Novel Flavivirus Attenuation Markers Identified in the Envelope Protein of Alfuy Virus.

abstract：:Innate immunity is the first line of defense against viral infection, and in turn, viruses have evolved to evade host immune surveillance. As a result, viruses may persist in host and develop chronic infections. Type I interferons (IFN-α/β) are among the most potent antiviral cytokines triggered by viral infections. P...

journal_title：Viruses

authors： Sun Y,Han M,Kim C,Calvert JG,Yoo D

更新日期：2012-04-01 00:00:00

abstract：:The objective of this study was to evaluate the effects of A3R phage and Staphylococcus aureus lysate obtained after phage infection on neutrophil degranulation. The exocytosis of primary and secondary granules from neutrophils was investigated in vitro in whole blood specimens by flow cytometry based on the expressio...

journal_title：Viruses

authors： Borysowski J,Międzybrodzki R,Wierzbicki P,Kłosowska D,Korczak-Kowalska G,Weber-Dąbrowska B,Górski A

更新日期：2017-02-21 00:00:00

abstract：:Several viral factors impact the natural course of hepatitis B virus (HBV) infection, the sensitivity of diagnostic tests, or treatment response to interferon-α and nucleos(t)ide analogues. These factors include the viral genotype and serotype but also mutations affecting the HBV surface antigen, basal core promoter/p...

journal_title：Viruses

authors： Velkov S,Protzer U,Michler T

更新日期：2020-11-23 00:00:00

abstract：:Bats are an important source of viral zoonoses, including paramyxoviruses. The paramyxoviral Pararubulavirus genus contains viruses mostly derived from bats that are common, diverse, distributed throughout the Old World, and known to be zoonotic. Here, we describe a new member of the genus Achimota pararubulavirus 3 (...

journal_title：Viruses

authors： Baker KS,Tachedjian M,Barr J,Marsh GA,Todd S,Crameri G,Crameri S,Smith I,Holmes CEG,Suu-Ire R,Fernandez-Loras A,Cunningham AA,Wood JLN,Wang LF

更新日期：2020-10-30 00:00:00

abstract：:A wide gap exists between the rapid acceptance of genetically modified (GM) crops for cultivation by farmers in many countries and in the global markets for food and feed, and the often-limited acceptance by consumers. This review contrasts the advances of practical applications of agricultural biotechnology with the ...

journal_title：Viruses

authors： Lucht JM

更新日期：2015-07-30 00:00:00

abstract：:While PCR amplicons extend to a few thousand bases, the length of sequences from direct Sanger sequencing is limited to 500-800 nucleotides. Therefore, several fragments may be required to cover an amplicon, a gene or an entire genome. These fragments are typically sequenced in an overlapping fashion and assembled by ...

journal_title：Viruses

authors： Bell TG,Kramvis A

更新日期：2013-03-12 00:00:00

abstract：:Background: Bats are known to host a number of nonpathogenic viruses, as well as highly pathogenic viruses causing fatal diseases like rabies. Serological surveys as part of active and passive bat rabies surveillance mainly use seroneutralization assays, demonstrating the presence of lyssavirus-specific antibodies in ...

journal_title：Viruses

authors： Orłowska A,Smreczak M,Freuling CM,Müller T,Trębas P,Rola J

更新日期：2020-02-28 00:00:00

abstract：:Flaviviruses, most of which are emerging and re-emerging human pathogens and significant public health concerns worldwide, are positive-sense RNA viruses. Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which consists of a C-terminal RdRp domain and an N-terminal methyltra...

journal_title：Viruses

authors： Duan Y,Zeng M,Jiang B,Zhang W,Wang M,Jia R,Zhu D,Liu M,Zhao X,Yang Q,Wu Y,Zhang S,Liu Y,Zhang L,Yu Y,Pan L,Chen S,Cheng A

更新日期：2019-10-10 00:00:00

abstract：:It has been demonstrated that MEK1, one of the two MEK isoforms in Raf-MEK-ERK1/2 pathway, is essential for successful EV71 propagation. However, the distinct function of ERK1 and ERK2 isoforms, the downstream kinases of MEKs, remains unclear in EV71 replication. In this study, specific ERK siRNAs and selective inhibi...

journal_title：Viruses

authors： Zhu M,Duan H,Gao M,Zhang H,Peng Y

更新日期：2015-03-20 00:00:00

abstract：:Porcine circovirus 3 (PCV3) has been identified as a putative swine pathogen with a subset of infections resulting in stillborn and mummified fetuses, encephalitis and myocarditis in perinatal, and periarteritis in growing pigs. Three PCV3 isolates were isolated from weak-born piglets or elevated stillborn and mummifi...

journal_title：Viruses

authors： Mora-Díaz J,Piñeyro P,Shen H,Schwartz K,Vannucci F,Li G,Arruda B,Giménez-Lirola L

更新日期：2020-02-16 00:00:00

abstract：:Cyclophilins are peptidyl-prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for c...

journal_title：Viruses

authors： Frausto SD,Lee E,Tang H

更新日期：2013-07-11 00:00:00

abstract：:Since the emergence of NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) in China in 2013, PRRSVs have undergone rapid evolution. In this study, a novel variant of PRRSV strain (designated SCcd17) was successfully isolated from piglets with clinical signs in Sichuan Province in China in 2017, and...

journal_title：Viruses

authors： Zhou L,Kang R,Xie B,Tian Y,Wu X,Lv X,Yang X,Wang H

更新日期：2018-03-27 00:00:00

abstract：:During infection, Citrus tristeza virus (CTV) produces a non-coding subgenomic RNA referred to as low-molecular-weight tristeza 1 (LMT1), which for a long time has been considered as a by-product of the complex CTV replication machinery. In this study, we investigated the role of LMT1 in the virus infection cycle usin...

journal_title：Viruses

authors： Kang SH,Sun YD,Atallah OO,Huguet-Tapia JC,Noble JD,Folimonova SY

更新日期：2019-05-14 00:00:00

abstract：:Influenza A viruses (IAVs) harbor a segmented RNA genome that is organized into eight distinct viral ribonucleoprotein (vRNP) complexes. Although a segmented genome may be a major advantage to adapt to new host environments, it comes at the cost of a highly sophisticated genome packaging mechanism. Newly synthesized v...

journal_title：Viruses

authors： Giese S,Bolte H,Schwemmle M

更新日期：2016-06-17 00:00:00

abstract：:Oropouche fever is an emerging zoonotic disease caused by Oropouche virus (OROV), an arthropod transmitted Orthobunyavirus circulating in South and Central America. During the last 60 years, more than 30 epidemics and over half a million clinical cases attributed to OROV infection have been reported in Brazil, Peru, P...

journal_title：Viruses

authors： Sakkas H,Bozidis P,Franks A,Papadopoulou C

更新日期：2018-04-04 00:00:00

abstract：:Internal ribosome entry is a key mechanism for viral protein synthesis in a subset of RNA viruses. Cricket paralysis virus (CrPV), a member of Dicistroviridae, has a positive-sense single strand RNA genome that contains two internal ribosome entry sites (IRES), a 5'untranslated region (5'UTR) and intergenic region (IG...

journal_title：Viruses

authors： Khong A,Bonderoff JM,Spriggs RV,Tammpere E,Kerr CH,Jackson TJ,Willis AE,Jan E

更新日期：2016-01-19 00:00:00

abstract：:Bacterial infections pose a challenge to human health and burden the health care system, especially with the spread of antibiotic-resistant populations. To provide effective treatment and improved prognosis, effective diagnostic methods are of great importance. Here we present phage-mediated molecular detection (PMMD)...

journal_title：Viruses

authors： Malagon F,Estrella LA,Stockelman MG,Hamilton T,Teneza-Mora N,Biswas B

更新日期：2020-04-11 00:00:00

abstract：:RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in t...

journal_title：Viruses

authors： Wei R,Chen G,Algehainy N,Zeng C,Liu C,Liu H,Liu W,Stacey D,Zhou A

更新日期：2020-01-07 00:00:00

abstract：:Nasopharyngeal cancer (NPC) is associated with Epstein Barr virus (EBV) infection. However different viral strains have been implicated in NPC worldwide. This study aimed to detect and characterize EBV in patients diagnosed with NPC in Ghana. A total of 55 patients diagnosed with NPC by CT scan and endoscopy were age-...

journal_title：Viruses

authors： Ayee R,Ofori MEO,Tagoe EA,Languon S,Searyoh K,Armooh L,Bilson-Amoah E,Baidoo K,Kitcher E,Wright E,Quaye O

更新日期：2020-07-16 00:00:00

abstract：:Samples of two Ageratum conyzoides, one Sonchus oleraceus and one turnip (Brassica rapa var. rapa) exhibiting virus-like symptoms were collected from Pakistan and Nepal. Full-length begomovirus clones were obtained from the four plant samples and betasatellite clones from three of these. The begomovirus sequences were...

journal_title：Viruses

authors： Tahir M,Amin I,Haider MS,Mansoor S,Briddon RW

更新日期：2015-02-10 00:00:00

abstract：:Next-generation sequencing (NGS) has opened up the possibility of detecting new viruses in unresolved diseases. Recently, astrovirus brain infections have been identified in neurologically diseased humans and animals by NGS, among them bovine astrovirus (BoAstV) CH13/NeuroS1, which has been found in brain tissues of c...

journal_title：Viruses

authors： Selimovic-Hamza S,Boujon CL,Hilbe M,Oevermann A,Seuberlich T

更新日期：2017-01-18 00:00:00

abstract：:The Bunyaviridae is the largest family of RNA viruses, with over 350 members worldwide. Several of these viruses cause severe diseases in livestock and humans. With an increasing number and frequency of outbreaks, bunyaviruses represent a growing threat to public health and agricultural productivity globally. Yet, the...

journal_title：Viruses

authors： Albornoz A,Hoffmann AB,Lozach PY,Tischler ND

更新日期：2016-05-24 00:00:00

abstract：:Human immunodeficiency virus (HIV) is a causative agent of acquired immune deficiency syndrome (AIDS). Highly active antiretroviral therapy (HAART) can slow down the replication of HIV-1, leading to an improvement in the survival of HIV-1-infected patients. However, drug toxicities and poor drug administration has led...

journal_title：Viruses

authors： Chupradit K,Moonmuang S,Nangola S,Kitidee K,Yasamut U,Mougel M,Tayapiwatana C

更新日期：2017-09-29 00:00:00

abstract：:A myriad of factors favor the emergence and re-emergence of arthropod-borne viruses (arboviruses), including migration, climate change, intensified livestock production, an increasing volume of international trade and transportation, and changes to ecosystems (e.g., deforestation and loss of biodiversity). Consequentl...

journal_title：Viruses

authors： Hollidge BS,Weiss SR,Soldan SS

更新日期：2011-06-01 00:00:00

abstract：:Lassa mammarenavirus (LASV) is the etiologic agent of Lassa fever. In endemic regions in West Africa, LASV genetic diversity tends to cluster by geographic area. Seven LASV lineages are recognized, but the role of viral genetic determinants on disease presentation in humans is uncertain. We investigated the geographic...

journal_title：Viruses

authors： Forni D,Sironi M

更新日期：2020-04-13 00:00:00

abstract：:The hepatitis C virus (HCV), a hepatotropic plus-strand RNA virus of the family Flaviviridae, encodes a set of 10 viral proteins. These viral factors act in concert with host proteins to mediate virus entry, and to coordinate RNA replication and virus production. Recent evidence has highlighted the complexity of HCV a...

journal_title：Viruses

authors： Steinmann E,Pietschmann T

更新日期：2010-09-01 00:00:00

abstract：:Simian hemorrhagic fever virus (SHFV) causes a fulminant and typically lethal viral hemorrhagic fever (VHF) in macaques (Cercopithecinae: Macaca spp.) but causes subclinical infections in patas monkeys (Cercopithecinae: Erythrocebus patas). This difference in disease course offers a unique opportunity to compare host ...

journal_title：Viruses

authors： Cornish JP,Moore IN,Perry DL,Lara A,Minai M,Promeneur D,Hagen KR,Virtaneva K,Paneru M,Buechler CR,O'Connor DH,Bailey AL,Cooper K,Mazur S,Bernbaum JG,Pettitt J,Jahrling PB,Kuhn JH,Johnson RF

更新日期：2019-01-15 00:00:00

abstract：:Both temperature and humidity may independently or jointly contribute to the risk of human rhinovirus (HRV) infections, either through altered survival and spread of viruses in the environment or due to changes in host susceptibility. This study examined the relationship between short-term variations in temperature an...

journal_title：Viruses

authors： Ikäheimo TM,Jaakkola K,Jokelainen J,Saukkoriipi A,Roivainen M,Juvonen R,Vainio O,Jaakkola JJ

更新日期：2016-09-02 00:00:00

abstract：:Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research l...

journal_title：Viruses

authors： Wahl-Jensen V,Bollinger L,Safronetz D,de Kok-Mercado F,Scott DP,Ebihara H

更新日期：2012-12-14 00:00:00

abstract：:Human cytomegalovirus (HCMV), the largest human herpesvirus, infects a majority of the world's population. Like all herpesviruses, following primary productive infection, HCMV establishes a life-long latent infection, from which it can reactivate years later to produce new, infectious virus. Despite the presence of a ...

journal_title：Viruses

authors： McSharry BP,Avdic S,Slobedman B

更新日期：2012-10-25 00:00:00