Whole Genome Sequencing of Peruvian Klebsiella pneumoniae Identifies Novel Plasmid Vectors Bearing Carbapenem Resistance Gene NDM-1.

Abstract:

Background:Klebsiella pneumoniae is a bacterial pathogen with increasing rates of resistance to carbapenem antibiotics, but the population structure and genetic drivers of carbapenem-resistant K pneumoniae (CRKP) remain underexplored in developing countries. Carbapenem-resistant K pneumoniae were recently introduced into Peru but have grown rapidly in prevalence, enabling study of this pathogen as it expands into an unaffected environment. Methods:In this study, using whole genome sequencing, we show that 3 distinct lineages encompass almost all CRKP identified in the hospital where it was first reported in Peru. Results:The most prevalent lineage, ST348, has not been described outside of Europe, raising concern for global dissemination. We identified metallo- β -lactamase NDM-1 as the primary carbapenem resistance effector, which was harbored on a novel vector resulting from recombination between 2 different plasmids, pKP1-NDM-1 and pMS7884A. Conclusions:This study is the first of its kind performed in Peru, and it furthers our understanding of the landscape of CRKP infections in Latin America.

journal_name

Open Forum Infect Dis

authors

Roach D,Waalkes A,Abanto J,Zunt J,Cucho C,Soria J,Salipante SJ

doi

10.1093/ofid/ofaa266

subject

Has Abstract

pub_date

2020-07-02 00:00:00

pages

ofaa266

issue

8

issn

2328-8957

pii

ofaa266

journal_volume

7

pub_type

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