Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques.

abstract：:Peptides derived from the C-terminal heptad repeat (CHR) region of HIV-1 gp41 is potent viral membrane fusion inhibitors, such as the first clinically approved peptide drug T20 and a group of newly-designed peptides. The resistance profiles of various HIV-1 fusion inhibitors were previously characterized, and the seco...

journal_title：Viruses

authors： Yu D,Su Y,Ding X,Zhu Y,Qin B,Chong H,Cui S,He Y

更新日期：2020-03-18 00:00:00

abstract：:Delivering rapid protection against infectious agents to non-immune populations is a formidable public health challenge. Although passive immunotherapy is a fast and effective method of protection, large-scale production and administration of monoclonal antibodies (mAbs) is expensive and unpractical. Viral vector-medi...

journal_title：Viruses

authors： Michelini Z,Minkoff JM,Yang J,Negri D,Cara A,Hanson BJ,Salvatore M

更新日期：2020-12-17 00:00:00

abstract：:Shigella ssp. and enterotoxigenic Escherichiacoli are the most common etiological agents of diarrheal diseases in malnourished children under five years of age in developing countries. The ever-growing issue of antibiotic resistance and the potential negative impact of antibiotic use on infant commensal microbiota are...

journal_title：Viruses

authors： Kaczorowska J,Casey E,Neve H,Franz CMAP,Noben JP,Lugli GA,Ventura M,Sinderen DV,Mahony J

更新日期：2019-09-26 00:00:00

abstract：:We studied whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs). As a model, we used well-characterized CpG-recoded Zika virus vaccine candidates that p...

journal_title：Viruses

authors： Trus I,Berube N,Jiang P,Rak J,Gerdts V,Karniychuk U

更新日期：2020-05-25 00:00:00

abstract：:Cytoskeleton defines the shape and structural organization of the cell. Its elements participate in cell motility, intracellular transport and chromosome movement during mitosis. Papillomaviruses (PV) are strictly epitheliotropic and induce self-limiting benign tumors of skin and mucosa, which may progress to malignan...

journal_title：Viruses

authors： Bienkowska-Haba M,Sapp M

更新日期：2011-03-01 00:00:00

abstract：:The human respiratory syncytial virus (hRSV) and human Metapneumovirus (hMPV) are two of the leading etiological agents of acute lower respiratory tract infections, which constitute the main cause of mortality in infants. However, there are currently approved vaccines for neither hRSV nor hMPV. Moreover, despite the s...

journal_title：Viruses

authors： Andrade CA,Pacheco GA,Gálvez NMS,Soto JA,Bueno SM,Kalergis AM

更新日期：2020-06-12 00:00:00

abstract：:Janus kinase (JAK) inhibitors have been developed as novel immunomodulatory drugs and primarily used for treating rheumatoid arthritis and other inflammatory diseases. Recent studies have suggested that this category of anti-inflammatory drugs could be potentially useful for the control of inflammation "storms" in res...

journal_title：Viruses

authors： Wang J,Prinz RA,Liu X,Xu X

更新日期：2020-10-08 00:00:00

abstract：:Type-I interferons (IFN-I) play an important role in the innate immune response to several retroviruses. They seem to be effective in controlling the in vivo infection, though many of the clinical signs of retroviral infection may be due to their continual presence which over-stimulates the immune system and activates...

journal_title：Viruses

authors： Gómez-Lucía E,Collado VM,Miró G,Doménech A

更新日期：2009-12-01 00:00:00

abstract：:The International Virus Bioinformatics Meeting 2020 was originally planned to take place in Bern, Switzerland, in March 2020. However, the COVID-19 pandemic put a spoke in the wheel of almost all conferences to be held in 2020. After moving the conference to 8-9 October 2020, we got hit by the second wave and finally ...

journal_title：Viruses

authors： Hufsky F,Beerenwinkel N,Meyer IM,Roux S,Cook GM,Kinsella CM,Lamkiewicz K,Marquet M,Nieuwenhuijse DF,Olendraite I,Paraskevopoulou S,Young F,Dijkman R,Ibrahim B,Kelly J,Le Mercier P,Marz M,Ramette A,Thiel V

更新日期：2020-12-06 00:00:00

abstract：:The extension of virology beyond its traditional medical, veterinary, or agricultural applications, now called environmental virology, has shown that viruses are both the most numerous and diverse biological entities on Earth. In particular, virus isolations from unicellular eukaryotic hosts (heterotrophic and photosy...

journal_title：Viruses

authors： Claverie JM

更新日期：2020-10-06 00:00:00

abstract：:The honey bee queen is the central hub of a colony to produce eggs and release pheromones to maintain social cohesion. Among many environmental stresses, viruses are a major concern to compromise the queen's health and reproductive vigor. Viruses have evolved numerous strategies to infect queens either via vertical tr...

journal_title：Viruses

authors： Amiri E,Strand MK,Tarpy DR,Rueppell O

更新日期：2020-03-17 00:00:00

abstract：:RNA secondary structures play diverse roles in positive-sense (+) RNA virus infections, but those located with the replication protein coding sequence can be difficult to investigate. Structures that regulate the translation of replication proteins pose particular challenges, as their potential involvement in post-tra...

journal_title：Viruses

authors： Sun R,Zhang S,Zheng L,Qu F

更新日期：2020-03-22 00:00:00

abstract：:Lymphoma is one of the most common malignancies in domestic cats. The lymphomagenic potential of Felis catus gammaherpesvirus 1 (FcaGHV1), a common infection in domestic cats, is unknown. In other species, including humans, cellular transformation by gammaherpesviruses is typically mediated by viral genes expressed du...

journal_title：Viruses

authors： Aghazadeh M,Shi M,Pesavento PA,Durham AC,Polley T,Donahoe SL,Troyer RM,Barrs VR,Holmes EC,Beatty JA

更新日期：2018-08-30 00:00:00

abstract：:The family Totiviridae currently contains five genera Totivirus, Victorivirus, Leishmavirus, Trichomonasvirus, and Giardiavirus. Members in this family generally have a set of two-open reading frame (ORF) elements in their genome with the 5'-proximal ORF (ORF1) encoding a capsid protein (CP) and the 3'-proximal one (O...

journal_title：Viruses

authors： Jamal A,Sato Y,Shahi S,Shamsi W,Kondo H,Suzuki N

更新日期：2019-06-25 00:00:00

abstract：:Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees. A total of seventy-five treatment-naïve subjects were enrolled during...

journal_title：Viruses

authors： Turk G,Ghiglione Y,Hormanstorfer M,Laufer N,Coloccini R,Salido J,Trifone C,Ruiz MJ,Falivene J,Holgado MP,Caruso MP,Figueroa MI,Salomón H,Giavedoni LD,Pando MLÁ,Gherardi MM,Rabinovich RD,Pury PA,Sued O

更新日期：2018-01-13 00:00:00

abstract：:The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide analogue (NUC) drugs, and the widespread use of immune stimulators such as interferon-alpha (IFNα) or PEGylated interferon-alpha (PEG-IFNα), sub...

journal_title：Viruses

authors： Duraisamy GS,Bhosale D,Lipenská I,Huvarova I,Růžek D,Windisch MP,Miller AD

更新日期：2020-09-07 00:00:00

abstract：:The Iridoviridae family are large viruses (∼120-200 nm) that contain a linear double-stranded DNA genome. The genomic size of Iridoviridae family members range from 105,903 bases encoding 97 open reading frames (ORFs) for frog virus 3 to 212,482 bases encoding 211 ORFs for Chilo iridescent virus. The family Iridovirid...

journal_title：Viruses

authors： Eaton HE,Ring BA,Brunetti CR

更新日期：2010-07-01 00:00:00

abstract：:Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research l...

journal_title：Viruses

authors： Wahl-Jensen V,Bollinger L,Safronetz D,de Kok-Mercado F,Scott DP,Ebihara H

更新日期：2012-12-14 00:00:00

abstract：:Feline immunodeficiency virus (FIV) is a naturally occurring T-cell tropic lentiviral disease of felids with many similarities to HIV/AIDS in humans. Similar to primate lentiviral-host interactions, feline APOBEC3 (A3) has been shown to inhibit FIV infection in a host-specific manner and feline A3 degradation is media...

journal_title：Viruses

authors： Troyer RM,Malmberg JL,Zheng X,Miller C,MacMillan M,Sprague WS,Wood BA,VandeWoude S

更新日期：2019-09-07 00:00:00

abstract：:Avian influenza virus (AIV) is a highly diverse and widespread poultry pathogen. Itsevolution and adaptation may be affected by multiple host and ecological factors, which are stillpoorly understood. In the present study, a turkey-origin H9N2 AIV was used as a model toinvestigate the within-host diversity of the virus...

journal_title：Viruses

authors： Świętoń E,Tarasiuk K,Olszewska-Tomczyk M,Iwan E,Śmietanka K

更新日期：2020-03-16 00:00:00

abstract：:Viral CD8 T-cell epitopes, represented by viral peptides bound to major histocompatibility complex class-I (MHC-I) glycoproteins, are often identified by "reverse immunology", a strategy not requiring biochemical and structural knowledge of the actual viral protein from which they are derived by antigen processing. In...

journal_title：Viruses

authors： Fink A,Büttner JK,Thomas D,Holtappels R,Reddehase MJ,Lemmermann NA

更新日期：2014-02-14 00:00:00

abstract：:Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man died as a result of renal and respiratory failure after admission to a hospital in Jeddah, Saudi A...

journal_title：Viruses

authors： Chafekar A,Fielding BC

更新日期：2018-02-24 00:00:00

abstract：:A number of characteristics including lack of virulence and the ability to grow to high titers, have made bovine adenovirus-3 (BAdV-3) a vector of choice for further development as a vaccine-delivery vehicle for cattle. Despite the importance of blood leukocytes, including dendritic cells (DC), in the induction of pro...

journal_title：Viruses

authors： Khosa S,Araya MB,Griebel P,Arsic N,Tikoo SK

更新日期：2020-12-12 00:00:00

abstract：:The mosquito antiviral response has mainly been studied in the context of arthropod-borne virus (arbovirus) infection in female mosquitoes. However, in nature, both female and male mosquitoes are frequently infected with insect-specific viruses (ISVs). ISVs are capable of infecting the reproductive organs of both sexe...

journal_title：Viruses

authors： Frangeul L,Blanc H,Saleh MC,Suzuki Y

更新日期：2020-04-21 00:00:00

abstract：:The Gammacoronavirus infectious bronchitis virus (IBV) causes a highly contagious and economically important respiratory disease in poultry. In the laboratory, most IBV strains are restricted to replication in ex vivo organ cultures or in ovo and do not replicate in cell culture, making the study of their basic virolo...

journal_title：Viruses

authors： Stevenson-Leggett P,Keep S,Bickerton E

更新日期：2020-09-29 00:00:00

abstract：:West Nile virus (WNV) is prevalent in Africa, Europe, the Middle East, West Asia, and North America, and causes epidemic encephalitis. To date, no effective therapy for WNV infection has been developed; therefore, there is urgent need to find an efficient method to prevent WNV disease. In this study, we prepared and e...

journal_title：Viruses

authors： Cui J,Zhao Y,Wang H,Qiu B,Cao Z,Li Q,Zhang Y,Yan F,Jin H,Wang T,Sun W,Feng N,Gao Y,Sun J,Wang Y,Perlman S,Zhao J,Yang S,Xia X

更新日期：2016-12-18 00:00:00

abstract：:Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma samples obtained from 50...

journal_title：Viruses

authors： Matsuzawa Y,Iwatsuki-Horimoto K,Nishimoto Y,Abe Y,Fukuyama S,Hamabata T,Okuda M,Go Y,Watanabe T,Imai M,Arai Y,Fouchier RAM,Yamayoshi S,Kawaoka Y

更新日期：2019-10-23 00:00:00

abstract：:We developed an innovative strategy to induce a cytotoxic T cell (CTL) immune response against protein antigens of choice. It relies on the production of exosomes, i.e., nanovesicles spontaneously released by all cell types. We engineered the upload of huge amounts of protein antigens upon fusion with an anchoring pro...

journal_title：Viruses

authors： Di Bonito P,Ridolfi B,Columba-Cabezas S,Giovannelli A,Chiozzini C,Manfredi F,Anticoli S,Arenaccio C,Federico M

更新日期：2015-03-09 00:00:00

abstract：:Bats are an important source of viral zoonoses, including paramyxoviruses. The paramyxoviral Pararubulavirus genus contains viruses mostly derived from bats that are common, diverse, distributed throughout the Old World, and known to be zoonotic. Here, we describe a new member of the genus Achimota pararubulavirus 3 (...

journal_title：Viruses

authors： Baker KS,Tachedjian M,Barr J,Marsh GA,Todd S,Crameri G,Crameri S,Smith I,Holmes CEG,Suu-Ire R,Fernandez-Loras A,Cunningham AA,Wood JLN,Wang LF

更新日期：2020-10-30 00:00:00

abstract：:West Nile virus (WNV) is a member of the genus Flavivirus in the family Flaviviridae. Flaviviruses replicate in the cytoplasm of infected cells and modify the host cell environment. Although much has been learned about virion structure and virion-endosomal membrane fusion, the cell receptor(s) used have not been defin...

journal_title：Viruses

authors： Brinton MA

更新日期：2013-12-27 00:00:00