Abstract:
:Herpesviruses use a vesicle-mediated transfer of intranuclearly assembled nucleocapsids through the nuclear envelope (NE) for final maturation in the cytoplasm. The molecular basis for this novel vesicular nucleo-cytoplasmic transport is beginning to be elucidated in detail. The heterodimeric viral nuclear egress complex (NEC), conserved within the classical herpesviruses, mediates vesicle formation from the inner nuclear membrane (INM) by polymerization into a hexagonal lattice followed by fusion of the vesicle membrane with the outer nuclear membrane (ONM). Mechanisms of capsid inclusion as well as vesicle-membrane fusion, however, are largely unclear. Interestingly, a similar transport mechanism through the NE has been demonstrated in nuclear export of large ribonucleoprotein complexes during Drosophila neuromuscular junction formation, indicating a widespread presence of a novel concept of cellular nucleo-cytoplasmic transport.
journal_name
Virusesjournal_title
Virusesauthors
Mettenleiter TCdoi
10.3390/v8100266subject
Has Abstractpub_date
2016-09-27 00:00:00issue
10issn
1999-4915pii
v8100266journal_volume
8pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract::Human cytomegalovirus (HCMV), the largest human herpesvirus, infects a majority of the world's population. Like all herpesviruses, following primary productive infection, HCMV establishes a life-long latent infection, from which it can reactivate years later to produce new, infectious virus. Despite the presence of a ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4112448
更新日期:2012-10-25 00:00:00
abstract::The Bunyaviridae is the largest family of RNA viruses, with over 350 members worldwide. Several of these viruses cause severe diseases in livestock and humans. With an increasing number and frequency of outbreaks, bunyaviruses represent a growing threat to public health and agricultural productivity globally. Yet, the...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v8050143
更新日期:2016-05-24 00:00:00
abstract::Influenza A virus (IAV) in swine, so-called swine influenza A virus (swIAV), causes respiratory illness in pigs around the globe. In Danish pig herds, a H1N2 subtype named H1N2dk is one of the main circulating swIAV. In this cohort study, the infection dynamic of swIAV was evaluated in a Danish pig herd by sampling an...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12091013
更新日期:2020-09-10 00:00:00
abstract::Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk asses...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9110318
更新日期:2017-10-29 00:00:00
abstract::Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) systems are key immune mechanisms helping prokaryotic species fend off RNA and DNA viruses. CRISPR/Cas9 has broad applications in basic research and biotechnology and has been widely used across eukaryotic species for genome...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10120732
更新日期:2018-12-19 00:00:00
abstract::Commentary on Pais-Correia, A.M.; Sachse, M.; Guadagnini, S.; Robbiati, V.; Lasserre, R.; Gessain, A.; Gout, O.; Alcover, A.; Thoulouze, M.I. Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses. Nat. Med.2010, 16, 83-89. ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2020601
更新日期:2010-02-01 00:00:00
abstract::The complete sequence and genome organization of a novel Endornavirus from the hypovirulent strain GD-2 of Rhizoctonia solani AG-1 IA, the causal agent of rice sheath blight, were identified using a deep sequencing approach and it was tentatively named as Rhizoctonia solani endornavirus 1 (RsEV1). It was composed of o...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020178
更新日期:2019-02-20 00:00:00
abstract:BACKGROUND:Retroviruses rely on host factors for cell entry, replication, transcription, and other major steps during their life cycle. Human Immunodeficiency Virus-1 (HIV-1) is well known for utilizing a plethora of strategies to evade the host immune response, including the establishment of latent infection within a ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7020543
更新日期:2015-02-05 00:00:00
abstract::Influenza A virus (IAV) has caused seasonal influenza epidemics and influenza pandemics, which resulted in serious threat to public health and socioeconomic impacts. Until now, only 5 drugs belong to two categories are used for prophylaxis and treatment of IAV infection. Hemagglutinin (HA), the envelope glycoprotein o...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5010352
更新日期:2013-01-22 00:00:00
abstract::Mutations are incorporated into the genomes of RNA viruses at an optimal frequency and altering this precise frequency has been proposed as a strategy to create live-attenuated vaccines. However, determining the effect of specific mutations that alter fidelity has been difficult because of the rapid selection of the v...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12050546
更新日期:2020-05-15 00:00:00
abstract::While bats are increasingly recognized as a source of coronavirus epidemics, the diversity and emergence potential of bat coronaviruses remains to be fully understood. Among 1779 bat samples collected in China, diverse coronaviruses were detected in 32 samples from five different bat species by RT-PCR. Two novel alpha...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11050423
更新日期:2019-05-07 00:00:00
abstract::The human cytomegalovirus (HCMV)-encoded cyclin-dependent kinase (CDK) ortholog pUL97 associates with human cyclin B1 and other types of cyclins. Here, the question was addressed whether cyclin interaction of pUL97 and additional viral proteins is detectable by mass spectrometry-based approaches. Proteomic data were v...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8080219
更新日期:2016-08-18 00:00:00
abstract::The genomes of polyomaviruses are characterized by their tripartite organization with an early region, a late region and a noncoding control region (NCCR). The early region encodes proteins involved in replication and transcription of the viral genome, while expression of the late region generates the capsid proteins....
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12121406
更新日期:2020-12-07 00:00:00
abstract::Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures tha...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10120720
更新日期:2018-12-17 00:00:00
abstract::The objective of this study was to evaluate the effects of A3R phage and Staphylococcus aureus lysate obtained after phage infection on neutrophil degranulation. The exocytosis of primary and secondary granules from neutrophils was investigated in vitro in whole blood specimens by flow cytometry based on the expressio...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9020036
更新日期:2017-02-21 00:00:00
abstract::Kaposi's sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes. KSHV infection is typically asymptomatic, but immunosuppression can predispose KSHV-infected individuals to primary effusion lymphoma (PEL); a malignancy ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12010012
更新日期:2019-12-20 00:00:00
abstract::Glycoprotein B (gB) plays an important role in alphaherpesvirus cellular entry and acts in concert with gD and the gH/gL complex. To evaluate whether functional differences exist between gB1 and gB4, the corresponding genes were exchanged between the two viruses. The gB4-containing-EHV-1 (EHV-1_gB4) recombinant virus ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7020522
更新日期:2015-02-03 00:00:00
abstract::Viral lysis is a main mortality factor for bacteria in deep-sea sediments, leading to changing microbial community structures and the release of cellular components to the environment. Nature and fate of these compounds and the role of viruses for microbial diversity is largely unknown. We investigated the effect of v...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12090922
更新日期:2020-08-22 00:00:00
abstract::The virion proteins of Kaposi sarcoma-associated herpesvirus (KSHV) were initially characterized in 2005 in two separate studies that combined the detection of 24 viral proteins and a few cellular components via LC-MS/MS or MALDI-TOF. Despite considerable advances in the sensitivity and specificity of mass spectrometr...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121382
更新日期:2020-12-02 00:00:00
abstract::Half a century of research on membrane-containing phages has had a major impact on virology, providing new insights into virus diversity, evolution and ecological importance. The recent revolutionary technical advances in imaging, sequencing and lipid analysis have significantly boosted the depth and volume of knowled...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11010076
更新日期:2019-01-18 00:00:00
abstract::RNA viruses are extraordinary evolution machines that efficiently ensure their replication by taking advantage of the association with viral and cellular components to form ribonucleic complexes (vRNPs) [...]. ...
journal_title:Viruses
pub_type: 社论
doi:10.3390/v12121355
更新日期:2020-11-26 00:00:00
abstract::HIV-1 is a global health crisis that has infected more than 37 million people. Latent reservoirs throughout the body are a major hurdle when it comes to eradicating the virus. In our previous study, we found that exosomes, a type of extracellular vesicle (EV), from uninfected cells activate the transcription of HIV-1 ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12060665
更新日期:2020-06-19 00:00:00
abstract::The development of high-throughput technologies allows for evaluating gene expression at the whole-genome level. Together with proteomic and metabolomic studies, these analyses have resulted in the identification of plant genes whose function or expression is altered as a consequence of pathogen attacks. Members of th...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5030998
更新日期:2013-03-22 00:00:00
abstract::The MinION sequencer is increasingly being used for the detection and outbreak surveillance of pathogens due to its rapid throughput. For RNA viruses, MinION's new direct RNA sequencing is the next significant development. Direct RNA sequencing studies are currently limited and comparisons of its diagnostic performanc...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12080801
更新日期:2020-07-25 00:00:00
abstract::The honey bee queen is the central hub of a colony to produce eggs and release pheromones to maintain social cohesion. Among many environmental stresses, viruses are a major concern to compromise the queen's health and reproductive vigor. Viruses have evolved numerous strategies to infect queens either via vertical tr...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12030322
更新日期:2020-03-17 00:00:00
abstract::Usutu virus (USUV) is a neurotropic flavivirus closely related to West Nile virus (WNV). Its enzootic cycle mainly involves mosquitoes and birds. Human infection can occur with occasional, but sometimes severe, neurological complications. Since its emergence and spread in Europe over the last two decades, USUV has bee...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12020164
更新日期:2020-01-31 00:00:00
abstract::The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on differ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v1020276
更新日期:2009-09-01 00:00:00
abstract::Astroviral infection is considered to be one of the causes of mammalian diarrheal diseases. It has been shown that astrovirus infections cause varying degrees of diarrhea in turkeys and mice. However, the pathogenesis of porcine astrovirus is unknown. In this study, the virulence of a cytopathic porcine astrovirus (PA...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11121156
更新日期:2019-12-13 00:00:00
abstract::Enteric viral co-infections, infections involving more than one virus, have been reported for a diverse group of etiological agents, including rotavirus, norovirus, astrovirus, adenovirus, and enteroviruses. These pathogens are causative agents for acute gastroenteritis and diarrheal disease in immunocompetent and imm...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12080904
更新日期:2020-08-18 00:00:00
abstract::Cotton leaf curl disease (CLCuD) is one of the most economically important diseases and is a constraint to cotton production in major producers, Pakistan and India. CLCuD is caused by monopartite plant viruses belonging to the family Geminiviridae (genus Begomovirus), in association with an essential, disease-specific...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9100280
更新日期:2017-09-29 00:00:00