当前位置： SCI文献检索 > Open Forum Infectious Diseases期刊下所有文献 > Whole Genome Sequencing of Peruvian Klebsiella pneumoniae Identifies Novel Plasmid Vectors Bearing Carbapenem Resistance Gene NDM-1.

Whole Genome Sequencing of Peruvian Klebsiella pneumoniae Identifies Novel Plasmid Vectors Bearing Carbapenem Resistance Gene NDM-1.

Abstract：

Background:Klebsiella pneumoniae is a bacterial pathogen with increasing rates of resistance to carbapenem antibiotics, but the population structure and genetic drivers of carbapenem-resistant K pneumoniae (CRKP) remain underexplored in developing countries. Carbapenem-resistant K pneumoniae were recently introduced into Peru but have grown rapidly in prevalence, enabling study of this pathogen as it expands into an unaffected environment. Methods:In this study, using whole genome sequencing, we show that 3 distinct lineages encompass almost all CRKP identified in the hospital where it was first reported in Peru. Results:The most prevalent lineage, ST348, has not been described outside of Europe, raising concern for global dissemination. We identified metallo- β -lactamase NDM-1 as the primary carbapenem resistance effector, which was harbored on a novel vector resulting from recombination between 2 different plasmids, pKP1-NDM-1 and pMS7884A. Conclusions:This study is the first of its kind performed in Peru, and it furthers our understanding of the landscape of CRKP infections in Latin America.

journal_name

Open Forum Infect Dis

journal_title

Open forum infectious diseases

authors

Roach D,Waalkes A,Abanto J,Zunt J,Cucho C,Soria J,Salipante SJ

doi

10.1093/ofid/ofaa266

subject

Has Abstract

pub_date

2020-07-02 00:00:00

pages

ofaa266

issue

8

issn

2328-8957

pii

ofaa266

journal_volume

7

pub_type

杂志文章

相关文献

Open Forum Infectious Diseases文献大全
  • Hourly Effect of Pretreatment With IV Antibiotics on Blood Culture Positivity Rate in Emergency Department Patients.

    abstract：:Although it is intuitive that antibiotics administered before obtaining a blood culture would reduce the likelihood of obtaining a positive culture, it is not clear exactly how rapidly and to what extent blood becomes sterile after administration of intravenous (IV) antibiotics. Using a large data set of patients admi...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz179

    authors： Rand KH,Beal SG,Rivera K,Allen B,Payton T,Lipori GP

    更新日期：2019-05-20 00:00:00

  • Liver Fibrosis Regression Measured by Transient Elastography in Human Immunodeficiency Virus (HIV)-Hepatitis B Virus (HBV)-Coinfected Individuals on Long-Term HBV-Active Combination Antiretroviral Therapy.

    abstract：:Background.  Advanced fibrosis occurs more commonly in human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfected individuals; therefore, fibrosis monitoring is important in this population. However, transient elastography (TE) data in HIV-HBV coinfection are lacking. We aimed to assess liver fibrosis using...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw035

    authors： Audsley J,Robson C,Aitchison S,Matthews GV,Iser D,Sasadeusz J,Lewin SR

    更新日期：2016-02-12 00:00:00

  • Antimicrobial Stewardship Review of Automated Candidemia Alerts Using the Epic Stewardship Module Improves Bundle-of-Care Adherence.

    abstract：Background:Antimicrobial stewardship interventions utilizing real-time alerting through the electronic medical record enable timely implementation of the bundle of care (BOC) for patients with severe infections, such as candidemia. Automated alerting for candidemia using the Epic stewardship module has been in place si...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz412

    authors： Pettit NN,Han Z,Nguyen CT,Choksi A,Charnot-Katsikas A,Beavis KG,Tesic V,Pisano J

    更新日期：2019-10-11 00:00:00

  • Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections.

    abstract：:Cryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage function. Immunologic evaluation for a...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofx211

    authors： Crum-Cianflone NF,Lam PV,Ross-Walker S,Rosen LB,Holland SM

    更新日期：2017-10-05 00:00:00

  • PrEP Nonadherence, White Coat Dosing, and HIV Risk Among a Cohort of MSM.

    abstract：:Among a cohort of men who have sex with men in a pre-exposure prophylaxis (PrEP) adherence trial, syphilis requiring treatment was associated with white coat dosing (increased PrEP adherence immediately preceding study visits) when compared with participants with optimal drug concentrations. The findings highlight the...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa329

    authors： Blair CS,Beymer MR,Kofron RM,Bolan RK,Jordan WC,Haubrich RH,Wohl AR,Landovitz RJ

    更新日期：2020-08-07 00:00:00

  • Rapid Emergence of a New Clone Impacts the Population at Risk and Increases the Incidence of Type emm89 Group A Streptococcus Invasive Disease.

    abstract：BACKGROUND:Invasive group A Streptococcus (iGAS) disease caused by type emm89 strains has been increasing worldwide, driven by the emergence of an epidemic clonal variant (clade 3 emm89). The clinical characteristics of patients with emm89 iGAS disease, and in particular with clade 3 emm89 iGAS disease, are poorly desc...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofx042

    authors： Teatero S,Coleman BL,Beres SB,Olsen RJ,Kandel C,Reynolds O,Athey TBT,Musser JM,McGeer A,Fittipaldi N

    更新日期：2017-03-04 00:00:00

  • Continued Sensitivity of Plasmodium falciparum to Artemisinin in Guyana, With Absence of Kelch Propeller Domain Mutant Alleles.

    abstract：:Because of concerns about possible emergence of artemisinin resistance strains of Plasmodium falciparum in mining areas of the interior of Guyana, a 7-day artesunate trial was conducted from March to December 2014. The day-3 parasite clearance rate, the efficacy of artesunate at day 28, and polymorphism of Kelch 13 (P...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw185

    authors： Rahman R,Martin MJ,Persaud S,Ceron N,Kellman D,Musset L,Carter KH,Ringwald P

    更新日期：2016-08-30 00:00:00

  • Group B Streptococci Colonization in Pregnant Guatemalan Women: Prevalence, Risk Factors, and Vaginal Microbiome.

    abstract：BACKGROUND:Infection causes 1 of every 5 neonatal deaths globally. Group B Streptococcus (GBS) is the most significant pathogen, although little is known about its epidemiology and risk in low-income countries. METHODS:A cross-sectional study in 2015 at a public hospital in Guatemala City enrolled women ≥35 weeks' ges...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofx020

    authors： Rick AM,Aguilar A,Cortes R,Gordillo R,Melgar M,Samayoa-Reyes G,Frank DN,Asturias EJ

    更新日期：2017-02-08 00:00:00

  • Seroprevalence of Strongyloides stercoralis and Evaluation of Universal Screening in Kidney Transplant Candidates: A Single-Center Experience in Houston (2012-2017).

    abstract：BACKGROUND:Disseminated strongyloidiasis in solid organ transplant recipients is a rare but devastating infection. In our center, we implemented a universal screening of all candidates for kidney transplantation. We assessed the seroprevalence and utility of universal screening for strongyloidiasis in our center. METH...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz172

    authors： Al-Obaidi M,Hasbun R,Vigil KJ,Edwards AR,Chavez V,Hall DR,Dar WA,De Golovine A,Ostrosky-Zeichner L,Bynon JS,Nigo M

    更新日期：2019-07-01 00:00:00

  • Time for Precision: A World Without Susceptibility Breakpoints.

    abstract：:Interpretive criteria for in vitro susceptibility testing criteria, "susceptibility breakpoints," underpin the evaluation and selection of antimicrobial regimens. However, despite their strengths, susceptibility breakpoints are a relatively blunt instrument employed to address an extremely complex question-what is the...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy282

    authors： Bader JC,Lakota EA,Andes DR,Rubino CM,Ambrose PG,Bhavnani SM

    更新日期：2018-10-31 00:00:00

  • Risk Factors for Indeterminate Outcome on Interferon Gamma Release Assay in Non-US-Born Persons Screened for Latent Tuberculosis Infection.

    abstract：Background:Non-US-born individuals account for the majority of active tuberculosis (TB) in the United States. Interferon gamma release assay (IGRA) is the preferred diagnostic test for latent TB but can produce an indeterminate result. We investigated the prevalence and predictors of an indeterminate IGRA (IND-IGRA) in...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy184

    authors： Sharninghausen JC,Shapiro AE,Koelle DM,Kim HN

    更新日期：2018-07-27 00:00:00

  • Epidemiological and Clinical Findings of Short-Term Recurrence of Severe Acute Respiratory Syndrome Coronavirus 2 Ribonucleic Acid Polymerase Chain Reaction Positivity in 1282 Discharged Coronavirus Disease 2019 Cases: A Multicenter, Retrospective, Observ

    abstract：Background:Short-term recurrence of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) polymerase chain reaction (PCR) in discharged coronavirus disease 2019 (COVID-19) patients attracts the public's concern. This study aimed to determine the clinical and epidemiological result...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa432

    authors： Chen SL,Xu H,Feng HY,Sun JF,Li X,Zhou L,Song WL,Huang SS,He JL,Deng YY,Wang RJ,Fang M

    更新日期：2020-09-13 00:00:00

  • Detection of Loa loa Microfilariae in Follicular Fluid During Assisted Reproductive Technology: Case Report and Review of the Literature.

    abstract：:We report on a case of loiasis revealed during an assisted reproductive technology (ART) cycle. Loa loa could limit implantation outcome. We propose to focus on an ART strategy with frozen embryos to treat the patient before any transfer. ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofx208

    authors： Puy V,Scheffler F,Tinez C,Belhadri-Mansouri N,Huguenin A,Capelle S,Agnamey P,Devaux A,Frydman N,Copin H,Benkhalifa M

    更新日期：2017-10-06 00:00:00

  • Antimicrobial Susceptibility Trends Observed in Urinary Pathogens Obtained From New York State.

    abstract：:International guidelines recommend using local susceptibility data to direct empiric therapy for acute uncomplicated cystitis. We evaluated outpatient urinary isolate susceptibility trends in New York State. Nitrofurantoin had the lowest resistance prevalence whereas trimethoprim-sulfamethoxazole and fluoroquinolones ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy297

    authors： Rank EL,Lodise T,Avery L,Bankert E,Dobson E,Dumyati G,Hassett S,Keller M,Pearsall M,Lubowski T,Carreno JJ

    更新日期：2018-11-16 00:00:00

  • Artificial Intelligence Platform Demonstrates High Adherence in Patients Receiving Fixed-Dose Ledipasvir and Sofosbuvir: A Pilot Study.

    abstract：:This study evaluated health outcomes among people who inject drugs who are infected with hepatitis C virus using an artificial intelligence platform. Mean (SD) cumulative adherence (visual confirmation of administration) was 91.3% (10.5%). Most subjects (88.2%) achieved ≥80% adherence to treatment, and 88.2% (15 of 17...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa290

    authors： Litwin AH,Shafner L,Norton B,Akiyama MJ,Agyemang L,Guzman M,Vera T,Heo M

    更新日期：2020-07-20 00:00:00

  • The spread and control of norovirus outbreaks among hospitals in a region: a simulation model.

    abstract：BACKGROUND:Because hospitals in a region are connected via patient sharing, a norovirus outbreak in one hospital may spread to others. METHODS:We utilized our Regional Healthcare Ecosystem Analyst software to generate an agent-based model of all the acute care facilities in Orange County (OC), California and simulated...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofu030

    authors： Bartsch SM,Huang SS,Wong KF,Avery TR,Lee BY

    更新日期：2014-07-02 00:00:00

  • Do I Have HIV or Not? Lack of RNA Detection and the Case for Sensitive DNA Testing.

    abstract：:We present a case of a 20-year-old male who had ambiguous HIV test results after entering new provider care and whose status was later complicated by undetectable viral RNA off antiretroviral therapy (ART). Verifying HIV infection status may occasionally require sensitive DNA testing that might need to be considered i...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa478

    authors： Springer SA,Masciotra S,Johnson JA,Campbell S

    更新日期：2020-10-10 00:00:00

  • Occurrence of 4 Dengue Virus Serotypes and Chikungunya Virus in Kilombero Valley, Tanzania, During the Dengue Outbreak in 2018.

    abstract：Background:Dengue and Chikungunya viruses can cause large-scale epidemics, with attack rates of up to 80%. In Tanzania, there have been repeated outbreaks of dengue fever, the most recent in 2018 and 2019, mostly affecting the coastal areas. Despite the importance of these viruses, there is limited knowledge on the epi...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa626

    authors： Chipwaza B,Sumaye RD,Weisser M,Gingo W,Yeo NK,Amrun SN,Okumu FO,Ng LFP

    更新日期：2020-12-26 00:00:00

  • Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial.

    abstract：:Background.  First- and second-generation smallpox vaccines are contraindicated in individuals infected with human immunodeficiency virus (HIV). A new smallpox vaccine is needed to protect this population in the context of biodefense preparedness. The focus of this study was to compare the safety and immunogenicity of...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofv040

    authors： Overton ET,Stapleton J,Frank I,Hassler S,Goepfert PA,Barker D,Wagner E,von Krempelhuber A,Virgin G,Meyer TP,Müller J,Bädeker N,Grünert R,Young P,Rösch S,Maclennan J,Arndtz-Wiedemann N,Chaplin P

    更新日期：2015-05-05 00:00:00

  • ERRATUM.

    abstract：:[This corrects the article DOI: 10.1093/ofid/ofv111.]. ...

    journal_title：Open forum infectious diseases

    pub_type： 已发布勘误

    doi：10.1093/ofid/ofv132

    authors：

    更新日期：2015-09-04 00:00:00

  • Human Immunodeficiency Virus-1 Sequence Changes and Drug Resistance Mutation Among Virologic Failures of Lopinavir/Ritonavir Monotherapy: AIDS Clinical Trials Group Protocol A5230.

    abstract：: Background.  The mechanism of virologic failure (VF) of lopinavir/ritonavir (LPV/r) monotherapy is not well understood. We assessed sequence changes in human immunodeficiency virus-1 reverse-transcriptase (RT) and protease (PR) regions. Methods. ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw154

    authors： Vardhanabhuti S,Katzenstein D,Bartlett J,Kumarasamy N,Wallis CL

    更新日期：2016-08-24 00:00:00

  • Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess.

    abstract：:Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A Streptococcus (GAS) is involved, is controversial. We conducted a syste...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章,评审

    doi：10.1093/ofid/ofx232

    authors： Bowen AC,Carapetis JR,Currie BJ,Fowler V Jr,Chambers HF,Tong SYC

    更新日期：2017-11-02 00:00:00

  • Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy.

    abstract：:In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophag...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz374

    authors： Audemard-Verger A,Gasnault J,Faisant M,Besse MC,Martin-Silva N,Berra M,Fournier L,Boutemy J,Maigne G,De Boysson H,Ruet A,Vabret A,Chapon F,Martin-Blondel G,Aouba A

    更新日期：2019-09-30 00:00:00

  • Congenital Parvovirus B19 Infection: Persistent Viremia and Red Blood Cell Aplasia.

    abstract：:We describe a case of fetal parvovirus B19 infection resulting in preterm birth and leading to hydrops fetalis requiring multiple in utero transfusions. The infant developed chronic postnatal anemia responsive to intravenous immunoglobulin therapy. Serum viral load decreased after immunoglobulin treatment but remained...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofv049

    authors： Nadimpalli SS,Miller RS,Kamath VM,Farkouh CR,Nhan-Chang CL,Rathe JA,Collins A,Duchon JM,Neu N,Simpson LL,Ratner AJ

    更新日期：2015-04-15 00:00:00

  • Human Immunodeficiency Virus-Negative Men Who Have Sex With Men Have an Altered T-Cell Phenotype and Bioenergy Metabolism.

    abstract：Background:We recently reported that the levels of activation, exhaustion, and terminal differentiation within the peripheral T-cell compartment were increased in men who have sex with men (MSM) compared with blood bank donors. During activation and differentiation, T cells undergo metabolic changes to maintain their e...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa284

    authors： Kruize Z,Maurer I,van Dort KA,van den Elshout MAM,Hoornenborg E,Booiman T,Prins M,Kootstra NA

    更新日期：2020-07-05 00:00:00

  • Considerations for the Selection and Use of Disinfectants Against SARS-CoV-2 in a Health Care Setting.

    abstract：:Proper disinfection using adequate disinfecting agents will be necessary for infection control strategies against coronavirus disease 2019 (COVID-19). However, limited guidance exists on effective surface disinfectants or best practices for their use against severe acute respiratory coronavirus 2. We outlined a proces...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa396

    authors： Tyan K,Levin A,Avalos-Pacheco A,Plana D,Rand EA,Yang H,Maliszewski LE,Chylek LA,Atta L,Tye MA,Carmack MM,Oglesby NS,Burgin S,Yu SH,LeBoeuf NR,Kemp JM

    更新日期：2020-08-31 00:00:00

  • Health-Related Quality of Life in Outpatient Parenteral Antimicrobial Therapy.

    abstract：:Health-related quality of life (HRQoL) in outpatient parenteral antimicrobial therapy (OPAT) has not been well characterized in the United States. In an OPAT cohort, the short-form-12's median physical component score and mental component score were 40.3 and 54.4, respectively. HRQoL measures could be helpful in studi...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy143

    authors： Keller SC,Williams D,Levering M,Cosgrove SE

    更新日期：2018-06-20 00:00:00

  • Ordering Patterns and Costs of Specialized Laboratory Testing by Hospitalists and House Staff in Hospitalized Patients With HIV at a County Hospital: An Opportunity for Diagnostic Stewardship.

    abstract：Background:Inpatient HIV care often requires specialized laboratory testing with which practitioners may not be familiar. In addition, computerized physician order entry allows for ordering tests without understanding test indications, but it can also provide a venue for education and diagnostic stewardship. Methods:A...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz158

    authors： Bolles K,Woc-Colburn L,Hamill RJ,Hemmige V

    更新日期：2019-03-29 00:00:00

  • Modeling Donor Screening Strategies to Reduce the Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission via Fecal Microbiota Transplantation.

    abstract：:The potential for transmission of severe acute respiratory syndrome coronavirus 2 shed in stool via fecal microbiota transplantation is not yet known, and the effectiveness of various testing strategies to prevent fecal microbiota transplantation-based transmission has also not yet been quantified. In this study, we u...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa499

    authors： Olesen SW,Zaman A,Osman M,Ramakrishna B

    更新日期：2020-10-19 00:00:00

  • I-FABP Is Higher in People With Chronic HIV Than Elite Controllers, Related to Sugar and Fatty Acid Intake and Inversely Related to Body Fat in People With HIV.

    abstract：Background:Intestinal fatty acid binding protein (I-FABP) has been shown to be a marker of intestinal damage among people living with HIV. We hypothesized that I-FABP would be increased in chronically HIV-infected patents more than elite controllers and would relate to specific nutrient intake and body composition. Me...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy288

    authors： Cheru LT,Park EA,Saylor CF,Burdo TH,Fitch KV,Looby S,Weiner J,Robinson JA,Hubbard J,Torriani M,Lo J

    更新日期：2018-11-05 00:00:00