A Novel Duplex Real-Time Reverse-Transcription PCR Assay for the Detection of Influenza A and the Novel Influenza A(H1N1) Strain.

abstract：:The ability of a cell to combat an intracellular pathogen requires a mechanism to recognize the threat and elicit a transcriptional response against it. In the context of virus infection, the cell must take measures to inhibit viral replication, meanwhile, convey warning signals to neighboring cells of the imminent th...

journal_title：Viruses

authors： Pham AM,Tenoever BR

更新日期：2010-01-01 00:00:00

abstract：:Although most hepatitis E virus (HEV) infections are asymptomatic, some can be severe, causing fulminant hepatitis and extra-hepatic manifestations, including neurological and kidney injuries. Chronic HEV infections may also occur in immunocompromised patients. This review describes how our understanding of the pathog...

journal_title：Viruses

authors： Lhomme S,Marion O,Abravanel F,Chapuy-Regaud S,Kamar N,Izopet J

更新日期：2016-08-05 00:00:00

abstract：:Background: Bats are known to host a number of nonpathogenic viruses, as well as highly pathogenic viruses causing fatal diseases like rabies. Serological surveys as part of active and passive bat rabies surveillance mainly use seroneutralization assays, demonstrating the presence of lyssavirus-specific antibodies in ...

journal_title：Viruses

authors： Orłowska A,Smreczak M,Freuling CM,Müller T,Trębas P,Rola J

更新日期：2020-02-28 00:00:00

abstract：:Sandfly-borne phleboviruses pathogenic to humans, such as Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV), are endemic in the Mediterranean region. In France, several autochthonous cases of TOSV infection have been described, causing either meningitis or encephalitis. The aim of the present study was to i...

journal_title：Viruses

authors： Masse S,Ayhan N,Capai L,Bosseur F,de Lamballerie X,Charrel R,Falchi A

更新日期：2019-09-04 00:00:00

abstract：:A myriad of factors favor the emergence and re-emergence of arthropod-borne viruses (arboviruses), including migration, climate change, intensified livestock production, an increasing volume of international trade and transportation, and changes to ecosystems (e.g., deforestation and loss of biodiversity). Consequentl...

journal_title：Viruses

authors： Hollidge BS,Weiss SR,Soldan SS

更新日期：2011-06-01 00:00:00

abstract：:A lytic bacteriophage PHB01 specific for Pasteurella multocida type D was isolated from the sewage water collected from a pig farm. This phage had the typical morphology of the family Podoviridae, order Caudovirales, presenting an isometric polyhedral head and a short noncontractile tail. PHB01 was able to infect most...

journal_title：Viruses

authors： Chen Y,Guo G,Sun E,Song J,Yang L,Zhu L,Liang W,Hua L,Peng Z,Tang X,Chen H,Wu B

更新日期：2019-01-21 00:00:00

abstract：:It has been demonstrated that MEK1, one of the two MEK isoforms in Raf-MEK-ERK1/2 pathway, is essential for successful EV71 propagation. However, the distinct function of ERK1 and ERK2 isoforms, the downstream kinases of MEKs, remains unclear in EV71 replication. In this study, specific ERK siRNAs and selective inhibi...

journal_title：Viruses

authors： Zhu M,Duan H,Gao M,Zhang H,Peng Y

更新日期：2015-03-20 00:00:00

abstract：:We describe herein, limitations on research at biosafety level 4 (BSL-4) containment laboratories, with regard to biosecurity regulations, safety considerations, research space limitations, and physical constraints in executing experimental procedures. These limitations can severely impact the number of collaborations...

journal_title：Viruses

authors： Shurtleff AC,Garza N,Lackemeyer M,Carrion R Jr,Griffiths A,Patterson J,Edwin SS,Bavari S

更新日期：2012-12-01 00:00:00

abstract：:Monoderm bacteria possess a cell envelope made of a cytoplasmic membrane and a cell wall, whereas diderm bacteria have and extra lipid layer, the outer membrane, covering the cell wall. Both cell types can also produce extracellular protective coats composed of polymeric substances like, for example, polysaccharidic c...

journal_title：Viruses

authors： Fernandes S,São-José C

更新日期：2018-07-27 00:00:00

abstract：:Simian hemorrhagic fever virus (SHFV) causes a fulminant and typically lethal viral hemorrhagic fever (VHF) in macaques (Cercopithecinae: Macaca spp.) but causes subclinical infections in patas monkeys (Cercopithecinae: Erythrocebus patas). This difference in disease course offers a unique opportunity to compare host ...

journal_title：Viruses

authors： Cornish JP,Moore IN,Perry DL,Lara A,Minai M,Promeneur D,Hagen KR,Virtaneva K,Paneru M,Buechler CR,O'Connor DH,Bailey AL,Cooper K,Mazur S,Bernbaum JG,Pettitt J,Jahrling PB,Kuhn JH,Johnson RF

更新日期：2019-01-15 00:00:00

abstract：:There is an ongoing global pandemic of human respiratory syncytial virus (RSV) infection that results in substantial annual morbidity and mortality. In Australia, RSV is a major cause of acute lower respiratory tract infections (ALRI). Nevertheless, little is known about the extent and origins of the genetic diversity...

journal_title：Viruses

authors： Di Giallonardo F,Kok J,Fernandez M,Carter I,Geoghegan JL,Dwyer DE,Holmes EC,Eden JS

更新日期：2018-09-06 00:00:00

abstract：:Hepatitis C is a major global health burden with an estimated 160 million infected individuals worldwide. This long-term disease evolves slowly, often leading to chronicity and potentially to liver failure. There is no anti-HCV vaccine, and, until recently, the only treatment available, based on pegylated interferon a...

journal_title：Viruses

authors： Calland N,Dubuisson J,Rouillé Y,Séron K

更新日期：2012-10-17 00:00:00

abstract：:Viral encephalitis causes acute inflammation of the brain parenchyma and is a significant cause of human morbidity and mortality. Although Herpes Simplex encephalitis is the most frequent known cause of fatal sporadic encephalitis in humans, an increasingly wide range of viruses and other microbial pathogens are impli...

journal_title：Viruses

authors： Kennedy PGE,Quan PL,Lipkin WI

更新日期：2017-06-06 00:00:00

abstract：:The use of the rabies vaccine for post-exposure prophylaxis started as early as 1885, revealing a safe and efficient tool to prevent human rabies cases. Preventive vaccination is the basis for the control of canine-mediated rabies, which has already been eliminated from extensive parts of the world, including Europe. ...

journal_title：Viruses

authors： Echevarría JE,Banyard AC,McElhinney LM,Fooks AR

更新日期：2019-09-24 00:00:00

abstract：:Since the emergence of NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) in China in 2013, PRRSVs have undergone rapid evolution. In this study, a novel variant of PRRSV strain (designated SCcd17) was successfully isolated from piglets with clinical signs in Sichuan Province in China in 2017, and...

journal_title：Viruses

authors： Zhou L,Kang R,Xie B,Tian Y,Wu X,Lv X,Yang X,Wang H

更新日期：2018-03-27 00:00:00

abstract：:Positive-strand RNA (+RNA) viruses are an important group of human and animal pathogens that have significant global health and economic impacts. Notable members include West Nile virus, Dengue virus, Chikungunya, Severe acute respiratory syndrome (SARS) Coronavirus and enteroviruses of the Picornaviridae family.Unfor...

journal_title：Viruses

authors： Reid CR,Airo AM,Hobman TC

更新日期：2015-08-06 00:00:00

abstract：:Rabies is a highly fatal zoonotic disease which is primarily caused by rabies virus (RABV) although other members of the genus Lyssavirus can cause rabies as well. As yet, 14 serologically and genetically diverse lyssaviruses have been identified, mostly in bats. To assess the quality of rabies vaccines and immunoglob...

journal_title：Viruses

authors： Moeschler S,Locher S,Conzelmann KK,Krämer B,Zimmer G

更新日期：2016-09-16 00:00:00

abstract：:Influenza A viruses (IAV) have been a major public health threat worldwide, and options for antiviral therapy become increasingly limited with the emergence of drug-resisting virus strains. New and effective anti-IAV drugs, especially for highly pathogenic influenza, with different modes of action, are urgently needed...

journal_title：Viruses

authors： Ye M,Liao Y,Wu L,Qi W,Choudhry N,Liu Y,Chen W,Song G,Chen J

更新日期：2020-02-18 00:00:00

abstract：:Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-...

journal_title：Viruses

authors： Usadi B,Bruhn R,Lin J,Lee TH,Blackburn E,Murphy EL

更新日期：2016-08-11 00:00:00

abstract：:Coronaviruses are enveloped RNA viruses capable of causing respiratory, enteric, or systemic diseases in a variety of mammalian hosts that vary in clinical severity from subclinical to fatal. The host range and tissue tropism are largely determined by the coronaviral spike protein, which initiates cellular infection b...

journal_title：Viruses

authors： Haake C,Cook S,Pusterla N,Murphy B

更新日期：2020-09-13 00:00:00

abstract：:RNA secondary structures play diverse roles in positive-sense (+) RNA virus infections, but those located with the replication protein coding sequence can be difficult to investigate. Structures that regulate the translation of replication proteins pose particular challenges, as their potential involvement in post-tra...

journal_title：Viruses

authors： Sun R,Zhang S,Zheng L,Qu F

更新日期：2020-03-22 00:00:00

abstract：:Although there have been many epidemiological reports of the inter-country transmission of measles, systematic analysis of the global transmission dynamics of the measles virus (MV) is limited. In this study, we applied phylogeographic analysis to characterize the global transmission dynamics of the MV using large-sca...

journal_title：Viruses

authors： Furuse Y,Oshitani H

更新日期：2017-04-16 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the etiological agent for a serious lower respiratory tract disease responsible for close to 200,000 annual deaths worldwide. The first infection is generally most severe, while re-infections usually associate with a milder disease. This observation and the finding that re-infecti...

journal_title：Viruses

authors： Rudraraju R,Jones BG,Sealy R,Surman SL,Hurwitz JL

更新日期：2013-02-05 00:00:00

abstract：:Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma samples obtained from 50...

journal_title：Viruses

authors： Matsuzawa Y,Iwatsuki-Horimoto K,Nishimoto Y,Abe Y,Fukuyama S,Hamabata T,Okuda M,Go Y,Watanabe T,Imai M,Arai Y,Fouchier RAM,Yamayoshi S,Kawaoka Y

更新日期：2019-10-23 00:00:00

abstract：:The HIV/AIDS epidemic remains a global health problem, especially in Sub-Saharan Africa. An effective HIV-1 vaccine is therefore badly required to mitigate this ever-expanding problem. Since HIV-1 infects its host through the mucosal surface, a vaccine for the virus needs to trigger mucosal as well as systemic immune ...

journal_title：Viruses

authors： Chin'ombe N

更新日期：2013-08-28 00:00:00

abstract：:Evidence that Hepatitis D virus (HDV) genotype is involved in HDV infection pathogenesis is increasing. Indeed, HDV genotypes have been shown to be linked to different outcomes in terms of liver fibrosis and treatment response. Herein, we show that the promising HDVdb genotyping tool available online can lead to wrong...

journal_title：Viruses

authors： Charre C,le Gal F,Dény P,Scholtès C

更新日期：2020-09-23 00:00:00

abstract：:Small Ruminant Lentiviruses (SRLVs) are widespread in many countries and cause economically relevant, slow, and persistent diseases in sheep and goats. Monitoring the genetic diversity of SRLVs is useful to improve the diagnostic tools used in the eradication programs. In this study, SRLVs detected in Spanish Assaf sh...

journal_title：Viruses

authors： Gayo E,Cuteri V,Polledo L,Rossi G,García Marín JF,Preziuso S

更新日期：2018-06-09 00:00:00

abstract：BACKGROUND:Retroviruses rely on host factors for cell entry, replication, transcription, and other major steps during their life cycle. Human Immunodeficiency Virus-1 (HIV-1) is well known for utilizing a plethora of strategies to evade the host immune response, including the establishment of latent infection within a ...

journal_title：Viruses

authors： Vemula SV,Veerasamy R,Ragupathy V,Biswas S,Devadas K,Hewlett I

更新日期：2015-02-05 00:00:00

abstract：:With ongoing colony losses driven in part by the Varroa mite and the associated exacerbation of the virus load, there is an urgent need to protect honey bees (Apis mellifera) from fatal levels of virus infection and from the non-target effects of insecticides used in agricultural settings. A continuously replicating c...

journal_title：Viruses

authors： Guo Y,Goodman CL,Stanley DW,Bonning BC

更新日期：2020-02-20 00:00:00

abstract：:Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in m...

journal_title：Viruses

authors： Warfield KL,Barnard DL,Enterlein SG,Smee DF,Khaliq M,Sampath A,Callahan MV,Ramstedt U,Day CW

更新日期：2016-03-07 00:00:00