abstract：:Sjögren's syndrome (SS) is a chronic autoimmune disease that mainly damages the salivary and lacrimal glands. Immune complex (IC) formation triggers local inflammation through IC deposition and decreased antigen function. Some ICs can leak from the lesion and into the saliva but no salivary ICs have been reported to d...

journal_title：Clinical and experimental immunology

authors： Yamane K,Nakamura H,Hamasaki M,Minei Y,Aibara N,Shimizu T,Kawakami A,Nakashima M,Kuroda N,Ohyama K

更新日期：2021-01-12 00:00:00

abstract：:Mycoplasma pneumoniae is an obligate pathogen that causes pneumonia, tracheobronchitis, pharyngitis and asthma in humans. It is well recognized that membrane lipoproteins are immunostimulants exerting as lipopolysaccharides (LPS) and play a crucial role in the pathogenesis of inflammatory responses upon M. pneumoniae ...

journal_title：Clinical and experimental immunology

authors： Luo H,He J,Qin L,Chen Y,Chen L,Li R,Zeng Y,Zhu C,You X,Wu Y

更新日期：2021-01-01 00:00:00

abstract：:Although increasing evidence demonstrates the association between intestinal dysbiosis and pancreatic diseases such as chronic pancreatitis and pancreatic cancer, it remains largely unknown whether intestinal dysbiosis is involved in the immunopathogenesis of autoimmune pancreatitis (AIP). Recently, we found that inte...

journal_title：Clinical and experimental immunology

authors： Kamata K,Watanabe T,Minaga K,Hara A,Sekai I,Otsuka Y,Yoshikawa T,Park AM,Kudo M

更新日期：2020-12-01 00:00:00

abstract：:Epigenetic studies reveal how our genes (nature) are influenced by environment (nurture) leading to wide variability in clinical presentations, especially in autoimmune diseases. Patients with C1-inhibitor deficiency, even within the same family, have diverse clinical presentations that may reflect epigenetic control ...

journal_title：Clinical and experimental immunology

authors： Khan S,Longhurst H

更新日期：2020-11-01 00:00:00

abstract：:Inducible co-stimulator-positive (ICOS) and programmed cell death 1-positive (PD-1) are important markers for follicular helper T cells (Tfh); however, their roles and clinical values in ulcerative colitis (UC) remain unknown. In this study, we recruited 68 UC patients and 34 healthy controls. Circulating ICOS+ , PD-1...

journal_title：Clinical and experimental immunology

authors： Long Y,Zhao X,Liu C,Xia C,Liu C

更新日期：2020-10-01 00:00:00

abstract：:Modern era advancements in medical care, with improved treatment of infections, can result in delayed diagnosis of congenital immunodeficiencies. In this study we present a retrospective cohort of 16 patients diagnosed with Chronic Granulomatous Disease (CGD) at adulthood. Some of the patients had a milder clinical ph...

journal_title：Clinical and experimental immunology

authors： Barkai T,Somech R,Broides A,Gavrieli R,Wolach B,Marcus N,Hagin D,Stauber T

更新日期：2020-09-01 00:00:00

abstract：:The search for novel chemical classes of anti-malarial compounds to cope with the current state of chemoresistance of malaria parasites has led to the identification of Plasmodium falciparum aminopeptidase 1 (PfA-M1) as a new therapeutic target. PfA-M1, known to be involved in the hemoglobin digestion cascade which he...

journal_title：Clinical and experimental immunology

authors： Oyegue-Liabagui SL,Imboumy-Limoukou RK,Kouna CL,Bangueboussa F,Schmitt M,Florent I,Lekana-Douki JB

更新日期：2020-06-01 00:00:00

abstract：:Commercial cellular tests are used to diagnose Lyme borreliosis (LB), but studies on their clinical validation are lacking. This study evaluated the utility of an in-house and a commercial enzyme-linked immunosorbent spot (ELISpot) assay for the diagnosis of Lyme neuroborreliosis (LNB). Prospectively, peripheral blood...

journal_title：Clinical and experimental immunology

authors： van Gorkom T,Voet W,Sankatsing SUC,Nijhuis CDM,Ter Haak E,Kremer K,Thijsen SFT

更新日期：2020-03-01 00:00:00

abstract：:Neopterin is primarily synthesized and released by activated macrophages/monocytes upon stimulation with interferon-γ and is considered as a marker for macrophage activation. This study aimed to analyze the serum levels of neopterin in patients with dermatomyositis (DM) in association with clinical manifestations, lab...

journal_title：Clinical and experimental immunology

authors： Peng QL,Zhang YM,Liang L,Liu X,Ye LF,Yang HB,Zhang L,Shu XM,Lu X,Wang GC

更新日期：2020-03-01 00:00:00

abstract：:There have been many studies on the mechanisms of internalization of DNA-anti-DNA immune complexes by cells, including the one used for rheumatoid factor-expressing mouse B cells. In parallel, studies on the role of intracellular DNA sensors in the pathogenesis of systemic lupus erythematosus (SLE) have been conducted...

journal_title：Clinical and experimental immunology

authors： Inoue K,Ishizawa M,Kubota T

更新日期：2020-02-01 00:00:00

abstract：:Recurrent respiratory papillomatosis (RRP) is characterized by benign exophytic lesions of the respiratory tract caused by the human papillomavirus (HPV), in particular low-risk HPV6 and HPV11. Aggressiveness varies greatly among patients. Surgical excision is the current standard of care for RRP, with adjuvant therap...

journal_title：Clinical and experimental immunology

authors： Ivancic R,Iqbal H,deSilva B,Pan Q,Matrka L

更新日期：2020-02-01 00:00:00

abstract：:Tertiary lymphoid structure (TLS) provides a local and critical microenvironment for both cellular and humoral immunity and supports effective antigen presentation and lymphocyte activation. However, the gene expression profile and prognostic significance of TLS in oral cancer remain largely unrevealed. In this study,...

journal_title：Clinical and experimental immunology

authors： Li K,Guo Q,Zhang X,Dong X,Liu W,Zhang A,Li Y,Yan J,Jia G,Zheng Z,Tang W,Pan L,An M,Zhang B,Liu S,Fu B

更新日期：2020-02-01 00:00:00

abstract：:Cytokines have been extensively studied in coeliac disease, but cytokine release related to exposure to gluten and associated symptoms has only recently been described. Prominent, early elevations in serum interleukin (IL)-2 after gluten support a central role for T cell activation in the clinical reactions to gluten ...

journal_title：Clinical and experimental immunology

authors： Goel G,Daveson AJM,Hooi CE,Tye-Din JA,Wang S,Szymczak E,Williams LJ,Dzuris JL,Neff KM,Truitt KE,Anderson RP

更新日期：2020-01-01 00:00:00

abstract：:The human body is populated by a large number of microorganisms and exist in symbiosis with these immensely diverse communities, which are suggested to influence health and disease. The microbiota plays an essential role in the maturation and function of the immune system. The prevalence of atopic diseases has increas...

journal_title：Clinical and experimental immunology

authors： Nibbering B,Ubags NDJ

更新日期：2020-01-01 00:00:00

abstract：:Psoriasis is an immune-mediated inflammatory skin disease that mainly affects the skin barrier. Treatment for psoriasis mainly includes conventional immunosuppressive drugs. However, long-term treatment with global immunosuppressive agents may cause a variety of side effects, including nephrotoxicity and infections. K...

journal_title：Clinical and experimental immunology

authors： Liu C,Liu H,Lu C,Deng J,Yan Y,Chen H,Wang Y,Liang CL,Wei J,Han L,Dai Z

更新日期：2019-12-01 00:00:00

abstract：:Vaccination against meningococcal serogroup B is recommended for patients with a complement deficiency; however, although immunogenicity in this patient group has been shown, efficacy has not yet been established. In this study, we collected serum from children with a complement deficiency in the alternative pathway o...

journal_title：Clinical and experimental immunology

authors： van den Broek B,van Els CACM,Kuipers B,van Aerde K,Henriet SS,de Groot R,de Jonge MI,Langereis JD,van der Flier M

更新日期：2019-12-01 00:00:00

abstract：:The role of suppressive anti-retroviral therapy (ART) in eliciting restoration of dysregulated immune function remains unclear in HIV-1 infection. Also, due to tailoring of therapeutic regimens towards HIV-1, this possible impairment of therapy may be even more pronounced in HIV-2 and dual (HIV-D) infection. Thus, we ...

journal_title：Clinical and experimental immunology

authors： Salwe S,Padwal V,Nagar V,Patil P,Patel V

更新日期：2019-11-01 00:00:00

abstract：:Neutrophils are often exclusively considered as a first-line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over-activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrat...

journal_title：Clinical and experimental immunology

authors： Hahn S,Hasler P,Vokalova L,van Breda SV,Lapaire O,Than NG,Hoesli I,Rossi SW

更新日期：2019-10-01 00:00:00

abstract：:Neutrophils maintain immune homeostasis by engulfing apoptotic cells and debris. We describe the rapid activation of neutrophils after engulfing hemoglobin (Hb)-activated platelets, which are abundant in the circulation of hemolytic patients. Neutrophils from healthy individuals after engulfing Hb-activated platelets ...

journal_title：Clinical and experimental immunology

authors： Bhasym A,Annarapu GK,Saha S,Shrimali N,Gupta S,Seth T,Guchhait P

更新日期：2019-08-01 00:00:00

abstract：:There is currently scarce knowledge of the immunological profile of patients with latent autoimmune diabetes mellitus in the adult (LADA) when compared with healthy controls (HC) and patients with classical type 1 diabetes (T1D) and type 2 diabetes (T2D). The objective of this study was to investigate the cellular imm...

journal_title：Clinical and experimental immunology

authors： Singh K,Martinell M,Luo Z,Espes D,Stålhammar J,Sandler S,Carlsson PO

更新日期：2019-07-01 00:00:00

abstract：:Psoriasis (Ps), psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are common diseases dependent on environmental factors that activate the immune system in unknown ways. Mannan is a group of polysaccharides common in the environment; they are potentially pathogenic, because at least some of them induce Ps-, PsA-...

journal_title：Clinical and experimental immunology

authors： Hagert C,Siitonen R,Li XG,Liljenbäck H,Roivainen A,Holmdahl R

更新日期：2019-06-01 00:00:00

abstract：:HIV-2 is thought to have entered the human population in the 1930s through cross-species transmission of SIV from sooty mangabeys in West Africa. Unlike HIV-1, HIV-2 has not led to a global pandemic, and recent data suggest that HIV-2 prevalence is declining in some West African states where it was formerly endemic. A...

journal_title：Clinical and experimental immunology

authors： Boswell MT,Rowland-Jones SL

更新日期：2019-06-01 00:00:00

abstract：:Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the exacerbated response in the gut, but no treatment is fully effective for many refractory patients. Mesenchymal stromal cells (MSC) are multi-potent cells with regulatory immunosuppressive activity that may control inflammatory disease...

journal_title：Clinical and experimental immunology

authors： Alves VBF,de Sousa BC,Fonseca MTC,Ogata H,Caliári-Oliveira C,Yaochite JNU,Rodrigues Júnior V,Chica JEL,da Silva JS,Malmegrim KCR,Pernomian L,Cardoso CR

更新日期：2019-05-01 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis. Historically believed to be a relatively rare human disease in tropical countries, a recent study estimated that, worldwide, there are approximately 165 000 human melioidosis cases per year, more than half of whom die. The bacterium is inherently resista...

journal_title：Clinical and experimental immunology

authors： Morici L,Torres AG,Titball RW

更新日期：2019-05-01 00:00:00

abstract：:During the past decade several notable viruses have suddenly emerged from obscurity or anonymity to become serious global health threats, provoking concern regarding their sustained epidemic transmission in immunologically naive human populations. With each new threat comes the call for rapid vaccine development. Inde...

journal_title：Clinical and experimental immunology

authors： Afrough B,Dowall S,Hewson R

更新日期：2019-05-01 00:00:00

abstract：:Anti-phospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity. It is well known that in these patients thrombosis may be the result of a hypercoagulable state related to anti-β2-glycoprotein I (β2-GPI) antibodies. Moreover, platelets may play a role in thrombotic manife...

journal_title：Clinical and experimental immunology

authors： Capozzi A,Manganelli V,Riitano G,Recalchi S,Truglia S,Alessandri C,Longo A,Garofalo T,Misasi R,Valesini G,Conti F,Sorice M

更新日期：2019-04-01 00:00:00

abstract：:The antigenic specificity of T cells occurs via generation and rearrangement of different gene segments producing a functional T cell receptor (TCR). High-throughput sequencing (HTS) allows in-depth assessment of TCR repertoire patterns. There are limited data concerning whether TCR repertoires are altered in inflamma...

journal_title：Clinical and experimental immunology

authors： Werner L,Nunberg MY,Rechavi E,Lev A,Braun T,Haberman Y,Lahad A,Shteyer E,Schvimer M,Somech R,Weiss B,Lee YN,Shouval DS

更新日期：2019-04-01 00:00:00

abstract：:Turner syndrome (TS) is associated with an increased frequency of autoimmunity. Frequently observed autoimmune diseases in TS are also seen in the autoimmune polyendocrine syndrome type I (APS I), of which Addison disease is a key component. An overlapping antibody profile between TS and APS I could be considered. The...

journal_title：Clinical and experimental immunology

authors： Berglund A,Cleemann L,Oftedal BE,Holm K,Husebye ES,Gravholt CH

更新日期：2019-03-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) is a widely used immunomodulatory therapy for the treatment of various T cell-mediated disorders such as cutaneous T cell lymphoma (CTCL), graft-versus-host disease (GvHD) or systemic sclerosis. Although clinical benefits of ECP are already well described, the underlying mechanism of...

journal_title：Clinical and experimental immunology

authors： Wiese F,Reinhardt-Heller K,Volz M,Gille C,Köstlin N,Billing H,Handgretinger R,Holzer U

更新日期：2019-03-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction in SSc is characterized by the activation and recruitment of immune cells and the production of autoantibodies and cytokines. How immune ...

journal_title：Clinical and experimental immunology

authors： Brown M,O'Reilly S

更新日期：2019-03-01 00:00:00

abstract：:In this study, we aimed to explore the effects of imatinib on the proliferation of rheumatoid arthritis synovial cell (RA-FLS) and inflammatory responses by regulating CSF1R. Differential genes were screened via microarray analysis, followed by being analysed through the weighted co-expression network (WGCNA) network,...

journal_title：Clinical and experimental immunology

authors： Hu X,Tang J,Hu X,Bao P,Pan J,Ou Y,Deng W,Liang Y

更新日期：2019-02-01 00:00:00

abstract：:Pneumococcal infections cause a large global health burden, and the search for serotype-independent vaccines continues. Existing conjugate vaccines reduce nasopharyngeal colonization by target serotypes. Such mucosal effects of novel antigens may similarly be important. CD4+ Th17 cell-dependent, antibody-independent r...

journal_title：Clinical and experimental immunology

authors： Oliver E,Pope C,Clarke E,Langton Hewer C,Ogunniyi AD,Paton JC,Mitchell T,Malley R,Finn A

更新日期：2019-02-01 00:00:00

abstract：:Autoantibodies characteristic for anti-phospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are anti-β2 -glycoprotein I (β2 GPI) antibodies and anti-DNA antibodies, respectively, and almost half of APS cases occur in SLE. Anti-β2 GPI antibodies are recognized to play a pivotal role in inducing a prothrom...

journal_title：Clinical and experimental immunology

authors： Virachith S,Saito M,Watanabe Y,Inoue K,Hoshi O,Kubota T

更新日期：2019-02-01 00:00:00

abstract：:Primary biliary cholangitis (PBC) is a multi-factorial disease caused by the interaction of both genetic predisposition and environmental triggers. Bacterial infection has been investigated most intensively, both epidemiologically and experimentally, as a prime environmental aetiology in PBC. The association of recurr...

journal_title：Clinical and experimental immunology

authors： Tanaka A,Leung PSC,Gershwin ME

更新日期：2019-01-01 00:00:00

abstract：:Autoimmune Addison's disease (AAD), or primary adrenocortical insufficiency, is a classical organ-specific autoimmune disease with 160 years of history. AAD is remarkably homogeneous with one major dominant self-antigen, the cytochrome P450 21-hydroxylase enzyme, which is targeted by both autoantibodies and autoreacti...

journal_title：Clinical and experimental immunology

authors： Hellesen A,Bratland E

更新日期：2019-01-01 00:00:00

abstract：:Kawasaki disease (KD) is an immune-mediated vasculitis with symptoms that mimic febrile illness; the immune origin has been suggested but never proved. First, cell chip technology was used to screen immune targets cells. With the indirect immunofluorescence assay we found that the HeLa cell chip could be recognized by...

journal_title：Clinical and experimental immunology

authors： Cui J,Zhou Y,Hu H,Zhao L,Du Z,Du H

更新日期：2018-12-01 00:00:00

abstract：:The objective of the present study was to evaluate the role of CDKN1A in rheumatoid arthritis (RA). Related gene expression data screened from Gene Expression Omnibus (GEO) were processed with network analysis. Protein-protein interaction was analysed through string database. Quantitative reverse transcription-polymer...

journal_title：Clinical and experimental immunology

authors： Gang X,Xu H,Si L,Zhu X,Yu T,Jiang Z,Wang Y

更新日期：2018-11-01 00:00:00

abstract：:Nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 (NLRP3) gene polymorphism was reported to be associated with susceptibility, disease activity or anti-tumour necrosis factor (TNF) treatment response in rheumatoid arthritis (RA). However, the roles of NLRP3 inflammasome i...

journal_title：Clinical and experimental immunology

authors： Guo C,Fu R,Wang S,Huang Y,Li X,Zhou M,Zhao J,Yang N

更新日期：2018-11-01 00:00:00

abstract：:The immune and bone systems maintain homeostasis by interacting closely with each other. Rheumatoid arthritis is a pathological consequence of their interplay, as activated T cell immune responses result in osteoclast-mediated bone erosion. An imbalance between forkhead box protein 3 (Foxp3)+ regulatory T (Treg ) cell...

journal_title：Clinical and experimental immunology

authors： Komatsu N,Takayanagi H

更新日期：2018-10-01 00:00:00

abstract：:In inflammatory bowel disease (IBD), inflammation is sustained by an exaggerated response of lymphocytes. This results from enhanced expression of anti-apoptotic B cell lymphoma (BCL-2) and BCL-XL associated with a diminished turnover. Azathioprine (AZA) directly targets BCL-2 family-mediated apoptosis. We investigate...

journal_title：Clinical and experimental immunology

authors： Weder B,Mozaffari M,Biedermann L,Mamie C,Moncsek A,Wang L,Clarke SH,Rogler G,McRae BL,Graff CL,Ruiz PA,Hausmann M

更新日期：2018-09-01 00:00:00