解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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公共、环境和职业卫生
放射学,核医学和医学成像
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生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne infectious disease, therefore, the information on the whole genome of the SFTS virus (SFTSV) is still limited. This study demonstrates a nearly whole genome of the SFTSV identified in Osaka in 2017 and 2018 by next-generation sequencing (NGS). Th...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13020177
更新日期:2021-01-25 00:00:00
abstract::JC Virus (JCPyV), a member of the Polyomaviridiæ family, is a human neurotropic virus with world-wide distribution. JCPyV is the established opportunistic infectious agent of progressive multifocal leukoencephalopathy, a fatal demyelinating disease, which results from the cytolytic infection of oligodendrocytes. Mutat...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13020162
更新日期:2021-01-22 00:00:00
abstract::Alfuy (ALFV) is an attenuated flavivirus related to the Murray Valley encephalitis virus (MVEV). We previously identified markers of attenuation in the envelope (E) protein of the prototype strain (ALFV3929), including the hinge region (E273-277) and lack of glycosylation at E154-156. To further determine the mechanis...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13020147
更新日期:2021-01-20 00:00:00
abstract::The assembly of a hexameric lattice of retroviral immature particles requires the involvement of cell factors such as proteins and small molecules. A small, negatively charged polyanionic molecule, myo-inositol hexaphosphate (IP6), was identified to stimulate the assembly of immature particles of HIV-1 and other lenti...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010129
更新日期:2021-01-18 00:00:00
abstract::The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses. APOBEC3 genes are highly amplified and diversified in mammals, suggesting that their evolution and diversification have been driven by conflicts with ancie...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v13010124
更新日期:2021-01-17 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1) causes a lifelong latent infection with an estimated global prevalence of 66%. Primary and recurrent HSV infections are characterized by a tingling sensation, followed by an eruption of vesicles, which can cause painful erosions. Commonly used antiviral drugs against HSV infection a...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010086
更新日期:2021-01-09 00:00:00
abstract::Phylodynamic inference is a pivotal tool in understanding transmission dynamics of viral outbreaks. These analyses are strongly guided by the input of an epidemiological model as well as sequence data that must contain sufficient intersequence variability in order to be informative. These criteria, however, may not be...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010079
更新日期:2021-01-08 00:00:00
abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), employs host-cell angiotensin-converting enzyme 2 (ACE2) for cell entry. Genetic analyses of ACE2 have identified several single-nucleotide polymorphisms (SNPs) specific to different human populati...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010067
更新日期:2021-01-06 00:00:00
abstract::Rotavirus causes severe gastroenteritis in children. Although vaccines are implemented, rotavirus-related diarrhea still claims ~200,000 lives annually worldwide, mainly in low-income settings, pointing to a need for improved vaccine tactics. To meet such a public health need, a P24-VP8* nanoparticle displaying the gl...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010072
更新日期:2021-01-06 00:00:00
abstract::Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1-4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and M...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010057
更新日期:2021-01-04 00:00:00
abstract::In rabies diagnosis, it is essential to count on a rapid test to give a quick response. The combined sensitivity and robustness of the TaqMan RT-PCR assays (qRT-PCR) have made these methods a valuable alternative for rabies virus (RABV) detection. We conducted a study to compare the applicability of two widely used qR...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010023
更新日期:2020-12-25 00:00:00
abstract::Severe fever with thrombocytopenia syndrome (SFTS), a tick-borne infectious disease, is difficult to differentiate from other common febrile diseases. Clinically distinctive features and climate variates associated with tick growth can be useful predictors for SFTS. This retrospective study (2013-2019) demonstrated th...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010010
更新日期:2020-12-23 00:00:00
abstract::Double-stranded DNA viruses package their genomes into pre-assembled protein procapsids. This process is driven by macromolecular motors that transiently assemble at a unique vertex of the procapsid and utilize homomeric ring ATPases to couple genome encapsidation to ATP hydrolysis. Here, we describe the biochemical a...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010015
更新日期:2020-12-23 00:00:00
abstract::Virus-induced inflammation plays a critical role in determining the clinical outcome of an acute respiratory virus infection. We have shown previously that the administration of immunobiotic Lactobacillus plantarum (Lp) directly to the respiratory tract prevents lethal inflammatory responses to subsequent infection wi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010002
更新日期:2020-12-22 00:00:00
abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. The 3' untranslated region (UTR) of this β-CoV contains essential cis-acting RNA elements for the viral genome transcription and replication. These elements include an equilibrium between an extended bulged s...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121473
更新日期:2020-12-21 00:00:00
abstract::African swine fever (ASF) has become the major threat for the global swine industry. Furthermore, the epidemiological situation of African swine fever virus (ASFV) in some endemic regions of Sub-Saharan Africa is worse than ever, with multiple virus strains and genotypes currently circulating in a given area. Despite ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121474
更新日期:2020-12-21 00:00:00
abstract::Delivering rapid protection against infectious agents to non-immune populations is a formidable public health challenge. Although passive immunotherapy is a fast and effective method of protection, large-scale production and administration of monoclonal antibodies (mAbs) is expensive and unpractical. Viral vector-medi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121460
更新日期:2020-12-17 00:00:00
abstract::Around 257 million people are living with hepatitis B virus (HBV) chronic infection and 71 million with hepatitis C virus (HCV) chronic infection. Both HBV and HCV infections can lead to liver complications such as cirrhosis and hepatocellular carcinoma (HCC). To take care of these chronically infected patients, one s...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12121440
更新日期:2020-12-14 00:00:00
abstract::Innate immune interferons (IFNs), including type I and III IFNs, constitute critical antiviral mechanisms. Recent studies reveal that IFN dysregulation is key to determine COVID-19 pathogenesis. Effective IFN stimulation or prophylactic administration of IFNs at the early stage prior to severe COVID-19 may elicit an a...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12121433
更新日期:2020-12-13 00:00:00
abstract::A number of characteristics including lack of virulence and the ability to grow to high titers, have made bovine adenovirus-3 (BAdV-3) a vector of choice for further development as a vaccine-delivery vehicle for cattle. Despite the importance of blood leukocytes, including dendritic cells (DC), in the induction of pro...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121431
更新日期:2020-12-12 00:00:00
abstract::Canid alphaherpesvirus 1 (CHV-1) is a widespread pathogen of dogs with multiple associated clinical signs. There has been limited prior investigation into the genomics and phylogeny of this virus using whole viral genome analysis. Fifteen CHV-1 isolates were collected from animals with ocular disease based in the USA....
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121421
更新日期:2020-12-10 00:00:00
abstract::Viruses represent important test cases for data federation due to their genome size and the rapid increase in sequence data in publicly available databases. However, some consequences of previously decentralized (unfederated) data are lack of consensus or comparisons between feature annotations. Unifying or displaying...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121424
更新日期:2020-12-10 00:00:00
abstract::Koala retrovirus (KoRV) poses a major threat to koala health and conservation, and currently has 10 identified subtypes: an endogenous subtype (KoRV-A) and nine exogenous subtypes (KoRV-B to KoRV-J). However, subtype-related variations in koala immune response to KoRV are uncharacterized. In this study, we investigate...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121415
更新日期:2020-12-09 00:00:00
abstract::Although polyethylene glycol (PEG) application is the most widely used method in removing nonstructural proteins (NSPs) for foot-and-mouth disease (FMD) vaccine production, some NSPs remaining in the antigen could elicit antibodies against these proteins after repeated vaccinations in livestock. Therefore, the purpose...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121405
更新日期:2020-12-07 00:00:00
abstract::The genomes of polyomaviruses are characterized by their tripartite organization with an early region, a late region and a noncoding control region (NCCR). The early region encodes proteins involved in replication and transcription of the viral genome, while expression of the late region generates the capsid proteins....
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12121406
更新日期:2020-12-07 00:00:00
abstract::The International Virus Bioinformatics Meeting 2020 was originally planned to take place in Bern, Switzerland, in March 2020. However, the COVID-19 pandemic put a spoke in the wheel of almost all conferences to be held in 2020. After moving the conference to 8-9 October 2020, we got hit by the second wave and finally ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121398
更新日期:2020-12-06 00:00:00
abstract::Changes over time in HIV-1 subtype diversity within a population reflect changes in factors influencing the development of local epidemics. Here we report on the genetic diversity of 2364 reverse transcriptase sequences from people living with HIV-1 in New South Wales (NSW) notified between 2004 and 2018. These data r...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121402
更新日期:2020-12-06 00:00:00
abstract::Via virome sequencing, six viruses were detected from Magnaporthe oryzae strains YC81-2, including one virus in the family Tombusviridae, one virus in the family Narnaviridae and four viruses in the family Botourmiaviridae. Since the RNA-dependent RNA polymerase (RdRp) of one botourmiavirus show the highest identity (...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121383
更新日期:2020-12-03 00:00:00
abstract::Bovine rotavirus A (RVA), a major causative pathogen of diarrhea in dairy and Japanese beef calves, has led to severe economic losses in numerous countries. A dual genotyping system based on genomic segments encoding VP7 (G genotype) and VP4 (P genotype), comprising the outer layer of the virion, has been used to unde...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121386
更新日期:2020-12-03 00:00:00
abstract::The virion proteins of Kaposi sarcoma-associated herpesvirus (KSHV) were initially characterized in 2005 in two separate studies that combined the detection of 24 viral proteins and a few cellular components via LC-MS/MS or MALDI-TOF. Despite considerable advances in the sensitivity and specificity of mass spectrometr...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121382
更新日期:2020-12-02 00:00:00
abstract::Specific chromatin immunoprecipitation of salt-fractionated infected cell extracts has demonstrated that the CCCTC-binding factor (CTCF), a highly conserved, 11-zinc-finger DNA-binding protein with known roles in cellular and viral genome organization and gene expression, specifically binds the genome of Minute Virus ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121368
更新日期:2020-11-30 00:00:00
abstract::RNA viruses are extraordinary evolution machines that efficiently ensure their replication by taking advantage of the association with viral and cellular components to form ribonucleic complexes (vRNPs) [...]. ...
journal_title:Viruses
pub_type: 社论
doi:10.3390/v12121355
更新日期:2020-11-26 00:00:00
abstract::Despite worldwide efforts to understand the transmission dynamics of Zika virus (ZIKV), scanty evaluation has been made on the vector competence of Aedes aegypti fed directly on viremic human and non-human primates (NHPs). We blood-fed Ae. aegypti from two districts in Rio de Janeiro on six ZIKV infected pregnant rhes...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121345
更新日期:2020-11-24 00:00:00
abstract::Several viral factors impact the natural course of hepatitis B virus (HBV) infection, the sensitivity of diagnostic tests, or treatment response to interferon-α and nucleos(t)ide analogues. These factors include the viral genotype and serotype but also mutations affecting the HBV surface antigen, basal core promoter/p...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111344
更新日期:2020-11-23 00:00:00
abstract::Sea star wasting disease (SSWD) is a condition that has affected asteroids for over 120 years, yet mechanistic understanding of this wasting etiology remains elusive. We investigated temporal virome variation in two Pisaster ochraceus specimens that wasted in the absence of external stimuli and two specimens that did ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111332
更新日期:2020-11-20 00:00:00
abstract:BACKGROUND:coronavirus disease 2019 (COVID-19) causes severe illness including cytokine storms, but mortality among countries differs largely. In the present study, we investigated the association between human leukocyte antigen (HLA) class I, which plays a major role in susceptibility to viral infections, and the mort...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111333
更新日期:2020-11-20 00:00:00
abstract::During the last 25 years, swine vesicular disease (SVD) has occurred in Italy mostly sub-clinically. Therefore, regular testing of fecal samples from suspected holdings and high turnover premises was fundamental to identifying virus circulation and to achieve SVD eradication. In this study, we evaluated diagnostic per...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111336
更新日期:2020-11-20 00:00:00
abstract::An outbreak of winter dysentery, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3-4 days after the appearanc...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111331
更新日期:2020-11-19 00:00:00
abstract::In recent decades, chikungunya virus (CHIKV) has become geographically widespread. In 2004, the CHIKV East/Central/South African (ECSA) genotype moved from Africa to Indian ocean islands and India followed by a large epidemic in Southeast Asia. In 2013, the CHIKV Asian genotype drove an outbreak in the Americas. Since...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111319
更新日期:2020-11-17 00:00:00
abstract::How microbial populations interact influences the availability and flux of organic carbon in the ocean. Understanding how these interactions vary over broad spatial scales is therefore a fundamental aim of microbial oceanography. In this study, we assessed variations in the abundances, production, virus and grazing in...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111293
更新日期:2020-11-12 00:00:00