Development of Genotype-Specific Anti-Bovine Rotavirus A Immunoglobulin Yolk Based on a Current Molecular Epidemiological Analysis of Bovine Rotaviruses A Collected in Japan during 2017-2020.

abstract：:Salmonid alphavirus (SAV) is the cause of pancreas disease and sleeping disease in farmed salmonid fish in Europe. The spread of these diseases has been difficult to control with biosecurity and current vaccination strategies, and increased understanding of the viral pathogenesis could be beneficial for the developmen...

journal_title：Viruses

authors： Aksnes I,Markussen T,Braaen S,Rimstad E

更新日期：2020-09-24 00:00:00

abstract：:Marek's disease virus (MDV) is a member of alphaherpesviruses associated with Marek's disease, a highly contagious neoplastic disease in chickens. Complete sequencing of the viral genome and recombineering techniques using infectious bacterial artificial chromosome (BAC) clones of Marek's disease virus genome have ide...

journal_title：Viruses

authors： Zhang Y,Tang N,Sadigh Y,Baigent S,Shen Z,Nair V,Yao Y

更新日期：2018-05-24 00:00:00

abstract：:Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1-4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and M...

journal_title：Viruses

authors： Dieng I,Cunha M,Diagne MM,Sembène PM,Zanotto PMA,Faye O,Faye O,Sall AA

更新日期：2021-01-04 00:00:00

abstract：:RNA virus invasion induces a cytosolic RIG-I-like receptor (RLR) signaling pathway by promoting assembly of the Mitochondrial antiviral-signaling protein (MAVS) signalosome and triggers the rapid production of type I interferons (IFNs) and proinflammatory cytokines. During this process, the pivotal kinase TANK binding...

journal_title：Viruses

authors： He TS,Xie T,Li J,Yang YX,Li C,Wang W,Cao L,Rao H,Ju C,Xu LG

更新日期：2019-02-15 00:00:00

abstract：:Cyclophilins are peptidyl-prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for c...

journal_title：Viruses

authors： Frausto SD,Lee E,Tang H

更新日期：2013-07-11 00:00:00

abstract：:About 70% of all Ewing sarcoma (EWS) patients are diagnosed under the age of 20 years. Over the last decades little progress has been made towards finding effective treatment approaches for primarily metastasized or refractory Ewing sarcoma in young patients. Here, in the context of the search for novel therapeutic op...

journal_title：Viruses

authors： Lacroix J,Kis Z,Josupeit R,Schlund F,Stroh-Dege A,Frank-Stöhr M,Leuchs B,Schlehofer JR,Rommelaere J,Dinsart C

更新日期：2018-06-03 00:00:00

abstract：:HIV-1 causes a chronic infection in humans that is characterized by high plasma viremia, progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in opportunistic disease and AIDS. Viral persistence is mediated in part by the ability of the Nef protein to down-regulate HLA molecules on the infecte...

journal_title：Viruses

authors： Mwimanzi P,Markle TJ,Ueno T,Brockman MA

更新日期：2012-09-01 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk asses...

journal_title：Viruses

authors： Okeke MI,Okoli AS,Diaz D,Offor C,Oludotun TG,Tryland M,Bøhn T,Moens U

更新日期：2017-10-29 00:00:00

abstract：:Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and maintenance of genomic information in both cells and a variety of viral pathogens. While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been extensively inves...

journal_title：Viruses

authors： Coggins SA,Mahboubi B,Schinazi RF,Kim B

更新日期：2020-03-31 00:00:00

abstract：:Until vaccines and effective therapeutics become available, the practical solution to transit safely out of the current coronavirus disease 19 (CoVID-19) lockdown may include the implementation of an effective testing, tracing and tracking system. However, this requires a reliable and clinically validated diagnostic p...

journal_title：Viruses

authors： Rohaim MA,Clayton E,Sahin I,Vilela J,Khalifa ME,Al-Natour MQ,Bayoumi M,Poirier AC,Branavan M,Tharmakulasingam M,Chaudhry NS,Sodi R,Brown A,Burkhart P,Hacking W,Botham J,Boyce J,Wilkinson H,Williams C,Whittingham-Dow

更新日期：2020-09-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) can infect a wide range of cell types, including cells of the adaptive and innate immunity but, normally, it completes a fully-permissive replication cycle only in epithelial or neural cells. Complex mechanisms controlling this delicate balance in immune cells and consequent restriction ...

journal_title：Viruses

authors： Marino-Merlo F,Papaianni E,Frezza C,Pedatella S,De Nisco M,Macchi B,Grelli S,Mastino A

更新日期：2019-05-10 00:00:00

abstract：:Since the human immunodeficiency virus (HIV) was discovered as the etiological agent of acquired immunodeficiency syndrome (AIDS), it has encouraged much research into antiviral compounds. The reverse transcriptase (RT) of HIV has been a main target for antiviral drugs. However, all drugs developed so far inhibit the ...

journal_title：Viruses

authors： Beilhartz GL,Götte M

更新日期：2010-04-01 00:00:00

abstract：:A wide gap exists between the rapid acceptance of genetically modified (GM) crops for cultivation by farmers in many countries and in the global markets for food and feed, and the often-limited acceptance by consumers. This review contrasts the advances of practical applications of agricultural biotechnology with the ...

journal_title：Viruses

authors： Lucht JM

更新日期：2015-07-30 00:00:00

abstract：:Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can lead to integration of the viral genome in human chromosomes. When integration occurs in germinal cells, the integrated HHV-6A/B genome can be transmitted to 50% of descendants. Such individuals, carrying one copy of the HHV-6A/B ge...

journal_title：Viruses

authors： Collin V,Flamand L

更新日期：2017-06-26 00:00:00

abstract：:The hypothesis is presented that bacteriophage DNA packaging motors have a cycle comprised of bind/release thermal ratcheting with release-associated DNA pushing via ATP-dependent protein folding. The proposed protein folding occurs in crystallographically observed peptide segments that project into an axial channel o...

journal_title：Viruses

authors： Serwer P

更新日期：2010-09-01 00:00:00

abstract：:Influenza A viruses (IAVs) harbor a segmented RNA genome that is organized into eight distinct viral ribonucleoprotein (vRNP) complexes. Although a segmented genome may be a major advantage to adapt to new host environments, it comes at the cost of a highly sophisticated genome packaging mechanism. Newly synthesized v...

journal_title：Viruses

authors： Giese S,Bolte H,Schwemmle M

更新日期：2016-06-17 00:00:00

abstract：:The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on differ...

journal_title：Viruses

authors： Zeisel MB,Fafi-Kremer S,Robinet E,Habersetzer F,Baumert TF,Stoll-Keller F

更新日期：2009-09-01 00:00:00

abstract：:The levels of vascular endothelial growth factor-A (VEGF) were estimated in 102 serum samples from 63 hospitalized Greek patients with hemorrhagic fever with renal syndrome (HFRS) caused by Dobrava/Belgrade virus. Significantly higher VEGF levels were seen in the severe when compared with non-severe cases (mean values...

journal_title：Viruses

authors： Tsergouli K,Papa A

更新日期：2013-12-10 00:00:00

abstract：:Andrias davidianus ranavirus (ADRV) is an emerging viral pathogen that causes severe systemic hemorrhagic disease in Chinese giant salamanders. There is an urgent need for developing an effective vaccine against this fatal disease. In this study, DNA vaccines containing the ADRV 2L gene (pcDNA-2L) and the 58L gene (pc...

journal_title：Viruses

authors： Chen ZY,Li T,Gao XC,Wang CF,Zhang QY

更新日期：2018-01-24 00:00:00

abstract：:Antigen-specific T lymphocytes play a critical role in controlling viral infections. However, we report here that preexisting virus-specific T cell responses also contribute to promoting adenovirus (Ad) infection. Previously, we found that CD14+ monocytes from Ad-seropositive individuals exhibited an increased suscept...

journal_title：Viruses

authors： Feng F,Zhao J,Li P,Li R,Chen L,Sun C

更新日期：2019-02-13 00:00:00

abstract：:Global climate change-induced warming of the Artic seas is predicted to shift the phytoplankton community towards dominance of smaller-sized species due to global warming. Yet, little is known about their viral mortality agents despite the ecological importance of viruses regulating phytoplankton host dynamics and div...

journal_title：Viruses

authors： Maat DS,Biggs T,Evans C,van Bleijswijk JDL,van der Wel NN,Dutilh BE,Brussaard CPD

更新日期：2017-06-02 00:00:00

abstract：:Current measles vaccines suffer from poor effectiveness in young infants due primarily to the inhibitory effect of residual maternal immunity on vaccine responses. The development of a measles vaccine that resists such passive immunity would strongly contribute to the stalled effort toward measles eradication. In this...

journal_title：Viruses

authors： Julik E,Reyes-Del Valle J

更新日期：2017-09-21 00:00:00

abstract：:We previously hypothesized that increased capillary permeability observed in both hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS) may be caused by hantavirus-specific cytotoxic T cells attacking endothelial cells presenting viral antigens on their surface based on clinical o...

journal_title：Viruses

authors： Terajima M,Ennis FA

更新日期：2011-07-01 00:00:00

abstract：:Although polyethylene glycol (PEG) application is the most widely used method in removing nonstructural proteins (NSPs) for foot-and-mouth disease (FMD) vaccine production, some NSPs remaining in the antigen could elicit antibodies against these proteins after repeated vaccinations in livestock. Therefore, the purpose...

journal_title：Viruses

authors： Park SY,Lee JM,Kim AY,Park SH,Kim JS,Kim H,Park JW,Park JH,Ko YJ,Park CK

更新日期：2020-12-07 00:00:00

abstract：:Dendritic cells (DCs) are involved in human and simian immunodeficiency virus (HIV and SIV) pathogenesis but also play a critical role in orchestrating innate and adaptive vaccine-specific immune responses. Effective HIV/SIV vaccines require strong antigen-specific CD4 T cell responses, cytotoxic activity of CD8 T cel...

journal_title：Viruses

authors： Ko EJ,Robert-Guroff M

更新日期：2019-12-24 00:00:00

abstract：:The hepatitis B virus (HBV) represents a worldwide public health problem; the virus is present in one third of the global population. However, this rate may in fact be higher due to occult hepatitis B virus infection (OBI). This condition is characterized by the presence of the viral genome in the liver of individuals...

journal_title：Viruses

authors： Morales-Romero J,Vargas G,García-Román R

更新日期：2014-04-08 00:00:00

abstract：:HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the cellular ESCRT factor TSG101 and the viral protein Vpr. The processing of Ga...

journal_title：Viruses

authors： Mouhand A,Pasi M,Catala M,Zargarian L,Belfetmi A,Barraud P,Mauffret O,Tisné C

更新日期：2020-09-29 00:00:00

abstract：:African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected soft tick bites. As already described, European soft ticks (Orni...

journal_title：Viruses

authors： Pereira De Oliveira R,Hutet E,Duhayon M,Guionnet JM,Paboeuf F,Vial L,Le Potier MF

更新日期：2020-03-11 00:00:00

abstract：:Enteroviruses are small RNA viruses that affect millions of people each year by causing an important burden of disease with a broad spectrum of symptoms. In routine diagnostic laboratories, enteroviruses are identified by PCR-based methods, often combined with partial sequencing for genotyping. In this proof-of-princi...

journal_title：Viruses

authors： Grädel C,Terrazos Miani MA,Baumann C,Barbani MT,Neuenschwander S,Leib SL,Suter-Riniker F,Ramette A

更新日期：2020-07-31 00:00:00

abstract：:The hydrophobic pocket in the HIV-1 gp41 N-terminal heptad repeat (NHR) domain plays an important role in viral fusion and entry into the host cell, and serves as an attractive target for development of HIV-1 fusion/entry inhibitors. The peptide anti-HIV drug targeting gp41 NHR, T-20 (generic name: enfuvirtide; brand ...

journal_title：Viruses

authors： Yu F,Lu L,Du L,Zhu X,Debnath AK,Jiang S

更新日期：2013-01-11 00:00:00