Innate Immune Components that Regulate the Pathogenesis and Resolution of hRSV and hMPV Infections.

abstract：:Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma samples obtained from 50...

journal_title：Viruses

authors： Matsuzawa Y,Iwatsuki-Horimoto K,Nishimoto Y,Abe Y,Fukuyama S,Hamabata T,Okuda M,Go Y,Watanabe T,Imai M,Arai Y,Fouchier RAM,Yamayoshi S,Kawaoka Y

更新日期：2019-10-23 00:00:00

abstract：:Highly pathogenic avian influenza (HPAI) and Newcastle disease are economically important avian diseases worldwide. Effective vaccination is critical to control these diseases in poultry. Live attenuated Newcastle disease virus (NDV) vectored vaccines have been developed for bivalent vaccination against HPAI viruses a...

journal_title：Viruses

authors： Kim SH,Samal SK

更新日期：2019-03-26 00:00:00

abstract：:Bats provide important ecosystem services as pollinators, seed dispersers, and/or insect controllers, but they have also been found harboring different viruses with zoonotic potential. Virome studies in bats distributed in Asia, Africa, Europe, and North America have increased dramatically over the past decade, wherea...

journal_title：Viruses

authors： Bolatti EM,Zorec TM,Montani ME,Hošnjak L,Chouhy D,Viarengo G,Casal PE,Barquez RM,Poljak M,Giri AA

更新日期：2020-04-09 00:00:00

abstract：:The recent emergence and rapid geographic expansion of Zika virus (ZIKV) poses a significant challenge for public health. Although historically causing only mild febrile illness, recent ZIKV outbreaks have been associated with more severe neurological complications, such as Guillain-Barré syndrome and fetal microcepha...

journal_title：Viruses

authors： Barnard TR,Rajah MM,Sagan SM

更新日期：2018-12-19 00:00:00

abstract：:Photodynamic inactivation (PDI) has been used to inactivate microorganisms through the use of photosensitizers. The inactivation of mammalian viruses and bacteriophages by photosensitization has been applied with success since the first decades of the last century. Due to the fact that mammalian viruses are known to p...

journal_title：Viruses

authors： Costa L,Faustino MA,Neves MG,Cunha A,Almeida A

更新日期：2012-07-01 00:00:00

abstract：:Virus-induced inflammation plays a critical role in determining the clinical outcome of an acute respiratory virus infection. We have shown previously that the administration of immunobiotic Lactobacillus plantarum (Lp) directly to the respiratory tract prevents lethal inflammatory responses to subsequent infection wi...

journal_title：Viruses

authors： Mai E,Percopo CM,Limkar AR,Sek AC,Ma M,Rosenberg HF

更新日期：2020-12-22 00:00:00

abstract：:Countries rely on good diagnostic tests and appropriate testing schemes to fight against economically important small ruminant lentivirus (SRLV) infections. We undertook an extensive comparative analysis of seven commercially available serological tests and one in-house real-time PCR (qPCR) detecting genotype A and B ...

journal_title：Viruses

authors： Michiels R,Van Mael E,Quinet C,Adjadj NR,Cay AB,De Regge N

更新日期：2018-12-08 00:00:00

abstract：:Food security is currently a global socio-political pressure point that is exacerbated by the everincreasing world population[...]. ...

journal_title：Viruses

authors： Mahony J,Casey E,van Sinderen D

更新日期：2020-02-13 00:00:00

abstract：:Rabies is a viral infection that targets the nervous system, specifically neurons. The clinical manifestations of the disease are dramatic and their outcome fatal; paradoxically, conventional histopathological descriptions reveal only subtle changes in the affected nervous tissue. Some researchers have considered that...

journal_title：Viruses

authors： Monroy-Gómez J,Santamaría G,Torres-Fernández O

更新日期：2018-03-06 00:00:00

abstract：:Hepatitis B surface antigen (HBsAg) promotes persistent hepatitis B virus (HBV) infection. It primarily corresponds to small (S) envelope protein secreted as subviral particles. We previously found that genotype D clones expressed less S protein than genotype A clones but showed higher extracellular/intracellular rati...

journal_title：Viruses

authors： Wang Q,Fu S,Zhang J,Yuan Q,Li J,Xia N,Wen YM,Wang Y,Tong S

更新日期：2020-09-01 00:00:00

abstract：:Influenza virus is among the most common causes of respiratory illness worldwide and can be complicated by secondary bacterial pneumonia, a frequent cause of mortality. When influenza virus infects the lung, the innate immune response is activated, and interferons and inflammatory mediators are released. This "cytokin...

journal_title：Viruses

authors： Gopal R,Mendy A,Marinelli MA,Richwalls LJ,Seger PJ,Patel S,McHugh KJ,Rich HE,Grousd JA,Forno E,Alcorn JF

更新日期：2019-06-01 00:00:00

abstract：:Exosomes are extracellular vesicles released upon fusion of multivesicular bodies(MVBs) with the cellular plasma membrane. They originate as intraluminal vesicles (ILVs) during the process of MVB formation. Exosomes were shown to contain selectively sorted functional proteins, lipids, and RNAs, mediating cell-to-cell ...

journal_title：Viruses

authors： Alenquer M,Amorim MJ

更新日期：2015-09-17 00:00:00

abstract：:Peste des petits ruminants virus (PPRV) causes a contagious disease of high morbidity and mortality in global sheep and goat populations. To better control this disease and inform eradication strategies, an improved understanding of how PPRV transmission risk varies by age is needed. Our study used a piece-wise cataly...

journal_title：Viruses

authors： Herzog CM,de Glanville WA,Willett BJ,Cattadori IM,Kapur V,Hudson PJ,Buza J,Swai ES,Cleaveland S,Bjørnstad ON

更新日期：2020-02-07 00:00:00

abstract：:Enteroviruses, the most common human viral pathogens worldwide, have been associated with serous meningitis, encephalitis, syndrome of acute flaccid paralysis, myocarditis and the onset of diabetes type 1. In the future, the rapid identification of the etiological agent would allow to adjust the therapy promptly and t...

journal_title：Viruses

authors： Krasota A,Loginovskih N,Ivanova O,Lipskaya G

更新日期：2016-01-06 00:00:00

abstract：:Duck Tembusu virus (DTMUV) is a recently emerging pathogenic flavivirus that has resulted in a huge economic loss in the duck industry. However, no vaccine is currently available to control this pathogen. Consequently, a practical strategy to construct a vaccine against this pathogen should be determined. In this stud...

journal_title：Viruses

authors： Zou Z,Liu Z,Jin M

更新日期：2014-06-20 00:00:00

abstract：:Peste des Petits Ruminants (PPR) is a highly infectious disease caused by a virus of the Morbillivirus genus. The current PPR eradication effort relies mainly on the implementation of massive vaccination campaigns. One of the most widely used PPR vaccines is the Nigeria 75/1 strain obtained after attenuation by 75 ser...

journal_title：Viruses

authors： Eloiflin RJ,Boyer M,Kwiatek O,Guendouz S,Loire E,Servan de Almeida R,Libeau G,Bataille A

更新日期：2019-08-07 00:00:00

abstract：:The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system is widely explored for sequence-specific attack on HIV-1 proviral DNA. We recently identified dual-guide RNA (dual-gRNA) combinations that can block HIV-1 replication permanently in infected cell cultures and prevent viral escape. Altho...

journal_title：Viruses

authors： Darcis G,Binda CS,Klaver B,Herrera-Carrillo E,Berkhout B,Das AT

更新日期：2019-03-13 00:00:00

abstract：:Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore,...

journal_title：Viruses

authors： Felmlee DJ,Hafirassou ML,Lefevre M,Baumert TF,Schuster C

更新日期：2013-05-23 00:00:00

abstract：:Janus kinase (JAK) inhibitors have been developed as novel immunomodulatory drugs and primarily used for treating rheumatoid arthritis and other inflammatory diseases. Recent studies have suggested that this category of anti-inflammatory drugs could be potentially useful for the control of inflammation "storms" in res...

journal_title：Viruses

authors： Wang J,Prinz RA,Liu X,Xu X

更新日期：2020-10-08 00:00:00

abstract：:Monkeypox is a smallpox-like illness that can be accompanied by a range of significant medical complications. To date there are no standard or optimized guidelines for the clinical management of monkeypox (MPX) patients, particularly in low-resource settings. Consequently, patients can experience protracted illness an...

journal_title：Viruses

authors： Reynolds MG,McCollum AM,Nguete B,Shongo Lushima R,Petersen BW

更新日期：2017-12-12 00:00:00

abstract：:CD4 and CD8 T lymphocytes are adaptive immune cells that play a key role in the immune response to pathogens. They have been extensively studied in a variety of model systems and the mechanisms by which they function are well described. However, the responses by these cell types vary widely from pathogen to pathogen. ...

journal_title：Viruses

authors： Netland J,Bevan MJ

更新日期：2013-10-22 00:00:00

abstract：:An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a membrane-anchored form of the SARS-CoV-2 spike receptor binding domain (RBD) in place of the neuraminidase (NA) coding sequence in an influenza viru...

journal_title：Viruses

authors： Loes AN,Gentles LE,Greaney AJ,Crawford KHD,Bloom JD

更新日期：2020-09-05 00:00:00

abstract：:Enteric viral co-infections, infections involving more than one virus, have been reported for a diverse group of etiological agents, including rotavirus, norovirus, astrovirus, adenovirus, and enteroviruses. These pathogens are causative agents for acute gastroenteritis and diarrheal disease in immunocompetent and imm...

journal_title：Viruses

authors： Makimaa H,Ingle H,Baldridge MT

更新日期：2020-08-18 00:00:00

abstract：:BST-2 or tetherin is a host cell restriction factor that prevents the budding of enveloped viruses at the cell surface, thus impairing the viral spread. Several countermeasures to evade this antiviral factor have been positively selected in retroviruses: the human immunodeficiency virus type 2 (HIV-2) relies on the en...

journal_title：Viruses

authors： Dufrasne FE,Lombard C,Goubau P,Ruelle J

更新日期：2016-10-14 00:00:00

abstract：:Since 2015, severe hydropericardium-hepatitis syndrome (HHS), caused by a highly pathogenic fowl adenovirus 4 (FAdV-4), emerged in China. In our previous study, the FAdV-4 has been identified as a novel genotype with a unique 1966-bp nucleotide deletion (1966Del) between open reading frame 42 and 43. In this study, th...

journal_title：Viruses

authors： Pan Q,Wang J,Gao Y,Cui H,Liu C,Qi X,Zhang Y,Wang Y,Wang X

更新日期：2018-09-13 00:00:00

abstract：:Nef proteins from all primate Lentiviruses, including the simian immunodeficiency virus of chimpanzees (SIVcpz), increase viral progeny infectivity. However, the function of Nef involved with the increase in viral infectivity is still not completely understood. Nonetheless, until now, studies investigating the functio...

journal_title：Viruses

authors： Sabino Cunha M,Lima Sampaio T,Peterlin BM,Jesus da Costa L

更新日期：2016-07-07 00:00:00

abstract：:Currently, only three phages that infect the medically important bacterium Clostridium difficile have been discussed by the International Committee of Viral Taxonomy (ICTV). They are all myoviruses, and have been assigned to the genus "phicd119likevirus". An additional nine phages have since been described in the lite...

journal_title：Viruses

authors： Hargreaves KR,Clokie MR

更新日期：2015-05-21 00:00:00

abstract：:Timely implementation of antiviral treatment and other public health based responses are dependent on accurate and rapid diagnosis of the novel pandemic influenza A(H1N1) strain. In this study we developed a duplex real-time PCR (RT-PCR) (dFLU-TM) assay for the simultaneous detection of a broad range of influenza A su...

journal_title：Viruses

authors： Rockett RJ,Bialasiewicz S,Whiley DM,Bletchly C,Faux CE,Lambert SB,Nimmo GR,Nissen MD,Sloots TP

更新日期：2009-12-01 00:00:00

abstract：:African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected soft tick bites. As already described, European soft ticks (Orni...

journal_title：Viruses

authors： Pereira De Oliveira R,Hutet E,Duhayon M,Guionnet JM,Paboeuf F,Vial L,Le Potier MF

更新日期：2020-03-11 00:00:00

abstract：:The two human oncogenic -herpesviruses, Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV), are prototypic pathogens that are controlled by T cell responses. Despite their ubiquitous distribution, persistent infections and transforming potential, most carriers' immune systems control them for li...

journal_title：Viruses

authors： Münz C

更新日期：2019-12-05 00:00:00