Dysregulated Interferon Response Underlying Severe COVID-19.

abstract：:Human adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these "old" HAd...

journal_title：Viruses

authors： Zhang J,Kang J,Dehghan S,Sridhar S,Lau SKP,Ou J,Woo PCY,Zhang Q,Seto D

更新日期：2019-01-31 00:00:00

abstract：:Baboons are susceptible to natural Ebola virus (EBOV) infection and share 96% genetic homology with humans. Despite these characteristics, baboons have rarely been utilized as experimental models of human EBOV infection to evaluate the efficacy of prophylactics and therapeutics in the United States. This review will s...

journal_title：Viruses

authors： Perry DL,Bollinger L,White GL

更新日期：2012-10-23 00:00:00

abstract：:Neuraminidase inhibitors (NAIs) are vital in managing seasonal and pandemic influenza infections. NAI susceptibilities of virus isolates (n = 5540) collected during the 2008-2009 influenza season were assessed in the chemiluminescent neuraminidase inhibition (NI) assay. Box-and-whisker plot analyses of log-transformed...

journal_title：Viruses

authors： Okomo-Adhiambo M,Sleeman K,Ballenger K,Nguyen HT,Mishin VP,Sheu TG,Smagala J,Li Y,Klimov AI,Gubareva LV

更新日期：2010-10-01 00:00:00

abstract：:HIV continues to spread among vulnerable heterosexual (HET), Men-having-Sex with Men (MSM) and intravenous drug user (IDU) populations, influenced by a complex array of biological, behavioral and societal factors. Phylogenetics analyses of large sequence datasets from national drug resistance testing programs reveal t...

journal_title：Viruses

authors： Brenner BG,Ibanescu RI,Hardy I,Roger M

更新日期：2017-12-28 00:00:00

abstract：:We are currently facing a pandemic of COVID-19, caused by a spillover from an animal-originating coronavirus to humans occurring in the Wuhan region of China in December 2019. From China, the virus has spread to 188 countries and regions worldwide, reaching the Sahel region on March 2, 2020. Since whole genome sequenc...

journal_title：Viruses

authors： Kouriba B,Dürr A,Rehn A,Sangaré AK,Traoré BY,Bestehorn-Willmann MS,Ouedraogo J,Heitzer A,Sogodogo E,Maiga A,Walter MC,Zimmermann F,Wölfel R,Antwerpen MH

更新日期：2020-11-02 00:00:00

abstract：:Zika virus recently re-emerged and caused global outbreaks mainly in Central Africa, Southeast Asia, the Pacific Islands and in Central and South America. Even though there is a declining trend, the virus continues to spread throughout different geographical regions of the world. Since its re-emergence in 2015, massiv...

journal_title：Viruses

authors： Alves MP,Vielle NJ,Thiel V,Pfaender S

更新日期：2018-10-30 00:00:00

abstract：:The Human immunodeficiency virus-1 (HIV-1) accessory protein Vpu modulates numerous proteins, including the host proteins CD4 and BST-2/tetherin. Vpu interacts with the Skp, Cullin, F-Box (SCF) ubiquitin ligase through interactions with the F-Box protein βTrCP (1 and/or 2). This interaction is dependent on phosphoryla...

journal_title：Viruses

authors： Song YE,Cyburt D,Lucas TM,Gregory DA,Lyddon TD,Johnson MC

更新日期：2018-10-19 00:00:00

abstract：:Equine influenza, caused by the H3N8 subtype, is a highly contagious respiratory disease affecting equid populations worldwide and has led to serious epidemics and transboundary pandemics. This study describes the phylogenetic characterization and replication kinetics of recently-isolated H3N8 virus from a nasal swab ...

journal_title：Viruses

authors： Sreenivasan CC,Jandhyala SS,Luo S,Hause BM,Thomas M,Knudsen DEB,Leslie-Steen P,Clement T,Reedy SE,Chambers TM,Christopher-Hennings J,Nelson E,Wang D,Kaushik RS,Li F

更新日期：2018-01-11 00:00:00

abstract：:Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis. In NSVs, the single strand RNA genome is encapsidated in the line...

journal_title：Viruses

authors： Luo M,Terrell JR,Mcmanus SA

更新日期：2020-07-30 00:00:00

abstract：:Merkel cell polyomavirus (MCV) is the only known human oncogenic virus in the polyomaviridae family and the etiological agent of most Merkel cell carcinomas (MCC). MCC is an aggressive and highly metastatic skin cancer with a propensity for recurrence and poor prognosis. Large tumor antigen (LT), is an essential oncop...

journal_title：Viruses

authors： Nwogu N,Ortiz LE,Kwun HJ

更新日期：2020-09-18 00:00:00

abstract：:Non-human primates (NHP) are the only animal model suitable to evaluate the protection efficacy of HIV-1 vaccines. It is important to understand how and when neutralizing antibodies (nAbs) with specificities similar to those of human broadly neutralizing antibodies (bnAbs) develop in NHPs. To address these questions, ...

journal_title：Viruses

authors： Gao N,Gai Y,Meng L,Wang C,Zhang X,Wang W,Qin C,Yu X,Gao F

更新日期：2020-01-31 00:00:00

abstract：:Campylobacter jejuni is a frequent foodborne pathogen of humans. As C. jejuni infections commonly arise from contaminated poultry, phage treatments have been proposed to reduce the C. jejuni load on farms to prevent human infections. While a prior report documented the transcriptome of C. jejuni phages during the carr...

journal_title：Viruses

authors： Sacher JC,Flint A,Butcher J,Blasdel B,Reynolds HM,Lavigne R,Stintzi A,Szymanski CM

更新日期：2018-06-16 00:00:00

abstract：:Papaya ringspot virus (PRSV), a common potyvirus infecting papaya plants worldwide, can lead to either antagonism or synergism in mixed infections with Papaya mosaic virus (PapMV), a potexvirus. These two unrelated viruses produce antagonism or synergism depending on their order of infection in the plant. When PRSV is...

journal_title：Viruses

authors： Vargas-Mejía P,Vega-Arreguín J,Chávez-Calvillo G,Ibarra-Laclette E,Silva-Rosales L

更新日期：2020-02-19 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is an important cancer-causing human retrovirus that has infected approximately 15 million individuals worldwide. Many aspects of HTLV-1 replication, including virus particle structure and assembly, are poorly understood. Group-specific antigen (Gag) proteins labeled at the ...

journal_title：Viruses

authors： Maldonado JO,Angert I,Cao S,Berk S,Zhang W,Mueller JD,Mansky LM

更新日期：2017-07-19 00:00:00

abstract：:The begomoviruses (BGVs) are plant pathogens that evolved in the Old World during the Cretaceous and arrived to the New World (NW) in the Cenozoic era. A subgroup of NW BGVs, the "Squash leaf curl virus (SLCV) lineage" (S-Lin), includes viruses with unique characteristics. To get clues on the evolutionary origin of th...

journal_title：Viruses

authors： Torres-Herrera SI,Romero-Osorio A,Moreno-Valenzuela O,Pastor-Palacios G,Cardenas-Conejo Y,Ramírez-Prado JH,Riego-Ruiz L,Minero-García Y,Ambriz-Granados S,Argüello-Astorga GR

更新日期：2019-07-13 00:00:00

abstract：:Sandfly-borne phleboviruses pathogenic to humans, such as Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV), are endemic in the Mediterranean region. In France, several autochthonous cases of TOSV infection have been described, causing either meningitis or encephalitis. The aim of the present study was to i...

journal_title：Viruses

authors： Masse S,Ayhan N,Capai L,Bosseur F,de Lamballerie X,Charrel R,Falchi A

更新日期：2019-09-04 00:00:00

abstract：:Commentary on Doceul, V.; Hollinshead, M.; van der Linden, L.; Smith, G.L. Repulsion of superinfecting virions: a mechanism for rapid virus spread. Science2010, 327, 873-876. ...

journal_title：Viruses

authors： Condit RC

更新日期：2010-05-01 00:00:00

abstract：:The honey bee queen is the central hub of a colony to produce eggs and release pheromones to maintain social cohesion. Among many environmental stresses, viruses are a major concern to compromise the queen's health and reproductive vigor. Viruses have evolved numerous strategies to infect queens either via vertical tr...

journal_title：Viruses

authors： Amiri E,Strand MK,Tarpy DR,Rueppell O

更新日期：2020-03-17 00:00:00

abstract：:Ebola virus is the causative agent of Ebola virus disease in humans. The lethality of Ebola virus infection is about 50%, supporting the urgent need to develop anti-Ebola drugs. Glycoprotein (GP) is the only surface protein of the Ebola virus, which is functionally critical for the virus to attach and enter the host c...

journal_title：Viruses

authors： Cui Q,Cheng H,Xiong R,Zhang G,Du R,Anantpadma M,Davey RA,Rong L

更新日期：2018-11-30 00:00:00

abstract：:Although polyethylene glycol (PEG) application is the most widely used method in removing nonstructural proteins (NSPs) for foot-and-mouth disease (FMD) vaccine production, some NSPs remaining in the antigen could elicit antibodies against these proteins after repeated vaccinations in livestock. Therefore, the purpose...

journal_title：Viruses

authors： Park SY,Lee JM,Kim AY,Park SH,Kim JS,Kim H,Park JW,Park JH,Ko YJ,Park CK

更新日期：2020-12-07 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) can infect a wide range of cell types, including cells of the adaptive and innate immunity but, normally, it completes a fully-permissive replication cycle only in epithelial or neural cells. Complex mechanisms controlling this delicate balance in immune cells and consequent restriction ...

journal_title：Viruses

authors： Marino-Merlo F,Papaianni E,Frezza C,Pedatella S,De Nisco M,Macchi B,Grelli S,Mastino A

更新日期：2019-05-10 00:00:00

abstract：:A highly virulent porcine epidemic diarrhea virus (PEDV) appeared in China and spread rapidly to neighbor countries, which have led to great economic losses to the pig industry. In the present study, we isolated a PEDV using Vero cells and serially propagated 100 passages. PEDV SDSX16 was characterized in vitro and in...

journal_title：Viruses

authors： Zhao P,Wang S,Chen Z,Yu J,Tang R,Qiu W,Zhao L,Liu Y,Guo X,He H,Xu G,Li J,Wu J

更新日期：2020-04-01 00:00:00

abstract：:Cervical cancer is the fourth most frequently occurring cancer in women around the world and can affect them during their reproductive years. Since the development of the Papanicolaou (Pap) test, screening has been essential in identifying cervical cancer at a treatable stage. With the identification of the human papi...

journal_title：Viruses

authors： Chrysostomou AC,Stylianou DC,Constantinidou A,Kostrikis LG

更新日期：2018-12-19 00:00:00

abstract：:Despite worldwide efforts to understand the transmission dynamics of Zika virus (ZIKV), scanty evaluation has been made on the vector competence of Aedes aegypti fed directly on viremic human and non-human primates (NHPs). We blood-fed Ae. aegypti from two districts in Rio de Janeiro on six ZIKV infected pregnant rhes...

journal_title：Viruses

authors： Fernandes RS,David MR,De Abreu FVS,Ferreira-de-Brito A,Gardinali NR,Lima SMB,Andrade MCR,Kugelmeier T,Oliveira JM,Pinto MA,Lourenço-de-Oliveira R

更新日期：2020-11-24 00:00:00

abstract：:Varroa destructor is an ectoparasitic mite of Asian or Eastern honeybees Apis cerana(A. cerana) which has become a serious threat to European subspecies of Western honeybees Apis mellifera (A. mellifera) within the last century. V.destructor and its vectored honeybee viruses became serious threats for colony survival....

journal_title：Viruses

authors： Levin S,Sela N,Erez T,Nestel D,Pettis J,Neumann P,Chejanovsky N

更新日期：2019-01-24 00:00:00

abstract：:Decay accelerating factor (DAF/CD55) is targeted by many pathogens for cell entry. It has been implicated as a co-receptor for hantaviruses. To examine the binding of hantaviruses to DAF, we describe the use of Protein G beads for binding human IgG Fc domain-functionalized DAF ((DAF)₂-Fc). When mixed with Protein G be...

journal_title：Viruses

authors： Buranda T,Swanson S,Bondu V,Schaefer L,Maclean J,Mo Z,Wycoff K,Belle A,Hjelle B

更新日期：2014-03-10 00:00:00

abstract：:The ability of the host to trigger apoptosis in infected cells is perhaps the most powerful tool by which viruses can be cleared from the host organism. To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and i...

journal_title：Viruses

authors： Yuan CH,Filippova M,Duerksen-Hughes P

更新日期：2012-12-18 00:00:00

abstract：:The Vibrio cholerae biotype "El Tor" is responsible for all of the current epidemic and endemic cholera outbreaks worldwide. These outbreaks are clonal, and it is hypothesized that they originate from the coastal areas near the Bay of Bengal, where the lytic bacteriophage ICP1 (International Centre for Diarrhoeal Dise...

journal_title：Viruses

authors： Angermeyer A,Das MM,Singh DV,Seed KD

更新日期：2018-06-01 00:00:00

abstract：:Streptococcus thermophilus is considered one of the most important species for the dairy industry. Due to their diffusion in dairy environments, bacteriophages can represent a threat to this widely used bacterial species. Despite the presence of a CRISPR-Cas system in the S. thermophilus genome, some lysogenic strains...

journal_title：Viruses

authors： da Silva Duarte V,Giaretta S,Campanaro S,Treu L,Armani A,Tarrah A,Oliveira de Paula S,Giacomini A,Corich V

更新日期：2018-12-22 00:00:00

abstract：:Tospovirus is a tripartite negative stranded RNA virus and is considered as one of the most devastating plant viruses. Successful virus infection in plant requires many host factors. To date, very few host factors have been identified as important in Tospovirus infection in plants. We reported earlier that NSm protein...

journal_title：Viruses

authors： Qian X,Xiang Q,Yang T,Ma H,Ding XS,Tao X

更新日期：2018-11-17 00:00:00