with men in a pre-exposure prophylaxis (PrEP) adherence trial, syphilis requiring treatment was associated with white coat dosing (increased PrEP adherence immediately preceding study visits) when compared with participants with optimal drug concentrations. The findings highlight the...

journal_title：Open forum infectious diseases

authors： Blair CS,Beymer MR,Kofron RM,Bolan RK,Jordan WC,Haubrich RH,Wohl AR,Landovitz RJ

更新日期：2020-08-07 00:00:00

abstract：:Cryptococcus gattii represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to C. gattii meningoencephalitis successfully treated with corticosteroids. We also report succes...

journal_title：Open forum infectious diseases

authors： Canfield GS,Henao-Martínez AF,Franco-Paredes C,Zhelnin K,Wilson ML,Shihadeh KC,Wyles D,Gardner EM

更新日期：2019-10-23 00:00:00

abstract：:The complexity and cost of current diagnostics for hepatitis C virus (HCV) may act as a prevention to the scale-up of treatment in the developing world. Currently, ribonucleic acid (RNA)-polymerase chain reaction tests are the gold standard. However, there is potential for the use of simpler and cheaper antigen tests ...

journal_title：Open forum infectious diseases

authors： Khan H,Hill A,Main J,Brown A,Cooke G

更新日期：2017-05-26 00:00:00

abstract：:Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A Streptococcus (GAS) is involved, is controversial. We conducted a syste...

journal_title：Open forum infectious diseases

authors： Bowen AC,Carapetis JR,Currie BJ,Fowler V Jr,Chambers HF,Tong SYC

更新日期：2017-11-02 00:00:00

abstract：:We report a family who acquired acute toxoplasmosis after a trip to Central America. One member developed severe clinical manifestations including bilateral chorioretinitis, hepatitis, and myocarditis requiring therapy. Symptomatic acute toxoplasmosis is unusual and possesses a diagnostic challenge. We discuss the cli...

journal_title：Open forum infectious diseases

authors： Henao-Martínez AF,Franco-Paredes C,Palestine AG,Montoya JG

更新日期：2018-03-09 00:00:00

abstract：Background:Mismanagement of asymptomatic patients with positive urine cultures (referred to as asymptomatic bacteriuria [ASB] in the literature) promotes antimicrobial resistance and results in unnecessary antimicrobial-related adverse events and increased health care costs. Methods:We conducted a systematic review an...

journal_title：Open forum infectious diseases

authors： Flokas ME,Andreatos N,Alevizakos M,Kalbasi A,Onur P,Mylonakis E

更新日期：2017-11-20 00:00:00

abstract：Background:Few published studies exist to describe the off-label use of multiple-dose fosfomycin for outpatient treatment of complicated urinary tract infections (UTI). The purpose of this study was to characterize the patients, infections, drug susceptibilities, and outcomes of multiple-dose fosfomycin episodes for ou...

journal_title：Open forum infectious diseases

authors： Derington CG,Benavides N,Delate T,Fish DN

更新日期：2020-01-29 00:00:00

abstract：Background:This study investigates the association of clinical and demographic predictors with abdominal fat gain, measured using waist circumference (WC) and self-reported abdominal size. Methods:We analyzed data from ACTG A5257, a clinical trial that randomized treatment-naïve HIV-infected participants to 1 of 3 ant...

journal_title：Open forum infectious diseases

authors： Bhagwat P,Ofotokun I,McComsey GA,Brown TT,Moser C,Sugar CA,Currier JS

更新日期：2018-11-16 00:00:00

abstract：:Microvascular function and oxygen consumption affect oxygen homeostasis but have not been assessed in African children with malaria. Microvascular function in Tanzanian children with severe malaria (SM) or uncomplicated malaria were 39% and 72%, respectively, of controls (P < .001). Uncomplicated malaria (P = .04), no...

journal_title：Open forum infectious diseases

authors： Yeo TW,Florence SM,Kalingonji AR,Chen Y,Granger DL,Anstey NM,Mwaikambo ED,Weinberg JB

更新日期：2017-04-22 00:00:00

abstract：:Francisella tularensis has a low infectious dose and can infect laboratory staff handling clinical specimens. The risk to health care providers exposed during patient care is poorly defined. We describe 9 examples of health care providers who did not develop tularemia after significant exposures to infected patients. ...

journal_title：Open forum infectious diseases

authors： Nelson CA,Brown J,Riley L,Dennis A,Oyer R,Brown C

更新日期：2019-11-19 00:00:00

abstract：:[This corrects the article DOI: 10.1093/ofid/ofy251.]. ...

journal_title：Open forum infectious diseases

authors： Abdullahi A,Fopoussi OM,Torimiro J,Atkins M,Kouanfack C,Geretti AM

更新日期：2019-04-03 00:00:00

abstract：Background:Clinical features of Lyme disease (LD) range from localized skin lesions to serious disseminated disease. Information on risk factors for Lyme arthritis, facial palsy, carditis, and meningitis is limited but could facilitate disease recognition and elucidate pathophysiology. Methods:Patients from high-incid...

journal_title：Open forum infectious diseases

authors： Kwit NA,Nelson CA,Max R,Mead PS

更新日期：2017-11-18 00:00:00