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Respiratory syncytial virus: current progress in vaccine development.

Abstract：

:Respiratory syncytial virus (RSV) is the etiological agent for a serious lower respiratory tract disease responsible for close to 200,000 annual deaths worldwide. The first infection is generally most severe, while re-infections usually associate with a milder disease. This observation and the finding that re-infection risks are inversely associated with neutralizing antibody titers suggest that immune responses generated toward a first RSV exposure can significantly reduce morbidity and mortality throughout life. For more than half a century, researchers have endeavored to design a vaccine for RSV that can mimic or improve upon natural protective immunity without adverse events. The virus is herein described together with the hurdles that must be overcome to develop a vaccine and some current vaccine development approaches.

journal_name

Viruses

journal_title

Viruses

authors

Rudraraju R,Jones BG,Sealy R,Surman SL,Hurwitz JL

doi

10.3390/v5020577

subject

Has Abstract

pub_date

2013-02-05 00:00:00

pages

577-94

issue

2

issn

1999-4915

pii

v5020577

journal_volume

5

pub_type

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